KR102413756B1 - 신경퇴행성 질병을 위한 치료제 - Google Patents

신경퇴행성 질병을 위한 치료제 Download PDF

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Publication number
KR102413756B1
KR102413756B1 KR1020197007032A KR20197007032A KR102413756B1 KR 102413756 B1 KR102413756 B1 KR 102413756B1 KR 1020197007032 A KR1020197007032 A KR 1020197007032A KR 20197007032 A KR20197007032 A KR 20197007032A KR 102413756 B1 KR102413756 B1 KR 102413756B1
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patient
disease
leucine
acetyl
neurodegenerative disease
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English (en)
Korean (ko)
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KR20190039227A (ko
Inventor
마이클 스트럽
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인트라바이오 리미티드
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=59859424&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR102413756(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB1613829.9A external-priority patent/GB201613829D0/en
Priority claimed from GBGB1702551.1A external-priority patent/GB201702551D0/en
Priority claimed from GBGB1705766.2A external-priority patent/GB201705766D0/en
Priority claimed from GBGB1706867.7A external-priority patent/GB201706867D0/en
Application filed by 인트라바이오 리미티드 filed Critical 인트라바이오 리미티드
Priority to KR1020227021012A priority Critical patent/KR20220093385A/ko
Publication of KR20190039227A publication Critical patent/KR20190039227A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Addiction (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)
  • Anesthesiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020197007032A 2016-08-11 2017-08-11 신경퇴행성 질병을 위한 치료제 Active KR102413756B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020227021012A KR20220093385A (ko) 2016-08-11 2017-08-11 신경퇴행성 질병을 위한 치료제

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GBGB1613829.9A GB201613829D0 (en) 2016-08-11 2016-08-11 Therapeutic agents for neurodegenerative diseases, lysosomal storage disorders and neurodegenerative diseases associated with defects in lysosomal storage
GB1613829.9 2016-08-11
GBGB1702551.1A GB201702551D0 (en) 2017-02-16 2017-02-16 Therapeutic agents for neurodegenerative diseases, lysosomal storage disorders and neurodegenerative diseases associated with defects in lysosomal storage
GB1702551.1 2017-02-16
GB1705766.2 2017-04-10
GBGB1705766.2A GB201705766D0 (en) 2017-04-10 2017-04-10 Therapeutic agents for neurodegenerative diseases, lysosomal storage disorders and neurodegenerative diseases associated with defects in lysosomal storage
GBGB1706867.7A GB201706867D0 (en) 2017-04-28 2017-04-28 Therapeutic agents for neurodegenerative diseases, lysosomal storage disorders and neurodegenerative diseases associated with defects in lysosomal storage
GB1706867.7 2017-04-28
PCT/IB2017/054929 WO2018029658A1 (en) 2016-08-11 2017-08-11 Therapeutic agents for neurodegenerative diseases

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020227021012A Division KR20220093385A (ko) 2016-08-11 2017-08-11 신경퇴행성 질병을 위한 치료제

Publications (2)

Publication Number Publication Date
KR20190039227A KR20190039227A (ko) 2019-04-10
KR102413756B1 true KR102413756B1 (ko) 2022-06-27

Family

ID=59859424

Family Applications (4)

Application Number Title Priority Date Filing Date
KR1020197007032A Active KR102413756B1 (ko) 2016-08-11 2017-08-11 신경퇴행성 질병을 위한 치료제
KR1020257008819A Pending KR20250042197A (ko) 2016-08-11 2017-08-11 신경퇴행성 질병을 위한 치료제
KR1020247014635A Active KR102785448B1 (ko) 2016-08-11 2017-08-11 신경퇴행성 질병을 위한 치료제
KR1020227021012A Ceased KR20220093385A (ko) 2016-08-11 2017-08-11 신경퇴행성 질병을 위한 치료제

Family Applications After (3)

Application Number Title Priority Date Filing Date
KR1020257008819A Pending KR20250042197A (ko) 2016-08-11 2017-08-11 신경퇴행성 질병을 위한 치료제
KR1020247014635A Active KR102785448B1 (ko) 2016-08-11 2017-08-11 신경퇴행성 질병을 위한 치료제
KR1020227021012A Ceased KR20220093385A (ko) 2016-08-11 2017-08-11 신경퇴행성 질병을 위한 치료제

Country Status (29)

