JP3439672B2 - Method for producing aerosol composition - Google Patents

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to an aerosol composition containing a hydrous stock solution for aerosol and a propellant for aerosol.
Manufacturing method .

[0002]

2. Description of the Related Art Conventional aerosol products include those that spray active ingredients in the form of fog such as insecticides for space, those that spray active ingredients as foam such as hair styling foam, and antiperspirant. A powder of an active ingredient is sprayed together with a propellant, such as an agent, or a scalp when the heat of vaporization is sprayed on the scalp and the like when the propellant as shown in JP-A-61-68406 vaporizes. Hair nourishing agents and the like that cool and physically stimulate skin have been put on the market and developed.

[0003]

However, the aerosol product as described above adheres to the coated surface in the form of fine particles, bubbles, or a liquid containing a small amount of propellant, and the propellant quickly vaporizes to leave an undiluted solution. Form, not an aerosol product intended to cool the coated surface. There are also aerosol products that use the latent heat of vaporization of liquefied gas to give a cool sensation to the scalp and provide physical irritation like the above-mentioned hair nourishing agents. This is an aerosol product that is not suitable for dripping or for cooling a specific part because the stock solution easily flows, or for giving a cool feeling to the specific part for a little longer. An object of the present invention is to provide an aerosol composition suitable for giving a sensation of cooling to a specific site for a long time without causing dripping or the like on the coated surface.

[0004]

In order to achieve the above-mentioned object, the present invention provides a composition for an aerosol comprising a hydrous stock solution for an aerosol and a propellant for an aerosol, which is sprayed in the form of foam, foam or mist. It is characterized in that a part or almost all of the water-containing stock solution cooled by the heat of vaporization of the propellant has a property of adhering to the coated surface in the form of ice or snow.

Preferred specific examples of the aerosol composition of the present invention include: 5 to 35% by weight of a hydrous stock solution for aerosol containing 50% by weight or more of water; Mixture of agent and spraying aid 65 ~
And 95% by weight, and a part or almost all of the propellant or the mixture is emulsified or dispersed in the water-containing undiluted solution for aerosol, and the composition for aerosol having the above-mentioned properties can be mentioned.

As the above-mentioned propellant having a boiling point of 5 ° C. or lower,
Dichlorodifluoromethane (hereinafter referred to as F12), difluoromonochloroethane (hereinafter referred to as F142b), monochlorodifluoromethane (hereinafter referred to as F22), dichlorotetrafluoroethane (hereinafter referred to as F114), tetrafluoroethane (hereinafter referred to as F134a) , Dimethyl ether (hereinafter referred to as DME), liquefied petroleum gas (hereinafter referred to as LPG) (mainly containing propane, isobutane, and normal butane), or a mixture thereof. As a particularly preferable propellant
Propellants mixed with liquefied petroleum gas containing 20 to 55% by weight of DME and isobutane having a purity of 95% by weight or more (usually propane and normal butane are mostly impurities) can be mentioned.

The term "injection aid" as used herein means a solvent having a relatively low boiling point exceeding 5 ° C., and specifically, trichloromonofluoromethane (hereinafter referred to as F11) and trichlorotrifluoroethane (hereinafter referred to as F113). ), Dichlorotrifluoroethane (hereinafter referred to as F123), isopentane, normal pentane, hexane, or a mixture thereof.

The propellant or the combination of the propellant and the propellant exemplified above is appropriately selected, and a part or all of the propellant or the propellant and the propellant is emulsified (dispersed) in the undiluted solution to perform the injection. At times, it is possible to produce a composition that can be applied in the form of ice or snow without causing dripping on the application surface. The freezing state or snow-like state here means, for example, when the aerosol composition of the present invention is sprayed onto the back of a hand, in appearance it is just before water turns into ice on the coated surface or snow is placed on the back of the hand. However, when I put sensory water, ice, snow, or a mixture of these on my back,
It means a state in which a cold feeling is felt locally.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION Specific examples of preferable combinations of a propellant and a propellant will be shown below. If a part of F114 is replaced by F12, which has a lower boiling point and a higher latent heat of vaporization, the content of the F12 evaporates quickly and the contents freeze up as soon as they leave the button nozzle, causing button clogging (overheating). cooling). Therefore, we adopted a combination of F12 / F114 / isopentane that has a different boiling point stepwise and that does not break the emulsified state of one liquid to slow down the cooling rate (soft cooling).

