KR102330844B1 - Composition For Improving Sexual Function Containing 17 Herbal Ingredients And Schisandra Chinensis, Rubus Coreanus, Lycium Chinense, Torilis Japonica, And Cuscuta Australis - Google Patents

Abstract

The present invention relates to a composition for improving the sexual function containing 17 herbal ingredients and fruits of Schisandra chinensis, Rubus coreanus, Lycium chinense, and Torilis japonica, and Cuscuta australis seeds. Specifically, the present invention relates to a composition for improving the sexual function which includes: a first extract comprising Lycium chinense fruit extract, a Cuscuta australis seed extract, a Rubus coreanus fruit extract, a Torilis japonica fruit extract and a Schisandra chinensis fruit extract; and a second extract comprising Lespedeza cuneata G. Don extract, a Lepidium meyenii extract, a Eucommia ulmoides extract, a Ganoderma lucidum extract, a black garlic extract, an Angelica gigas extract, a Glycyrrhiza uralensis extract, an Astragalus membranaceus extract, a honey extract, a Rehmannia glutinosa extract, a Cornus officinalis fruit extract, a Hovenia dulcis fruit extract.

Description

Composition For Improving Sexual Function Containing 17 Herbal Ingredients And Schisandra Chinensis, Rubus Coreanus, Lycium Chinense, Torilis Japonica, And Cuscuta Australis

The present invention relates to a composition for improving sexual function comprising 17 kinds of oriental herbal ingredients and oja, specifically, a first extract comprising Goji berry extract, Tosaja extract, Bokbunja extract, Sasangsaeng extract and Schisandra extract; and a second extract comprising a sagebrush extract, a maca extract, a duchung extract, a reishi mushroom extract, a black garlic extract, an angelica extract, a licorice extract, an astragalus extract, a honey extract, a sorghum extract, a cornus extract, and an extract from sagebrush; It relates to a composition for improvement.

According to recent statistics, about 20 to 60% of adult males complain of sexual dysfunction, and the proportion shows a tendency to increase with age. Such sexual dysfunction was considered to be a psychologic impotence cause in the past, but with advances in medicine, about 50% or more of patients with sexual dysfunction have an organic impotence rather than a psychogenic cause, for example, the vascular system, the nervous system. and endocrine system diseases, diabetes, hypertension, drug use, etc. have been found to be the cause.

Male sexual dysfunction can be broadly divided into erectile dysfunction, which is the inability to maintain and/or erection necessary for sexual activity, and sexual sensitization caused by loss of ejaculation control ability.

The erectile dysfunction generally refers to erectile dysfunction (impotence of erection), priapism (permanent and painful erection of the penis), and disorders of the spongy tissue and related fascia of the penis. The erectile dysfunction is caused by psychogenic, organic, or a combination thereof, and the organic erectile dysfunction is classified into neurogenic, vascular and endocrine impotence. This decline in sexual function is closely related to the decline in physiological functions of the human body, and in severe cases, it can develop into chronic erectile dysfunction. In addition, sexual sensitization represented by premature ejaculation is known as a symptom that occurs due to the loss of sexual control ability due to disruption of the balance of the peripheral nervous system and the central nervous system and failure to maintain a smooth cooperative system.

Conventionally, sexual function-related products can be classified into drugs for erectile dysfunction using chemical substances and products using natural products.

Examples of the treatment for erectile dysfunction using chemicals include Viagra, Levitra, Cialis, and the like, which include PDE5 (Phosphodiesterase type-5) inhibitors, which are enzymes that interfere with the expansion of the cavernous body, as an active ingredient; Caverject, Muse, Befar, etc. containing an agonist of PGE1 (Prostaglandin E1), which acts directly on erectile tissue to dilate blood vessels, as an active ingredient; Uprima, which acts on dopamine D1/D2 receptors, etc., in addition to these, α-adrenergic receptor antagonists, guanylyl cyclase stimulants, and serotonin (5-hydroxytryptamine) receptor agonists have been developed.

In addition, sexual function improving agents using natural products have been developed. For example, Korean Patent Laid-Open No. 10-2002-0071326 discloses a composition for improving erectile dysfunction comprising red ginseng extract powder, moon kernel oil, egg yolk oil, beeswax, soybean oil and lecithin and a food containing the same, and a Korean registered patent No. 10-0475647 discloses a composition for improving sexual dysfunction comprising a ginseng extract.

