KR102330930B1 - Hair cosmetic composition for preventing hair loss, promoting hair growth and protecting scalp comprising natural herb extract - Google Patents

Abstract

The present invention relates to a cosmetic composition for preventing hair loss, promoting hair growth, and protecting the scalp containing a natural herbal extract, and more specifically, each centella asiatica extract, chamomile extract, green tea extract, bay leaf extract, oregano obtained by low-temperature ultrasonic treatment. By mixing the leaf extract and the rosemary extract, the extraction yield of the active ingredient from the raw materials is improved, and the denaturation or destruction of the active ingredient can be minimized. In addition, the cosmetic composition for preventing hair loss and promoting hair growth and for protecting the scalp of the present invention prevents hair loss by mixing 6 kinds of herbal extracts in an optimal ratio, promotes hair growth and protects the scalp at the same time to strengthen the hair roots, excellent antioxidant And it may have an antibacterial effect.

Description

Cosmetic composition for preventing hair loss and promoting hair growth, and for scalp protection containing natural herbal extracts

The present invention is for preventing hair loss and promoting hair growth containing natural herbal extracts obtained by low-temperature ultrasonic treatment, including centella asiatica extract, chamomile extract, green tea extract, bay leaf extract, oregano leaf extract and rosemary extract as active ingredients, and scalp It relates to a cosmetic composition for protection.

The causes of hair damage include damage caused by perming or dyeing, damage caused by heat and brushing, and damage caused by UV rays. First, damage caused by perming or dyeing causes a lot of cuticles that are visible after perming or dyeing, which causes rough hair or poorly combed and tangled hair. In this case, the cuticle is thin and partly peeled off or the tip is broken and weakened. Second, damage caused by heat and brushing is stimulated at a temperature of 60 ℃ when there is moisture in the hair, and when it exceeds 80 ℃, the heat adversely affects the strength of the hair, and strong brushing causes static electricity and hair loss. Third, the damage caused by ultraviolet rays causes the hair to become dry and weak by ultraviolet rays, become rough, lose luster, and break easily. Damage that starts from the cuticle of the hair affects the cortex, and the melanin pigment in the hair is oxidized by ultraviolet rays, resulting in discoloration. In other cases, hair damage is also caused by cuts, air pollution, friction, excessive dieting, and unbalanced diet.

In addition, damaged scalp is also caused by dandruff and itching, seborrheic dermatitis and allergic contact dermatitis. The dandruff and itch are mainly caused by psoriasis, metabolic disorders, blood circulation disorders, sweat secretion, sebum secretion, bacteria and nutritional deficiencies. The seborrheic dermatitis is a fungal inflammation caused by abnormally excessively secreted sebum. The allergic contact dermatitis is a kind of skin hypersensitivity reaction, and is an inflammation that occurs when a product containing hair dye, perm, coating agent, or sunscreen comes into contact with the scalp.

In particular, hair loss refers to a state in which there is no hair in a part where hair should normally exist, and generally means the hair loss of the scalp. All hairs stop growing after a certain period of growth, go through the catagen phase, enter the resting phase, and repeat the process of hair loss and hair growth again. This is called the hair growth cycle. The hair growth period is longer than 2 to 5 years and the rest period is short, less than 2 to 3 months. The hair that enters the resting period is light in color and lacks luster, and the root of the hair is thin, and it is easily removed with a hair brush or comb. Excessive hair loss due to an abnormality in the hair growth cycle is referred to as hair loss.

The cause of hair loss is not yet known precisely, but not only aging or genetic factors, but also excessive male hormones, mental stress, blood circulation disorders, other nutritional disorders, endocrine disorders, aging, autoimmune diseases, environmental pollution, dyeing, and diet It is rapidly increasing due to the influence of acquired factors such as abnormal hormone secretion according to changes in Recently, it has been reported that growth factors related to the hair growth cycle are involved in hair loss, but the cause has not yet been identified, and there is no satisfactory treatment method.

In addition, most of the previously developed hair growth agents or hair growth agents are those that prevent hair loss and induce hair growth by improving indirect causes of baldness, such as poor blood circulation, nutritional disorders, seborrheic dermatitis, and stress, and their effects were not perfect. In addition, if you stop using it, the hair starts to fall out again and returns to the original hair loss state, so the effect is not sustainable. In addition, Minoxidil (MXD) and finasteride, which are representative hair growth agents that are currently known for their medicinal effects and are widely used worldwide, require continuous use throughout life to maintain the effect of preventing hair growth and hair loss. As a result, its use is limited.

Conventional Korean Patent Application Laid-Open No. 2018-0111015 discloses a cosmetic composition for preventing hair loss or promoting hair growth containing lavender, lemongrass, rosemary, chamomile and peppermint oil as active ingredients. However, the cosmetic composition has a problem in that the process for extracting oil from the raw material is complicated, and the active ingredient contained in the raw material is denatured or destroyed by heat because it is extracted at high temperature and high pressure. Due to this, there is a problem that the pharmacological effect of the active ingredient of the herb contained in the cosmetic composition is not sufficiently exhibited.

Therefore, the present inventors have excellent stability among natural herbs and, in particular, while conducting research to find raw materials that have the effect of preventing hair loss and improving hair growth, extracts obtained from Centella asiatica, chamomile, green tea, bay leaf, oregano leaf and rosemary prevent hair loss and soothe the scalp , it was found that there is a hair growth promotion, antioxidant and antibacterial effect, thereby completing the present invention.

Korean Patent Publication No. 2018-0111015

In order to solve the above problems, an object of the present invention is to provide a cosmetic composition for preventing hair loss and promoting hair growth, and having excellent scalp protection effects due to antioxidant and antibacterial effects, and for scalp protection.

The object of the present invention is not limited to the object mentioned above. The objects of the present invention will become more apparent from the following description, and will be realized by means and combinations thereof described in the claims.