[0010]

[Table 1]

By doing so, it is possible to apply the composition to the target surface in a frozen state without freezing when the button is pushed out. On the other hand, when a part of F114 is replaced with DME, the boiling point of DME (-25 ° C) is heat of vaporization of 112 cal / g,
Thermodynamically, it seems to freeze easily, but DME
In the case of, the solubility with the water-containing stock solution is high, the vaporization rate is slow,
The gas is released slowly, and the DME is mixed into the target coating surface, so it has the feature that the content changes into a icy ice after adhering to the coating surface. In some cases, the foam sherbet has a strong cooling sensation. of course,
There is no problem even if compressed gases such as CO ₂ , N ₂ and air are mixed into the aerosol product filled with the above-mentioned one-liquid emulsified stock solution.
Also, as a propellant, monochlorodifluoroethane (F142
b) can be used alone. Since it is not persistent like so-called CFC gas, it rarely causes the destruction of the ozone layer in the atmosphere, and it is less flammable and safer to use than LPG or DME. It's quite expensive. When an aerosol composition emulsified using F142b is sprayed, the water-containing stock solution is appropriately cooled and forms a frozen or snow-like, more specifically, sherbet-like or rime or snow-like application surface. can do.

In this case, the ratio of the water-containing stock solution to F142b is 10
/ 90 to 20/80 parts by weight are preferred. 10% water-containing stock solution
If it is less than wt%, the amount of the active ingredient dissolved is limited, or it becomes difficult to emulsify or disperse it. If the water-containing stock solution is higher than 20% by weight, F1 F142b will not freeze the stock solution. Therefore, if it is desired to increase the amount of the stock solution containing water, it is possible to freeze the stock solution by replacing a part of F142b with LPG, DME, F12 having a lower boiling point and a large latent heat of vaporization. Even if F142b (boiling point -9 ° C) and isobutane (boiling point -11.7 ° C), which has a near boiling point, are used as propellants, a good aerosol composition can be produced by appropriately selecting the surfactant. .

It is also possible to use LPG to make the aerosol composition of the present invention. By appropriately combining propane, isobutane, and normal butane having different boiling points, and further adding isopentane and normal pentane, if necessary, a composition for an aerosol having a snow-covered surface can be prepared.

Further, the composition for aerosol of the present invention can be easily prepared by mixing DME with LPG and using it as a propellant. Since DME has the property of dissolving in water,
When DME is used in the range of 20 to 55% by weight in the mixed gas, it adheres to the coated surface and forms a water-poor snow-like sherbet. DME
If the content is less than 20% by weight, it is difficult to show the characteristics due to the above DME dissolving in water, and if it exceeds 55% by weight, it will dissolve the water-containing undiluted solution if it exceeds 55% by weight. When sprayed, it becomes a fine mist and it becomes difficult to form a sherbet on the adhered surface.

The water-containing undiluted solution for aerosol in the present invention is
It may contain an active ingredient and a surfactant depending on the intended use, and may further contain an alcohol and a water-soluble silicone oil, if necessary. Specific examples of the above-mentioned undiluted solution include, for example, 100 parts by weight of an aqueous solution of 0 to 60% by weight of alcohol and 0.01% of a surfactant.
~ 10 parts by weight and / or water-soluble silicone oil 0.01 ~ 10 parts by weight and / or powder 0.1 ~ 50 parts by weight and active ingredient 0.01 ~
An example is one in which 50 parts by weight is added.

Although alcohol may or may not be used in the stock solution, 60% by weight or less of alcohol may be added when the composition is used as an aerosol composition in which the stickiness after application is disliked. In that case alcohol 10
It is particularly preferred to use an aqueous solution of -40% by weight. Since alcohol is soluble in water-soluble components and various organic compounds insoluble in water, it is used as a solubilizer or dispersant for both these components, but alcohol has a low boiling point and is easily vaporized. It is also useful as an ingredient for having a refreshing feeling.

The surfactant is a component for emulsifying or dispersing the undiluted solution and the propellant, for example, an interface of polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene alkylphenyl ether, polyoxyethylene castor oil derivative and the like. Examples of the active agent include, but are not limited to, as long as they can be emulsified or dispersed.