These conventional sexual function improving agents, especially erectile dysfunction drugs, are products developed to show an immediate erection effect, and although a temporary erection effect can be obtained, the normal physiological function of the human body is destroyed and there are side effects such as reduced physical strength or a threat to life. may appear. In addition, there is a problem that sexual function improving agents using natural products are only temporary or have insufficient absolute effects.

Therefore, there is a need to develop a composition for improving sexual function that can ultimately improve the lowered sexual function by activating the normal physiological function of the human body and does not cause side effects to the human body.

Korean Patent Laid-Open Publication No. 10-2002-0071326 (2002.09.12.) Korean Patent Publication No. 10-0475647 (2005.03.10.)

The present invention relates to a first extract comprising Goji berry extract, Tosaja extract, Bokbunja extract, Sasangsaeng extract and Schisandra extract; and a second extract comprising a sagebrush extract, a maca extract, a duchung extract, a reishi mushroom extract, a black garlic extract, an angelica extract, a licorice extract, an astragalus extract, a honey extract, a sorghum extract, a cornus extract, and an extract from sagebrush; A composition for improvement is provided.

The present invention provides a health functional food comprising a composition for improving sexual function.

Hereinafter, this will be described in detail. All combinations of the various elements disclosed herein are within the scope of the present invention. In addition, it cannot be seen that the scope of the present invention is limited by the following specific description.

The present invention relates to a first extract comprising Goji berry extract, Tosaja extract, Bokbunja extract, Sasangsaeng extract and Schisandra extract; and

Sexual function improvement, including; a second extract comprising a sagebrush extract, maca extract, duchung extract, reishi mushroom extract, black garlic extract, angelica extract, licorice extract, astragalus extract, honey extract, Sukhumi hwang extract, cornflower extract, and sagebrush extract; A composition is provided.

In the present invention, "Goji berry" means the fruit of Lycium chinense or L. barbarum, and has the effect of discharging or detoxifying toxic substances, preventing aging, removing fatty liver, and improving chronic liver disease, and coughing , dizziness, etc. are known to have various effects.

In the present invention, “Cuscutae Semen” refers to the seeds of ginseng, an annual creeping plant belonging to the family Convolvulaceae, and flavonoids are known as major physiologically active ingredients. Tosaja has effects on liver protection, antioxidant, anti-aging, anti-cancer, and reproductive system.

In the present invention, "Rubus coreanus" refers to bokbunja strawberry, a deciduous shrub of the Rosaceae, or its fruit, and is known to contain organic sugars, saccharides, and small amounts of vitamin C as physiologically active ingredients. Bokbunja is effective for loss of vision and stamina due to decreased liver function.

In the present invention, "dealer (orilis japonica)" refers to a biennial herb of the buttercup family called Bamdorat or Bambabweed, which strengthens the kidneys, enriches water, eliminates customs and has an insecticidal effect, male reproductive function, and female infertility. It is used for uterine coldness, severe itching caused by Trchomonas vaginitis, and it is known to be effective for dermatitis and pruritus of the skin. According to embodiments of the present invention, the casualty extract may be, but is not limited to, an extract from the bovine botanical extract.

In the present invention, “Schisandra chinensis” refers to the fruit of the Schisandra tree, which is a creeping plant that lives in the rocky areas of mountain valleys, and improves blood flow, hypertension, stroke, cardiovascular disease, immunity, diabetes prevention, and liver function improvement. , recovery, and improvement of respiratory diseases.

In the present invention, "Lespedeza cuneata G. Don" refers to a perennial plant belonging to the genus Lespedeza of the leguminosae family, also referred to as bisusu or trifolieae, and has been used in folklore to treat cough, asthma, etc. . Physiologically active substances contained in Yagwanmun include pinitol, flavonoids, phenols, and the like, and are reported to have free radical scavenging and antioxidant activity. According to embodiments of the present invention, the extract of ginseng may be, but not limited to, leaf or stem extracts of ginseng.

In the present invention, "Maca (Lepidium meyenii Walpers)" refers to a plant belonging to the Brassicaceae that is mainly cultivated in the Andes Mountains of Peru at an altitude of 4,000 m or higher, and Maca growing in difficult natural environments such as cold, strong wind, and drought has vitality It is very strong and contains carbohydrates, proteins, lipids, vitamins, minerals, and fibres, so it has high nutritional value and is known to contain various physiologically functional substances such as alkaloids, steroids, tannins, and saponins. In the present invention, the maca extract may be a maca root extract, but is not limited thereto.

