KR102394637B1 - Aerosol type composition for preventing hair loss or promoting hair growth - Google Patents

Abstract

The present specification discloses a composition for preventing hair loss or promoting hair growth in an aerosol formulation comprising a ginseng extract. The composition implements an aerosol formulation using a liquefied gas suitable for this to maximize the efficacy of the active ingredient contained in ginseng, so that it does not flow down when applied to the scalp, unlike conventional liquid formulations for preventing hair loss, so the feeling of use is excellent and the effectiveness of ginseng Minutes last a long time on the scalp and increase the penetration time, thereby exhibiting more effective hair loss prevention or hair growth promoting efficacy.

Description

Composition for preventing hair loss or promoting hair growth in an aerosol formulation {AEROSOL TYPE COMPOSITION FOR PREVENTING HAIR LOSS OR PROMOTING HAIR GROWTH}

The present specification discloses a composition for preventing hair loss or promoting hair growth in an aerosol formulation comprising a ginseng extract.

Aerosol refers to a colloidal state in which particles of solid or liquid are physically dispersed in a gas. Recently, it has been applied to various skin care and makeup products.

The principle of aerosol is to put the content and propellant to be sprayed into a pressure-resistant sealed container to uniformly spray or discharge the content under the pressure of the propellant. A non-compressible gas, etc. can be used, and different injection patterns and sparkling power are shown depending on the gas type. In addition, due to the characteristics of the container, the aerosol is stored in a state in which the contents are shielded from the outside after manufacture, and thus the stability of the active ingredient, which is difficult to stabilize due to heat, light, etc., can be greatly improved.

On the other hand, ginseng is a widely known herbal medicine that promotes hair growth. This ginseng fundamentally strengthens the hair root to prevent hair loss and promotes hair growth, and restores hair weakened by frequent dyeing, perm, and UV exposure. It is known to enhance elasticity by doing so (Journal of Dermatological Science 77 (2015) 125-134). Conventionally, most hair loss prevention products are liquid formulations and are applied to the scalp through a tube or a pump. In the case of an aerosol formulation containing, there is a problem in that the feeling of use is not good as the gas escapes over time.

Korean Patent Publication No. 1999-0042456

In one aspect, the present specification is an aerosol formulation capable of spraying ginseng active ingredients with gas by mixing a propellant containing liquefied gas with an aerosol stock solution containing ginseng as a main component having an effect of preventing hair loss or promoting hair growth. An object of the present invention is to provide a composition for promoting hair growth.

In one aspect, the technology disclosed herein is an aerosol stock solution comprising a ginseng extract; and propane gas, butane gas, n-butane gas, isobutane gas, pentane gas, n-pentane gas, isopentane gas, neopentane gas, liquefied petroleum gas (LPG), liquefied natural gas (LNG) and dimethyl ether (DME) : An aerosol propellant containing one or more liquefied gas selected from the group consisting of dimethyl ether) provides a composition for preventing hair loss or promoting hair growth in an aerosol formulation, including.

In an exemplary embodiment, the aerosol stock solution and the aerosol propellant may be included in a weight ratio of 1: 2.6 to 3.

In an exemplary embodiment, the aerosol propellant may include at least one liquefied gas selected from the group consisting of propane gas, butane gas, isopentane gas, and dimethyl ether (DME).

In an exemplary embodiment, the aerosol propellant may include isopentane gas and butane gas.

In an exemplary embodiment, the isopentane gas and the butane gas may be included in a weight ratio of 1:7.5 to 8.

In one aspect, the technology disclosed herein implements an aerosol formulation using a liquefied gas suitable for this in order to maximize the efficacy of the active ingredient contained in ginseng, so unlike the conventional liquid formulation anti-hair loss agent, it does not flow down when applied to the scalp The feeling of use is excellent and the active ingredient of ginseng lasts for a long time on the scalp, thereby increasing the penetration time, thereby exhibiting more effective hair loss prevention or hair growth promoting effect.

In another aspect, the technology disclosed in the present specification implements an aerosol formulation having excellent sparkling power for an aerosol stock solution containing an active ginseng ingredient, and the penetration rate of the ginseng active ingredient along with the scalp massage effect due to the bubbles generated by the gas It has the effect of showing a more effective hair loss prevention or hair growth promoting effect by increasing the .

1 is a bubble force observation result according to a test example of the present specification, (a) is Example 1, (b) is Example 2, (c) is the result of Example 3.
2 is a result of observing the amount of change in hair density according to a test example of the present specification.
3 is a result of observing the amount of change in hair diameter according to a test example of the present specification.

Hereinafter, the present invention will be described in detail.

