KR102412997B1 - 특정 환자 집단에서 신경퇴행성 장애를 치료하는 방법 - Google Patents

특정 환자 집단에서 신경퇴행성 장애를 치료하는 방법 Download PDF

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KR102412997B1
KR102412997B1 KR1020187009381A KR20187009381A KR102412997B1 KR 102412997 B1 KR102412997 B1 KR 102412997B1 KR 1020187009381 A KR1020187009381 A KR 1020187009381A KR 20187009381 A KR20187009381 A KR 20187009381A KR 102412997 B1 KR102412997 B1 KR 102412997B1
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pharmaceutical composition
apoe4
mmse
baseline
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KR20180051561A (ko
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수잔 아부샤크라
에이단 파워
마틴 톨라
존 헤이
제레미 유
페트르 코시스
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알제온, 인크.
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Application filed by 알제온, 인크. filed Critical 알제온, 인크.
Priority to KR1020227009418A priority Critical patent/KR102547164B1/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020187009381A 2015-09-10 2016-09-09 특정 환자 집단에서 신경퇴행성 장애를 치료하는 방법 Active KR102412997B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020227009418A KR102547164B1 (ko) 2015-09-10 2016-09-09 특정 환자 집단에서 신경퇴행성 장애를 치료하는 방법

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201562216404P 2015-09-10 2015-09-10
US62/216,404 2015-09-10
US201662290287P 2016-02-02 2016-02-02
US62/290,287 2016-02-02
US201662302027P 2016-03-01 2016-03-01
US62/302,027 2016-03-01
US201662365809P 2016-07-22 2016-07-22
US62/365,809 2016-07-22
PCT/US2016/051091 WO2017044840A1 (en) 2015-09-10 2016-09-09 Methods of treating neurodegenerative disorders in a particular patient population

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020227009418A Division KR102547164B1 (ko) 2015-09-10 2016-09-09 특정 환자 집단에서 신경퇴행성 장애를 치료하는 방법

Publications (2)

Publication Number Publication Date
KR20180051561A KR20180051561A (ko) 2018-05-16
KR102412997B1 true KR102412997B1 (ko) 2022-06-23

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KR1020187009381A Active KR102412997B1 (ko) 2015-09-10 2016-09-09 특정 환자 집단에서 신경퇴행성 장애를 치료하는 방법
KR1020227009418A Active KR102547164B1 (ko) 2015-09-10 2016-09-09 특정 환자 집단에서 신경퇴행성 장애를 치료하는 방법

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US (3) US11191742B2 (enExample)
EP (2) EP3347002B1 (enExample)
JP (4) JP6789579B2 (enExample)
KR (2) KR102412997B1 (enExample)
CN (3) CN116712423A (enExample)
AU (1) AU2016319107B2 (enExample)
CA (1) CA2997376C (enExample)
DK (1) DK3347002T3 (enExample)
ES (1) ES2952727T3 (enExample)
FI (1) FI3347002T3 (enExample)
HR (1) HRP20230809T1 (enExample)
HU (1) HUE062511T2 (enExample)
LT (1) LT3347002T (enExample)
MD (1) MD3347002T2 (enExample)
MX (2) MX392677B (enExample)
PL (1) PL3347002T3 (enExample)
PT (1) PT3347002T (enExample)
RS (2) RS68293B1 (enExample)
SI (1) SI3347002T1 (enExample)
SM (2) SMT202300250T1 (enExample)
WO (1) WO2017044840A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
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ES2960625T3 (es) 2014-03-21 2024-03-05 Alzheon Inc Compuestos para uso en el tratamiento de la enfermedad de Alzheimer en pacientes de ApoE4+/+
EP3347002B1 (en) * 2015-09-10 2023-06-07 Alzheon, Inc. Treatment of alzheimer's disease in a particular patient population
CN114805211B (zh) 2017-03-21 2024-08-23 润佳（苏州）医药科技有限公司 同位素富集3-氨基-1-丙磺酸衍生物、药物组合物及其用途
CN110003058B (zh) 2018-01-04 2022-01-25 润佳（苏州）医药科技有限公司 3-((l-缬氨酰基)氨基)-3,3-二氘-1-丙磺酸晶型、制备方法及用途
MX2021001287A (es) * 2018-08-01 2021-07-15 Alzheon Inc Métodos para tratar trastornos neurodegenerativos.
SI4296670T1 (sl) * 2018-08-01 2026-04-30 Alzheon, Inc. Derivati sulfopropanojske kisline za zdravljenje nevrodegenerativnih motenj
CN111170901A (zh) * 2018-11-13 2020-05-19 润佳（苏州）医药科技有限公司 3-((l-缬氨酰基)氨基)-1-丙磺酸晶型、制备方法及其用途
PH12021553196A1 (en) * 2019-06-17 2022-11-07 Alzheon Inc Methods for treating neurodegenerative disorders
CN112791078B (zh) 2019-11-13 2022-12-06 润佳（苏州）医药科技有限公司 同位素富集的3-氨基-1-丙磺酸及其衍生物的用途
AU2022405026A1 (en) * 2021-12-09 2024-06-20 Alzheon, Inc. Alz-801 for use in treating alzheimer's disease
WO2023150381A1 (en) * 2022-02-07 2023-08-10 Alzheon, Inc. Alz-801 for use in treating a covid-19 associated neurological symptom