In the present invention, "Eucommia ulmoides" refers to a deciduous tree belonging to the Eucommiaceae family, and the main pharmacological actions include blood pressure reduction by vascular smooth muscle expansion, anti-aging action, and the like. In addition, it enhances the adrenocortical hormone and exhibits anti-inflammatory action, and suppresses and enhances cellular immunity by regulating the sedative analgesic action and immune function of the body. In addition, it has a shortening of bleeding time, a diuretic action, an antiallergic action and a uterine contraction action. In the present invention, the cephalothorax extract may be extracted from the bark, but is not limited thereto.

In the present invention, "reishi mushroom (Ganoderma Luciderm)" refers to a mushroom that occurs and grows from the roots of a broad-leaved tree in summer, which is also referred to as an oyster mushroom, and is effective in diuresis, interpolation, tonicity, mental stability, arthritis and bronchitis, lowering blood pressure, hyperlipidemia Improvement, hypoglycemia, immune enhancement and anti-tumor effects have also been reported.

In the present invention, "black garlic" refers to black garlic converted into a substance called S-allyl cysteine by inhibiting the production of allicin in raw garlic and aging it for about 30 to 40 days as fermented and aged garlic. Black garlic is known to reduce gastrointestinal disorders such as gastric ulcer or gastritis and reduce residual odor, and to increase polyphenol content and antioxidant effect compared to raw garlic.

In the present invention, “Angelica” refers to perennial herbs belonging to the Umbelliferae, Angelica gigas Nakai, A. sinensis DIELS, Angelica acutiloba KITAG., and related plants. It means the dried root of the plant, and it is known to have the effects of bohyeolhwahyeol, landscape pain, and lubrication. The root has sedative, antispasmodic, and blood pressure lowering effects, and an aqueous solution of root essential oil for arthritis has analgesic and anti-inflammatory effects. According to embodiments of the present invention, the Angelica root extract may be, but is not limited thereto.

In the present invention, "licorice (Glycyrrhiza glabra)" refers to a perennial grass of the family Rosaceae, a dicotyledonous plant, and contains glycyrrhizin, flavonoid, mannitol, etc. as physiologically active ingredients, and It is known to have anti-inflammatory, anti-allergic and antibacterial effects. According to embodiments of the present invention, the licorice extract may be a licorice root or stem extract, but is not limited thereto.

In the present invention, "Astragalus" refers to the root of Astragalus membranaceus BUNCE, a perennial herb of Legumninosae distributed in Korea, China, and Japan, and includes sucrose, glucuronic acid, mucilage, amino acids, It contains choline, betaine, and folic acid. It is known to have no toxicity and side effects, and has been used in various ways as traditional medicines in Korea, China and Asia.

In the present invention, “honey” refers to honeybees collecting nectar from flowers or secretions containing sugar (secrets from insects that eat plant sap), or both, and stored in the hexagonal honeycomb of the hive. An edible sweet substance. Although there are differences depending on the type of flower and the collection period, in general honey contains 17 to 20% moisture, 76 to 80% sugar, a small amount of amino acids, pollen (pollen), beeswax, acids, proteins, minerals (calcium, magnesium, phosphorus, Potassium), and is known to be completely absorbed into the human body without side effects.

In the present invention, “Sukjihwang” refers to a herbal medicine obtained by steaming and drying the root of Rehmannia glutinosa. It has a sweet and bitter taste and has a warm nature, so as to replenish the blood and replenish the essence, so that the lower back and knees suffer from soreness or menstruation. It is effective in treating abnormalities, dizziness, etc. and darkening the hair. It is the main medicinal product of Samultang and is known to be used for symptoms such as heat resistance, dry throat, and thirst, which are caused by weakness of the body among various chronic diseases.

In the present invention, “cornus officinalis” refers to the fruit of cornus oil, which is a plant of the Dogwood family, and has a slightly warm property, sour and astringent taste, and non-toxic properties. The content of saponin is 15% or more, so it has an excellent astringent effect and is also known to have an effect of improving the skin by removing harmful oxygen. According to embodiments of the present invention, the cornus oil extract may be a cornus fruit extract, but is not limited thereto.

