KR102363479B1 - 로티고틴 함유 경피 흡수 제제 - Google Patents

로티고틴 함유 경피 흡수 제제 Download PDF

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Publication number
KR102363479B1
KR102363479B1 KR1020210033021A KR20210033021A KR102363479B1 KR 102363479 B1 KR102363479 B1 KR 102363479B1 KR 1020210033021 A KR1020210033021 A KR 1020210033021A KR 20210033021 A KR20210033021 A KR 20210033021A KR 102363479 B1 KR102363479 B1 KR 102363479B1
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KR
South Korea
Prior art keywords
drug
rotigotine
polymer
examples
colorless transparency
Prior art date
Application number
KR1020210033021A
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English (en)
Korean (ko)
Inventor
김낙원
송재곤
류민지
신호철
란잔 칸 판카즈
권혁일
Original Assignee
환인제약 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 환인제약 주식회사 filed Critical 환인제약 주식회사
Priority to KR1020210033021A priority Critical patent/KR102363479B1/ko
Priority to KR1020220017832A priority patent/KR20220128273A/ko
Application granted granted Critical
Publication of KR102363479B1 publication Critical patent/KR102363479B1/ko
Priority to PCT/KR2022/003491 priority patent/WO2022191675A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020210033021A 2021-03-12 2021-03-12 로티고틴 함유 경피 흡수 제제 KR102363479B1 (ko)

Priority Applications (3)

Application Number Priority Date Filing Date Title
KR1020210033021A KR102363479B1 (ko) 2021-03-12 2021-03-12 로티고틴 함유 경피 흡수 제제
KR1020220017832A KR20220128273A (ko) 2021-03-12 2022-02-10 로티고틴 함유 경피 흡수 제제
PCT/KR2022/003491 WO2022191675A1 (fr) 2021-03-12 2022-03-12 Formulation d'absorption transdermique contenant de la rotigotine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020210033021A KR102363479B1 (ko) 2021-03-12 2021-03-12 로티고틴 함유 경피 흡수 제제

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020220017832A Division KR20220128273A (ko) 2021-03-12 2022-02-10 로티고틴 함유 경피 흡수 제제

Publications (1)

Publication Number Publication Date
KR102363479B1 true KR102363479B1 (ko) 2022-02-15

Family

ID=80325823

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020210033021A KR102363479B1 (ko) 2021-03-12 2021-03-12 로티고틴 함유 경피 흡수 제제
KR1020220017832A KR20220128273A (ko) 2021-03-12 2022-02-10 로티고틴 함유 경피 흡수 제제

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020220017832A KR20220128273A (ko) 2021-03-12 2022-02-10 로티고틴 함유 경피 흡수 제제

Country Status (2)

Country Link
KR (2) KR102363479B1 (fr)
WO (1) WO2022191675A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022191675A1 (fr) * 2021-03-12 2022-09-15 환인제약 주식회사 Formulation d'absorption transdermique contenant de la rotigotine

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20240102880A (ko) * 2022-12-26 2024-07-03 환인제약 주식회사 경피흡수용 제제 및 이의 제조 방법

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100875532B1 (ko) 2002-12-30 2008-12-24 쉬바르츠파르마에이지 로티고틴 염기의 경피투여시스템
KR20110082142A (ko) * 2008-10-06 2011-07-18 밀란 테크놀로지즈 인코포레이티드 비정질 로티고틴 경피 시스템

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2299989B1 (fr) * 2008-05-30 2019-01-02 Mylan Inc. Système d administration de médicament transdermique stabilisé
KR20130112413A (ko) * 2012-04-04 2013-10-14 조선대학교산학협력단 리도카인 또는 그의 염 및 프릴로카인 또는 그의 염을 포함하는 경피흡수제제
KR101686987B1 (ko) * 2013-05-30 2016-12-15 에스케이케미칼주식회사 로티고틴과 지방산 및 스티렌 점착제를 함유한 경피치료시스템
KR102499141B1 (ko) * 2016-10-31 2023-02-13 신신제약 주식회사 수면장애 치료용 경피흡수제제
KR102363479B1 (ko) * 2021-03-12 2022-02-15 환인제약 주식회사 로티고틴 함유 경피 흡수 제제

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100875532B1 (ko) 2002-12-30 2008-12-24 쉬바르츠파르마에이지 로티고틴 염기의 경피투여시스템
KR20110082142A (ko) * 2008-10-06 2011-07-18 밀란 테크놀로지즈 인코포레이티드 비정질 로티고틴 경피 시스템

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022191675A1 (fr) * 2021-03-12 2022-09-15 환인제약 주식회사 Formulation d'absorption transdermique contenant de la rotigotine

Also Published As

Publication number Publication date
KR20220128273A (ko) 2022-09-20
WO2022191675A1 (fr) 2022-09-15

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