In one aspect, the present specification provides an aerosol stock solution comprising a ginseng extract; and propane gas, butane gas, n-butane gas, isobutane gas, pentane gas, n-pentane gas, isopentane gas, neopentane gas, liquefied petroleum gas (LPG), liquefied natural gas (LNG) and dimethyl ether (DME) : An aerosol propellant containing one or more liquefied gas selected from the group consisting of dimethyl ether) provides a composition for preventing hair loss or promoting hair growth in an aerosol formulation, including.

As used herein, "hair loss" refers to a phenomenon in which hair falls off from the scalp or a phenomenon in which hair becomes sparse or thin, and "hair loss prevention" refers to preventing and inhibiting the phenomenon of hair loss as described above, and "promoting hair growth" "The term refers to the function of generating new hair or promoting hair growth, as well as the function of facilitating the delay from the growth phase to the degenerative phase and allowing the existing hair to grow healthy.

The aerosol undiluted solution is a substance other than the propellant in the entire aerosol content, and a composition containing ginseng as a main component to prevent hair loss or promote hair growth is used as the stock solution.

The aerosol propellant includes liquefied gas as a component necessary to release the contents, that is, the aerosol stock solution from the container.

The ginseng extract contains ginseng active ingredients that are effective in preventing hair loss or promoting hair growth, including crude extracts as well as processed products of the extract, for example, all forms by additional processing such as drying, concentration, fractionation, fermentation, etc. It is the broadest concept containing a specific active ingredient that is effective in preventing hair loss or promoting hair growth isolated from ginseng.

In an exemplary embodiment, the aerosol stock solution and the aerosol propellant are in a weight ratio of 1: 2.6 to 3, or 1: 2.7 to 3, or 1: 2.8 to 3, or 1: 2.6 to 2.9, by weight, Or 1: By being included in a weight ratio of 2.6 to 2.8, it is possible to implement an aerosol formulation that can maximize the efficacy of the active ingredient contained in ginseng when applied to the scalp. In addition, by including the aerosol propellant in the above range, it is possible to spray an appropriate amount of smooth foam and uniform spray of the aerosol stock solution.

In an exemplary embodiment, the aerosol propellant may include at least one liquefied gas selected from the group consisting of propane gas, butane gas, isopentane gas, and dimethyl ether (DME).

In an exemplary embodiment, the aerosol propellant contains isopentane gas and butane gas, and by implementing an aerosol formulation having excellent sparkling power, ginseng is effective with scalp massage effect due to air bubbles generated by gas when applied to the scalp By increasing the penetration rate and penetration time of the component, there is an effect of more efficiently preventing hair loss or promoting hair growth.

In an exemplary embodiment, the isopentane gas and butane gas are in a weight ratio of 1: 7.5 to 8, or 1: 7.6 to 8, or 1: 7.7 to 8, or 1: 7.8 to 8 by weight, Or 1: 7.5 to 7.9 weight ratio, or 1: 7.5 to 7.8 weight ratio, or 1: 7.5 to 7.7 by being included in a weight ratio of 1 : 7.5 to 7.7 of an aerosol formulation that can maximize the efficacy of the active ingredient contained in ginseng when applied to the scalp implementation is possible.

In an exemplary embodiment, the composition may include an aerosol stock solution, isopentane gas and butane gas in a weight ratio of 6.5:2:15.

In an exemplary embodiment, the composition may further include ingredients commonly used in the manufacture of hair products, such as fragrances, solubilizers, silicones, proteins, and the like.

Aerosol formulations according to the present disclosure may be prepared by conventional aerosol filling methods. Specifically, the aerosol stock solution is put into the aerosol container, then the valve is mounted and the air in the container is evacuated to a vacuum state, and then the crimped valve is closed at an appropriate position, and then the dispersant is introduced into the container through the valve. It can be prepared by filling.

Hereinafter, the present invention will be described in more detail through examples. These examples are only for illustrating the present invention, and it will be apparent to those of ordinary skill in the art that the scope of the present invention is not to be construed as being limited by these examples.

Example.

(1) Preparation of aerosol formulation according to liquefied gas

According to the composition of Table 1 below, the aerosol formulations of Examples 1 to 3 were prepared and each sparkling power was observed.

First, an aerosol stock solution of the main component of ginseng containing ginseng extract was prepared. The ginseng extract does not boil Korean ginseng ( Panax ginseng ) with heat, but applies Amorepacific’s patented differential pressure circulation method (Application ^No. Efficacy components were extracted by repeating pressure (0.8 kgf/cm ² ). As a result, the sugar of ginsenosides in ginseng could be maintained without decomposition, and the cell wall was broken due to the pressure difference, thereby maximizing the extraction of active ingredients. In particular, the content of specific saponins, such as Rg1 and Re, was significantly increased compared to the conventional extraction method. The ginseng extract thus prepared was formulated as a liquid to prepare an aerosol stock solution containing the main component of ginseng.

