RU2756519C2 - Терапевтические средства против нейродегенеративных заболеваний - Google Patents

Терапевтические средства против нейродегенеративных заболеваний Download PDF

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Publication number
RU2756519C2
RU2756519C2 RU2019106506A RU2019106506A RU2756519C2 RU 2756519 C2 RU2756519 C2 RU 2756519C2 RU 2019106506 A RU2019106506 A RU 2019106506A RU 2019106506 A RU2019106506 A RU 2019106506A RU 2756519 C2 RU2756519 C2 RU 2756519C2
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patient
disease
neurodegenerative disease
acetyleucine
treatment
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RU2019106506A
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English (en)
Russian (ru)
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RU2019106506A (ru
RU2019106506A3 (enExample
Inventor
Михаэль ШТРУП
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Интрабио Лимитед
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Priority claimed from GBGB1613829.9A external-priority patent/GB201613829D0/en
Priority claimed from GBGB1702551.1A external-priority patent/GB201702551D0/en
Priority claimed from GBGB1705766.2A external-priority patent/GB201705766D0/en
Priority claimed from GBGB1706867.7A external-priority patent/GB201706867D0/en
Application filed by Интрабио Лимитед filed Critical Интрабио Лимитед
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Addiction (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)
  • Anesthesiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU2019106506A 2016-08-11 2017-08-11 Терапевтические средства против нейродегенеративных заболеваний RU2756519C2 (ru)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GB1613829.9 2016-08-11
GBGB1613829.9A GB201613829D0 (en) 2016-08-11 2016-08-11 Therapeutic agents for neurodegenerative diseases, lysosomal storage disorders and neurodegenerative diseases associated with defects in lysosomal storage
GB1702551.1 2017-02-16
GBGB1702551.1A GB201702551D0 (en) 2017-02-16 2017-02-16 Therapeutic agents for neurodegenerative diseases, lysosomal storage disorders and neurodegenerative diseases associated with defects in lysosomal storage
GBGB1705766.2A GB201705766D0 (en) 2017-04-10 2017-04-10 Therapeutic agents for neurodegenerative diseases, lysosomal storage disorders and neurodegenerative diseases associated with defects in lysosomal storage
GB1705766.2 2017-04-10
GB1706867.7 2017-04-28
GBGB1706867.7A GB201706867D0 (en) 2017-04-28 2017-04-28 Therapeutic agents for neurodegenerative diseases, lysosomal storage disorders and neurodegenerative diseases associated with defects in lysosomal storage
PCT/IB2017/054929 WO2018029658A1 (en) 2016-08-11 2017-08-11 Therapeutic agents for neurodegenerative diseases

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2021128045A Division RU2849887C2 (ru) 2016-08-11 2017-08-11 Терапевтические средства против нейродегенеративных заболеваний

Publications (3)

Publication Number Publication Date
RU2019106506A RU2019106506A (ru) 2020-09-17
RU2019106506A3 RU2019106506A3 (enExample) 2020-10-29
RU2756519C2 true RU2756519C2 (ru) 2021-10-01

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RU2019106506A RU2756519C2 (ru) 2016-08-11 2017-08-11 Терапевтические средства против нейродегенеративных заболеваний

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US (4) US12144792B2 (enExample)
EP (3) EP3416631B1 (enExample)
JP (4) JP6957602B2 (enExample)
KR (4) KR20220093385A (enExample)
CN (4) CN121081445A (enExample)
AU (4) AU2017308865B2 (enExample)
BR (1) BR112019002730A2 (enExample)
CA (1) CA3033564A1 (enExample)
CY (1) CY1121930T1 (enExample)
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HR (1) HRP20191055T1 (enExample)
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NZ (2) NZ790893A (enExample)
PL (1) PL3416631T3 (enExample)
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RS (1) RS59048B1 (enExample)
RU (1) RU2756519C2 (enExample)
SG (1) SG11201901063SA (enExample)
SI (1) SI3416631T1 (enExample)
SM (1) SMT201900370T1 (enExample)
TN (1) TN2019000033A1 (enExample)
WO (1) WO2018029658A1 (enExample)

