CN108289870A - 治疗特定患者群体的神经变性病症的方法 - Google Patents

治疗特定患者群体的神经变性病症的方法 Download PDF

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Publication number
CN108289870A
CN108289870A CN201680052760.4A CN201680052760A CN108289870A CN 108289870 A CN108289870 A CN 108289870A CN 201680052760 A CN201680052760 A CN 201680052760A CN 108289870 A CN108289870 A CN 108289870A
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CN
China
Prior art keywords
subject
apoe4
disease
alzheimer
moderate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201680052760.4A
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English (en)
Chinese (zh)
Inventor
S.阿布沙克拉
A.鲍尔
M.托拉尔
J.海伊
J.于
P.科西斯
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Alzheon Inc
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Alzheon Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=58240195&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN108289870(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alzheon Inc filed Critical Alzheon Inc
Priority to CN202310582365.9A priority Critical patent/CN116712422A/zh
Priority to CN202310582394.5A priority patent/CN116712423A/zh
Publication of CN108289870A publication Critical patent/CN108289870A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201680052760.4A 2015-09-10 2016-09-09 治疗特定患者群体的神经变性病症的方法 Pending CN108289870A (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202310582365.9A CN116712422A (zh) 2015-09-10 2016-09-09 治疗特定患者群体的神经变性病症的方法
CN202310582394.5A CN116712423A (zh) 2015-09-10 2016-09-09 治疗特定患者群体的神经变性病症的方法

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201562216404P 2015-09-10 2015-09-10
US62/216,404 2015-09-10
US201662290287P 2016-02-02 2016-02-02
US62/290,287 2016-02-02
US201662302027P 2016-03-01 2016-03-01
US62/302,027 2016-03-01
US201662365809P 2016-07-22 2016-07-22
US62/365,809 2016-07-22
PCT/US2016/051091 WO2017044840A1 (en) 2015-09-10 2016-09-09 Methods of treating neurodegenerative disorders in a particular patient population

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN202310582394.5A Division CN116712423A (zh) 2015-09-10 2016-09-09 治疗特定患者群体的神经变性病症的方法
CN202310582365.9A Division CN116712422A (zh) 2015-09-10 2016-09-09 治疗特定患者群体的神经变性病症的方法

Publications (1)

Publication Number Publication Date
CN108289870A true CN108289870A (zh) 2018-07-17

Family

ID=58240195

Family Applications (3)

Application Number Title Priority Date Filing Date
CN202310582365.9A Pending CN116712422A (zh) 2015-09-10 2016-09-09 治疗特定患者群体的神经变性病症的方法
CN202310582394.5A Pending CN116712423A (zh) 2015-09-10 2016-09-09 治疗特定患者群体的神经变性病症的方法
CN201680052760.4A Pending CN108289870A (zh) 2015-09-10 2016-09-09 治疗特定患者群体的神经变性病症的方法

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CN202310582365.9A Pending CN116712422A (zh) 2015-09-10 2016-09-09 治疗特定患者群体的神经变性病症的方法
CN202310582394.5A Pending CN116712423A (zh) 2015-09-10 2016-09-09 治疗特定患者群体的神经变性病症的方法

Country Status (21)

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US (3) US11191742B2 (enExample)
EP (2) EP4275750A3 (enExample)
JP (4) JP6789579B2 (enExample)
KR (2) KR102547164B1 (enExample)
CN (3) CN116712422A (enExample)
AU (1) AU2016319107B2 (enExample)
CA (1) CA2997376C (enExample)
DK (1) DK3347002T3 (enExample)
ES (1) ES2952727T3 (enExample)
FI (1) FI3347002T3 (enExample)
HR (1) HRP20230809T1 (enExample)
HU (1) HUE062511T2 (enExample)
LT (1) LT3347002T (enExample)
MD (1) MD3347002T2 (enExample)
MX (2) MX392677B (enExample)
PL (1) PL3347002T3 (enExample)
PT (1) PT3347002T (enExample)
RS (1) RS64481B1 (enExample)
SI (1) SI3347002T1 (enExample)
SM (1) SMT202300250T1 (enExample)
WO (1) WO2017044840A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111170901A (zh) * 2018-11-13 2020-05-19 润佳（苏州）医药科技有限公司 3-((l-缬氨酰基)氨基)-1-丙磺酸晶型、制备方法及其用途
CN112867485A (zh) * 2018-08-01 2021-05-28 阿尔泽恩股份有限公司 用于治疗神经变性病症的方法
CN112867487A (zh) * 2018-08-01 2021-05-28 阿尔泽恩股份有限公司 用于治疗神经变性病症的磺基丙酸衍生物
CN114269949A (zh) * 2019-06-17 2022-04-01 阿尔泽恩股份有限公司 用于治疗神经变性病症的方法