Thereafter, the aerosol stock solution was put into an aerosol container at room temperature, and then the gas was filled in proportion through a valve. After inserting the actuator, shake it sufficiently to mix the contents and gas well, and spray it on the paper for about 3 seconds. After about 10 seconds, the spray shape was observed.

Table 1. (Unit: g)

1 shows the results of observation of the sparkling power of (a) Example 1, (b) Example 2, and (c) Example 3, and it confirmed the excellent sparkling power, and in particular, liquefaction containing pure butane and isopentane The aerosol formulation of Example 1 made of gas exhibited the best sparkling power, that is, foaming power.

A high injection pressure does not mean an excellent aerosol formulation, and the aerosol stock solution, that is, gas must be able to remain in the contents. was found to have an effect. Accordingly, it was confirmed that the composition for preventing hair loss or promoting hair growth of the aerosol formulation according to the present specification has excellent sparkling power as well as injection pressure, so that the scalp massage effect can be enhanced.

(2) Preparation of a composition for preventing hair loss or promoting hair growth

Using the aerosol stock solution of the main component of ginseng prepared in the preparation of the above (1) aerosol formulation According to the composition of Table 2 below, the composition of Comparative Example 1, which is an aerosol formulation containing no ginseng main component, Comparative Example 2, which is a liquid formulation containing the main component of ginseng, and Example 1, which is an aerosol formulation containing the main component of ginseng, was prepared, It was used for the following test example.

Table 2. (Unit: g)

Test Example 1. Change in hair density

By treating the compositions of Comparative Examples 1, 2 and Example 4, the amount of change in hair density was compared.

The site to be evaluated mechanically was a site with symptoms of hair loss, and the area near the crown of the head was used as the main measurement site. For the instrumental evaluation, the subject was allowed to adjust the temperature and humidity of the skin surface to the environment of the measurement space by resting for 30 minutes in a waiting room under constant temperature and humidity conditions with an indoor temperature of 20 to 25 °C and a humidity of 40 to 60%. In order to measure the thickness and density of the hair, the hair at the hair loss area was uniformly cut to a length of 2 mm or less in a circle with a diameter of 1 cm, and then the test site was marked with a black dot (tattoo) with a diameter of 1 mm on the center of the hair. For objective measurement, one researcher measured, and the same area was measured for each measurement. Hair density was measured on a scalp of a certain area (1 cm ² ), and the number of hairs in the area was used as evaluation data.

As a result, as shown in FIG. 2 , it was found that the amount of change in hair density in Example 1 was significantly increased compared to Comparative Example 1 which did not contain ginseng active ingredient and Comparative Example 2 which was a liquid formulation containing ginseng active ingredient. Moreover, even when compared with Comparative Example 2 containing a large amount of ginseng active ingredient, the composition of Example 1 showed a more improved increase in hair density. Accordingly, it was confirmed that the composition of the aerosol formulation containing the ginseng active ingredient according to the present specification has an excellent hair loss prevention or hair growth promoting effect.

Test Example 2. Change in hair diameter

The amount of change in hair diameter was compared by treating the compositions of Comparative Examples 1, 2 and Example 4.

Evaluation test conditions are the same as the amount of change in hair density of Test Example 1, and hair diameter measurement was performed on a scalp of a certain area (1 cm ² ), and the average value of the thickness of 5 hairs among hairs in the area was used as evaluation data.

As a result, as shown in FIG. 3 , it was found that the amount of change in hair diameter of Example 1 was significantly increased compared to Comparative Example 1 which did not contain ginseng active ingredient and Comparative Example 2 which was a liquid formulation containing ginseng active ingredient. Moreover, even when compared with Comparative Example 2 containing a large amount of ginseng active ingredient, the composition of Example 1 showed a more improved increase in hair diameter. Accordingly, it was confirmed that the composition of the aerosol formulation containing the ginseng active ingredient according to the present specification has an excellent hair loss prevention or hair growth promoting effect.

Above, specific parts of the present invention have been described in detail, for those of ordinary skill in the art, these specific descriptions are only preferred embodiments, and the scope of the present invention is not limited thereby. It will be obvious. Accordingly, it is intended that the substantial scope of the present invention be defined by the appended claims and their equivalents.

Claims (5)

Aerosol stock solution containing ginseng extract; and
An aerosol propellant comprising isopentane gas and butane gas; an aerosol formulation comprising a composition for preventing hair loss or promoting hair growth.
The method of claim 1,
The aerosol stock solution and the aerosol propellant are included in a weight ratio of 1: 2.6 to 3, an aerosol formulation for preventing hair loss or promoting hair growth.
delete delete The method of claim 1,
The isopentane gas and butane gas are included in a weight ratio of 1: 7.5 to 8, an aerosol formulation for preventing hair loss or promoting hair growth.

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