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US10219815B2 (en) 2005-09-22 2019-03-05 The Regents Of The University Of Michigan Histotripsy for thrombolysis
WO2016210133A1 (en) 2015-06-24 2016-12-29 The Regents Of The Universtiy Of Michigan Histotripsy therapy systems and methods for the treatment of brain tissue
PT3482754T (pt) 2016-08-11 2021-02-03 Intrabio Ltd Composições farmacêuticas e utilizações contra os distúrbios de armazenamento lisossómico
TN2019000033A1 (fr) 2016-08-11 2020-07-15 Intrabio Ltd Agents thérapeutiques pour maladies neurodégénératives
GB201709459D0 (en) 2017-06-14 2017-07-26 Intrabio Ltd Treatment for migraine
US11793782B2 (en) * 2017-10-18 2023-10-24 Intrabio Limited Therapeutic agents for neurodegenerative diseases
RS65663B1 (sr) 2018-02-15 2024-07-31 Intrabio Ltd Acetil leucin za upotrebu u lečenju sindroma nemirnih nogu
US11813484B2 (en) 2018-11-28 2023-11-14 Histosonics, Inc. Histotripsy systems and methods
CN120157593A (zh) * 2018-12-06 2025-06-17 内在生物技术有限公司 乙酰基-亮氨酸的氘代类似物
CN119097618A (zh) * 2019-03-02 2024-12-10 内在生物技术有限公司 用于治疗疾病的亮氨酸、乙酰基亮氨酸和相关类似物
MD3989962T2 (ro) 2019-06-28 2025-12-31 Intrabio Ltd Gb Terapie combinată cu acetil-leucină și miglustat pentru tratamentul unei boli de depozitare lizozomală
CN114727761A (zh) * 2019-09-17 2022-07-08 豪夫迈·罗氏有限公司 患有运动障碍的患者的个性化保健的改善
WO2021144720A1 (en) * 2020-01-13 2021-07-22 Intrabio Ltd Treatment of late-onset neurodegenerative diseases in heterozygous npc1 gene mutation carriers
KR20230015433A (ko) * 2020-05-22 2023-01-31 인트라바이오 리미티드 운동실조를 치료하기 위한 아세틸 류신과 4-아미노피리딘 또는 아세타졸아미드의 조합물
WO2022264037A1 (en) * 2021-06-14 2022-12-22 Intrabio Ltd. Branched-chain amino acid derivatives to treat disease
US20240149078A1 (en) 2022-10-28 2024-05-09 Histosonics, Inc. Histotripsy systems and methods
JP2026516719A (ja) 2023-04-20 2026-05-26 ヒストソニックス，インコーポレーテッド 治療計画および治療のためのユーザインターフェースとワークフローとを含むヒストトリプシーシステムおよび関連方法
WO2025090672A1 (en) 2023-10-23 2025-05-01 Histosonics, Inc. Histotripsy systems and methods
CN122055147A (zh) * 2024-01-12 2026-05-15 内在生物技术股份有限公司 用于治疗前驱期α-突触核蛋白病的N-乙酰亮氨酸
WO2025163129A1 (en) * 2024-02-01 2025-08-07 Intrabio Ltd. Acetyl-leucine for treating parkinson´s disease
WO2025166100A1 (en) 2024-02-02 2025-08-07 SynGAP Research Fund Compositions and methods for treating neurodevelopmental disorders
WO2025175092A1 (en) * 2024-02-14 2025-08-21 Intrabio Inc. Acetyl leucine for treating syngap1-related disorders

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WO2011151685A1 (en) * 2010-06-03 2011-12-08 Raouf Rekik N-acetyl-dl-leucine, neuroprotective and retinoprotective medicament

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FR2905600A1 (fr) * 2006-09-13 2008-03-14 Pierre Fabre Medicament Sa Traitement des vertiges par l'acetyl-l-leucine.
WO2011151685A1 (en) * 2010-06-03 2011-12-08 Raouf Rekik N-acetyl-dl-leucine, neuroprotective and retinoprotective medicament