Country Link
US (3) US12144792B2 (enExample)
EP (3) EP4467195A3 (enExample)
JP (3) JP6957602B2 (enExample)
KR (4) KR102413756B1 (enExample)
CN (4) CN109789114A (enExample)
AU (3) AU2017308865B2 (enExample)
BR (1) BR112019002730A2 (enExample)
CA (1) CA3033564A1 (enExample)
CY (1) CY1121930T1 (enExample)
DK (1) DK3416631T3 (enExample)
ES (1) ES2733677T3 (enExample)
HR (1) HRP20191055T1 (enExample)
HU (1) HUE045043T2 (enExample)
IL (3) IL264641B2 (enExample)
LT (1) LT3416631T (enExample)
MA (2) MA43828B1 (enExample)
MD (1) MD3416631T2 (enExample)
ME (1) ME03454B (enExample)
MX (3) MX383499B (enExample)
NZ (2) NZ750421A (enExample)
PL (1) PL3416631T3 (enExample)
PT (1) PT3416631T (enExample)
RS (1) RS59048B1 (enExample)
RU (1) RU2756519C2 (enExample)
SG (1) SG11201901063SA (enExample)
SI (1) SI3416631T1 (enExample)
SM (1) SMT201900370T1 (enExample)
TN (1) TN2019000033A1 (enExample)
WO (1) WO2018029658A1 (enExample)

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US10219815B2 (en) 2005-09-22 2019-03-05 The Regents Of The University Of Michigan Histotripsy for thrombolysis
WO2016210133A1 (en) 2015-06-24 2016-12-29 The Regents Of The Universtiy Of Michigan Histotripsy therapy systems and methods for the treatment of brain tissue
KR102467953B1 (ko) 2016-08-11 2022-11-16 인트라바이오 리미티드 리소좀 축적 질환과 관련된 약제 조성물 및 용도
MA43828B1 (fr) 2016-08-11 2019-09-30 Intrabio Ltd Agents thérapeutiques pour maladies neurodégénératives
GB201709459D0 (en) 2017-06-14 2017-07-26 Intrabio Ltd Treatment for migraine
SG11202003390UA (en) * 2017-10-18 2020-05-28 Intrabio Ltd Therapeutic agents for neurodegenerative diseases
CA3091353A1 (en) * 2018-02-15 2019-08-22 Intrabio Ltd Therapeutic agents for treating restless legs syndrome
CA3120586A1 (en) 2018-11-28 2020-06-04 Histosonics, Inc. Histotripsy systems and methods
BR112021010923A2 (pt) * 2018-12-06 2021-08-24 Intrabio Ltd Análogos deuterados de acetileucina
KR20250171484A (ko) * 2019-03-02 2025-12-08 인트라바이오 리미티드 질환을 치료하기 위한 류신, 아세틸 류신, 및 관련된 유사체
JP7432711B2 (ja) * 2019-09-17 2024-02-16 エフ． ホフマン－ラ ロシュ アーゲー 動作障害患者に対する個別化医療の改善
WO2021144720A1 (en) * 2020-01-13 2021-07-22 Intrabio Ltd Treatment of late-onset neurodegenerative diseases in heterozygous npc1 gene mutation carriers
KR20230015433A (ko) * 2020-05-22 2023-01-31 인트라바이오 리미티드 운동실조를 치료하기 위한 아세틸 류신과 4-아미노피리딘 또는 아세타졸아미드의 조합물
WO2022264037A1 (en) * 2021-06-14 2022-12-22 Intrabio Ltd. Branched-chain amino acid derivatives to treat disease
WO2024092272A1 (en) 2022-10-28 2024-05-02 Histosonics, Inc. Histotripsy systems and methods
KR20260003742A (ko) 2023-04-20 2026-01-07 히스토소닉스, 인크. 치료 계획 및 요법을 위한 사용자 인터페이스들 및 작업 흐름들을 포함하는 히스토트립시 시스템들 및 연관된 방법들
WO2025151578A1 (en) * 2024-01-12 2025-07-17 Intrabio Inc. N-acetyl-leucine for use in the treatment of prodromal alpha-synucleinopathies
WO2025163129A1 (en) * 2024-02-01 2025-08-07 Intrabio Ltd. Acetyl-leucine for treating parkinson´s disease
WO2025166100A1 (en) 2024-02-02 2025-08-07 SynGAP Research Fund Compositions and methods for treating neurodevelopmental disorders
WO2025175092A1 (en) * 2024-02-14 2025-08-21 Intrabio Inc. Acetyl leucine for treating syngap1-related disorders