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120071468A1 (en) 2010-08-19 2012-03-22 Buck Institute For Age Research Methods of treating mild cognitive impairment (mci) and related disorders
US20140220122A1 (en) 2006-10-12 2014-08-07 Bhi Limited Partnership Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid

Family Cites Families (17)

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US5698155A (en) 1991-05-31 1997-12-16 Gs Technologies, Inc. Method for the manufacture of pharmaceutical cellulose capsules
CA2142300C (en) 1992-10-13 2005-08-23 Allen D. Roses Methods for detecting alzheimer's disease
US20050031651A1 (en) 2002-12-24 2005-02-10 Francine Gervais Therapeutic formulations for the treatment of beta-amyloid related diseases
US20070010573A1 (en) 2003-06-23 2007-01-11 Xianqi Kong Methods and compositions for treating amyloid-related diseases
US20060079578A1 (en) 2003-06-23 2006-04-13 Julie Laurin Pharmaceutical formulations of amyloid inhibiting compounds
US20050142191A1 (en) 2003-06-23 2005-06-30 Neurochem (International) Limited Pharmaceutical formulations of amyloid inhibiting compounds
EP1664601B1 (en) 2003-08-11 2016-10-12 California Institute Of Technology Microfluidic large scale integration
US20060251714A1 (en) * 2005-04-12 2006-11-09 Julie Laurin Pharmaceutical formulations of amyloid inhibiting compounds
SG173409A1 (en) 2006-11-24 2011-08-29 Ac Immune Sa N-(methyl)-1h-pyrazol-3-amine, n-(methyl)-pyridin-2-amine and n-(methyl)-thiazol-2-amine derivatives for the treatment of diseases associated with amyloid or amyloid-like proteins, like e.g. alzheimers
JO3076B1 (ar) 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap نظم العلاج المناعي المعتمد على حالة apoe
EP2322163A1 (en) * 2009-11-03 2011-05-18 Pharnext New therapeutics approaches for treating alzheimer disease
US20120009125A1 (en) 2010-07-06 2012-01-12 Lombard Jay L Apoe4 and apoj biomarker-based prevention and treatment of dementia
US20150118231A1 (en) * 2012-05-08 2015-04-30 Ramot At Tel-Aviv University Ltd. Apoe4 antibodies for treatment of neurodegenerative conditions
HUE044737T2 (hu) * 2013-05-06 2019-11-28 Baxalta Inc Alzheimer-kór szubpopulációk kezelése egyesített immunglubulin G-vel
NZ723884A (en) 2014-02-08 2023-02-24 Genentech Inc Methods of treating alzheimer’s disease
ES2960625T3 (es) * 2014-03-21 2024-03-05 Alzheon Inc Compuestos para uso en el tratamiento de la enfermedad de Alzheimer en pacientes de ApoE4+/+
EP3347002B1 (en) * 2015-09-10 2023-06-07 Alzheon, Inc. Treatment of alzheimer's disease in a particular patient population

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140220122A1 (en) 2006-10-12 2014-08-07 Bhi Limited Partnership Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid
US20120071468A1 (en) 2010-08-19 2012-03-22 Buck Institute For Age Research Methods of treating mild cognitive impairment (mci) and related disorders

Also Published As

Publication number Publication date
EP4275750C0 (en) 2026-05-06
JP7128536B2 (ja) 2022-08-31
DK3347002T3 (da) 2023-08-14
LT3347002T (lt) 2023-09-11
RS68293B1 (en) 2026-07-31
JP6789579B2 (ja) 2020-11-25
EP3347002A4 (en) 2019-04-24
EP3347002A1 (en) 2018-07-18
US20220096406A1 (en) 2022-03-31
CA2997376A1 (en) 2017-03-16
KR102547164B1 (ko) 2023-06-22
SI3347002T1 (sl) 2023-12-29
AU2016319107B2 (en) 2021-02-25
EP4275750B1 (en) 2026-05-06
PL3347002T3 (pl) 2023-11-13
FI3347002T3 (fi) 2023-08-10
US20230414541A1 (en) 2023-12-28
ES2952727T3 (es) 2023-11-03
CN116712423A (zh) 2023-09-08
HRP20230809T1 (hr) 2023-10-27
RS64481B1 (sr) 2023-09-29
MX392677B (es) 2025-03-24
EP4275750A3 (en) 2024-01-17
JP2020200352A (ja) 2020-12-17
SMT202300250T1 (it) 2023-09-06
EP4275750A2 (en) 2023-11-15
US11191742B2 (en) 2021-12-07
KR20220042480A (ko) 2022-04-05
CN108289870A (zh) 2018-07-17
MD3347002T2 (ro) 2023-10-31
HK1257874A1 (en) 2019-11-01
AU2016319107A1 (en) 2018-03-22
MX2022003128A (es) 2022-08-02
JP2025065545A (ja) 2025-04-17
CN116712422A (zh) 2023-09-08
SMT202600257T1 (it) 2026-07-16
EP3347002B1 (en) 2023-06-07
MX2018003023A (es) 2018-06-06
JP2018526407A (ja) 2018-09-13
HUE062511T2 (hu) 2023-11-28
KR20180051561A (ko) 2018-05-16
WO2017044840A1 (en) 2017-03-16
CA2997376C (en) 2024-05-14
JP2022145949A (ja) 2022-10-04
PT3347002T (pt) 2023-07-27

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