The cosmetic composition for preventing hair loss and promoting hair growth according to the present invention, and for scalp protection, obtains extracts of centella asiatica, chamomile, green tea, bay leaf, oregano leaf and rosemary by low-temperature ultrasonic treatment, respectively, thereby increasing the extraction yield of active ingredients from raw materials It can improve and minimize the denaturation or destruction of the active ingredient. In addition, the cosmetic composition may have the effect of strengthening the hair roots by preventing hair loss by mixing six kinds of natural herbal extracts in an optimal ratio, promoting hair growth, and protecting the scalp at the same time. In addition, the cosmetic composition has an excellent antioxidant effect, which helps to soothe the scalp and hair growth, and has an antibacterial effect against the causative bacteria that cause dandruff and seborrheic dermatitis, thereby preventing dandruff of the scalp and preventing seborrheic dermatitis. may have a protective effect.

The present invention relates to a cosmetic composition for preventing hair loss and promoting hair growth, and for protecting the scalp. Specifically, the cosmetic composition for preventing hair loss and promoting hair growth and scalp protection of the present invention includes Centella asiatica extract, chamomile extract, green tea extract, bay leaf extract, oregano leaf extract and rosemary extract.

Preferably, the centella asiatica extract 12-25 wt%, chamomile extract 15-30 wt%, green tea extract 10-18 wt%, bay leaf extract 14-25 wt%, oregano leaf extract 12-20 wt%, and rosemary extract 10- 18% by weight.

More preferably, 14 to 22% by weight of the Centella asiatica extract, 16 to 25% by weight of chamomile extract, 12 to 17% by weight of green tea extract, 15 to 20% by weight of bay leaf extract, 14 to 18% by weight of oregano leaf extract and 14% by weight of rosemary extract -17% by weight.

Hereinafter, each extract included in the cosmetic composition for preventing hair loss and promoting hair growth and for protecting the scalp of the present invention will be described in detail.

(1) Centella asiatica extract

In the present invention, the centella asiatica ( Centella asiatica ) is a perennial herb of the Umbelliferae family, the main stem extends sideways, and there are two degenerated scaly leaves near the root node. It is an ideal native plant at 600 m above sea level in a moist and shady place.

The centella asiatica contains asiaticoside, madecasosside, asiatic acid and madecassic acid as major physiologically active substances, so it has excellent antioxidant and antibacterial effects, It reduces sebum and supplies moisture to improve the scalp and prevent hair loss.

In the present invention, the Centella asiatica extract is 12 to 25% by weight, preferably 14 to 25% by weight, based on the total weight of the cosmetic composition for preventing hair loss and promoting hair growth, and for protecting the scalp so that the pharmacological effect on hair and scalp can be sufficiently exhibited. 22% by weight, most preferably 17% by weight. At this time, if the content of the Centella asiatica extract is less than 12% by weight, the antioxidant and antibacterial effects may be lowered, and if it is more than 25% by weight, on the contrary, the content balance with other components is broken and an improved antioxidant and antibacterial effect cannot be expected, and the scalp Excessive control of sebum control or moisture supply may cause problems on the scalp.

It is preferable that the Centella asiatica extract is extracted by low-temperature sonication compared to the hot water extraction method. The low-temperature ultrasonication refers to a method of stably extracting the active ingredient by minimizing the destruction of the active ingredient by irradiating ultrasonic waves at a low temperature of 15 to 25 ℃. Active ingredients contained in herbs such as Centella asiatica generally have the disadvantage of being weak to heat. Accordingly, in order to extract pure nutrients without applying heat during the extraction process, it is better to extract with low-temperature sonication. When the centella asiatica is pulverized and extracted by low-temperature sonication, the extraction yield is increased by controlling the intensity of ultrasonic energy change, and the possibility of denaturation and destruction of active ingredients exhibiting pharmacological activity can be minimized. In addition, the low-temperature ultrasonic extraction enables extraction in a very short time compared to solvent extraction, thereby shortening the extraction time. This is because the high pressure caused by the synergistic effect of ultrasound destroys the internal tissues of the cells, shortens the movement distance of the lipids and facilitates diffusion.

Specifically, the Centella asiatica extract, which is a raw material, is washed 2-4 times in running water repeatedly for 20-40 minutes to remove foreign substances, and after drying the washed Centella asiatica using a dryer, it can be pulverized to a size of 0.1 to 1 mm. have.

It may be obtained by adding an extraction solvent in an amount of 1 to 15 times by weight to the pulverized Centella asiatica and performing low-temperature sonication at a frequency of 20 to 40 kHz at 15 to 25° C. for 30 minutes to 3 hours. Preferably, the low-temperature sonication may be performed at a temperature of 17 to 22 °C for 30 minutes to 2 hours, at a frequency of 22 to 38 kHz, most preferably at a temperature of 20 °C for 1 hour, at a temperature of 25 to 27 kHz. frequency can be performed. In this case, when all of the temperature, time and frequency conditions are not satisfied during the low-temperature ultrasonic treatment, the active ingredient cannot be maximally extracted from the raw material, and the extracted active ingredient may be denatured or destroyed. The centella asiatica extract may be extracted by repeating low-temperature sonication 1 to 5 times, preferably 2 to 4 times, and most preferably 3 times.

The extraction solvent may be at least one selected from the group consisting of purified water, methanol, ethanol, glycerin, ethyl acetate, butylene glycol and propylene glycol. Preferably, the Centella asiatica extract may be one extracted using ethanol or butylene glycol, and most preferably, it may be one obtained by low-temperature sonication using ethanol.

(2) chamomile extract

In the present invention, the chamomile ( Chamomilla recutita ) is a kind of herb with the meaning of an apple from the ground as a grass of the dicotyledonous plant Camphoraceae Asteraceae. The chamomile flowers around May, and the flowers are harvested and dried in a well-ventilated shade and stored.

The chamomile contains guaiazulene and apigenin as major physiologically active substances, so it can act as a conditioning agent that gives vitality to the hair, and has an effect of calming the scalp and controlling excessive sebum secretion have In addition, it has excellent antioxidant and antibacterial effects, and it is effective in preventing hair loss and promoting hair growth by blocking moisture evaporation to keep the scalp moisturized.