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KR102645633B1 (ko) 2014-03-21 2024-03-11 알제온, 인크. 신경학적 장애를 치료하는 방법
PL3347002T3 (pl) * 2015-09-10 2023-11-13 Alzheon, Inc. Leczenie choroby alzheimera w konkretnej populacji pacjentów
CN108623501B (zh) 2017-03-21 2022-04-19 润佳（苏州）医药科技有限公司 同位素富集的3-氨基-1-丙磺酸衍生物及其用途
CN110003058B (zh) 2018-01-04 2022-01-25 润佳（苏州）医药科技有限公司 3-((l-缬氨酰基)氨基)-3,3-二氘-1-丙磺酸晶型、制备方法及用途
CN116059192B (zh) 2019-11-13 2024-10-29 润佳（苏州）医药科技有限公司 同位素富集的3-氨基-1-丙磺酸及其衍生物的用途
CN118678950A (zh) * 2021-12-09 2024-09-20 阿尔泽恩股份有限公司 用于治疗阿尔茨海默氏病的alz-801
AU2023215421A1 (en) * 2022-02-07 2024-08-29 Alzheon, Inc. Alz-801 for use in treating a covid-19 associated neurological symptom

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CN101600730A (zh) * 2006-10-12 2009-12-09 贝鲁斯健康(国际)有限公司 递送3-氨基-1-丙磺酸的方法、化合物、组合物和载体

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AU677614B2 (en) 1992-10-13 1997-05-01 Duke University Methods of detecting Alzheimer's disease
US20050031651A1 (en) 2002-12-24 2005-02-10 Francine Gervais Therapeutic formulations for the treatment of beta-amyloid related diseases
US20070010573A1 (en) 2003-06-23 2007-01-11 Xianqi Kong Methods and compositions for treating amyloid-related diseases
US20050142191A1 (en) 2003-06-23 2005-06-30 Neurochem (International) Limited Pharmaceutical formulations of amyloid inhibiting compounds
US20060079578A1 (en) 2003-06-23 2006-04-13 Julie Laurin Pharmaceutical formulations of amyloid inhibiting compounds
EP1664601B1 (en) 2003-08-11 2016-10-12 California Institute Of Technology Microfluidic large scale integration
US20060257480A1 (en) 2005-04-12 2006-11-16 Julie Laurin Pharmaceutical formulations of amyloid inhibiting compounds
KR101450356B1 (ko) 2006-11-24 2014-10-15 에이씨 이뮨 에스.에이. 알츠하이머와 같은 아밀로이드 또는 아밀로이드-유사 단백질과 관련된 질환의 치료를 위한 ｎ-(메틸)-1ｈ-피라졸-3-아민, ｎ-(메틸)-피리딘-2-아민 및 ｎ-(메틸)-티아졸-2-아민 유도체
JO3076B1 (ar) 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap نظم العلاج المناعي المعتمد على حالة apoe
EP2322163A1 (en) * 2009-11-03 2011-05-18 Pharnext New therapeutics approaches for treating alzheimer disease
US20120009125A1 (en) 2010-07-06 2012-01-12 Lombard Jay L Apoe4 and apoj biomarker-based prevention and treatment of dementia
BR112013003847A8 (pt) 2010-08-19 2017-12-26 Buck Institute For Age Res métodos de tratar a deterioração cognitiva moderada (mci) e os distúrbios relacionados
US20150118231A1 (en) * 2012-05-08 2015-04-30 Ramot At Tel-Aviv University Ltd. Apoe4 antibodies for treatment of neurodegenerative conditions
DK2994160T3 (da) 2013-05-06 2019-08-12 Baxalta Inc Behandling af alzheimers sygdom subpopulationer med poolet immunoglobulin g
TWI705824B (zh) * 2014-02-08 2020-10-01 美商建南德克公司 治療阿茲海默症之方法
KR102645633B1 (ko) 2014-03-21 2024-03-11 알제온, 인크. 신경학적 장애를 치료하는 방법
PL3347002T3 (pl) * 2015-09-10 2023-11-13 Alzheon, Inc. Leczenie choroby alzheimera w konkretnej populacji pacjentów

