KR102289942B1 - Manufacturing method of jelly containing nanoparticleized medicinal herbs and the jelly prepared using the same - Google Patents

Abstract

The present invention provides a preparing method of jelly containing nanoparticulated medicinal herbs and jelly prepared thereby. The preparing method of jelly containing nanoparticulated medicinal herbs includes washing and soaking a plurality of medicinal herbs with and in water at different temperatures according to a functional group and then performing dry pulverization of the washed and soaked plurality of medicinal herbs so that the maximum particle diameter thereof is 500 ㎛ or less, sequentially performing wet pulverization so as to make the same into nano-sized powder slurry, and mixing the nano-slurry with collagen, to prepare the same in the form of jelly. Accordingly, not only the intake of medicinal herbs can be easy, but also the extraction efficiency and in-vivo absorption rate of polyphenols and zinc can be improved.

Description

Manufacturing method of jelly containing nanoparticleized medicinal herbs and jelly prepared by this method

The present invention relates to a method for producing a jelly containing a nanoparticulate herbal medicine and to a jelly produced by the method, and more particularly, to a plurality of herbal medicines washed and soaked with water at different temperatures according to functional groups, followed by dry grinding to make it less than 500 μm, and then sequentially wet grinding to make a nano-sized powder slurry. It relates to a method for manufacturing a jelly containing a nanoparticulated herbal medicine so that extraction efficiency and absorption rate in the body can be improved, and to a jelly produced by the method.

Herbal medicine usually refers to a decoction of a crude drug, but in some cases, the herbal medicine is made into powder or made into pills. Therefore, in order to take herbal medicines, not only there are inconveniences such as having to decoction herbal medicines, but also there is a problem that it is difficult or difficult to take due to the bitter taste or smell peculiar to herbal medicines when taking herbal medicine powders or liquid preparations made with decoctions of medicinal herbs. .

In addition, in the prior art, these herbal medicines were cut to an appropriate size, dried, ironed, and eaten as a liquid soup. When herbal medicines are ironed and eaten with this high-temperature calorie extraction method, the extraction rate of various pharmacological components contained in the herbal medicines is lowered, making it difficult to properly realize the effects of herbal medicines. there was.

Since the traditional herbal soup has a bitter taste and the ironing process is complicated and cumbersome, it must be ironed at an oriental medicine clinic or a place that irons oriental medicines. There was a problem.

In addition, in the case of pre-cooked herbal medicines, there may be problems with preservation and stability. In recent years, in order to solve this problem, many inconveniences have been improved by making extracts and herbal powders extracted from herbal medicines into oriental medicine preparations such as powders, granules, tablets or liquids, and taking them, and the stability of preservation has also been improved.

Korean Patent Publication No. 10-1969236, which is a prior document, discloses a jelly made from herbal medicine. However, the prior literature does not disclose a means for preventing the destruction of the components of the herbal medicine in the process of gelling the herbal medicine and, in particular, for increasing the extraction efficiency of polyphenols and zinc.

Polyphenol is a molecular substance composed of two or more phenol structures and is not toxic, unlike benzene, phenol, naphthalene, and benzopyrene, which are the same aromatic. Polyphenols include tannins, flavonoids, and catechins. It is known that polyphenols are produced by plants to protect themselves from UV rays, reactive oxygen species, and predators. Examples include the black pigment of black beans, green tea, and black tea, such as the astringent taste of tea. You can also consume red wine, beer, vegetables and fruits such as blueberries, blackberries, and aronia.

In addition, polyphenols, as antioxidants, help the overall health of the body, blood vessels, and skin. According to the National Cancer Research Center in Japan, drinking 1 to 3 cups of coffee a day reduces the risk of liver cancer by 70% (3 cups).

A study found that drinking 3 cups of coffee a day reduced the risk of death by half (Korea University) and a study that found that drinking 3 to 5 cups of coffee lived 3 to 7 years longer (Harvard University, 40,000 males and 160,000 females) 30 years of research). Drinking more than 1-2 cups or 6 cups of coffee does not have this effect. In fact, this is not the effect of coffee, but the effect of polyphenols. Unlike coffee, tea and catechins actively prevent caffeine from being absorbed into the body, so you need to be less careful about the side effects of caffeine than coffee.

Zinc exists as a divalent cation in living things, and is an essential inorganic material for nucleic acid and amino acid metabolism of living things, and an important element forming the earth's crust. Zinc is involved in digestion and respiration, as well as insulin action, immune function, and reproductive cells.

