TWI702958B - Aerosol type composition for preventing hair loss or promoting hair growth - Google Patents

Abstract

Disclosed is an aerosol type composition including ginseng extract.  The composition realizes an aerosol formulation providing a maximized effect of active ingredients contained in ginseng by using a liquefied gas suitable therefor.  Therefore, unlike the conventional hair loss-preventing agent having a liquid formulation, the aerosol formulation does not run down upon the application to the scalp to show an excellent feeling of use, allows the active ingredients of ginseng to be retained on the scalp for a long time to increase the infiltration time thereof, and thus shows more efficient effects of preventing hair loss or promoting hair growth.

Description

Aerosol type composition to prevent hair loss or promote hair growth

This article discloses an aerosol-type composition comprising a ginseng extract that can prevent hair loss or promote hair growth.

Aerosol physically means a colloidal state, which contains solid or liquid particles dispersed in a gas. In the field of beauty, many spray type (such as hair spray) and extrusion type (such as hair mousse) products have been commercialized. Recently, aerosols have been widely used in skin care and cosmetic products. The aerosol composition of the existing related technology can be found in Korean Patent Publication No. 1999-0042456.

The principle of aerosol is to introduce the content to be sprayed and the propellant into a pressure-resistant sealed container, and spray or extrude the content under the pressure of the propellant. Here, depending on the type of propellant, a liquefiable gas that is liquefied under internal pressure or a compressible gas that is not liquefiable can be used. Moreover, different spraying modes and foaming capabilities are provided by different types of gas. In addition, once the contents of the aerosol are prepared, due to the characteristics of the aerosol container, it is stored in a sealed state from the outside. Therefore, the advantage is that it can significantly improve the stability of the active ingredient, otherwise it will be difficult to stabilize due to some reasons such as heat and light.

At the same time, ginseng is a well-known medicinal plant material and its function is to promote hair growth. Ginseng is known to strengthen hair roots to prevent hair loss fundamentally, promote hair growth, restore hair weakened by frequent hair dyeing, perming, exposure to ultraviolet rays, etc., and enhance hair elasticity (Journal of Dermatological Science 77 (2015) 125-134) .

According to the related art, most of the products for preventing hair loss are liquid preparations, which are applied to the scalp through a tube or a pump. Therefore, it has the disadvantage of shedding when applied to the scalp, causing inconvenience in use. In the case of an aerosol formulation containing a compressible gas (such as compressible nitrogen, compressible oxygen, or compressible air), the gas will escape from the formulation over time, resulting in a deterioration in the feeling of use.

technical problem

The technical problem to be solved by this manual is to provide an aerosol-type composition that prevents hair loss or promotes hair growth. The composition contains an aerosol stock solution, which contains the main ingredients of preventing hair loss or promoting hair growth. The combination of agents so that the active ingredients of ginseng can be sprayed together with gas. Technical solutions

In a general aspect, an aerosol composition for preventing hair loss or promoting hair growth is provided, which comprises: an aerosol stock stock solution containing ginseng extract; and an aerosol propellant containing at least one selected from propane Gas, butane gas, n-butane gas, isobutane gas, pentane gas, n-pentane gas, isopentane gas, neopentane gas, liquefied petroleum gas (LPG), liquefied natural gas (liquefied natural gas, LNG) and dimethyl ether (DME) group of liquefied gas.

According to specific embodiments, the aerosol stock solution and the aerosol propellant are used in a weight ratio of 1:2.6-3.

According to another embodiment, the aerosol propellant may include at least one liquefied gas selected from the group consisting of propane gas, butane gas, isopentane gas, and dimethyl ether (DME).

According to yet another specific embodiment, the aerosol propellant may include isopentane gas and butane gas.

