KR102344620B1 - 항-cd137 항체 - Google Patents

항-cd137 항체 Download PDF

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Publication number
KR102344620B1
KR102344620B1 KR1020207002814A KR20207002814A KR102344620B1 KR 102344620 B1 KR102344620 B1 KR 102344620B1 KR 1020207002814 A KR1020207002814 A KR 1020207002814A KR 20207002814 A KR20207002814 A KR 20207002814A KR 102344620 B1 KR102344620 B1 KR 102344620B1
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seq
cancer
antibody
amino acid
acid sequence
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Korean (ko)
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KR20200023439A (ko
Inventor
크리스토퍼 칼 프라이
마이클 드웨인 칼로스
헬렌 코타나이즈
스테파니 린 샌디퍼
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일라이 릴리 앤드 캄파니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04L—TRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
    • H04L7/00—Arrangements for synchronising receiver with transmitter
    • H04L7/04—Speed or phase control by synchronisation signals
    • H04L7/10—Arrangements for initial synchronisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04B—TRANSMISSION
    • H04B10/00—Transmission systems employing electromagnetic waves other than radio-waves, e.g. infrared, visible or ultraviolet light, or employing corpuscular radiation, e.g. quantum communication
    • H04B10/25—Arrangements specific to fibre transmission
    • H04B10/2575—Radio-over-fibre, e.g. radio frequency signal modulated onto an optical carrier
    • H04B10/25752—Optical arrangements for wireless networks
    • H04B10/25753—Distribution optical network, e.g. between a base station and a plurality of remote units

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Signal Processing (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020207002814A 2017-08-01 2018-07-25 항-cd137 항체 Active KR102344620B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020217041897A KR20210158420A (ko) 2017-08-01 2018-07-25 항-cd137 항체

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762539687P 2017-08-01 2017-08-01
US62/539,687 2017-08-01
PCT/US2018/043632 WO2019027754A1 (en) 2017-08-01 2018-07-25 ANTI-CD137 ANTIBODIES

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020217041897A Division KR20210158420A (ko) 2017-08-01 2018-07-25 항-cd137 항체

Publications (2)

Publication Number Publication Date
KR20200023439A KR20200023439A (ko) 2020-03-04
KR102344620B1 true KR102344620B1 (ko) 2022-01-03

Family

ID=63165504

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KR1020207002814A Active KR102344620B1 (ko) 2017-08-01 2018-07-25 항-cd137 항체
KR1020217041897A Ceased KR20210158420A (ko) 2017-08-01 2018-07-25 항-cd137 항체

Family Applications After (1)

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KR1020217041897A Ceased KR20210158420A (ko) 2017-08-01 2018-07-25 항-cd137 항체

Country Status (25)

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US (2) US10906983B2 (enExample)
EP (2) EP4070811A1 (enExample)
JP (2) JP6743320B1 (enExample)
KR (2) KR102344620B1 (enExample)
CN (1) CN111182919B (enExample)
AU (2) AU2018311804B2 (enExample)
BR (1) BR112020001441A2 (enExample)
CA (2) CA3071383C (enExample)
CL (1) CL2020000233A1 (enExample)
CO (1) CO2020001050A2 (enExample)
CR (1) CR20200042A (enExample)
DO (1) DOP2020000020A (enExample)
EA (1) EA202090204A1 (enExample)
EC (1) ECSP20007663A (enExample)
ES (1) ES2912651T3 (enExample)
IL (1) IL272349B2 (enExample)
JO (1) JOP20200016B1 (enExample)
MA (1) MA49749A (enExample)
MX (1) MX2020001351A (enExample)
PE (1) PE20200839A1 (enExample)
PH (1) PH12020500225A1 (enExample)
SA (1) SA520411186B1 (enExample)
SG (1) SG11202000747VA (enExample)
UA (1) UA128388C2 (enExample)
WO (1) WO2019027754A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111278858B (zh) 2017-07-11 2024-07-23 指南针制药有限责任公司 结合人cd137的激动剂抗体及其用途
JOP20200016B1 (ar) * 2017-08-01 2022-10-30 Lilly Co Eli أجسام مضادة لـ cd137
US11512134B2 (en) 2017-08-01 2022-11-29 Eli Lilly And Company Anti-CD137 antibodies
WO2019089753A2 (en) 2017-10-31 2019-05-09 Compass Therapeutics Llc Cd137 antibodies and pd-1 antagonists and uses thereof
US11851497B2 (en) 2017-11-20 2023-12-26 Compass Therapeutics Llc CD137 antibodies and tumor antigen-targeting antibodies and uses thereof
US20210054089A1 (en) * 2018-03-23 2021-02-25 Eli Lilly And Company Anti-cd137 antibodies for combination with anti-pd-1 antibodies
AU2019239194B2 (en) * 2018-03-23 2023-09-14 Eli Lilly And Company Anti-CD137 antibodies for combination with anti-PD-L1 antibodies
US11939381B2 (en) * 2018-07-19 2024-03-26 Eli Lilly And Company Bispecific antibodies targeting immune checkpoints
WO2020023556A1 (en) 2018-07-23 2020-01-30 Magenta Therapeutics, Inc. Use of anti-cd137 antibody drug conjugate (adc) in allogeneic cell therapy
SG10202106830VA (en) 2018-08-10 2021-08-30 Chugai Pharmaceutical Co Ltd Anti-cd137 antigen-binding molecule and utilization thereof
KR20220003572A (ko) 2019-04-24 2022-01-10 하이델베르크 파마 리서치 게엠베하 아마톡신 항체-약물 결합체 및 이의 용도
AU2020308463A1 (en) 2019-06-26 2022-02-17 Ap Biosciences, Inc. Antibodies for T-cell activation
TWI895351B (zh) * 2020-02-12 2025-09-01 日商中外製藥股份有限公司 用於癌症之治療的抗cd137抗原結合分子
WO2022111571A1 (zh) 2020-11-25 2022-06-02 上海君赛生物科技有限公司 肿瘤浸润淋巴细胞培养基及其应用
CN120769904A (zh) 2023-02-27 2025-10-10 上海君赛生物科技有限公司 表达膜结合细胞因子的肿瘤浸润淋巴细胞
KR20250104669A (ko) 2023-12-29 2025-07-08 쿠팡 주식회사 옵션 선택 가이드 정보 제공 방법 및 그 장치
KR20250104655A (ko) 2023-12-29 2025-07-08 쿠팡 주식회사 옵션 피커 화면 제공 방법 및 그 장치
KR20250132789A (ko) 2024-02-29 2025-09-05 쿠팡 주식회사 옵션 피커 화면 제공 방법 및 그 장치