In addition, zinc is also involved in protein metabolism and has the effect of strengthening bones. And 　male hormone, 　muscle, 　sperm, 　production, and zinc are also involved in skin beauty. Also, zinc deficiency can cause hair loss. However, the absorption rate of zinc is quite low, less than 40%. The daily recommended amount of zinc recommended by the Ministry of Food and Drug Safety is 10-20 mg, and the WHO has set it as 30-60 mg for men and 30-45 mg for women.

Republic of Korea Patent Publication No. 2020-0138498 Republic of Korea Patent Publication No. 10-1969236

It is an object of the present invention to produce jelly containing nanoparticulate herbal medicines obtained by refining oriental medicines into ultra-fine powders to improve the extraction efficiency of polyphenols and zinc in the final product and absorption rate in the body upon ingestion as well as easy ingestion. To provide a method and a jelly produced by the method.

One aspect of the present invention provides a first step of washing and soaking a plurality of herbal medicines with one of cold water, tepid water, and hot water according to a functional group, followed by dry grinding to prepare a primary pulverized product having a maximum particle diameter of 500 μm or less; a second step of injecting purified water into the first pulverized material and wet pulverizing to prepare a second pulverized product made of a nano-sized powder slurry; and a third step of mixing collagen with the secondary pulverized product to form a jelly; It provides a method for producing a jelly containing a nanoparticulated herbal medicine, characterized in that it comprises a.

According to a preferred feature of the present invention, the herbal medicines corresponding to seeds or roots among the herbal medicines may be crushed before washing and soaking.

According to a preferred feature of the present invention, among the herbal medicines, the first group of herbal medicines having an immune action are washed and soaked with cold water, and the herbal medicines of the second group that have a blood-holding action are washed and soaked with lukewarm water, and digestion is performed. Herbal medicines of the third group that do this can be washed and soaked with hot water.

According to a preferred feature of the present invention, in the first step, before dry pulverizing the herbal medicine, the washed and soaked herbal medicine is dried with hot air, and then rapidly frozen and frozen for 1 to 2 minutes.

According to a preferred feature of the present invention, the secondary pulverized product may have an average particle diameter of 100 to 200 nm.

According to a preferred feature of the present invention, in the second step, the primary pulverized material is injected into a rotary rocking mixer and reacted for 30 minutes, followed by a reaction vessel of a planetary rotor mill ( bowl) and additionally rotated, the planetary rotor mill is rotated while increasing the speed from 100 rpm to 500 rpm for the first 1 minute, and then 30 to 50 ml of purified water per 100 ml of medicinal material is injected into a wet state, By increasing the rotation speed to 800 rpm and further rotating for 2 minutes, a secondary pulverized product made of a slurry can be prepared.

According to a preferred feature of the present invention, according to a preferred feature of the present invention, in the third step, the collagen comprises collagen whose molecular weight is 500 to 1000 by first hydrolyzing the fin of a fish with a proteolytic enzyme. Obtained by preparing a hydrolyzate, mixing lactic acid bacteria with the primary hydrolyzate, and performing secondary hydrolysis to prepare a secondary hydrolyzate having a lower molecular weight than the primary hydrolyzate, and purifying and drying the secondary hydrolyzate It may be a collagen peptide having a molecular weight of 100 to 400.

Another aspect of the present invention provides a jelly comprising a nanoparticulated herbal medicine prepared by the above manufacturing method.

According to an embodiment of the present invention, a plurality of herbal medicines are washed and soaked with water at different temperatures depending on the functional group, then dry-pulverized, then wet-pulverized into a nano-sized powder slurry, and wet-pulverized into ultra-fine powders. By mixing low-molecular collagen in the gel to form a jelly, not only can the herbal medicines be easily ingested in the form of jelly, but also it is possible to prevent the destruction of polyphenols and zinc during the manufacturing process, thereby improving the extraction efficiency of polyphenols and zinc in the final product. , it has the effect of allowing the active ingredients of herbal medicines to be more effectively absorbed into the body.

1 is a flowchart sequentially showing a method of manufacturing a jelly containing a nanoparticulated herbal medicine according to an embodiment of the present invention.
2 is a photograph showing a state in which a plurality of herbal medicines are mixed.
3 is a photograph showing a state after dry grinding a number of herbal medicines.
4 is a photograph showing a state after dry-pulverized herbal medicines are subsequently wet-pulverized.

Hereinafter, preferred embodiments of the present invention will be described. However, embodiments of the present invention may be modified in various other forms, and the scope of the present invention is not limited to the embodiments described below.