According to yet another specific embodiment, the isopentane gas and butane gas system is used in a weight ratio of 1:7.5-8. Beneficial effect

According to a specific embodiment of the present invention, an aerosol preparation is provided, which provides the maximum effect of the active ingredients contained in ginseng by using a liquefied gas suitable for it. Therefore, unlike traditional liquid formulations that prevent hair loss, the aerosol formulation does not shed when applied to the scalp to show an excellent feeling of use, so that the active ingredients of ginseng can remain on the scalp for a long time to increase its penetration time, and Therefore, it is more effective to prevent hair loss or promote hair growth.

Moreover, according to the specific embodiment of the present invention, an aerosol preparation with excellent foaming ability is improved, which is used in an aerosol stock solution containing ginseng active ingredients. Therefore, the bubbles generated by the gas provide the effect of massaging the scalp and increase the permeability of the active ingredients of ginseng, and thus show a more effective effect of preventing hair loss or promoting hair growth.

Illustrative specific embodiments will now be described more fully below.

In one aspect, an aerosol composition for preventing hair loss or promoting hair growth is provided, which comprises: an aerosol stock stock solution, which contains ginseng extract; and an aerosol propellant, which contains at least one selected from propane Gas, butane gas, n-butane gas, isobutane gas, pentane gas, n-pentane gas, isopentane gas, neopentane gas, liquefied petroleum gas (LPG), liquefied natural gas (LNG) and Dimethyl ether (DME) is a group of liquefied gases.

In another aspect, a method for preventing hair loss or promoting hair growth is provided, which comprises applying an aerosol-type composition for preventing hair loss or promoting hair growth to a body, the composition comprising: an aerosol stock solution; and a gas Sol propellant, which contains at least one selected from propane gas, butane gas, n-butane gas, isobutane gas, pentane gas, n-pentane gas, isopentane gas, neopentane gas, Liquefied petroleum gas (LPG), liquefied natural gas (LNG), and dimethyl ether (DME). For example, the method may comprise applying an effective amount of the composition to the skin or scalp of the individual.

In yet another aspect, there is provided an aerosol composition for preventing hair loss or promoting hair growth to an individual. The composition comprises: an aerosol stock solution; and an aerosol propellant, which contains at least one selection Free from propane gas, butane gas, n-butane gas, isobutane gas, pentane gas, n-pentane gas, isopentane gas, neopentane gas, liquefied petroleum gas (LPG), liquefied natural gas (LNG) and dimethyl ether (DME) is a group of liquefied gas. For example, the composition can be applied to the skin or scalp of an individual.

In this manual, "hair loss" refers to the phenomenon of scalp hair loss or thinning of hair, "preventing hair loss" refers to preventing and suppressing the phenomenon, and "promoting hair growth" refers to not only sprouting new hair or promoting hair germination It also promotes the delayed transition from the growth phase to the degenerative phase in the hair growth cycle and promotes the healthy growth of existing hair.

The term "aerosol reserve stock solution" refers to the entire aerosol content except for the propellant, and a composition containing ginseng as the main component that can effectively prevent hair loss or promote hair growth, which is used as a reserve stock solution.

The term "aerosol propellant" means a component capable of dispersing the contents and containing a liquefied gas, the contents being the aerosol stock solution in the container.

The term "ginseng extract" includes ginseng active ingredients that can effectively prevent hair loss or promote hair growth. The broadest concept includes not only the original ginseng extract but also the processed products of the extract, such as those made by other processing methods (including drying, concentrated , Fractionation, fermentation, etc.) of all types of products obtained, and have the significance of separating specific active ingredients from ginseng itself that can effectively prevent hair loss or promote hair growth.

According to specific embodiments, the aerosol stock solution and aerosol propellant are used in a weight ratio of 1:2.6-3, 1:2.7-3, 1:2.8-3, 1:2.6-2.9 or 1:2.6-2.8, This makes it possible to realize an aerosol formulation that maximizes the effect of the active ingredients contained in ginseng when applied to the scalp. Moreover, when the aerosol propellant is used in the above-defined range, an appropriate amount of composition in the form of a smooth foam can be sprayed and the aerosol stock solution can be sprayed uniformly.

