KR102335943B1 - 생물학적 물질 및 미생물의 보존과 보호를 위한 글리코펩티드 유도체 - Google Patents

생물학적 물질 및 미생물의 보존과 보호를 위한 글리코펩티드 유도체 Download PDF

Info

Publication number
KR102335943B1
KR102335943B1 KR1020167028862A KR20167028862A KR102335943B1 KR 102335943 B1 KR102335943 B1 KR 102335943B1 KR 1020167028862 A KR1020167028862 A KR 1020167028862A KR 20167028862 A KR20167028862 A KR 20167028862A KR 102335943 B1 KR102335943 B1 KR 102335943B1
Authority
KR
South Korea
Prior art keywords
group
alkyl
aryl
compound
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020167028862A
Other languages
English (en)
Korean (ko)
Other versions
KR20170003915A (ko
Inventor
제럴딘 딜리언코트-고드프루아
티보 마틴
Original Assignee
티에프켐
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 티에프켐 filed Critical 티에프켐
Publication of KR20170003915A publication Critical patent/KR20170003915A/ko
Application granted granted Critical
Publication of KR102335943B1 publication Critical patent/KR102335943B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/69—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/02—Acyclic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Physiology (AREA)
KR1020167028862A 2014-03-17 2015-03-17 생물학적 물질 및 미생물의 보존과 보호를 위한 글리코펩티드 유도체 Active KR102335943B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14305374.2 2014-03-17
EP14305374 2014-03-17
PCT/EP2015/055577 WO2015140178A1 (en) 2014-03-17 2015-03-17 Glycopeptide derivatives for the preservation and protection of biological materials and microorganisms

Publications (2)

Publication Number Publication Date
KR20170003915A KR20170003915A (ko) 2017-01-10
KR102335943B1 true KR102335943B1 (ko) 2021-12-03

Family

ID=50397079

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020167028862A Active KR102335943B1 (ko) 2014-03-17 2015-03-17 생물학적 물질 및 미생물의 보존과 보호를 위한 글리코펩티드 유도체

Country Status (7)

Country Link
US (1) US10100088B2 (https=)
EP (1) EP3119800B9 (https=)
JP (1) JP6629285B2 (https=)
KR (1) KR102335943B1 (https=)
CN (1) CN106459122B (https=)
CA (1) CA2942731C (https=)
WO (1) WO2015140178A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3011449A1 (en) 2016-01-27 2017-08-03 Protokinetix Inc. Use of anti-aging glycoprotein for enhancing survival of neurosensory precursor cells
US10744181B2 (en) 2017-01-30 2020-08-18 Tfchem Glycopeptide derivatives for use in the treatment and/or prevention and/or attenuation of fibrosis diseases
EP3999024A1 (en) * 2019-07-17 2022-05-25 Tfchem Glycopeptides increasing lipid synthesis
KR102274195B1 (ko) 2019-12-04 2021-07-08 고려대학교 산학협력단 자기 조립 화합물을 포함하는 항-동결 조성물
WO2021179081A1 (en) * 2020-03-10 2021-09-16 Protokinetix Inc. Use of anti-aging glycopeptides for treatment of dry eye disease, retinal degenerative diseases, or occular inflammation
CN117222655A (zh) * 2021-01-20 2023-12-12 Tf化学公司 环状糖氨基酸衍生物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006059227A1 (en) 2004-12-02 2006-06-08 Institut National Des Sciences Appliquees De Rouen (Insa) Gem difluorinated c-glycopeptides, their preparation and their use for the preservation of biological materials and/or in cryosurgery
WO2007125203A1 (fr) 2006-05-03 2007-11-08 Institut National Des Sciences Appliquees De Rouen (Insa) Composes c-glycopeptides gem-difluores, leur preparation et leur utilisation notamment pour la preservation de materiaux biologiques.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2117640T3 (es) 1990-01-17 1998-08-16 Univ California Composicion para mejorar la supervivencia de materiales biologicos.
FR2842810B1 (fr) 2002-07-25 2006-01-27 Inst Nat Sciences Appliq Nouveaux composes gem difluores, leur procedes de preparation et leurs applications.
FR2900154B1 (fr) 2006-04-25 2008-07-04 Inst Nat Sciences Appliq Nouveaux composes c-glycosides gem-difluores derives de la podophyllotoxine, leur preparation et leurs applications.
FR2900405B1 (fr) * 2006-04-27 2013-11-29 Inst Nat Sciences Appliq Nouveaux composes c-glycosides monofluores, leurs procedes de preparation et leurs applications
CA2653153A1 (en) 2008-02-07 2009-08-07 University Of Ottawa Antifreeze glycoprotein analogues and uses thereof
NZ613333A (en) 2010-12-22 2015-01-30 Tfchem Derivatives of glyco-cf2-serine and glyco-cf2-threonine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006059227A1 (en) 2004-12-02 2006-06-08 Institut National Des Sciences Appliquees De Rouen (Insa) Gem difluorinated c-glycopeptides, their preparation and their use for the preservation of biological materials and/or in cryosurgery
WO2007125203A1 (fr) 2006-05-03 2007-11-08 Institut National Des Sciences Appliquees De Rouen (Insa) Composes c-glycopeptides gem-difluores, leur preparation et leur utilisation notamment pour la preservation de materiaux biologiques.