In the present invention, "Hovenia dulcis" is a genus of Hovenia of the Rhamnaceae of the Rhamnales of the angiosperm phylum of the angiosperm phylum, also referred to as bolge, holly, or serrata. It means a plant belonging to the family, and is known to have effects such as poison detoxification, liver protection, antioxidant, blood sugar lowering, antitumor, and blood pressure lowering. According to embodiments of the present invention, the Heotgae tree extract may be a Heotgae tree fruit extract, but is not limited thereto.

In the present invention, "extract" means the result of extraction using an appropriate extraction solvent, and the extract is an extract obtained by extraction, a diluted or concentrated solution of the extract, a dried product obtained by drying the extract, a prepared or purified product thereof, or fractions.

In the present invention, "first extract" or "second extract" means an extract group comprising different specific extracts, respectively. According to embodiments of the present invention, the first extract is to include Goji berry extract, Tosaja extract, bokbunja extract, casualty locust extract and Schisandra extract, and the second extract is Yagwanmun extract, maca extract, Duchong extract, Reishi mushroom extract, and black garlic. It may include extracts, Angelica extract, licorice extract, Astragalus extract, honey extract, Sukhumus extract, Cornus officinalis extract, and Heotgae tree extract.

In the present invention, the first extract and the second extract may be a post-mixing of each extract extracted from the raw materials, and may be a complex extract extracted simultaneously after mixing the raw materials.

In the present invention, "post-mixing" refers to first obtaining an extract from each raw material, and then mixing the obtained product according to a specific weight ratio. The obtained product may be in a lyophilized form, but is not limited thereto.

In the present invention, “composite extract” refers to an extract extracted through a manufacturing process in a mixture state in which the raw materials of each extract are mixed at the same time.

According to embodiments of the present invention, the first extract may be a post-mixing of each extract extracted from the raw materials gugija, tosaja, bokbunja, sasansa and omija. In addition, according to embodiments of the present invention, the first extract may include Goji berry extract, Tosaja extract, bokbunja extract, Sasangsaeng extract and Schisandra extract in a weight ratio of 9:7:5:3:1. As confirmed in the experimental examples to be described later, the first extract containing the extract in the weight ratio exhibits an excellent sexual function improvement effect due to the synergistic effect with the second extract.

According to the embodiments of the present invention, the second extract is a complex extract extracted from a mixture of raw materials in the form of a mixture of sagebrush, maca, duchung, reishi mushroom, black garlic, angelica, licorice, astragalus, honey, sukjihwang, cornus oil, and sagebrush. can be As can be seen in Examples to be described later, the composition including the complex extract extracted from the raw material mixture has increased sexual function improvement effect compared to the case where the second extract is post-mixed with each raw material extract. In addition, it was confirmed that the complex extract extracted from the raw material mixture of a specific weight ratio has a better sexual function improvement effect even in the composition including the complex extract extracted from the mixture containing the raw material. Without being bound by a particular theory, it is believed that the active ingredient contained in each raw material is more easily extracted by the synergistic action of ingredients extracted from one or more raw materials stimulating the plant cell wall of other raw materials to increase the outflow of active ingredients .

In the present invention, when the second extract is extracted from a mixture of raw materials, the raw material mixture is a mixture of Yagwanmun, Maca, Duchong, Reishi mushroom, Black garlic, Angelica, Licorice, Astragalus, Honey, Sukhumang, Cornus oil and Heotgae fruit 1-2: It may be included in a weight ratio of 1-2:1-2:1-2:1-2:1-2:1-2:1-2:1-2:1-2:1-2:1-2 and preferably in a weight ratio of 1:2:1:1:1:1:2:2:1:1:2:1.

In the present invention, goji berry, tosaja, bokbunja, saengjae, omija, yagwanmun, maca, tofu, reishi mushroom, black garlic, angelica, licorice, astragalus, honey, suksukhwang, cornus oil, and heotgae tree fruit are those harvested from nature or directly grown or commercially available. What is being used can be used without limitation, and the plant parts used for extraction may be flowers, leaves, seeds, fruits, roots and/or stems.

The extract of the present invention can be prepared through an extraction method commonly used in the art. For example, methods such as hot water extraction, hot water extraction, cold extraction, reflux cooling extraction, ultrasonic extraction, and high-temperature pressure extraction may be used.