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US20060063827A1 (en) * 2004-09-23 2006-03-23 Yu Ruey J Systemic administration of therapeutic amino acids and N-acetylamino acids
US20050222209A1 (en) * 2004-04-01 2005-10-06 Zeldis Jerome B Methods and compositions for the treatment, prevention or management of dysfunctional sleep and dysfunctional sleep associated with disease
FR2905600B1 (fr) * 2006-09-13 2010-01-15 Pf Medicament Traitement des vertiges par l'acetyl-l-leucine.
EP2946779A1 (en) 2007-02-22 2015-11-25 Beiersdorf AG Cosmetic and pharmaceutical applications of n-acetylhydroxyproline
TN2010000566A1 (en) 2010-12-03 2012-05-24 Rekik Raouf Folic acid - ramipril combination : cell protective neuroprotective and retinoprotective ophtalmologic drugs
CA2928701A1 (en) * 2013-10-28 2015-05-07 Naurex, Inc. Nmda receptor modulators and prodrugs, salts, and uses thereof
WO2017182802A1 (en) 2016-04-19 2017-10-26 Intrabio Ltd Acetyl-leucine or a pharmaceutically acceptable salt thereof for improved mobility and cognitive function
MA43828B1 (fr) 2016-08-11 2019-09-30 Intrabio Ltd Agents thérapeutiques pour maladies neurodégénératives

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WO2011151685A1 (en) * 2010-06-03 2011-12-08 Raouf Rekik N-acetyl-dl-leucine, neuroprotective and retinoprotective medicament

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PL3416631T3 (pl) 2019-11-29
SMT201900370T1 (it) 2019-09-09
RS59048B1 (sr) 2019-08-30
RU2019106506A (ru) 2020-09-17
WO2018029658A1 (en) 2018-02-15
CN121081445A (zh) 2025-12-09
EP4467195A2 (en) 2024-11-27
DK3416631T3 (da) 2019-07-15
CY1121930T1 (el) 2020-10-14
MA43828A (fr) 2018-12-26
MA47521A (fr) 2021-04-21
MX2024004439A (es) 2025-11-03
CA3033564A1 (en) 2018-02-15
EP4467195A3 (en) 2025-03-19
AU2025202077B2 (en) 2026-04-30
MD3416631T2 (ro) 2019-09-30
TN2019000033A1 (fr) 2020-07-15
IL264641B2 (en) 2024-07-01
SG11201901063SA (en) 2019-03-28
JP2022003085A (ja) 2022-01-11
US20230210799A1 (en) 2023-07-06
AU2023202121A1 (en) 2023-05-04
MA43828B1 (fr) 2019-09-30
EP3416631B1 (en) 2019-05-15
JP6957602B2 (ja) 2021-11-02
JP7833272B2 (ja) 2026-03-19
ME03454B (me) 2020-01-20
US12144792B2 (en) 2024-11-19
JP2019524822A (ja) 2019-09-05
AU2025202077A1 (en) 2025-04-10
AU2023202121B2 (en) 2025-01-23
KR102785448B1 (ko) 2025-03-21
PT3416631T (pt) 2019-07-11
MX2021006901A (es) 2021-07-07
KR20240068761A (ko) 2024-05-17
ES2733677T3 (es) 2019-12-02
NZ790893A (en) 2026-03-27
AU2017308865A1 (en) 2019-02-21
MX2019001575A (es) 2019-08-01
RU2021128045A (ru) 2021-11-16
EP3416631A1 (en) 2018-12-26
SI3416631T1 (sl) 2019-09-30
CN116492328A (zh) 2023-07-28
AU2017308865B2 (en) 2023-04-13
IL264641B1 (en) 2024-03-01
JP2023175762A (ja) 2023-12-12
US20200179320A1 (en) 2020-06-11
IL310799A (en) 2024-04-01
MX383499B (es) 2025-03-14
HUE045043T2 (hu) 2019-12-30
CN109789114A (zh) 2019-05-21
IL264641A (en) 2019-04-30
CN116459244A (zh) 2023-07-21
US20240189267A1 (en) 2024-06-13
EP3583940A1 (en) 2019-12-25
RU2019106506A3 (enExample) 2020-10-29
RU2756519C2 (ru) 2021-10-01
KR20220093385A (ko) 2022-07-05
KR20190039227A (ko) 2019-04-10
KR20250042197A (ko) 2025-03-26
BR112019002730A2 (pt) 2019-05-14
HRP20191055T1 (hr) 2019-09-06
LT3416631T (lt) 2019-08-26
NZ750421A (en) 2026-03-27
IL310801A (en) 2024-04-01

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