In addition, 'including' a certain component throughout the specification means that other components may be further included, rather than excluding other components, unless otherwise stated.

Jelly containing nanoparticulate herbal medicines according to this embodiment is a method for maximizing the extraction efficiency of polyphenols and zinc of herbal medicines. It is pulverized and made into a nano, and then it is made into a jelly for easy consumption.

In order to prepare the jelly containing the nanoparticulate herbal medicine of the present invention, as in FIG. 1 , first, a plurality of herbal medicines are dry-pulverized to prepare a primary pulverized product pulverized to a micro size (S10). 2 is a photograph showing a state in which a plurality of herbal medicines are mixed before dry grinding, and FIG. 3 is a photograph showing a state of a primary pulverized product after the herbal medicine mixture is dry grinding.

In this embodiment, the plurality of herbal medicines may include 21 kinds. In addition, in order to provide the maximum effect on the human body by increasing the extraction efficiency and improving the absorption rate in the body in the grinding process to be described later, these herbal medicines may be pre-treated prior to dry grinding (S5).

The pre-treatment operation may be a process of washing and soaking herbal medicines with purified water, in which each herbal medicine is washed and soaked using one of cold water, tepid water and hot water depending on the functional group, followed by dry grinding and refinement It can be a micro-sized primary pulverized product through

The plurality of herbal medicines can be largely divided into three action groups by efficacy, and can be divided into a first group herbal medicine for immunity, a second group herbal medicine for blood preservation, and a third group herbal medicine for digestion. .

The herbal medicines of the first group include ginseng (golden and ginseng), sagebrush, golden ginseng, ginseng, red ginseng and amethyst. Herbal medicines of the second group include ear peony, geonjihwang, astragalus and champignon. Herbs of the third group include cinnamon, garlic root, sage seed, rhizome, health, jujube, licorice, gwakhyang, mint, koongin and dermis.

In this embodiment, a number of herbal medicines used for the primary grinding are 3-8% by weight of phosphorus (golden and silver), 4-9% by weight of forsythia stalk (Hong Kong lily stalk), 4-9% by weight of gold, 4 ginseng -9% by weight, red ginseng 4-9% by weight, amethyst 4-9% by weight, peony (pearl yak) 4-9% by weight, dried turmeric 4-9% by weight, astragalus 4-9% by weight, chamomile 4-9% by weight %, cinnamon 4-9% by weight, ground root 4-9% by weight, sine seed 4-9% by weight, rhizome 1-5% by weight, health 1-5% by weight, jujube 1-5% by weight, licorice 0.3 -2% by weight, Kwakhyang (baechohyang) 1-4% by weight, peppermint 3-7% by weight, constructionin 1-5% by weight, dermis (tangerine peel) 1-5% by weight.

More preferably, the plurality of herbal medicines include phosphorus (golden and silver) 5.7% by weight, forsythia stalk (Hong Kong lily scale stem) 6.6% by weight, gold 5.9% by weight, ginseng 6.4% by weight, red ginseng 6.4% by weight, amethyst 6.4 Weight%, Peony (Peony) 5.9% by weight, Dried Hwangchi 5.9% by Weight, Astragalus 5.9% by Weight, Black Angelica 5.9% by Weight, Cinnamon 5.6% by Weight, Root 5.6% by Weight, Sine Seed 5.6% by Weight, Genesis rhizome 3.3% by weight %, health 2.4% by weight, jujube 2.4% by weight, licorice 1.1% by weight, Kwakhyang (baechohyang) 2.5% by weight, peppermint 5.5% by weight, constructionin 2.5% by weight, dermis (tangerine peel) 2.5% by weight.

At this time, since the first group of herbal medicines acting as immunity has negative energy, it is injected into cold water of 18 to 22 ℃ according to these characteristics and left for 1 hour to wash and remove contaminants attached to the surface of the herbal medicine, In this process, the volume of the herbal medicine may be increased by being soaked by hydration. At this time, leaving the first group of herbal medicines in cold water at room temperature is to protect the ingredients contained in the herbal medicines and keep them from being destroyed.

In addition, since the herbal medicines of the second group that act as a blood retainer have a neutral characteristic compared to the herbal medicines of the first and third groups, it is injected into lukewarm water at 25 to 35 ° C. there is.