In the present invention, the chamomile extract is 15 to 30% by weight, preferably 16 to 30% by weight, based on the total weight of the cosmetic composition for preventing hair loss and promoting hair growth, and for protecting the scalp so that the pharmacological effect on hair and scalp can be sufficiently exhibited. 25% by weight, most preferably 17% by weight. At this time, if the content of the chamomile extract is less than 15% by weight, antioxidative and antibacterial effects cannot be expected. Conversely, if it exceeds 30% by weight, the hair loss prevention effect may be lowered, and excessive sebum control or moisture control of the scalp stimulates the scalp. can cause trouble.

When the chamomile is extracted by ultrasonication at a low temperature, the active ingredient may be denatured or destroyed by heat, and the extraction yield of the active ingredient may be reduced. In addition, it does not generate a substance that causes toxicity and scalp side effects contained in the chamomile, so it has an advantage of excellent stability. Accordingly, the chamomile extract is preferably obtained by low-temperature sonication of pulverized chamomile. The chamomile extract may be obtained by pulverizing chamomile in the same manner as the Centella asiatica extract as described above, and performing low-temperature sonication. In this case, the extraction solvent may be at least one selected from the group consisting of purified water, methanol, ethanol, glycerin, ethyl acetate, butylene glycol and propylene glycol. Preferably, the chamomile extract may be extracted using ethanol or butylene glycol, and most preferably, low temperature sonication treatment using ethanol may be used.

(3) Green Tea Extract

In the present invention, the green tea ( Camellia sinensis ) is an evergreen broad-leaved shrub belonging to the Pachydermaceae family, and the leaves are tea, and the fruits are milked and used as oil. The green tea is divided into green tea, oolong tea, and black tea depending on whether the tea leaves are fermented, and among them, green tea is processed by heating the fresh tea leaves collected at a high temperature to suppress the oxidative enzyme action in the leaves, then rubbing, drying, and refining them. makes

The green tea contains a large amount of polyphenol as a major physiologically active material, so it has excellent antioxidant and antibacterial effects, removes wastes and sebum from the scalp, and soothes the scalp, thereby preventing hair loss and promoting hair growth.

In the present invention, the green tea extract is 10 to 18% by weight, preferably 12 to 18% by weight, based on the total weight of the cosmetic composition for preventing hair loss and promoting hair growth, and for protecting the scalp so that the pharmacological effect on hair and scalp can be sufficiently exhibited. 17% by weight, most preferably 17% by weight. At this time, if the content of the green tea extract is less than 10% by weight, excellent antioxidant, antibacterial, scalp soothing and hair loss prevention effects cannot be expected. No anti-hair loss effect can be expected.

When the green tea is extracted with hot water, the active ingredient contained in the green tea may be denatured or destroyed by heat, and the extraction yield of the active ingredient may be reduced. Accordingly, the green tea extract is preferably subjected to low-temperature sonication. The green tea extract may be obtained by pulverizing green tea in the same manner as the Centella asiatica extract as described above, and performing low-temperature sonication. In this case, the extraction solvent may be at least one selected from the group consisting of purified water, methanol, ethanol, glycerin, ethyl acetate, butylene glycol and propylene glycol. Preferably, the green tea extract may be extracted using ethanol or butylene glycol, and most preferably, low-temperature sonication treatment using ethanol may be used.

(4) bay leaf extract

In the present invention, the laurel ( Laurus nobilis ) is an evergreen tree that grows more than about 10 m in height and belongs to the camphor tree camphoraceae, and it has a good fragrance and is often added to cooking or tea. In particular, the leaves of the laurel are sweet, strong, and have a unique scent, so they are also used as spices. The alternate leaves are dark green, hard and thick, the edges have wavy saw teeth, and have a long oval shape of about 5-8 cm in length.

The leaf of the laurel contains cineol as a major physiologically active material, thereby promoting blood circulation of the scalp, making the hair strong, discharging wastes, and having an excellent antibacterial effect.

In the present invention, the bay leaf extract is 14 to 25% by weight, preferably 15, based on the total weight of the cosmetic composition for preventing hair loss and promoting hair growth, and for protecting the scalp so that the pharmacological effect on hair and scalp can be sufficiently exhibited. -20% by weight, most preferably 17% by weight. At this time, if the content of the bay leaf extract is less than 14% by weight, the blood circulation promotion and antibacterial effect of the scalp may be reduced, and on the contrary, if it exceeds 25% by weight, further improved blood circulation promotion and antibacterial effect of the scalp cannot be expected.

The bay leaf extract is preferably extracted by low-temperature sonication, which has the advantage of minimizing denaturation or destruction of the active ingredient contained in the bay leaf and maximally extracting the active ingredient in a short time. The bay leaf extract may be obtained by pulverizing bay leaves in the same manner as the Centella asiatica extract, as described above, and low-temperature sonication. In this case, the extraction solvent may be at least one selected from the group consisting of purified water, methanol, ethanol, glycerin, ethyl acetate, butylene glycol and propylene glycol. Preferably, the bay leaf extract may be extracted using ethanol or butylene glycol, and most preferably, may be extracted by low-temperature sonication using ethanol.

(5) Oregano leaf extract

In the present invention, the oregano ( Origanum vulgare ) is an aromatic plant belonging to the dicotyledon family, and the dried leaves are mainly used as spices, and is an herb called marjoram, and has a pungent mint scent.

The leaf of oregano contains thymol as a major physiologically active material, and thus has an excellent effect in promoting hair growth by promoting dermal papilla cells as well as an antibacterial effect.

In the present invention, the oregano leaf extract is 12 to 20% by weight based on the total weight of the cosmetic composition for preventing hair loss and promoting hair growth, and protecting the scalp so that the pharmacological effect on hair and scalp can be sufficiently exhibited, preferably 14 -18% by weight, most preferably 16% by weight. At this time, if the content of the oregano leaf extract is less than 12% by weight, the antibacterial and hair growth promoting effect may be reduced, and conversely, if it exceeds 20% by weight, no further improved hair growth promoting effect can be expected.