According to another embodiment, the aerosol propellant may include at least one liquefied gas, which is selected from the group consisting of propane gas, butane gas, isopentane gas, and dimethyl ether (DME).

According to yet another specific embodiment, the aerosol propellant includes isopentane gas and butane gas to realize an aerosol formulation with excellent foaming ability. Therefore, the bubbles generated by the gas when applied on the scalp can effectively massage the scalp and increase the penetration rate and penetration time of the active ingredients of ginseng, thereby providing more effective prevention of hair loss or promoting hair growth.

According to yet another specific embodiment, the isopentane gas and butane gas system has a weight ratio of 1:7.5-8, 1:7.6-8, 1:7.7-8, 1:7.8-8, 1:7.5-7.9 , 1:7.5-7.8 or 1:7.5-7.7 use, so that it can achieve an aerosol formulation that maximizes the effect of the active ingredients in ginseng when applied to the scalp.

According to yet another specific embodiment, the composition may include the aerosol stock solution, isopentane gas, and butane gas in a weight ratio of 6.5:2:15.

According to yet another specific embodiment, the composition may be a cosmetic composition.

According to yet another specific embodiment, the composition may further include other ingredients traditionally used to produce hair care products, including fragrance, solubilizer, silicone, protein, and the like.

The aerosol preparation in this specification can be obtained by traditional aerosol filling method. In particular, the aerosol stock solution is guided to an aerosol container, a valve is installed on the aerosol container, a vacuum state is formed in the container, and air is removed from the container, and crimping is performed at an appropriate position. ), the valve is sealed, and a propellant is loaded into the container through the valve. Invention embodiment

Hereinafter, the specification will be explained in detail with reference to examples. However, those skilled in the art should understand that the following examples are for illustrative purposes only and are not intended to limit the scope of this specification. Example

(1) Preparation of aerosol preparations using liquefied gas

The aerosol formulations of Examples 1-3 were prepared according to the composition shown in Table 1 below. Then observe the foaming ability of each aerosol formulation.

First, an aerosol stock solution containing ginseng extract is prepared. The ginseng extract is obtained by extracting the active ingredients of ginseng. Instead of boiling Panax ginseng, it uses Amore Pacific Co., LTD's repeated high pressure (2 kgf/cm ² ) and low pressure (0.8 kgf/cm ² ) differential pressure cycle Method (Patent Application Number: 10-2009-0057901: System and Method for Negative and Positive Extraction). In this method, the cell wall is destroyed by the pressure difference, so the sugar components of ginsenosides can be retained without being decomposed, and the extraction of the active components can be maximized. In particular, compared with the existing extraction methods, the content of specific saponins such as Rg1 or Re is significantly increased. The prepared ginseng extract is made into a liquid preparation to obtain an aerosol stock solution containing the main components of ginseng.

Then, the aerosol stock solution is guided to an aerosol container at room temperature and a gas is filled into the container in an appropriate ratio by a valve. After inserting the stopper, the container was shaken sufficiently to make the contents and the gas mixed uniformly, and the contents were sprayed on carbon paper for about 3 seconds. Then, after about 10 seconds, the shape of the sprayed content was observed. Table 1. (Unit: g)

Fig. 1 shows the result of foaming ability of each of (a) Example 1, (b) Example 2 and (c) Example 3. It can be seen that each formulation has excellent foaming ability. In particular, the aerosol formulation of Example 1 containing liquefied gas (including butane and isopentane) showed the highest foaming ability, that is, foaming ability.

However, high spray pressure cannot guarantee an excellent aerosol formulation. The gas is required to remain in the stock solution (ie, the contents) of the aerosol stock. In the case of using the aerosol preparation of the liquefied gas in Example 1, the bubbles are collected and retained in the content, thereby providing an excellent foaming effect. Therefore, it can be seen that the aerosol type composition for preventing hair loss or promoting hair growth in this specification not only has excellent spray pressure but also has excellent foaming ability, thus showing the enhancement effect of massaging the scalp.