In the preparation of the extract of the present invention, water as an extraction solvent; lower alcohols having 1 to 4 carbon atoms, such as methanol, ethanol, propyl alcohol, and butyl alcohol; polyhydric alcohols such as glycerin, butylene glycol and propylene glycol; hydrocarbon solvents such as chloroform, methyl acetate, ethyl acetate, benzene, hexane, diethyl ether, petroleum ether and dichloromethane; Or a mixture thereof may be used, and preferably water may be used as an extraction solvent. According to the embodiments of the present invention, the extract of the present invention excludes the use of an organic solvent as an extraction solvent, and uses water to denaturate the active ingredient due to the organic solvent, generate additional substances, or residual organic harmful to the human body after extraction. Side effects caused by solvents were minimized.

The content of the first extract and the second extract included in the composition of the present invention may be appropriately determined in consideration of various factors, for example, purpose of use, period of use, type of formulation, route of administration, state of the site to be administered, etc. can According to embodiments of the present invention, the first extract and the second extract may be included in a weight ratio of 1:1 or 10:9, but is not limited thereto.

In the present invention, “improvement” may be construed to include not only all acts of reducing, delaying, alleviating or suppressing the degree of symptoms or progression related to sexual function, but also acts of reversing. Sexual function improvement in the present invention may be to improve one or more selected from the group consisting of erectile function, climax, sexual desire, sexual satisfaction, and overall satisfaction of sex life.

In the present invention, the composition for improving sexual function may further include glutinous rice in the first extract and the second extract. In the present invention, glutinous rice is preferably included within a range that does not reduce the sexual function improvement effect, and specifically, it is preferably included in an amount of 5 to 10% by weight, preferably 5% by weight, based on the weight of the total composition. According to an embodiment of the present invention, the composition for improving sexual function may include the first extract, the second extract, and glutinous rice in a weight ratio of 10:9:1. According to the experimental example to be described later, volunteers were allowed to ingest the pills prepared in the above weight ratio to confirm the effect of improving sexual function, and before and after intake, erectile function, climax, sexual desire, sexual satisfaction, and overall satisfaction of sexual life all increased. It was confirmed that the composition of the present invention had an excellent sexual function improvement effect.

The composition for improving sexual function of the present invention may further include an additional component to enhance efficacy. For example, the additional ingredients are not limited as long as they do not counteract or reduce the efficacy of the extract.

Another aspect of the present invention is a health functional food comprising the composition for improving sexual function of the present invention. Here, the composition for improving sexual function is the same as described above, and is omitted to avoid excessive repetition of the same content in the specification.

In the present invention, the health functional food may be prepared in the form of powder, granule, tablet, capsule, syrup or beverage, preferably in the form of a pill.

The method for preparing the first extract and the second extract in the present invention includes the following steps.

Drying after removing foreign substances from the raw material;

pulverizing the dried raw material;

a roasting step of steam roasting the pulverized raw material at 100° C. for 30 minutes;

immersing the roasted raw material by adding 15 times the volume of water;

extracting the immersed raw material at 80° C. under pressure for 3 hours;

centrifugation (8,000 rpm, 15° C.) for 20 minutes using a centrifuge;

filtering the centrifuged extract to remove solid residues; and

Concentrating the filtrate.

The composition for improving sexual function comprising 17 oriental herbal ingredients of the present invention restores the physiological function of the human body related to sexual function, and has an effect of not only temporarily improving sexual function but also ultimately improving sexual function.

In addition, the composition for improving sexual function of the present invention can increase erectile function, climax, sexual desire, sexual satisfaction and overall satisfaction.

In addition, since the composition of the present invention contains oriental medicine ingredients extracted from natural oriental medicine raw materials, it does not have the problems of conventional chemical therapeutic agents, that is, harmful to the human body.

Hereinafter, the present invention will be described in more detail by way of Examples. However, these examples are for illustrative purposes only, and the scope of the present invention is not limited by these examples. In addition, it should be understood that terms not specifically defined in this specification have meanings commonly used in the technical field to which the present invention pertains.

manufacturing example

(1) Preparation of the first extract

1) Preparation of Goji berry extract

100 g of dried goji berries were crushed and chopped, and then steam roasted at about 100° C. for 30 minutes (roaster: FEC006, Biotech, Korea). After putting the roasted goji berries in a reactor, about 15 times the volume of water was added. After that, the immersed sample was extracted for 3 hours at 80°C under pressure using a reactor, and then centrifuged (8,000 rpm, 15°C) for 20 minutes using a centrifuge (Supra 22K, Hanil, Korea). The extract was filtered using qualitative filter paper No. 2 (manufacturer: Whatman), concentrated, and then freeze-dried at 20°C.