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CN101600730A (zh) * 2006-10-12 2009-12-09 贝鲁斯健康(国际)有限公司 递送3-氨基-1-丙磺酸的方法、化合物、组合物和载体

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112867485A (zh) * 2018-08-01 2021-05-28 阿尔泽恩股份有限公司 用于治疗神经变性病症的方法
CN112867487A (zh) * 2018-08-01 2021-05-28 阿尔泽恩股份有限公司 用于治疗神经变性病症的磺基丙酸衍生物
US12083082B2 (en) 2018-08-01 2024-09-10 Alzheon, Inc. Methods for treating neurodegenerative disorders
US12285400B2 (en) 2018-08-01 2025-04-29 Alzheon, Inc. Sulfopropanoic acid derivatives for treating neurodegenerative disorders
CN111170901A (zh) * 2018-11-13 2020-05-19 润佳（苏州）医药科技有限公司 3-((l-缬氨酰基)氨基)-1-丙磺酸晶型、制备方法及其用途
CN114269949A (zh) * 2019-06-17 2022-04-01 阿尔泽恩股份有限公司 用于治疗神经变性病症的方法

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JP2025065545A (ja) 2025-04-17
RS64481B1 (sr) 2023-09-29
KR20180051561A (ko) 2018-05-16
EP3347002A1 (en) 2018-07-18
SI3347002T1 (sl) 2023-12-29
LT3347002T (lt) 2023-09-11
AU2016319107A1 (en) 2018-03-22
DK3347002T3 (da) 2023-08-14
JP2022145949A (ja) 2022-10-04
CN116712423A (zh) 2023-09-08
KR102547164B1 (ko) 2023-06-22
MX392677B (es) 2025-03-24
EP3347002B1 (en) 2023-06-07
KR20220042480A (ko) 2022-04-05
EP4275750A2 (en) 2023-11-15
ES2952727T3 (es) 2023-11-03
US20230414541A1 (en) 2023-12-28
US20220096406A1 (en) 2022-03-31
PL3347002T3 (pl) 2023-11-13
HRP20230809T1 (hr) 2023-10-27
CN116712422A (zh) 2023-09-08
AU2016319107B2 (en) 2021-02-25
KR102412997B1 (ko) 2022-06-23
CA2997376C (en) 2024-05-14
MD3347002T2 (ro) 2023-10-31
HK1257874A1 (en) 2019-11-01
MX2018003023A (es) 2018-06-06
JP6789579B2 (ja) 2020-11-25
SMT202300250T1 (it) 2023-09-06
MX2022003128A (es) 2022-08-02
CA2997376A1 (en) 2017-03-16
JP2018526407A (ja) 2018-09-13
EP4275750A3 (en) 2024-01-17
FI3347002T3 (fi) 2023-08-10
JP2020200352A (ja) 2020-12-17
WO2017044840A1 (en) 2017-03-16
HUE062511T2 (hu) 2023-11-28
JP7128536B2 (ja) 2022-08-31
EP3347002A4 (en) 2019-04-24
PT3347002T (pt) 2023-07-27
US11191742B2 (en) 2021-12-07

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Application publication date: 20180717