AU2016319107B2 - Methods of treating neurodegenerative disorders in a particular patient population - Google Patents

Methods of treating neurodegenerative disorders in a particular patient population Download PDF

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Publication number
AU2016319107B2
AU2016319107B2 AU2016319107A AU2016319107A AU2016319107B2 AU 2016319107 B2 AU2016319107 B2 AU 2016319107B2 AU 2016319107 A AU2016319107 A AU 2016319107A AU 2016319107 A AU2016319107 A AU 2016319107A AU 2016319107 B2 AU2016319107 B2 AU 2016319107B2
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AU
Australia
Prior art keywords
subject
apoe4
score
mmse
baseline
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AU2016319107A
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English (en)
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AU2016319107A1 (en
Inventor
Susan ABUSHAKRA
John Hey
Petr Kocis
Aidan POWER
Martin TOLAR
Jeremy Yu
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Alzheon Inc
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Alzheon Inc
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Application filed by Alzheon Inc filed Critical Alzheon Inc
Publication of AU2016319107A1 publication Critical patent/AU2016319107A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2016319107A 2015-09-10 2016-09-09 Methods of treating neurodegenerative disorders in a particular patient population Active AU2016319107B2 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201562216404P 2015-09-10 2015-09-10
US62/216,404 2015-09-10
US201662290287P 2016-02-02 2016-02-02
US62/290,287 2016-02-02
US201662302027P 2016-03-01 2016-03-01
US62/302,027 2016-03-01
US201662365809P 2016-07-22 2016-07-22
US62/365,809 2016-07-22
PCT/US2016/051091 WO2017044840A1 (en) 2015-09-10 2016-09-09 Methods of treating neurodegenerative disorders in a particular patient population

Publications (2)

Publication Number Publication Date
AU2016319107A1 AU2016319107A1 (en) 2018-03-22
AU2016319107B2 true AU2016319107B2 (en) 2021-02-25

Family

ID=58240195

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2016319107A Active AU2016319107B2 (en) 2015-09-10 2016-09-09 Methods of treating neurodegenerative disorders in a particular patient population

Country Status (21)

Country Link
US (3) US11191742B2 (enExample)
EP (2) EP3347002B1 (enExample)
JP (4) JP6789579B2 (enExample)
KR (2) KR102547164B1 (enExample)
CN (3) CN116712422A (enExample)
AU (1) AU2016319107B2 (enExample)
CA (1) CA2997376C (enExample)
DK (1) DK3347002T3 (enExample)
ES (1) ES2952727T3 (enExample)
FI (1) FI3347002T3 (enExample)
HR (1) HRP20230809T1 (enExample)
HU (1) HUE062511T2 (enExample)
LT (1) LT3347002T (enExample)
MD (1) MD3347002T2 (enExample)
MX (2) MX392677B (enExample)
PL (1) PL3347002T3 (enExample)
PT (1) PT3347002T (enExample)
RS (1) RS64481B1 (enExample)
SI (1) SI3347002T1 (enExample)
SM (1) SMT202300250T1 (enExample)
WO (1) WO2017044840A1 (enExample)

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Publication number Priority date Publication date Assignee Title
CA2941415A1 (en) 2014-03-21 2015-09-24 Alzheon, Inc. Methods for treating neurological disorders
KR102547164B1 (ko) * 2015-09-10 2023-06-22 알제온, 인크. 특정 환자 집단에서 신경퇴행성 장애를 치료하는 방법
CN108623501B (zh) 2017-03-21 2022-04-19 润佳（苏州）医药科技有限公司 同位素富集的3-氨基-1-丙磺酸衍生物及其用途
CN110003058B (zh) 2018-01-04 2022-01-25 润佳（苏州）医药科技有限公司 3-((l-缬氨酰基)氨基)-3,3-二氘-1-丙磺酸晶型、制备方法及用途
CN112867485A (zh) * 2018-08-01 2021-05-28 阿尔泽恩股份有限公司 用于治疗神经变性病症的方法
JP7466520B2 (ja) * 2018-08-01 2024-04-12 アルツェオン・インコーポレーテッド 神経変性障害を治療するためのスルホプロパン酸誘導体
CN111170901A (zh) * 2018-11-13 2020-05-19 润佳（苏州）医药科技有限公司 3-((l-缬氨酰基)氨基)-1-丙磺酸晶型、制备方法及其用途
WO2020257159A1 (en) 2019-06-17 2020-12-24 Alzheon, Inc. Methods for treating neurodegenerative disorders
CN112791078B (zh) 2019-11-13 2022-12-06 润佳（苏州）医药科技有限公司 同位素富集的3-氨基-1-丙磺酸及其衍生物的用途
KR20240116529A (ko) * 2021-12-09 2024-07-29 알제온, 인크. 알츠하이머병 치료에 사용하기 위한 alz-801
EP4475831A1 (en) * 2022-02-07 2024-12-18 Alzheon, Inc. Alz-801 for use in treating a covid-19 associated neurological symptom

Citations (1)

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Publication number Priority date Publication date Assignee Title
US20140220122A1 (en) * 2006-10-12 2014-08-07 Bhi Limited Partnership Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid

