KR102415259B1 - 조작된 고-친화도의 인간 t 세포 수용체 - Google Patents

조작된 고-친화도의 인간 t 세포 수용체 Download PDF

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KR102415259B1
KR102415259B1 KR1020167016131A KR20167016131A KR102415259B1 KR 102415259 B1 KR102415259 B1 KR 102415259B1 KR 1020167016131 A KR1020167016131 A KR 1020167016131A KR 20167016131 A KR20167016131 A KR 20167016131A KR 102415259 B1 KR102415259 B1 KR 102415259B1
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tcr
modified
cell receptor
antigen
amino acid
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KR20160087866A (ko
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시나 엔. 스미스
다니엘 티. 해리스
데이비드 엠. 크란츠
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더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020167016131A 2013-11-22 2014-11-21 조작된 고-친화도의 인간 t 세포 수용체 Active KR102415259B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361907887P 2013-11-22 2013-11-22
US61/907,887 2013-11-22
PCT/US2014/066892 WO2015077607A1 (en) 2013-11-22 2014-11-21 Engineered high-affinity human t cell receptors

Publications (2)

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KR20160087866A KR20160087866A (ko) 2016-07-22
KR102415259B1 true KR102415259B1 (ko) 2022-06-30

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KR1020167016132A Ceased KR20160085345A (ko) 2013-11-22 2014-11-21 조작된 고-친화도의 인간 t 세포 수용체

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US (4) US10023625B2 (enExample)
EP (2) EP3071594A4 (enExample)
JP (4) JP6476182B2 (enExample)
KR (2) KR102415259B1 (enExample)
CN (2) CN105873945B (enExample)
AU (4) AU2014352826B2 (enExample)
BR (1) BR112016011567A2 (enExample)
CA (2) CA2930847A1 (enExample)
DK (1) DK3071593T3 (enExample)
ES (1) ES2729406T3 (enExample)
IL (2) IL245468B (enExample)
MX (3) MX383471B (enExample)
PL (1) PL3071593T3 (enExample)
PT (1) PT3071593T (enExample)
RU (2) RU2729383C2 (enExample)
SA (1) SA516371174B1 (enExample)
SG (2) SG10201804335QA (enExample)
TR (1) TR201908404T4 (enExample)
WO (2) WO2015077607A1 (enExample)
ZA (2) ZA201603116B (enExample)

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EP3520810A3 (en) 2012-01-13 2019-11-06 Memorial Sloan-Kettering Cancer Center Immunogenic wt1 peptides and use thereof
PL2945647T3 (pl) 2013-01-15 2021-03-08 Memorial Sloan Kettering Cancer Center Immunogenne peptydy wt-1 i sposoby ich zastosowania
US10815273B2 (en) 2013-01-15 2020-10-27 Memorial Sloan Kettering Cancer Center Immunogenic WT-1 peptides and methods of use thereof
EP3071594A4 (en) 2013-11-22 2017-05-03 The Board of Trustees of the University of Illionis Engineered high-affinity human t cell receptors
CN108601849A (zh) * 2015-09-22 2018-09-28 尤利乌斯·马克西米利安维尔茨堡大学 一种在淋巴细胞中高水平的和稳定的基因转移的方法
US12364757B2 (en) 2015-10-01 2025-07-22 Ospedale San Raffaele S.R.L TCR and uses thereof
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EP3394092A1 (en) * 2015-12-23 2018-10-31 Fred Hutchinson Cancer Research Center High affinity t cell receptors and uses thereof
MA45491A (fr) * 2016-06-27 2019-05-01 Juno Therapeutics Inc Épitopes à restriction cmh-e, molécules de liaison et procédés et utilisations associés
CA3042890A1 (en) 2016-11-14 2018-05-17 Fred Hutchinson Cancer Research Center High affinity merkel cell polyomavirus t antigen-specific tcrs and uses thereof
MX2019010972A (es) * 2017-03-15 2019-12-02 Hutchinson Fred Cancer Res Receptores de linfocito t (tcr) específicos del antígeno asociado a melanoma 1 (mage-a1) de alta afinidad y usos de estos.
CN110785432B (zh) * 2017-04-24 2024-12-27 圣拉斐尔医院有限责任公司 Tcr和肽
JP7181517B2 (ja) 2018-01-23 2022-12-01 国立大学法人三重大学 Ｔ細胞レセプター
CN112739339B (zh) * 2018-07-23 2024-12-27 海德堡医药研究有限责任公司 抗cd137抗体药物缀合物(adc)在同种异体细胞疗法中的用途
WO2020185796A1 (en) 2019-03-11 2020-09-17 Fred Hutchinson Cancer Research Center High avidity wt1 t cell receptors and uses thereof
GB201911066D0 (en) 2019-08-02 2019-09-18 Achilles Therapeutics Ltd T cell therapy
CN114555790B (zh) * 2019-08-20 2025-02-25 弗雷德哈钦森癌症中心 Wt-1特异性t细胞免疫疗法
CN115335404A (zh) * 2020-02-12 2022-11-11 艾伯维公司 双特异性结合分子
KR20230002554A (ko) 2020-04-28 2023-01-05 아킬레스 테라퓨틱스 유케이 리미티드 T 세포 요법
CN112239495B (zh) * 2020-10-29 2022-04-12 上海药明生物技术有限公司 稳定的tcr结构及应用
GB202109886D0 (en) 2021-07-08 2021-08-25 Achilles Therapeutics Uk Ltd Assay
WO2022214835A1 (en) 2021-04-09 2022-10-13 Achilles Therapeutics Uk Limited Batch release assay for pharmaceutical products relating to t cell therapies
JP2024524185A (ja) 2021-06-22 2024-07-05 アキレス セラピューティクス ユーケー リミテッド 抗原特異的ｔ細胞を生成するための方法
KR20240046834A (ko) * 2021-07-19 2024-04-09 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 Fanci, rad51, 및 pbk 항원을 표적화하는 펩타이드 및 가공된 t 세포 수용체 및 이의 사용 방법
CN119220425A (zh) * 2023-07-28 2024-12-31 佳吾益(北京)科技有限公司 发现mhc新抗原肽表位的工程化细胞