The oregano leaf extract may be obtained by pulverizing oregano leaves in the same manner as the Centella asiatica extract as described above, and low-temperature sonication. When the oregano leaf is subjected to low-temperature ultrasonic treatment, the active ingredient contained in the oregano leaf is sufficiently released and the pharmacological effect can be sufficiently exhibited. In this case, the extraction solvent may be at least one selected from the group consisting of purified water, methanol, ethanol, glycerin, ethyl acetate, butylene glycol and propylene glycol. Preferably, the oregano leaf extract may be extracted using ethanol or butylene glycol, and most preferably, may be obtained by low-temperature sonication using ethanol.

(6) Rosemary Extract

In the present invention, the rosemary ( Rosmarinus officinalis ) is a herbaceous plant called dew of the sea and is an evergreen tree with aromaticity belonging to the family Lamiaceae. The rosemary is also used as a spice because its unique fresh scent activates brain functions.

The rosemary contains Borneol as a major physiologically active material, so it blocks moisture evaporation of the scalp to prevent drying, and suppresses the occurrence of dandruff to create a good environment for hair growth. It also keeps the scalp clean, helps with conditioning, and has the effect of preventing oxidative damage to the scalp. In addition, the rosemary has excellent antioxidant and antibacterial effects to prevent scalp troubles and to have an excellent soothing effect.

In the present invention, the rosemary extract is 10 to 18% by weight based on the total weight of the cosmetic composition for preventing hair loss and promoting hair growth, and for protecting the scalp so that the pharmacological effect on hair and scalp can be sufficiently exhibited, preferably 14 to 17% by weight, most preferably 16% by weight. At this time, if the content of the rosemary extract is less than 10% by weight, an excellent anti-hair loss effect cannot be expected, and on the contrary, if it exceeds 18% by weight, the content balance with other components is broken and further improved anti-hair loss effect cannot be expected.

The rosemary extract may be obtained by pulverizing rosemary in the same manner as the Centella asiatica extract as described above, and performing low-temperature sonication. When the pulverized rosemary is subjected to low-temperature sonication, the active ingredient can be maximally extracted from the rosemary, and the denaturation or destruction of the extracted active ingredient can be prevented. In this case, the extraction solvent may be at least one selected from the group consisting of purified water, methanol, ethanol, glycerin, ethyl acetate, butylene glycol and propylene glycol. Preferably, the rosemary extract may be extracted using ethanol or butylene glycol, and most preferably, may be extracted using ethanol.

In this way, the cosmetic composition for preventing hair loss and promoting hair growth and protecting the scalp improves the extraction yield of active ingredients from raw materials by extracting 6 kinds of herbs by low-temperature ultrasonic treatment, and at the same time denaturing or destroying the extracted active ingredients. can be minimized. In addition, the cosmetic composition may have the effect of preventing hair loss by mixing six kinds of natural herbal extracts in an optimal ratio, promoting hair growth, and strengthening the hair roots by protecting the scalp at the same time. In addition, it has an excellent antioxidant effect, which helps to calm the scalp and hair growth, and has an antibacterial effect against the causative bacteria that cause dandruff and seborrheic dermatitis, thereby preventing dandruff on the scalp and preventing seborrheic dermatitis.

In addition, the cosmetic composition for preventing hair loss and promoting hair growth and for protecting the scalp may further include a component selected from the group consisting of water-soluble vitamins, oil-soluble vitamins, polymer peptides, polymer polysaccharides, sphingolipids, and seaweed extract.

The water-soluble vitamin may be any type of vitamin that can be formulated in cosmetics, but preferably vitamin B1, vitamin B2, vitamin B6, pyridoxine, pyridoxine hydrochloride, vitamin B12, pantothenic acid, nicotinic acid, nicotinic acid amide, folic acid, vitamin C, vitamin H, etc. and their salts (thiamine hydrochloride, sodium ascorbate salt, etc.) and derivatives (ascorbic acid 2-phosphate sodium salt, ascorbic acid 2-phosphate magnesium salt, etc.) are also water-soluble vitamins that can be used in the present invention. may be included. The water-soluble vitamin can be obtained by a conventional method such as a microbial transformation method, a purification method from a microbial culture, an enzymatic method or a chemical synthesis method.

The oil-soluble vitamin may be any compound as long as it can be formulated in cosmetics, but preferably includes vitamin A, carotene, vitamin D2, vitamin D3, vitamin E (d1-alpha tocopherol, d-alpha tocopherol, d-alpha tocopherol). and their derivatives (ascorbine palmitate, ascorbine stearate, ascorbine dipalmitate, dl-alpha tocopherol acetate, dl-alpha tocopherol nicotinic acid, vitamin E, DL-pantothenyl alcohol, D-pantothenyl alcohol, pantothenyl) ethyl ether, etc.) may also be included in the oil-soluble vitamins used in the present invention. The oil-soluble vitamin can be obtained by a conventional method such as a microbial transformation method, a purification method from a microbial culture, an enzyme or a chemical synthesis method, and the like.

The macromolecular peptide may be any compound as long as it can be formulated in cosmetics, but preferably includes collagen, hydrolyzed collagen, gelatin, elastin, hydrolyzed elastin, and keratin. The polymer peptide can be purified and obtained by a conventional method such as purification from a microbial culture solution, an enzyme method, or a chemical synthesis method, or can be purified from natural products such as the dermis of pigs or cattle, silk fibers of silkworms, etc. .

The high molecular weight polysaccharide may be any compound as long as it can be formulated in cosmetics, but preferably, hydroxyethyl cellulose, xanthan gum, sodium hyaluronate, chondroitin sulfate, or a salt thereof (sodium salt, etc.) is mentioned. For example, chondroitin sulfate or a salt thereof can be purified and used from mammals or fish.

The sphingolipid may be any type as long as it can be formulated in cosmetics, but preferably includes ceramide, phytosphingosine, sphingoglycolipid, and the like. The sphingo lipid may be purified by a conventional method from mammals, fish, shellfish, yeast or plants, or may be obtained by chemical synthesis.

The seaweed extract may be any type as long as it can be formulated in cosmetics, but preferably brown algae extract, red algae extract, green algae extract, etc. Thorium, potassium alginate, etc. may also be included in the seaweed extract used in the present invention. The said seaweed extract can be obtained by refine|purifying by a conventional method from seaweed.