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US5698155A (en) 1991-05-31 1997-12-16 Gs Technologies, Inc. Method for the manufacture of pharmaceutical cellulose capsules
DE625212T1 (de) 1992-10-13 2000-11-02 Duke University, Durham Verfahren zum entdecken von krankheit von alzheimer.
US20050031651A1 (en) 2002-12-24 2005-02-10 Francine Gervais Therapeutic formulations for the treatment of beta-amyloid related diseases
US20070010573A1 (en) 2003-06-23 2007-01-11 Xianqi Kong Methods and compositions for treating amyloid-related diseases
US20060079578A1 (en) 2003-06-23 2006-04-13 Julie Laurin Pharmaceutical formulations of amyloid inhibiting compounds
US20050142191A1 (en) 2003-06-23 2005-06-30 Neurochem (International) Limited Pharmaceutical formulations of amyloid inhibiting compounds
JP2007502418A (ja) 2003-08-11 2007-02-08 カリフォルニア・インスティテュート・オブ・テクノロジー 微量流体大規模集積
US20060257480A1 (en) * 2005-04-12 2006-11-16 Julie Laurin Pharmaceutical formulations of amyloid inhibiting compounds
MX2009005279A (es) 2006-11-24 2009-05-28 Ac Immune Sa Derivados de n-(metil)-1h-pirazol-3-amina, n-(metil)-piridin-2-ami na y n-(metil)-tiazol-2-amina para el tratamiento de enfermedades asociadas con proteinas amiloides o tipo amiloide, tal como por ejemplo alzheimer.
JO3076B1 (ar) 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap نظم العلاج المناعي المعتمد على حالة apoe
EP2322163A1 (en) * 2009-11-03 2011-05-18 Pharnext New therapeutics approaches for treating alzheimer disease
WO2012006329A2 (en) 2010-07-06 2012-01-12 Genomind, Llc Apoe4 and apoj biomarker-based prevention and treatment of dementia
WO2012024616A1 (en) * 2010-08-19 2012-02-23 Buck Institute For Age Research Methods of treating miild cognitive impairment (mci) and related discorders
US20150118231A1 (en) * 2012-05-08 2015-04-30 Ramot At Tel-Aviv University Ltd. Apoe4 antibodies for treatment of neurodegenerative conditions
PT2994160T (pt) * 2013-05-06 2019-08-07 Baxalta Inc Tratamento de sub-populações com doença de alzheimer com imunoglobulina g combinada
EP3718563A1 (en) * 2014-02-08 2020-10-07 F. Hoffmann-La Roche AG Methods of treating alzheimer's disease
CA2941415A1 (en) 2014-03-21 2015-09-24 Alzheon, Inc. Methods for treating neurological disorders
KR102547164B1 (ko) * 2015-09-10 2023-06-22 알제온, 인크. 특정 환자 집단에서 신경퇴행성 장애를 치료하는 방법

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140220122A1 (en) * 2006-10-12 2014-08-07 Bhi Limited Partnership Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid

Non-Patent Citations (3)

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Title
CALTAGIRONE CARLO ET AL, AGING CLINICAL AND EXPERIMENTAL RESEARCH GERMANY, (2012-12-01), vol. 24, no. 6, doi:10.3275/8585, ISSN 1720-8319, pages 580 - 587 *
PAUL S. AISEN ET AL, ARCHIVES OF MEDICAL SCIENCE, (2011-01-01), vol. 1, doi:10.5114/aoms.2011.20612, ISSN 1734-1922, pages 102 - 111 *
SLEEGERS KRISTEL et al., "The pursuit of susceptibility genes for Alzheimer's disease: progress and prospects", Trends in Genetics, 18 Jan 2010, vol. 26(2), pages 84 - 93 *

Also Published As

Publication number Publication date
KR20220042480A (ko) 2022-04-05
FI3347002T3 (fi) 2023-08-10
US20220096406A1 (en) 2022-03-31
KR102547164B1 (ko) 2023-06-22
US11191742B2 (en) 2021-12-07
CN116712423A (zh) 2023-09-08
AU2016319107A1 (en) 2018-03-22
CN108289870A (zh) 2018-07-17
EP3347002A4 (en) 2019-04-24
KR20180051561A (ko) 2018-05-16
KR102412997B1 (ko) 2022-06-23
JP7128536B2 (ja) 2022-08-31
JP6789579B2 (ja) 2020-11-25
CA2997376C (en) 2024-05-14
WO2017044840A1 (en) 2017-03-16
JP2018526407A (ja) 2018-09-13
SMT202300250T1 (it) 2023-09-06
SI3347002T1 (sl) 2023-12-29
EP3347002B1 (en) 2023-06-07
PL3347002T3 (pl) 2023-11-13
LT3347002T (lt) 2023-09-11
EP3347002A1 (en) 2018-07-18
CN116712422A (zh) 2023-09-08
RS64481B1 (sr) 2023-09-29
HUE062511T2 (hu) 2023-11-28
CA2997376A1 (en) 2017-03-16
US20230414541A1 (en) 2023-12-28
JP2022145949A (ja) 2022-10-04
HK1257874A1 (en) 2019-11-01
EP4275750A3 (en) 2024-01-17
MD3347002T2 (ro) 2023-10-31
DK3347002T3 (da) 2023-08-14
HRP20230809T1 (hr) 2023-10-27
ES2952727T3 (es) 2023-11-03
MX2022003128A (es) 2022-08-02
MX2018003023A (es) 2018-06-06
MX392677B (es) 2025-03-24
JP2020200352A (ja) 2020-12-17
EP4275750A2 (en) 2023-11-15
PT3347002T (pt) 2023-07-27
JP2025065545A (ja) 2025-04-17

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