KR102297505B1 - Aimp2-dx2와 hsp70의 결합을 저해하는 항암제 스크리닝 방법 - Google Patents
Aimp2-dx2와 hsp70의 결합을 저해하는 항암제 스크리닝 방법 Download PDFInfo
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- KR102297505B1 KR102297505B1 KR1020160027077A KR20160027077A KR102297505B1 KR 102297505 B1 KR102297505 B1 KR 102297505B1 KR 1020160027077 A KR1020160027077 A KR 1020160027077A KR 20160027077 A KR20160027077 A KR 20160027077A KR 102297505 B1 KR102297505 B1 KR 102297505B1
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- aimp2
- hsp70
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
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- G01N33/574—
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
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- Life Sciences & Earth Sciences (AREA)
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- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
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- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Genetics & Genomics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020160027077A KR102297505B1 (ko) | 2016-03-07 | 2016-03-07 | Aimp2-dx2와 hsp70의 결합을 저해하는 항암제 스크리닝 방법 |
| CN201780027761.8A CN109073638B (zh) | 2016-03-07 | 2017-03-07 | 抑制aimp2-dx2和hsp70结合的抗癌剂的筛选方法 |
| JP2018548001A JP6914269B2 (ja) | 2016-03-07 | 2017-03-07 | Aimp2−dx2とhsp70との結合を阻害する抗がん剤スクリーニング方法 |
| PCT/KR2017/002442 WO2017155277A1 (ko) | 2016-03-07 | 2017-03-07 | Aimp2-dx2와 hsp70의 결합을 저해하는 항암제 스크리닝 방법 |
| EP17763538.0A EP3418739B1 (en) | 2016-03-07 | 2017-03-07 | Method for screening anticancer agent inhibiting binding of aimp2-dx2 and hsp70 |
| US16/125,113 US11442057B2 (en) | 2016-03-07 | 2018-09-07 | Method for screening anticancer agent inhibiting binding of AIMP2-DX2 and HSP70 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020160027077A KR102297505B1 (ko) | 2016-03-07 | 2016-03-07 | Aimp2-dx2와 hsp70의 결합을 저해하는 항암제 스크리닝 방법 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20170104263A KR20170104263A (ko) | 2017-09-15 |
| KR102297505B1 true KR102297505B1 (ko) | 2021-09-01 |
Family
ID=59790548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020160027077A Active KR102297505B1 (ko) | 2016-03-07 | 2016-03-07 | Aimp2-dx2와 hsp70의 결합을 저해하는 항암제 스크리닝 방법 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11442057B2 (enExample) |
| EP (1) | EP3418739B1 (enExample) |
| JP (1) | JP6914269B2 (enExample) |
| KR (1) | KR102297505B1 (enExample) |
| CN (1) | CN109073638B (enExample) |
| WO (1) | WO2017155277A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101831435B1 (ko) * | 2016-03-10 | 2018-02-22 | 재단법인 의약바이오컨버젼스연구단 | Aimp2-dx2 단백질에 특이적으로 결합하는 항체 |
| US11758948B2 (en) | 2018-01-29 | 2023-09-19 | Altria Client Services Llc | Lighting unit for aerosol-generating systems |
| RU2764430C1 (ru) | 2018-01-29 | 2022-01-17 | Филип Моррис Продактс С.А. | Блок подсветки для систем, генерирующих аэрозоль |
| KR102308134B1 (ko) | 2018-04-26 | 2021-10-01 | 재단법인 의약바이오컨버젼스연구단 | mTOR 저해제로서의 신규 화합물 및 이의 용도 |
| CN117769431A (zh) * | 2021-03-30 | 2024-03-26 | 德克萨斯大学体系董事会 | 瓜氨酸化蛋白作为用于癌症的生物标志物和疗法靶 |
| CN115786504B (zh) * | 2022-08-31 | 2023-09-19 | 中国人民解放军总医院京南医疗区 | Hspa4抑制剂在治疗黑素瘤中的应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110117572A1 (en) | 2004-11-24 | 2011-05-19 | Neomics Co., Ltd. | Antibody Specific to the AIMP2-DX2 |
| KR101577315B1 (ko) | 2013-03-14 | 2015-12-15 | 부산대학교 산학협력단 | AIMP2-DX2와 p14/ARF의 상호작용을 이용한 암 치료제의 스크리닝 방법 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8039218B2 (en) * | 2002-11-14 | 2011-10-18 | John Wayne Cancer Institute | Detection of cancer cells in body fluids |
| US7459529B2 (en) | 2004-11-24 | 2008-12-02 | Seoul National University Industry Foundation | AIMP2-DX2 and its uses |
| KR20060057992A (ko) * | 2004-11-24 | 2006-05-29 | 재단법인서울대학교산학협력재단 | p38-DX2 및 이의 용도 |