2) Preparation of extracts from Tosaja, bokbunja, sasansa and omija extracts

Tosaja extract, bokbunja extract, Sasangjae extract, and Schisandra extract were prepared in substantially the same manner as in the preparation of Goji extract except that Tosaja, bokbunja, Sasangsa fruit and Schisandra were used as raw materials.

3) Preparation of the first extract

A first extract of Sample 1-1 was prepared by mixing the freeze-dried Goji berry extract, Tosaja extract, Bokbunja extract, Sasangsaeng extract and Schisandra extract in a weight ratio of 9:7:5:3:1.

(2) Preparation of the second extract

1) Preparation of Sample 2-1

Dried raw material mixture {Yakwanmun (leaf), maca (root), Duchong (bark), Reishi mushroom, black garlic, Angelica (root), licorice (root), Astragalus (root), honey, Sukhumvitae (root), Cornus officinalis (fruit) ) and cypress (fruit)} in a weight ratio of 1:2:1:1:1:1:2:2:1:1:2:1} were minced through a grinder, and then the pulverized raw material mixture 100 g was subjected to steam roasting treatment at about 100° C. for 30 minutes (roaster: FEC006, Biotech, Korea). Thereafter, the roasted raw material mixture was put in a reactor, and then water was added by about 15 times the volume. After that, the immersed sample was extracted for 3 hours at 80°C under pressure using a reactor, and then centrifuged (8,000 rpm, 15°C) for 20 minutes using a centrifuge (Supra 22K, Hanil, Korea). The extract was filtered using qualitative filter paper No. 2 (manufacturer: Whatman), concentrated, and then freeze-dried at 20° C. to obtain a second extract of Sample 2-1.

2) Preparation of Samples 2-2 to 2-5

Ingredients included in the mixture of raw material mixture include sagebrush (leaf), maca (root), nutmeg (bark), reishi mushroom, black garlic, angelica (root), licorice (root), astragalus (root), honey, sukhumang (root), cornflower oil (fruit) ) and the second extract of Samples 2-2 to 2-5 were prepared in substantially the same manner as in Sample 2-1, except that the weight ratio of the tree (fruit) was changed as described in the table below.

sample
2-1 night gate maca headworm reishi mushroom black garlic donkey One 2 One One One One licorice Astragalus honey Sook Hwang corn milk hawthorn fruit 2 2 One One 2 One sample
2-2 night gate maca headworm reishi mushroom black garlic donkey One One One One One One licorice Astragalus honey Sook Hwang corn milk hawthorn fruit One One One One One One sample
2-3 night gate maca headworm reishi mushroom black garlic donkey 2 2 2 2 One One licorice Astragalus honey Sook Hwang corn milk hawthorn fruit One One One One One One sample
2-4 night gate maca headworm reishi mushroom black garlic donkey One One One One 2 2 licorice Astragalus honey Sook Hwang corn milk hawthorn fruit 2 2 One One One One sample
2-5 night gate maca headworm reishi mushroom black garlic donkey One One One One One One licorice Astragalus honey Sook Hwang corn milk hawthorn fruit One One 2 2 2 2

3) Preparation of samples 2-6

After preparing each extract (honey is added as it is) from Yagwanmun, maca, duchung, reishi mushroom, black garlic, angelica, licorice, astragalus, sorghum yellow, cornflower oil, and honeysuckle (honey is added as it is) in substantially the same manner as in Sample 2-1, 1:1:1:1:1:1:1:1 of wild ginseng extract, maca extract, duchong extract, reishi mushroom extract, black garlic extract, angelica lily extract, licorice extract, astragalus extract, honey, sujihwang extract, cornflower extract, and chrysanthemum extract Samples 2-6 were prepared by mixing in a weight ratio of 1:1:1:1:1:1.

Examples and Comparative Examples

The compositions of Examples and Comparative Examples were prepared by mixing the first extract and the second extract prepared in Preparation Example in a weight ratio of about 1:1 according to Table 2 below, and adding purified water to the mixture and suspending it.

first extract second extract Example 1 Sample 1-1 Sample 2-1 Example 2 Sample 1-1 Sample 2-2 Example 3 Sample 1-1 Sample 2-3 Example 4 Sample 1-1 Sample 2-4 Example 5 Sample 1-1 Sample 2-5 Comparative Example 1 Sample 1-1 Sample 2-6 Comparative Example 2 Sample 1-1 -

Experimental Example 1. Confirmation of sexual function improvement effect 1

In order to confirm the effect of promoting and maintaining penis erection of the composition for improving sexual function of the present invention, 250 to 300 g of sprag-dowley (spraque-dowley, Co.) Animal experiments were performed on male rats of Samtaco BIO KOREA) species.