Also Published As

Publication number Publication date
US20170015709A1 (en) 2017-01-19
WO2015140178A1 (en) 2015-09-24
CN106459122A (zh) 2017-02-22
EP3119800B9 (en) 2021-06-09
JP6629285B2 (ja) 2020-01-15
JP2017512829A (ja) 2017-05-25
CN106459122B (zh) 2019-12-03
US10100088B2 (en) 2018-10-16
EP3119800A1 (en) 2017-01-25
EP3119800B1 (en) 2018-02-28
KR20170003915A (ko) 2017-01-10
CA2942731A1 (en) 2015-09-24
CA2942731C (en) 2022-11-22

Similar Documents

Publication Publication Date Title
KR102335943B1 (ko) 생물학적 물질 및 미생물의 보존과 보호를 위한 글리코펩티드 유도체
ZA200409162B (en) Hepatitis C virus inhibitors.
CA2472114A1 (en) 2-o-(.beta.-d-glucopyranosyl) ascorbic acid, process for its production, and foods and cosmetics containing compositons comprising it
DE4115468A1 (de) Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien
WO2017048028A1 (ko) 마이시니딘 펩타이드로부터 유래한 신규 항균 펩타이드 및 이의 용도
BRPI0711156A2 (pt) compostos de c-glicopeptìdeos gem-difluorados, seu preparo e sua utilização particularmente para a preservação de materiais biológicos
JP2004323525A (ja) ２−オキソチアゾリジン−４−カルボン酸の新規ヘテロ環誘導体、および有効な光保護剤としての使用
JP2001181173A (ja) 美白外用剤
JP2001322941A (ja) 皮膚外用剤
JP4088021B2 (ja) 皮膚外用剤および皮膚外用剤組成物
JP5552741B2 (ja) 亜鉛を有効成分として含有する美白剤
CN117088941A (zh) 一种三肽衍生物及其组合物和用途
KR100876371B1 (ko) Ｌ-아스코르빈산-2-Ｏ-말레산-α-토코페롤디에스테르·1-프로판올 부가체 및 그 제조 방법
KR20150003440A (ko) 신규한 토코페롤 유도체 및 이를 함유하는 세포 보호 또는 세포 성장 촉진용 조성물
JP5349719B2 (ja) 皮膚外用剤
KR101451401B1 (ko) 비타민 c와 비타민 e의 컨쥬게이트 및 그를 포함하는 항산화제
CN109715594B (zh) 作为脱色剂或亮白剂的二氟化的化合物
WO2017051875A1 (ja) 紫外線吸収能を有する化合物またはその塩、およびその製造方法、皮膚外用剤、化粧料
KR101491728B1 (ko) 비타민 c와 비타민 b3의 컨쥬게이트 및 그를 포함하는 항산화제
EP3549574A1 (en) Composition for promoting hair growth or hair restoration, containing novel pantetheine-based substance
CN113939519B (zh) 促进毛发生长的新化合物及包含它们的组合物
WO2022157233A1 (en) Cyclic glycoaminoacid derivatives
WO2025100912A1 (ko) 라즈베리케톤 유도체 또는 이의 허용가능한 염
JP2007161684A (ja) トリテルペン化合物およびそれを有効成分として含む皮膚外用剤
KR20190124129A (ko) 겐티스산 유도체, 이의 제조방법 및 이를 포함하는 피부외용제 조성물

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20161017

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20200214

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20210416

Patent event code: PE09021S01D

E90F Notification of reason for final refusal
PE0902 Notice of grounds for rejection

Comment text: Final Notice of Reason for Refusal

Patent event date: 20210720

Patent event code: PE09021S02D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20211110

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20211130

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20211201

End annual number: 3

Start annual number: 1

PG1601 Publication of registration
PR1001 Payment of annual fee

Payment date: 20241121

Start annual number: 4

End annual number: 4