The surfactant is added in an amount of 0.01 to 10 parts, preferably 0.1 to 5 parts, relative to 100 parts of an aqueous alcohol solution (parts by weight, hereinafter "parts" means "parts by weight"). . If the addition amount is less than 0.01 part, strong shaking or long-time shaking is required to emulsify or disperse the stock solution and the propellant, and if it exceeds 10 parts, the surfactant itself may not be sticky. It is not preferable because it gives a pleasant feeling.

The water-soluble silicone is a component for dispersing (emulsifying) the undiluted solution and the propellant when used in combination with the above-mentioned surfactant, and also prevents the sticky feeling due to the above-mentioned surfactant and smoothes the skin. It not only gives a feel but also moisturizes. Specific examples include dimethylpolysiloxane polyethylene glycol copolymers in which the hydrophobic group is dimethyl silicone oil and the hydrophilic group is polyether. This water-soluble silicon is 0.01 to 20 parts, preferably 0.1 to 10 parts, relative to 100 parts of the alcohol aqueous solution.
Partly added and used. When the addition amount is less than 0.01 part, the surfactant does not play an auxiliary role for forming an emulsion of the stock solution and the propellant, and when it exceeds 20 parts, the stickiness on the coated surface becomes strong, which is not preferable.

Any powder can be used as long as it is a powder that is difficult to dissolve in the water-containing stock solution and the propellant, but it is particularly preferable to use talc, nylon powder or the like which has a shaping effect. The powder is used by adding 0.1 to 50 parts, preferably 1 to 30 parts, to 100 parts of the aqueous alcohol solution. If the addition amount is less than 0.1 part, the effect of obtaining an emulsion by shaking the stock solution and the propellant is small, and if it exceeds 50 parts, the composition for aerosol is sprayed onto the skin and the like and dried. However, the powder remains on the skin as spots, which is not preferable. For example, when a composition for aerosol is obtained by shaking the stock solution and the propellant by using talc in the range as described above, it has the same effect as the surfactant or enhances the effect of the surfactant, and depending on the case, The aerosol composition can be obtained by simple shaking without using a surfactant.

As the active ingredient used in the present invention, an ingredient selected according to various uses can be selected to prepare medicines, quasi-drugs, cosmetics, general miscellaneous goods, etc. For example, insect repellent, anti-itch active ingredient, Sunburn, snowburn sedative ingredient, aftershave lotion active ingredient, burn treatment active ingredient, astringent active ingredient, antiphlogistic analgesic active ingredient, refresh lotion active ingredient, cologne active ingredient, athlete's foot remedy active ingredient, shimoyake remedy active ingredient, round hair loss agent , Hair restorer,
Examples of the antiperspirant include, but are not limited to, various active ingredients can be used. The active ingredient is added in an amount of 0.1 to 50 parts, preferably 1 to 30 parts, based on 100 parts of the aqueous alcohol solution. If the amount added is less than 0.1 part, it is not effective for the intended use, and if it exceeds 50 parts, it becomes difficult to disperse the active ingredient, which is not preferable.

As described above, a stock solution usable in the present invention can be obtained by adding an active ingredient, a surfactant, and optionally water-soluble silicon, and a powder to an aqueous solution containing 0 to 60% by weight of alcohol. In addition to the components, depending on the active ingredient, depending on the application, as an emulsification aid, for example, monopropyl alcohols such as normal propyl alcohol and normal butyl alcohol and modified alcohols thereof; propylene glycol, ethylene glycol, diethylene glycol, triethylene glycol, Polyhydric alcohols such as glycerin; ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone; ethers such as diethyl ether, ethylene glycol monoethyl ether; isopropyl myristate, isopropyl palmitate, butyl Restated, esters such as castor oil, the addition of liquid paraffin, kerosene, xylene,
You may add and use kerosene.