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RU2729383C2 (ru) 2020-08-06
BR112016011567A2 (pt) 2017-10-24
ES2729406T3 (es) 2019-11-04
IL245467A0 (en) 2016-06-30
US20190055298A1 (en) 2019-02-21
CN105873945B (zh) 2020-07-17
WO2015077615A1 (en) 2015-05-28
JP6697386B2 (ja) 2020-05-20
US10023625B2 (en) 2018-07-17
JP6970724B2 (ja) 2021-11-24
CN105899530B (zh) 2020-05-08
SA516371174B1 (ar) 2019-04-14
JP2017501129A (ja) 2017-01-12
AU2014352834A1 (en) 2016-05-26
US20160280756A1 (en) 2016-09-29
NZ719720A (en) 2020-09-25
SG10201804335QA (en) 2018-06-28
MX2016006625A (es) 2016-12-02
RU2740648C2 (ru) 2021-01-19
SG10201804330YA (en) 2018-07-30
AU2014352826B2 (en) 2019-08-01
KR20160087866A (ko) 2016-07-22
US20160280755A1 (en) 2016-09-29
DK3071593T3 (da) 2019-06-11
CA2930852A1 (en) 2015-05-28
EP3071594A4 (en) 2017-05-03
BR112016011583A2 (pt) 2017-09-26
RU2016124179A (ru) 2017-12-27
JP2020007374A (ja) 2020-01-16
TR201908404T4 (tr) 2019-07-22
NZ719707A (en) 2020-09-25
MX383471B (es) 2025-03-14
IL245468B (en) 2020-10-29
JP6476182B2 (ja) 2019-02-27
AU2019272003A1 (en) 2019-12-19
AU2014352834B2 (en) 2019-08-29
AU2014352826A1 (en) 2016-05-26
KR20160085345A (ko) 2016-07-15
AU2021202274A1 (en) 2021-05-06
IL245467B (en) 2020-04-30
RU2016124163A (ru) 2017-12-27
CA2930852C (en) 2024-01-23
ZA201603169B (en) 2020-05-27
MX371202B (es) 2020-01-22
US10344075B2 (en) 2019-07-09
IL245468A0 (en) 2016-06-30
US20220396606A1 (en) 2022-12-15
EP3071593A4 (en) 2017-05-03
WO2015077607A1 (en) 2015-05-28
JP2022023196A (ja) 2022-02-07
PL3071593T3 (pl) 2019-11-29
MX2021006932A (es) 2021-07-07
ZA201603116B (en) 2018-12-19
JP2017501130A (ja) 2017-01-12
CA2930847A1 (en) 2015-05-28
CN105899530A (zh) 2016-08-24
MX2016006620A (es) 2017-05-11
EP3071593B1 (en) 2019-03-13
EP3071594A1 (en) 2016-09-28
AU2019272003B2 (en) 2021-05-06
EP3071593A1 (en) 2016-09-28
PT3071593T (pt) 2019-06-27
CN105873945A (zh) 2016-08-17

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