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160244528A1 (en) 2015-02-22 2016-08-25 Sorrento Therapeutics, Inc. Antibody therapeutics that bind cd137

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6362325B1 (en) 1988-11-07 2002-03-26 Advanced Research And Technology Institute, Inc. Murine 4-1BB gene
US6303121B1 (en) 1992-07-30 2001-10-16 Advanced Research And Technology Method of using human receptor protein 4-1BB
US7211259B1 (en) 1993-05-07 2007-05-01 Immunex Corporation 4-1BB polypeptides and DNA encoding 4-1BB polypeptides
IL129138A0 (en) 1996-10-11 2000-02-17 Bristol Myers Squibb Co Methods and compositions for immunomodulation
EP1434596B1 (en) 2001-10-09 2009-07-08 Mayo Foundation For Medical Education And Research Enhancement of immune responses by agonist 4-1bb-antibodies
US7288638B2 (en) 2003-10-10 2007-10-30 Bristol-Myers Squibb Company Fully human antibodies against human 4-1BB
WO2010042433A1 (en) 2008-10-06 2010-04-15 Bristol-Myers Squibb Company Combination of cd137 antibody and ctla-4 antibody for the treatment of proliferative diseases
PH12020550156A1 (en) * 2010-09-09 2024-01-15 Pfizer 4-1bb binding molecules
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
EP3686219A1 (en) 2014-02-04 2020-07-29 Pfizer Inc Combination of a pd-1 antagonist and a 4-1bb agonist for treating cancer
WO2016029073A2 (en) 2014-08-22 2016-02-25 Bristol-Myers Squibb Company Treatment of cancer using a combination of an anti-pd-1 antibody and an anti-cd137 antibody
WO2017024465A1 (en) 2015-08-10 2017-02-16 Innovent Biologics (Suzhou) Co., Ltd. Pd-1 antibodies
AR105654A1 (es) 2015-08-24 2017-10-25 Lilly Co Eli Anticuerpos pd-l1 (ligando 1 de muerte celular programada)
GB201619648D0 (en) * 2016-11-21 2017-01-04 Alligator Bioscience Ab Novel antibodies and uses thereof
JOP20200016B1 (ar) * 2017-08-01 2022-10-30 Lilly Co Eli أجسام مضادة لـ cd137

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160244528A1 (en) 2015-02-22 2016-08-25 Sorrento Therapeutics, Inc. Antibody therapeutics that bind cd137

Also Published As

Publication number Publication date
CN111182919B (zh) 2023-07-07
EP3661544A1 (en) 2020-06-10
EP4070811A1 (en) 2022-10-12
ECSP20007663A (es) 2020-06-30
JP7257364B2 (ja) 2023-04-13
JOP20200016B1 (ar) 2022-10-30
KR20200023439A (ko) 2020-03-04
CR20200042A (es) 2020-03-03
JP2020182492A (ja) 2020-11-12
KR20210158420A (ko) 2021-12-30
CA3146758A1 (en) 2019-02-07
ES2912651T3 (es) 2022-05-26
EA202090204A1 (ru) 2020-05-22
JOP20200016A1 (ar) 2020-01-28
NZ761548A (en) 2024-07-05
PE20200839A1 (es) 2020-08-13
WO2019027754A1 (en) 2019-02-07
CL2020000233A1 (es) 2020-07-31
CA3071383C (en) 2022-04-12
JP2020527356A (ja) 2020-09-10
AU2018311804A1 (en) 2020-02-13
AU2021277707A1 (en) 2021-12-23
MX2020001351A (es) 2020-03-09
US10906983B2 (en) 2021-02-02
EP3661544B1 (en) 2022-04-13
AU2018311804B2 (en) 2021-09-02
JP6743320B1 (ja) 2020-08-19
PH12020500225A1 (en) 2020-11-09
US12453771B2 (en) 2025-10-28
IL272349B1 (en) 2024-05-01
US20200377607A1 (en) 2020-12-03
BR112020001441A2 (pt) 2020-08-04
UA128388C2 (uk) 2024-07-03
MA49749A (fr) 2021-03-24
IL272349A (en) 2020-03-31
DOP2020000020A (es) 2020-02-28
CN111182919A (zh) 2020-05-19
IL272349B2 (en) 2024-09-01
CO2020001050A2 (es) 2020-02-18
SG11202000747VA (en) 2020-02-27
US20230279134A1 (en) 2023-09-07
CA3071383A1 (en) 2019-02-07
SA520411186B1 (ar) 2025-06-29

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