In the cosmetic of the present invention, in addition to the above essential ingredients, if necessary, other ingredients that are usually formulated in cosmetics may be blended. In addition, the blending ingredients that may be added include fats and oils, moisturizers, emollients, surfactants, organic and inorganic pigments, organic powders, ultraviolet absorbers, preservatives, disinfectants, antioxidants, extracts, pH adjusters, alcohols, pigments, and fragrances. , a blood circulation promoter, a cooling agent, an anti-inflammatory agent, purified water, and the like.

The cosmetic composition for preventing hair loss and promoting hair growth and for protecting the scalp includes hair tonic, hair nourishing lotion, hair essence, hair serum, scalp treatment, hair treatment, hair conditioner, hair shampoo, hair conditioner, hair lotion, hair cream, It may have any one formulation selected from the group consisting of hair wax, hair pack, hair soap, hair mousse, hair spray, hair cleansing foam, hair dye and hair bleach.

When the formulation of the cosmetic composition for preventing hair loss and promoting hair growth and protecting the scalp is a paste, cream or gel, animal fibers, vegetable fibers, waxes, paraffin, starch, tragacanth, cellulose derivatives, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide and the like.

When the formulation of the cosmetic composition for preventing hair loss and promoting hair growth and for scalp protection is a solution or emulsion, a solvent, solvating agent or emulsifying agent is used as a carrier component, for example, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, fatty acid esters of benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butylglycol oil, glycerol aliphatic esters, polyethylene glycol or sorbitan.

When the formulation of the cosmetic composition for preventing hair loss, promoting hair growth, and protecting the scalp is a suspension, as a carrier component, water, a liquid diluent such as ethanol or propylene glycol, ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester, and polyoxyethylene suspending agents such as sorbitan esters, microcrystalline cellulose, aluminum metahydroxide, bentonite, agar or tragacanth.

When the formulation of the cosmetic composition for preventing hair loss, promoting hair growth, and protecting the scalp is cleansing containing a surfactant, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative as carrier components , methyltaurate, sarcosinate, fatty acid amide ether sulfate, alkylamidobetaine, fatty alcohol, fatty acid glyceride, fatty acid diethanolamide, vegetable oil, linoline derivative or ethoxylated glycerol fatty acid ester, and the like.

The cosmetic composition for preventing hair loss and promoting hair growth according to the present invention, and for scalp protection, obtains extracts of centella asiatica, chamomile, green tea, bay leaf, oregano leaf and rosemary by low-temperature ultrasonic treatment, respectively, thereby increasing the extraction yield of active ingredients from raw materials It can improve and minimize the denaturation or destruction of the active ingredient.

In addition, the cosmetic composition for preventing hair loss and promoting hair growth and protecting the scalp according to the present invention prevents hair loss by mixing six kinds of natural herbal extracts in an optimal ratio, and at the same time promotes hair growth and protects the scalp to strengthen the hair roots can have

In addition, the cosmetic composition for preventing hair loss and promoting hair growth and protecting the scalp according to the present invention has an excellent antioxidant effect, helps to calm the scalp and hair growth, and has an antibacterial effect against the causative bacteria that cause dandruff and seborrheic dermatitis. It can prevent dandruff and prevent seborrheic dermatitis, so it can have a scalp protection effect.

The effects of the present invention are not limited to the above-mentioned effects. It should be understood that the effects of the present invention include all effects that can be inferred from the following description.

Hereinafter, the present invention will be described in more detail based on examples, but the present invention is not limited by the following examples.

manufacturing example

After washing 6 kinds of natural herbs, centella asiatica, chamomile, green tea, bay leaf, oregano leaf, and rosemary, in running water 3 times for 30 minutes, removing foreign substances, and drying the 6 kinds of washed herbs using a vegetable dryer, each It was pulverized to a size of 0.5 to 1 mm.

Ethanol (95%) was added at a weight ratio of 1:10 to each of the pulverized herb powders of 6 kinds, and immersed at room temperature of 25° C. for 12 hours. At this time, in order to keep the temperature constant, a water bath was connected at 30 °C. Then, each of the six herbal powders soaked in ethanol was subjected to low-temperature sonication at 20 °C for 1 hour at a frequency of 25-27 kHz, repeated three times to obtain each extract. Then, each of the extracts was filtered through a glass fiber/carbon (GF/C) filter paper, respectively, and then filtered through a PTFE membrane filter having a size of 0.8 μm and 0.45 μm to obtain each extract.

Examples 1 to 5 and Comparative Examples 1 to 16

A cosmetic composition was prepared by mixing each of the extracts prepared in Preparation Example at the mixing ratio shown in Table 1 below. Then, 95% by weight of purified water was mixed with 5% by weight of each cosmetic composition prepared in Table 1 to prepare a sample.

division Centella asiatica extract chamomile extract green tea extract bay leaf extract Oregano Leaf Extract rosemary extract total
(weight%) Example 1 12 20 18 18 16 16 100 Example 2 17 17 17 17 16 16 100 Example 3 25 15 14 16 15 15 100 Example 4 17 21 17 17 12 16 100 Example 5 16 17 16 16 20 15 100 Comparative Example 1 10 22 17 19 16 16 100 Comparative Example 2 27 17 17 17 12 10 100 Comparative Example 3 17 21 17 19 10 16 100 Comparative Example 4 14 15 17 16 22 16 100 Comparative Example 5 - 23 20 22 17 18 100 Comparative Example 6 22 - 18 25 17 18 100 Comparative Example 7 20 23 - 22 19 16 100 Comparative Example 8 23 22 18 - 19 18 100 Comparative Example 9 20 22 18 22 - 18 100 Comparative Example 10 20 25 21 17 17 - 100 Comparative Example 11 - - 32 26 22 20 100 Comparative Example 12 25 - 32 - 23 20 100 Comparative Example 13 26 30 - 26 - 18 100 Comparative Example 14 27 33 20 - 20 - 100 Comparative Example 15 - 35 20 25 - 20 100 Comparative Example 16 30 - 23 27 20 - 100

Comparative Examples 17-28

Each extract was prepared in the same manner as in Preparation Example, but some components of Table 2 were extracted in the following manner and then mixed in the same ratio as in Example 2 to prepare a cosmetic composition. Then, a sample was prepared by mixing 95% by weight of purified water with 5% by weight of the cosmetic composition.