Next, the composition for aerosol of the present invention is obtained by preparing a stock solution of water and a propellant or a mixture of a propellant and a propellant. The ratio of the stock solution to the propellant or the mixture of propellant and propellant can be used in the range of 5/95 to 35/65 weight ratio, preferably 10/90 to 25/75. When the mixing ratio is 5/95 or less, the content of the active ingredient in the stock solution is limited, and when it is 35/65 or more, the proportion of the water-containing stock solution increases, and the propellant has a low boiling point, that is, injection with high vapor pressure. This is because it becomes necessary to increase the proportion of the agent and it becomes difficult to form a frozen or snow-like coated surface.
When using the composition for aerosol of the present invention, for example, a human body article, each part of the human body in a state where the stock solution is simply frozen.
Since it can be attached to the head, palm, fingers, back of the hand, or the back of the foot, before the chemical effect of the active ingredient in the contents is exerted, athlete's foot treatment, itching of mosquitoes, insect repellent, etc. It has an effect that an antipruritic effect can be physically added to itching and the like.

In addition, calamine lotion for calming hot flashes on the skin due to sunburn or snowburn has a calming effect and an effect of adding a refreshing feeling. In addition, when used in products for the purpose of soothing chemical proteins in the skin such as astringent, preshave (make a whisker before using an electric razor), and an antiperspirant, the effect of adding a physical astringent effect Play.

Furthermore, it is said that a recent sensation of stimulating the scalp with a cold sensation has been recognized in recent studies on hair nourishment and hair growth. It is possible to provide a therapeutic agent to which a sensitizing effect is added. Further, the present invention provides a unique visual effect in terms of cosmetic properties such as a snowfield image, which has not been available in the past such that it can be applied on a palm in the shape of a rime or a snowfield, and a snowfield image.

[0026]

The present invention is illustrated by the following formulation examples, but the present invention is not limited thereto.

[0027]

[Table 2]

[0028]

[Table 3]

[0029]

[Table 4]

[0030]

[Table 5]

[0031]

[Table 6]

[0032]

[Table 7]

[0033]

[Table 8]

[0034]

[Table 9]

[0035]

The aerosol composition of the present invention, when sprayed onto various parts of the human body or the like, allows the undiluted solution to be adhered in a frozen state or in the form of snow, so that it does not cause dripping and the like It may give a cold feeling or other effects to the application site for a long time, or may exert a cooling effect. Further, it imparts a rime-like or snowfield-like formability and color on the application surface, and also has a unique visual effect in terms of makeup and play.

Continuation of front page (51) Int.Cl. ⁷ identification code FI C09K 3/30 C09K 3/30 R (56) References JP-A-61-112011 (JP, A) P. A. Sanders "Hand book of Aerosol Te chnology Second Ed ition ", Van Nostran d Reinhold Compan y, 1979, # 385, pp. (58) investigated the field (Int.Cl. ^7, DB name) C09K 3/30 A61K 9 / 12 A61K 7/00

Claims (6)

(57) [Claims] 1. A water-containing undiluted solution for an aerosol, which may optionally contain an active ingredient of pharmaceuticals or cosmetics and contains 50% by weight or more of water, and an aerosol propellant having a boiling point of 5 ° C. or less, which may optionally contain a propellant. And are cooled by the heat of vaporization of the propellant
Part or almost all of the water-containing undiluted solution mixed is mixed in a ratio that adheres to the coated surface in the form of ice or snow when sprayed ,
The aerosol propellant or a spray with the aerosol propellant
Part or almost all of the mixture of spray aids is
Comprising to emulsify or disperse in water stock for Lumpur, et
Method for manufacturing azole products . 2. A water-containing undiluted solution for aerosol, and the air.
Sol propellant or aerosol propellant and propellant
The method according to claim 1, wherein the ratio of the mixture of 5 to 35% by weight to 65 to 95% by weight. 3. The propellant for aerosol is dimethyl ether.
Ether, propane, isobutane, normal butane or
The method according to claim 1, which is a mixture thereof. 4. The aerosol propellant is dimethyl ether.
Ether, propane, isobutane, normal butane or
The method according to claim 2, which is a mixture thereof. 5. The hydrous stock solution for aerosol contains alcohol in an amount of 10 to 40% by weight.
The method described in the section. 6. The propellant for aerosol is a mixed propellant composed of liquefied petroleum gas containing 20 to 55% by weight of dimethyl ether, or isobutane having a purity of 95% or more, or propane, isobutane and normal butane. The method according to any one of claims 1 to 4, which is a mixture of