(2) Preparation of compositions that prevent hair loss or promote hair growth

The aerosol stock solution of the main components of ginseng obtained by the above-mentioned "(1) Preparation of aerosol preparations" was used to obtain the aerosol preparations containing no main components of ginseng (Comparative Example 1) The liquid preparation of the main components of ginseng (Comparative Example 2) and the aerosol preparation of the main components of ginseng (Example 1) are based on the composition shown in Table 2 below. This formulation was used in the following test examples. Table 2. (Unit: g)

Test example 1. Changes in hair density

The composition systems of Comparative Examples 1 and 2 and Example 1 were compared with each other in the hair density changes.

The part where the hair loss state appears is evaluated by the instrument, and the part near the top of the head is tested. For instrument evaluation, the subjects were allowed to rest in the waiting room for 30 minutes at a room temperature of 20-25°C and a humidity of 40-60% in a constant temperature and humidity condition to make the temperature and humidity of the skin surface suitable for the test space environment. In order to measure the thickness and density of the hair, the hair within a circle of 1 cm diameter of the hair loss part is uniformly cut to a length of 2 mm or less, and the central part is marked as the test part with a black dot (pattern). In order to make an objective measurement, the researcher participates in the test and observes the same part at each test time. A predetermined area (1 cm ² ) of the scalp was measured for hair density and the number of hairs in the area was used as an evaluation criterion.

As a result, when compared with the liquid formulation of Comparative Example 1 without ginseng active ingredients and Comparative Example 2 with ginseng active ingredients, it can be seen from FIG. 2 that Example 1 shows a significant increase in hair density. In addition, when compared with Comparative Example 2 containing a large amount of ginseng active ingredients, the composition of Example 1 showed a more significant increase in hair density. Therefore, it can be seen that the aerosol composition containing ginseng active ingredients of this specification has excellent hair loss prevention and hair growth promotion effects.

Test example 2. Change of hair path

The compositions of Comparative Examples 1 and 2 and Example 1 were compared with their hair diameter changes.

The evaluation test conditions are the same as in Test Example 1 (change in hair density). The hair diameter is measured on a predetermined area (1 cm ² ) of the scalp and the average thickness of 5 hair strands in the area is used as the evaluation criterion.

As a result, when compared with the liquid formulations of Comparative Example 1 without ginseng active ingredients and Comparative Example 2 with ginseng active ingredients, it can be seen from FIG. 3 that Example 1 shows a significant increase in hair diameter changes. In addition, when compared with Comparative Example 2 containing a large amount of ginseng active ingredients, the composition of Example 1 showed a more significant increase in hair diameter. Therefore, it can be seen that the aerosol composition containing ginseng active ingredients of this specification has excellent hair loss prevention and hair growth promotion effects.

When the illustrated specific embodiments are shown and described, those skilled in the art should understand that various changes in form and details can be made without departing from the scope of the specification defined in the scope of the appended application. Therefore, the scope of this specification includes all implementation aspects falling within the spirit and scope of the attached patent application.

no

FIG. 1 shows the observation results of the foaming ability of a test example, in which (a) shows the result of Example 1, (b) shows the result of Example 2, and (c) shows the result of Example 3. Figure 2 shows an observation result of the hair density change of a test example. Figure 3 shows the observation result of the hair diameter change of a test example.

Claims (3)

An aerosol type composition for preventing hair loss or promoting hair growth, comprising: an aerosol stock stock solution containing ginseng extract; and an aerosol propellant containing butane gas and isopentane gas. The aerosol composition for preventing hair loss or promoting hair growth as described in claim 1, wherein the aerosol stock solution and the aerosol propellant are used in a weight ratio of 1:2.6-3. The aerosol type composition for preventing hair loss or promoting hair growth as described in claim 1, wherein the isopentane gas and butane gas system is used in a weight ratio of 1:7.5-8.

Images