[Comparative Examples 17-27]

Each extract of Comparative Examples 17 to 27 was prepared in the same manner as in Preparation Example, respectively, centella asiatica, chamomile, green tea, bay leaf, oregano leaf and rosemary powder, and then purified water was added to each herbal powder at 1:10 by weight. Then, it was heated at 110 °C for 3 hours to obtain an extract. Then, each extract was filtered in the same manner as in Preparation Example to obtain extracts.

[Comparative Example 28]

In Comparative Example 28, six kinds of natural herbs, centella asiatica, chamomile, green tea, bay leaf, oregano leaf, and rosemary were each ground in the same manner as in Preparation Example. Then, the pulverized 6 kinds of Centella asiatica powder, chamomile powder, green tea powder, bay leaf powder, oregano leaf powder and rosemary powder were mixed in the same ratio as in Example 2, and ethanol (95%) was added to the mixture 1: It was added in a weight ratio of 10 and immersed at room temperature of 25 °C for 12 hours. Then, a cosmetic composition was prepared by low-temperature ultrasonication under the same conditions as in Preparation Example.

division ingredient Extraction method hot water extraction Low-temperature ultrasonic extraction Example 2 Centella asiatica extract - 0 chamomile extract - 0 green tea extract - 0 bay leaf extract - 0 Oregano Leaf Extract - 0 rosemary extract - 0 Comparative Example 17 Centella asiatica extract 0 - Comparative Example 18 chamomile extract 0 - Comparative Example 19 green tea extract 0 - Comparative Example 20 bay leaf extract 0 - Comparative Example 21 Oregano Leaf Extract 0 - Comparative Example 22 rosemary extract 0 - Comparative Example 23 Centella asiatica extract 0 - chamomile extract 0 - Comparative Example 24 green tea extract 0 - Oregano Leaf Extract 0 - Comparative Example 25 bay leaf extract 0 - rosemary extract 0 - Comparative Example 26 Centella asiatica extract 0 - Oregano Leaf Extract 0 - Comparative Example 27 Centella asiatica extract 0 - bay leaf extract 0 - Oregano Leaf Extract 0 - Comparative Example 28 Centella asiatica extract - 0 chamomile extract - 0 green tea extract - 0 bay leaf extract - 0 Oregano Leaf Extract - 0 rosemary extract - 0

Experimental Example 1: Evaluation of hair loss prevention and hair growth effect of cosmetic composition

As shown in Table 3 below, the samples prepared in Examples 1 to 5 and Comparative Examples 1-28 were applied to the scalp about once every 7 days for each of 20 adult males and females with hair loss. Then, evaluation was performed by surveying the effect of each composition use for 4 months. The evaluation score was aggregated on a scale of 8 to 10 points when symptoms significantly improved, 5 to 7 points when symptoms improved, and 0 to 4 points when symptoms did not change or worsened. The results are shown in Table 4 below.

division hair condition 1st Army When the hair loss phenomenon has progressed more than 50% when evaluated visually, 10 men and 10 women in their 20s and 50s 2nd Army It is not hair loss, but there is a lot of thin hair and a lot of hair falling out when evaluated visually, and 10 men and 10 women in their 20s and 50s

division 1st Army 2nd Army hair loss prevention effect hair growth effect hair loss prevention effect hair growth effect Example 1 8.6 5.6 8.3 5.8 Example 2 9.8 6.3 9.6 6.6 Example 3 8.7 6.0 8.4 6.1 Example 4 8.5 5.8 8.2 5.7 Example 5 8.6 5.7 8.3 5.6 Comparative Example 1 6.1 2.7 4.7 2.3 Comparative Example 2 6.3 2.6 4.5 2.5 Comparative Example 3 6.8 2.4 4.6 2.4 Comparative Example 4 6.5 2.3 4.2 2.3 Comparative Example 5 5.6 2.9 3.3 2.7 Comparative Example 6 5.4 2.4 3.3 2.1 Comparative Example 7 5.7 2.1 3.7 2.5 Comparative Example 8 5.4 2.6 3.2 2.6 Comparative Example 9 5.7 2.2 3.6 2.4 Comparative Example 10 5.2 2.7 3.2 2.3 Comparative Example 11 3.0 1.1 2.6 1.2 Comparative Example 12 2.9 1.6 2.4 1.4 Comparative Example 13 2.7 1.4 2.7 1.3 Comparative Example 14 2.6 1.5 2.8 1.3 Comparative Example 15 2.8 1.3 2.4 1.6 Comparative Example 16 2.4 1.7 2.7 1.4 Comparative Example 17 4.5 2.8 5.5 2.1 Comparative Example 18 4.6 2.5 5.3 2.0 Comparative Example 19 4.5 2.3 5.1 2.3 Comparative Example 20 4.7 2.4 5.3 2.4 Comparative Example 21 4.9 2.6 5.6 2.1 Comparative Example 22 5.1 2.8 5.7 1.5 Comparative Example 23 3.6 1.2 4.4 1.3 Comparative Example 24 3.3 1.3 4.2 1.4 Comparative Example 25 3.8 1.4 4.3 1.5 Comparative Example 26 3.2 1.3 4.1 1.6 Comparative Example 27 2.7 0.9 2.4 0.4 Comparative Example 28 5.6 2.1 5.2 2.0

According to the results of Table 4, in the case of Examples 1 to 5, it was confirmed that both hair loss prevention and hair growth promoting effects were excellent, and in particular, hair loss was stopped or fine hair was observed. could In addition, it was confirmed that the hair loss rate was low and the effect of preventing hair loss was excellent.

In addition, it was found that the cosmetic composition of Examples 1 to 5 did not show any specific skin irritation due to side effects, so it was found that it exhibits the effect of preventing hair loss and hair growth without any side effects.