Specifically, the compositions of Examples 1 to 5 (20 mg / kg and 100 mg / kg), the compositions of Comparative Examples 1 and 2, physiological saline (negative control group), and sildenafil (positive control group) were administered directly into the oral cavity using a syringe and sonde, and the cavernous pressure was measured after 30 to 40 minutes.

After intraperitoneal injection of urethane into the rat was given general anesthesia, the epidermis of the penis was incised to expose the cavernous body, and the pelvic ganglion was removed through a median incision in the abdomen to expose the pelvic nerve and the cavernous nerve. A platinum electrode was connected to the exfoliated corpus cavernosum nerve and then connected to an electrical stimulator. In addition, a polyethylene tube was inserted into the carotid artery to measure mean arterial pressure (MAP).

A 23-gauge needle is placed in the cavernous body, and the cavernosal nerve is stimulated through an electrical stimulator (10 Hz, 3 V, 5 ms, 1 min), and the resulting intracavernosal pressure is measured to determine the maximum intracavernosal pressure (ICP). And systemic blood pressure (MAP) was measured, and the ICP/MAP (maximum penile erection) ratio was recorded for 5 minutes and the maximum values were compared.

Systemic blood pressure and cavernous pressure were measured with a Gres telefactor RPS312RM and a data collection device, and the measured data were analyzed using a data analysis program.

(1) Evaluation of penile erection response by penile cavernous nerve stimulation

The evaluation of penile erection response by penile cavernous nerve stimulation was evaluated by comparing the ICP/MAP ratio for each group, and the specific results are shown in Table 3 below.

army ICP/MAP (%) 20 mg/kg 100 mg/kg Example 1 60.98 ± 2.23 61.35 ± 3.21 Example 2 56.21 ± 5.27 56.77 ± 7,02 Example 3 54.63 ± 3.32 54.11 ± 3.41 Example 4 55.32 ± 2.6 56.32 ± 2.53 Example 5 54.11 ± 3.32 53.11 ± 3.45 Comparative Example 1 52.94 ± 4.22 53.52 ± 4.31 Comparative Example 2 48.42 ± 7.42 49.11 ± 6.51 negative control 42.37 ± 3.21 positive control 62.02 ± 4.41

As can be seen in the table above, in the group administered with the compositions of Examples 1 to 5 containing the composition of the present invention, the maximum penile erection (ICP / MAP) was Comparative Example 1 (administration of a composition containing five herbal ingredients) , was higher than that of the negative control group (administered with physiological saline), and the maximum penile erection was comparable to that of the positive control group (administered with sildenafil 20 mg/kg). It was confirmed that it is possible. In addition, it was confirmed that the composition containing the second extract obtained from the mixture of raw materials in the preparation of the second extract compared to Example 2 and Comparative Example 1 exhibited a more excellent sexual function improvement effect than when each extract was mixed.

In particular, the composition of Example 1 (Yakwanmun, Maca, Duchong, Reishi mushroom, black garlic, Angelica, licorice, Astragalus, honey, Sukhumvitae, Cornus oil and Heotgae tree 1:2:1:1:1:1:2:2: In the case of the second extract extracted from the raw material mixture included in a weight ratio of 1:1:2:1), it exhibited better maximum penis erection power compared to the compositions of Examples 2 to 5, which is included in the composition of the present invention. When the second extract is extracted from a raw material mixture having a specific weight ratio, it means that a more excellent sexual function improvement effect can be exhibited due to a synergistic effect.