| WO2006113747A2 (en) * | 2005-04-19 | 2006-10-26 | Prediction Sciences Llc | Diagnostic markers of breast cancer treatment and progression and methods of use thereof |
| US20080280297A1 (en) * | 2005-07-15 | 2008-11-13 | The Trustees Of Columbia University In The City Of | Compositions and Methods for Differential Diagnosis of Chronic Lymphocytic Leukemia |
| KR20070113926A (ko) * | 2006-05-26 | 2007-11-29 | 재단법인서울대학교산학협력재단 | 암의 진단과 치료를 위한 aimp2dx2의 용도 |
| US8754094B2 (en) * | 2007-08-15 | 2014-06-17 | The Research Foundation Of State University Of New York | Methods for heat shock protein dependent cancer treatment |
| KR101067816B1 (ko) * | 2007-11-09 | 2011-09-27 | (주)네오믹스 | Aimp2-dx2의 억제제를 유효성분으로 포함하는 염증성질환 예방 및 치료용 조성물 |
| WO2011035433A1 (en) * | 2009-09-23 | 2011-03-31 | University Health Network | Selected strains on serum-free growth media for proteomics analysis of lung cancer biomarkers |
| CN102985103A (zh) * | 2010-05-04 | 2013-03-20 | Atyr医药公司 | 与p38多-tRNA合成酶复合物相关的治疗、诊断和抗体组合物的创新发现 |
| WO2013006076A1 (en) * | 2011-07-04 | 2013-01-10 | New York University | The use of intranasally administered hsp70 protein to treat neurodegenerative diseases |
| KR20130016041A (ko) * | 2011-08-04 | 2013-02-14 | 재단법인 의약바이오컨버젼스연구단 | 신규한 아닐린 유도체 및 이의 용도 |
| KR101500804B1 (ko) * | 2012-04-20 | 2015-03-11 | 단국대학교 산학협력단 | Aimp2 유전자의 스플라이싱 변이체 특이적인 트랜스-스플라이싱 활성을 갖는 핵산 분자 및 이를 이용한 폐암 치료용 약학 조성물 및 폐암 진단용 조성물 |
| KR20130118612A (ko) * | 2012-04-20 | 2013-10-30 | (주)네오믹스 | 신규한 아미노피리딘 유도체 및 이의 용도 |
| KR101464360B1 (ko) * | 2012-11-09 | 2014-11-21 | 주식회사 대웅 | 리보자임과 shRNA를 함유하는 아데노바이러스 및 이를 포함하는 암 치료용 조성물 |
| KR101762433B1 (ko) * | 2013-06-05 | 2017-07-28 | 재단법인 의약바이오컨버젼스연구단 | 신규한 말레인산 유도체 및 이의 제조방법 및 이를 포함하는 항암용 조성물 |
| KR101514320B1 (ko) * | 2013-06-14 | 2015-04-22 | 재단법인 의약바이오컨버젼스연구단 | 신규한 암 예방 또는 치료용 약학적 조성물 |
| KR101621963B1 (ko) * | 2014-03-06 | 2016-05-17 | 한국과학기술원 | Aimp2의 엑손2 결손체 돌연변이 검출용 분자신호기 및 이를 이용한 aimp2 돌연변이의 검출방법 |
| EP3162803B1 (en) * | 2014-06-30 | 2019-09-11 | Pusan National University Industry-University Cooperation Foundation | New compound for inhibiting binding between dx2 protein and p14/arf protein, and pharmaceutical composition for treating or preventing cancer disease containing same as effective ingredient |
-
2016
- 2016-03-07 KR KR1020160027077A patent/KR102297505B1/ko active Active
-
2017
- 2017-03-07 EP EP17763538.0A patent/EP3418739B1/en active Active
- 2017-03-07 CN CN201780027761.8A patent/CN109073638B/zh active Active
- 2017-03-07 JP JP2018548001A patent/JP6914269B2/ja active Active
- 2017-03-07 WO PCT/KR2017/002442 patent/WO2017155277A1/ko not_active Ceased
-
2018
- 2018-09-07 US US16/125,113 patent/US11442057B2/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110117572A1 (en) | 2004-11-24 | 2011-05-19 | Neomics Co., Ltd. | Antibody Specific to the AIMP2-DX2 |
| KR101577315B1 (ko) | 2013-03-14 | 2015-12-15 | 부산대학교 산학협력단 | AIMP2-DX2와 p14/ARF의 상호작용을 이용한 암 치료제의 스크리닝 방법 |
Also Published As
| Publication number | Publication date |
|---|---|
| US11442057B2 (en) | 2022-09-13 |
| CN109073638B (zh) | 2022-04-26 |
| EP3418739B1 (en) | 2021-05-12 |
| CN109073638A (zh) | 2018-12-21 |
| KR20170104263A (ko) | 2017-09-15 |
| WO2017155277A1 (ko) | 2017-09-14 |
| US20190033295A1 (en) | 2019-01-31 |
| WO2017155277A8 (ko) | 2018-11-08 |
| JP6914269B2 (ja) | 2021-08-04 |
| EP3418739A4 (en) | 2019-03-06 |
| JP2019512693A (ja) | 2019-05-16 |
| EP3418739A1 (en) | 2018-12-26 |
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St.27 status event code: A-4-4-Q10-Q13-nap-PG1601 |
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| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 4 |
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| P22-X000 | Classification modified |
St.27 status event code: A-4-4-P10-P22-nap-X000 |