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R. SCHNIEPP et al., Acetyl-DL-leucine improves gait variability in patients with cerebellar ataxia-a case series, CEREBELLUM & ATAXIAS, 2016, vol. 3(8), p.1-4; DOI: 10.1186/s40673-016-0046-2. T. BREMOVA et al., Acetyl-DL-leucine in Niemann-Pick type C: A case series, NEUROLOGY, 2015, vol. 85, no. 16, p. 1368-1375; DOI: 10.1212/WNL.0000000000002041. *
T. BREMOVA et al., Acetyl-DL-leucine in Niemann-Pick type C: A case series, NEUROLOGY, 2015, vol. 85, no. 16, p. 1368-1375; DOI: 10.1212/WNL.0000000000002041. *

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LT3416631T (lt) 2019-08-26
TN2019000033A1 (fr) 2020-07-15
JP2023175762A (ja) 2023-12-12
EP4467195A3 (en) 2025-03-19
RU2019106506A (ru) 2020-09-17
KR20190039227A (ko) 2019-04-10
RU2021128045A (ru) 2021-11-16
IL264641B2 (en) 2024-07-01
IL310799A (en) 2024-04-01
KR102785448B1 (ko) 2025-03-21
JP7885184B2 (ja) 2026-07-06
ME03454B (me) 2020-01-20
ES2733677T3 (es) 2019-12-02
MX2024004439A (es) 2025-11-03
US20230210799A1 (en) 2023-07-06
MD3416631T2 (ro) 2019-09-30
KR20250042197A (ko) 2025-03-26
JP6957602B2 (ja) 2021-11-02
MX2019001575A (es) 2019-08-01
EP3583940A1 (en) 2019-12-25
SMT201900370T1 (it) 2019-09-09
KR20220093385A (ko) 2022-07-05
CN116492328A (zh) 2023-07-28
AU2025202077A1 (en) 2025-04-10
CY1121930T1 (el) 2020-10-14
KR20240068761A (ko) 2024-05-17
US12144792B2 (en) 2024-11-19
MX2021006901A (es) 2021-07-07
CN109789114A (zh) 2019-05-21
CN116459244A (zh) 2023-07-21
EP3583940B1 (en) 2026-08-12
US20240189267A1 (en) 2024-06-13
US20260191808A1 (en) 2026-07-09
EP3416631A1 (en) 2018-12-26
EP3416631B1 (en) 2019-05-15
RU2019106506A3 (enExample) 2020-10-29
KR102413756B1 (ko) 2022-06-27
JP2022003085A (ja) 2022-01-11
IL264641B1 (en) 2024-03-01
MA43828A (fr) 2018-12-26
US20200179320A1 (en) 2020-06-11
AU2017308865B2 (en) 2023-04-13
AU2023202121A1 (en) 2023-05-04
BR112019002730A2 (pt) 2019-05-14
HUE045043T2 (hu) 2019-12-30
HRP20191055T1 (hr) 2019-09-06
IL264641A (en) 2019-04-30
IL310801A (en) 2024-04-01
MA43828B1 (fr) 2019-09-30
RS59048B1 (sr) 2019-08-30
SG11201901063SA (en) 2019-03-28
AU2025202077B2 (en) 2026-04-30
AU2026203549A1 (en) 2026-05-28
AU2017308865A1 (en) 2019-02-21
DK3416631T3 (da) 2019-07-15
AU2023202121B2 (en) 2025-01-23
NZ790893A (en) 2026-03-27
PT3416631T (pt) 2019-07-11
WO2018029658A1 (en) 2018-02-15
MA47521A (fr) 2021-04-21
NZ750421A (en) 2026-03-27
PL3416631T3 (pl) 2019-11-29
SI3416631T1 (sl) 2019-09-30
CA3033564A1 (en) 2018-02-15
EP4467195A2 (en) 2024-11-27
JP7833272B2 (ja) 2026-03-19
JP2019524822A (ja) 2019-09-05
JP2026094294A (ja) 2026-06-09
CN121081445A (zh) 2025-12-09
MX383499B (es) 2025-03-14

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