(2) Erection maintenance evaluation

Erectile holding power was confirmed through the cumulative area under the curve (AUC) of the cavernous body pressure/blood pressure (%) graph from 1 minute before penile cavernous stimulation to 5 minutes after stimulation, and the experimental results are the mean ± standard error ( The mean±standard error (SE) is shown in Table 4 below.

army Erectile holding power (AUC) Example 1 6132±444.2 Example 2 5891±622.1 Example 3 5777±312.7 Example 4 5922±628.2 Example 5 5832±541.2 Comparative Example 1 5511±541.1 Comparative Example 2 5432±723.3 positive control 5977±573.5 negative control 5069±382.3

As can be seen in the table above, in the group administered with the compositions of Examples 1 to 5 containing the composition of the present invention, erectile maintenance was compared to Comparative Example 1 (administration of a composition containing five oriental medicinal ingredients), a negative control group (physiological saline solution) administration), and showed the same or improved erection retention power compared to the positive control group (administered with sildenafil 20 mg/kg), confirming that the composition containing 17 herbal ingredients of the present invention can exhibit excellent sexual function improvement effect did. In addition, it was confirmed that the composition containing the second extract obtained from the mixture of raw materials in the preparation of the second extract compared to Example 2 and Comparative Example 1 exhibited a more excellent sexual function improvement effect than when each extract was mixed.

In particular, the composition of Example 1 (Yakwanmun, Maca, Duchong, Reishi mushroom, black garlic, Angelica, licorice, Astragalus, honey, Sukhumvitae, Cornus oil and Heotgae tree 1:2:1:1:1:1:2:2: In the case of the second extract extracted from the raw material mixture included in a weight ratio of 1:1:2:1), it exhibited better erection retention compared to the compositions of Examples 2 to 5, which is the agent included in the composition of the present invention. 2 When the extract is extracted from a mixture of raw materials having a specific weight ratio, it means that a better sexual function improvement effect can be exhibited due to the synergistic effect.

Experimental Example 2. Confirmation of sexual function improvement effect 2

In order to check whether the composition for improving sexual function of the present invention has an effect of improving sexual function, there is no organic or mental disease such as high blood pressure, diabetes, liver disease, kidney disease, mental disease, etc. Twenty married male volunteers between the ages of 30 and less than 60 with symptoms of deterioration were instructed to take a pill containing the composition of the present invention 3 g twice a day for 8 weeks. In this experiment, the pills were prepared by mixing about 50% by weight of sample 1-1, about 45% by weight of sample 2-1 and about 5% by weight of glutinous rice, and then using a conventional pill manufacturing method.

The survey was conducted before and after ingestion, respectively, and the erectile function measurement questionnaire classified by Rosen was erectile function (6 questions), climax (2 questions), sexual desire (2 questions), sexual satisfaction (3 questions). ) and overall sexual life satisfaction (2 questions).

Each question was marked with a score of 0 to 5, and the average was calculated after adding up the scores, and the results are shown in Table 5 below.

erectile function climax sexual desire sexual satisfaction overall satisfaction before intake after ingestion before intake after ingestion before intake after ingestion before intake after ingestion before intake after ingestion 12.3± 0.4 22.7
± 2.1 5.4
± 0.4 7.6
± 0.4 6.8
± 0.3 8.1
± 0.2 5.5
±0.4 10.6
±0.6 4.1
±0.3 7.8
±0.2

As can be seen in Table 5, the volunteers increased erectile function, climax, sexual desire, sexual satisfaction, and overall satisfaction with sex life before and after ingestion of a pill containing the composition of the present invention. Therefore, it was confirmed that the composition comprising 17 kinds of oriental herbal ingredients of the present invention can exhibit excellent sexual function improvement effect.

In addition, it was confirmed that the composition of the present invention has excellent stability because no special side effects related to the administration of the pills, for example, diarrhea, etc. were reported among the volunteers during the experiment.

Claims (8)

A first extract comprising a dry matter of Goji berry extract, a dry matter of a Tosaja extract, a dry matter of a bokbunja extract, a dry matter of the Sasangsaeng extract, and a dry matter of the Schisandra extract in a weight ratio of 9:7:5:3:1; and
Yagwanmun, Maca, Duchong, Reishi mushroom, Black Garlic, Angelica, Licorice, Astragalus, Honey, Sulfuricaceae, Cornus oil, and Heotgae fruit 1:2:1:1:1:1:1:2:2:1:1:2:1 As a composition for improving sexual function, comprising: after mixing in a weight ratio of
The composition further includes glutinous rice, the first extract, the dry matter of the second extract, and glutinous rice in a weight ratio of 10:9:1 for improving sexual function. delete delete delete delete delete A health functional food for improving sexual function comprising the composition of claim 1. 8. The method of claim 7,
The health functional food is a health functional food for improving sexual function in the form of pills.