On the other hand, in the case of Comparative Examples 1 to 16, the overall effect of preventing hair loss and promoting hair growth was lower than that of Examples 1 to 5. In particular, in the case of Comparative Examples 5 to 16, it was found that all six kinds of herbal extracts were not included, so that the value was remarkably low. In addition, in the case of Comparative Examples 17 to 28, it was confirmed that the active ingredient was not properly extracted from each raw material, or was denatured or destroyed, so that the effect of preventing hair loss and promoting hair growth was generally low.

Experimental Example 2: Sensory evaluation of skin irritation of cosmetic composition

In order to measure the sensory evaluation of the skin irritation of the samples prepared in Examples 1 to 5 and Comparative Examples 1-28, 10 subjects were subjected. In the experimental method, a patch containing 100 μl of the cosmetic composition and control was attached to a clean area inside the arm of the subject, washed with running water 48 hours later, and then the degree of irritation was determined 30 minutes later. Pure water was used as a control. The evaluation score was 0 to 2 points for minimal stimulation, 3 to 4 points for mild stimulation, 5 to 6 points for moderate stimulation, and 7 to 8 points for severe stimulation. The results are shown in Table 5 below.

division Irritation judgment division Irritation judgment control 0 Comparative Example 12 5 Example 1 0 Comparative Example 13 4 Example 2 0 Comparative Example 14 5 Example 3 0 Comparative Example 15 4 Example 4 0 Comparative Example 16 4 Example 5 0 Comparative Example 17 2 Comparative Example 1 One Comparative Example 18 2 Comparative Example 2 2 Comparative Example 19 3 Comparative Example 3 2 Comparative Example 20 2 Comparative Example 4 One Comparative Example 21 2 Comparative Example 5 3 Comparative Example 22 3 Comparative Example 6 2 Comparative Example 23 2 Comparative Example 7 2 Comparative Example 24 3 Comparative Example 8 3 Comparative Example 25 2 Comparative Example 9 2 Comparative Example 26 2 Comparative Example 10 3 Comparative Example 27 3 Comparative Example 11 4 Comparative Example 28 6

According to the results of Table 5, in the case of Examples 1 to 5 in the evaluation of skin irritation, there was no irritation level at all. In contrast, in Comparative Examples 1 to 10 and Comparative Examples 17 to 28, it was confirmed that minimal or mild irritation was exhibited as skin irritation. In addition, in the case of Comparative Examples 11 to 16, it was found that the skin irritation appeared somewhat due to the relatively excessive mixing of the herbal extracts containing only four kinds of herbal extracts. Through this, it was found that each extract must be properly mixed to reduce skin irritation, thereby affecting scalp protection. In addition, in the case of Comparative Example 28, skin irritation was high, and it was found that the active ingredient was destroyed or denatured by heat from the raw material, or the toxic component was extracted together to affect the skin irritation.

Experimental Example 3: Measurement of the antibacterial effect of a cosmetic composition

배양기에서 48시간 배양하였다. UV/Vis 형광광도계로 630 ㎚에서 균의 증식이 관찰되지 않는 농도를 시료의 MIC로 결정하였다. 그 결과는 하기 표 6에 나타내었다.In order to confirm the antibacterial effect of the samples prepared in Examples 1 to 5 and Comparative Examples 1-28, the minimum inhibitory concentration (MIC) test method was used. In order to measure the minimum inhibitory concentration, the MIC is measured while serially diluting the concentration of the sample by two times. M. restricta , M. furfur, the causative bacteria of dandruff and seborrheic dermatitis ) to measure the MIC. Prepare a strain suspension by diluting the pre-cultured test bacteria with a ^{liquid medium so as to be about 1Х10 6} CFU/ml, and then serially dilute two-fold and put 100 μl of the sample into each well of a 96-well U-type microplate. After adding 100 μl of bacteria to each well, 35

Incubated for 48 hours in an incubator. The concentration at which the growth of bacteria was not observed at 630 nm with a UV/Vis fluorimeter was determined as the MIC of the sample. The results are shown in Table 6 below.

division strain name M. restricta M. furfur Example 1 0.2 0.3 Example 2 0.1 0.2 Example 3 0.3 0.2 Example 4 0.2 0.3 Example 5 0.3 0.4 Comparative Example 1 One 2 Comparative Example 2 2 2 Comparative Example 3 One One Comparative Example 4 3 2 Comparative Example 5 3 3 Comparative Example 6 4 3 Comparative Example 7 4 4 Comparative Example 8 3 4 Comparative Example 9 4 3 Comparative Example 10 4 4 Comparative Example 11 6 6 Comparative Example 12 7 6 Comparative Example 13 7 6 Comparative Example 14 6 7 Comparative Example 15 7 6 Comparative Example 16 6 6 Comparative Example 17 5 4 Comparative Example 18 6 5 Comparative Example 19 5 5 Comparative Example 20 6 4 Comparative Example 21 5 5 Comparative Example 22 6 5 Comparative Example 23 7 6 Comparative Example 24 8 7 Comparative Example 25 8 8 Comparative Example 26 7 8 Comparative Example 27 9 7 Comparative Example 28 3 2 Unit: MIC (%)

According to the results of Table 6, Examples 1 to 5 showed antibacterial effects on dandruff and seborrheic dermatitis, and no specific skin irritation due to side effects was found.

In contrast, in Comparative Examples 1 to 4, it was confirmed that the six herbal extracts showed a relatively low antibacterial effect compared to Examples 1 to 5 due to deviations from the optimal mixing ratio. In addition, in Comparative Examples 5 to 16, it was found that the antibacterial effect on dandruff and seborrheic dermatitis was lowered even when the six kinds of herbal extracts were not essential. In addition, in the case of Comparative Examples 17 to 28, it was confirmed that the active ingredient was not properly extracted from the raw material, or was denatured or destroyed according to the difference in the extraction method of each herbal raw material, so that the antibacterial effect on dandruff and seborrheic dermatitis was also generally low.

