KR102413126B1 - 인지가 용이한 치아 부착용 패치 - Google Patents
인지가 용이한 치아 부착용 패치 Download PDFInfo
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- KR102413126B1 KR102413126B1 KR1020150127810A KR20150127810A KR102413126B1 KR 102413126 B1 KR102413126 B1 KR 102413126B1 KR 1020150127810 A KR1020150127810 A KR 1020150127810A KR 20150127810 A KR20150127810 A KR 20150127810A KR 102413126 B1 KR102413126 B1 KR 102413126B1
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/16—Fluorine compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0063—Periodont
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
실시예 1 | 실시예 2 | 비교예1 (무색소 반투명) | |
약물층 | 폴리비닐알코올 10% PVP 10% 죽염 1.0% SLS 2% 글리세린 3% 물 등 to 100% |
폴리비닐알코올 10% PVP 10% 염화아연 1.0% SLS 2% 글리세린 3% 물 등 to 100% |
폴리비닐알코올 10% PVP 10% 염화아연 1.0% SLS 2% 글리세린 3% 물 등 to 100% |
지지층 | Ethyl Cellulose 10.0% PVP 10.0% SPAN80 5.0% Castor oil 5.0% 청색1호 0.001% 에탄올 등 to 100% |
Ethyl Cellulose 10.0% PVP 10.0% SPAN80 5.0% Castor oil 5.0% 적색 226호 0.002% 에탄올 등 to 100% |
Ethyl Cellulose 10.0% PVP 10.0% SPAN80 5.0% Castor oil 5.0% 에탄올 등 to 100% |
실시예1 | 실시예2 | 비교예1 | |
제품외관평가 | 3.5 | 3.6 | 3.5 |
사용성 | 4.2 | 3.8 | 3.2 |
인지성 | 4.5 | 4.8 | 1.5 |
실시예 1 | 실시예 2 | 비교예 1 | |
치아에 부착된 잔여물 | 육안으로 잔여물 확인이 용이하였음. | 육안으로 잔여물 확인이 용이하였음. | 치아색과 구별이 용이하지 않아 혀를 이용하여 제거여부 확인하였음. 특히 어금니 부위는 더욱 확인이 곤란함. |
이물감 | 브러싱 후 이물감이 느껴졌으나, 육안으로 확인되어 물로 헹궈내어 쉽게 제거함. | 브러싱 후 이물감이 느껴졌으나, 육안으로 확인되어 물로 헹궈내어 쉽게 제거함. | 육안으로 확인이 어려워 삼키게 되는 경우가 생김. |
Claims (8)
- 약물층 및 상기 약물층의 치아 부착면 반대편에 위치하는 지지층을 포함하며,
상기 지지층은 인디케이터가 포함되며,
상기 인디케이터는
카르티노이드계, 키논계, 플라보노이드계, 안토시아닌계, 칼콘계, 플라본계, 포르필리계, 및 베타시아닌계 색소로 이루어진 군에서 선택된 어느 하나의 천연색소; 및
적색 3호, 황색 4호, 황색 5호, 녹색 3호, 청색 1호, 청색 2호, 적색 40호, 적색 2호, 적색 102호, 적색 103호, 적색 104호, 적색 105호, 적색 201호, 적색 202호, 적색 230호, 적색 204호, 적색 215호, 적색 218호, 적색 219호, 적색 220호, 적색 223호, 적색 225호, 적색 226호, 적색 227호, 적색 228호, 적색 229호, 등색 201호, 등색 203호, 등색 204호, 등색 205호, 등색 206호, 등색 207호, 황색 201호, 황색 202호, 황색 203호, 황색 204호, 황색 205호, 녹색 201호, 녹색 202호, 녹색 204호, 청색 201호, 청색 204호, 청색 205호, 갈색 202호, 및 자색 201로 이루어진 군에서 선택된 어느 하나의 식용성 타르계 색소로 이루어진 군에서 선택된 어느 하나 이상의 색소를 포함하는 것을 특징으로 하는 구강용 패치. - 삭제
- 삭제
- 제1항에 있어서, 상기 천연색소는 β-카로틴, 수용성 안나토, 동클로로필, 동클로로필린나트륨, 동클로로필린칼륨, β-아포-8'-카로티날, 및 카르민 색소로 이루어진 군에서 선택된 어느 하나 이상인 것을 특징으로 하는 구강용 패치.
- 제1항에 있어서, 상기 약물층은 염화스트론튬, 탄산칼슘, 구연산 나트륨, 불화나트륨, 실리카, 수산화인회석, 질산칼륨, 인산칼륨, 테트라사이크린(Tetracycline), 클로로헥시딘 글루코네이트(Chlorhexidine gluconate), 세틸피리디움 클로라이드(Cetylpyridium chloride), 상귀나린(Sanguinarine) 및 트리크로산(Triclosan)로 이루어진 군에서 선택된 어느 하나 이상의 약물을 포함하는 것을 특징으로 하는 구강용 패치.
- 제1항에 있어서, 상기 지지층은 수용성 고분자 및 수불용성 고분자를 함께 포함하는 것을 특징으로 하는 구강용 패치.
- 제1항에 있어서, 상기 패치는 폴리알킬비닐에테르-말레인산 공중합체, 폴리비닐 알코올, 폴리아크릴산, 폴록사머, 폴리에틸렌옥사이드, 폴리비닐피롤리돈-비닐아세테이트 공중합체, 폴리비닐피롤리돈, 폴리쿼터니움-11, 폴리쿼터니움-39, 카르복시폴리메틸렌, 하이드록시프로필메틸 셀룰로오즈, 하이드록시에틸 셀룰로오즈, 하이드록시프로필 셀룰로오즈, 젤라틴 및 알긴산으로 이루어진 군에서 선택된 어느 하나 이상의 수용성 고분자를 포함하는 것을 특징으로 하는 구강용 패치.
- 제1항에 있어서, 상기 패치가 부착되는 부위는 구강 내 구치부를 포함하는 것을 특징으로 하는 구강용 패치.
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