Experimental Example 4: Measurement of the antioxidant effect of a cosmetic composition

In order to measure the antioxidant effect of the sample prepared in Example 2, the method used by Furuno et al. (2002) was slightly modified and active oxygen radicals generated by the xanthine-xanthine oxidase system ( The scavenging effect on superoxide radical) was measured. Active oxygen generated by the reaction of xanthine and xanthine oxidase reacts with Nitro Blue Tetrazolium (NBT) to show blue color will do

First, 3Х10 ^-3 M xanthine, 3Х10 ^-4 M EDTA, 7.5Х10 ^-4 M NBT (nitroblue tetrazolium), and 0.15 mg/ml of bovine serum albumin (BSA) solution were added to each concentration sample and mixed. , and reacted for 10 minutes at room temperature. After that, a solution of xanthine oxidase (0.25 U/ml) was added to each test tube and reacted at room temperature for 20 minutes, and then absorbance was measured at 565 nm. As a positive control, a cornus extract was used instead of the sample of Example 2. The active oxygen radical scavenging effect of each sample was expressed as _{SC 50} by calculating the concentration at which 50% of the radicals were scavenged using Equation 1. At this time, as a negative control, the reaction absorbance of a solution not treated with the sample was used.

[Equation 1]

Free radical scavenging rate (%) = [(absorbance of negative control - absorbance of each sample) / absorbance of negative control] X 100

division SC ₅₀ (μl/ml) Example 2 20 positive control
(cornus oil extract) 312

According to the results of Table 7, it was confirmed that the cosmetic composition prepared in Example 2 had about 15 times or more of the active oxygen radical scavenging effect as compared to the control. Through this, it was found that the cosmetic composition of Example 2 had an excellent antioxidant effect.

Experimental Example 5: Evaluation of hair density and thickness of cosmetic composition

Using the sample prepared in Example 2, hair density and thickness in mice divided into 3 groups were measured using a colorimetric imaging device (Leadm, Korea) and a polyscope (Leadm, Korea). The results are shown in Table 8 below.

[Experiment Preparation]

6-week-old mice (C57/BL6, Orient, Korea, 18 to 20 g) before the telogen period were allowed to acclimatize in the breeding room for 1 week, and then anesthesia (ketamine or pentobalbital, Hanlim Pharmaceutical, Entobalju) was applied to the mice. 70601) was administered intraperitoneally (2.5 mg/individual) to anesthetize. Apply 1 g of depilatory agent to the back of anesthetized mice, spread them well, leave them at room temperature for about 2 minutes, and then gently push the back with a scraper to remove hair. The depilated mice were washed with lukewarm water to remove excess depilatory agent. In order to verify the effect of the cosmetic composition (A), rats were divided into 3 groups (Day 5: 5 mice per group; Day 15: 5 mice per group; Day 20: 5 mice per group), and the sample material was administered daily for 20 days. was applied once (2% minoxidil: 0.1 ml, A: 0.3 ml), the negative control was not treated with anything, the positive control was 2% minoxidil, and the cosmetic composition (A) prepared in Example 2 was used for the experimental group.

division Density of hair (number/cm ² ) Thickness of hair (mm) Day 15 Day 20 Day 15 Day 20 negative control 1,450 ± 12 2,362 ± 28 3.7 ± 1.57 4.5 ± 0.64 positive control 1,763 ± 23 ^* 2,301 ± 22 ^* 5.1 ± 0.35 ^* 4.7 ± 0.72 ^* Example 2 2,352±62 ^# 2,342±52 ^# 5.2±0.16 ^# 5.4 ± 0.61 ^# *, #: It increased significantly in Turkey test, p <0.001.

According to the results of Table 8, in the case of the group treated with the composition of Example 2, it was confirmed that the hair density and hair thickness were higher than that of the negative control group and the positive control group. Through this, compared to the existing hair growth agent minoxidil (positive control group), the physiologically active substances contained in the cosmetic composition of the present invention supply nutrients to the hair, thereby preventing hair loss and promoting hair growth at a similar level or more improved Could know.

Claims (5)

Centella asiatica extract 12-25 wt%, chamomile extract 15-30 wt%, green tea extract 10-18 wt%, bay leaf extract 14-25 wt%, oregano leaf extract 12-20 wt%, and rosemary extract 10-18 wt% As a cosmetic composition for preventing hair loss and promoting hair growth,
The centella asiatica extract, chamomile extract, green tea extract, bay leaf extract, oregano leaf extract and rosemary extract is obtained by adding 1 to 15 weight times of extraction solvent to each centella asiatica, chamomile, green tea, bay leaf, oregano leaf and rosemary, and 15 to 25 ° C. A cosmetic composition for preventing hair loss and promoting hair growth, characterized in that it was obtained by low-temperature ultrasonic treatment at a frequency of 20-40 kHz for 30 minutes to 3 hours.
Centella asiatica extract 12-25 wt%, chamomile extract 15-30 wt%, green tea extract 10-18 wt%, bay leaf extract 14-25 wt%, oregano leaf extract 12-20 wt%, and rosemary extract 10-18 wt% A cosmetic composition for scalp protection comprising:
The centella asiatica extract, chamomile extract, green tea extract, bay leaf extract, oregano leaf extract and rosemary extract is obtained by adding 1 to 15 weight times of extraction solvent to each centella asiatica, chamomile, green tea, bay leaf, oregano leaf and rosemary, and 15 to 25 ° C. A cosmetic composition for scalp protection, characterized in that it is obtained by low-temperature sonication at a frequency of 20-40 kHz for 30 minutes to 3 hours.
According to claim 1,
The extraction solvent is at least one selected from the group consisting of purified water, methanol, ethanol, glycerin, ethyl acetate, butylene glycol and propylene glycol, a cosmetic composition for preventing hair loss and promoting hair growth.
3. The method of claim 2,
The extraction solvent is at least one selected from the group consisting of purified water, methanol, ethanol, glycerin, ethyl acetate, butylene glycol and propylene glycol.
According to claim 1,
The cosmetic composition for preventing hair loss and promoting hair growth is hair tonic, hair nourishing lotion, hair essence, hair serum, scalp treatment, hair treatment, hair conditioner, hair shampoo, hair conditioner, hair lotion, hair cream, hair wax, hair pack , hair soap, hair mousse, hair spray, hair cleansing foam, hair dye, and a cosmetic composition for hair growth promotion that has any one formulation selected from the group consisting of.