In addition, the third group of medicinal herbs for digestion may be injected into hot water of 40 to 50° C. and allowed to stand for 1 hour to proceed with washing and soaking processes. At this time, since the herbal medicine of the third group is a hard material and has positive energy due to the characteristics of the material, in order to increase the washing and soaking effect according to these characteristics, it is placed in water at a relatively high temperature compared to the herbal medicine of the first and second groups. will make it

In addition, the process of crushing to an appropriate size using a physical method such as crushing, for example, with a mortar before washing and soaking, because the size of the oriental medicine corresponding to the seed or root among the herbal medicines is too large It is preferable to proceed first.

Here, herbal medicines corresponding to the root include ear peony, red ginseng, astragalus, red ginseng, crested rhizome, licorice, angelica, ginseng, golden, health, and red ginseng. Herbal medicines corresponding to seeds include dermis, kojiin, and jujube. And, herbal medicines corresponding to the leaves include cinnamon, gwakhyang, gold and silver flower, mint, and aloes.

In addition, these herbal medicines can be dried using a sieve in a washed and soaked state, and then dried with hot air for about 2 hours using a dryer that maintains an internal temperature of 45 to 55 ° C. After drying is completed After rapid freezing and freezing for 1 to 2 minutes, a dry grinding process may be performed.

At this time, heat is generated in the process of dry pulverizing the herbal material after drying it with warm air. This heat may cause a problem in that the components included in the herbal medicine, in particular polyphenol and zinc, are destroyed and lost.

As in this embodiment, if the pretreatment operation of washing and soaking the herbal medicines with water at different temperatures according to the working group is performed, the weakness of the herbal medicines is enhanced during the pretreatment process, and if frozen after hot air drying, excessive dry grinding is performed. It is possible to improve the extraction efficiency by preventing the loss of polyphenol and zinc in herbal medicines by suppressing the generation of heat from abrasion.

Next, the quick-frozen oriental medicine may be pulverized by a dry method through a disk mill to prepare a primary pulverized product having a maximum particle diameter of 500 μm or less as shown in FIG. 3 .

At this time, in order to pulverize each herbal medicine to have a maximum particle diameter of 500 μm or less, the working conditions of the disk mill are a disk gap of 500 μm and a disk rotation speed of 350 rpm for 10 minutes. will make it

In the case of wet grinding in the second step to be described later, the maximum particle diameter of the powder of the material injected into the disperser should be 500 μm or less. In addition, when a material containing a plurality of herbal medicines is wet-grinded from the beginning, the herbal medicines having different particle diameters are not evenly mixed, which may cause a rice cake phenomenon.

In this embodiment, it is possible to make the diameters of different oriental medicines uniform while making the maximum particle diameter of the powder of the material 500 μm or less through dry grinding in the first place, and the occurrence of rice cakes during the second wet grinding following this can be prevented

Next, purified water is injected into the first pulverized material and wet pulverized to prepare a second pulverized product composed of an ultrafine powdered nano-sized slurry (S20). In this case, the powder of the secondary pulverized product may have an average particle diameter of 100 to 200 nm.

In this embodiment, the herbal medicines are pulverized to a micro size through the primary dry grinding in this way, and then the secondary wet grinding of nano-size is sequentially performed. It can prevent the polyphenols and zinc contained in it from being destroyed, so it can greatly improve the extraction yield of polyphenols and zinc, which are effective for antioxidant and immunity improvement, compared to traditional herbal extracts extracted by the traditional hot water method in the process of commercializing herbal medicines. there is.

To describe this wet grinding process in more detail, the primary pulverized product having an average particle diameter of 500 μm or less through dry pulverization is injected into a rotary rocking mixer and reacted for 30 minutes to react with a number of herbal medicines to be mixed homogeneously.

Then, the homogeneously mixed primary pulverized product is injected into a reaction vessel located inside the planetary rotor mill, and dispersed so that the average particle diameter of each herbal medicine is 100 to 200 nm, followed by secondary pulverization prepare water

At this time, the planetary rotor mill injects a maximum of 400 ml of the primary pulverized material into two reaction vessels having a capacity of 500 ml, respectively, so that the reaction vessel is balanced when rotating. If the two reaction vessels are out of balance, they will not rotate properly.

In addition, 6 grinding balls made of zirconium are inserted into the inside of the reaction vessel, so that a total of 12 grinding balls can be used. In this case, the grinding ball may preferably have a size of 0.1 to 20 mm.

Then, the rotor of the planetary rotor mill is rotated while increasing the speed from 100 rpm to 500 rpm for the first minute. Accordingly, it is possible to prevent the oriental medicine injected into the reaction vessel from adhering to the inner surface of the reaction vessel, thereby improving the dispersion efficiency.

Thereafter, 30 to 50 ml of purified water per 100 ml of the drug is injected to convert the pulverized product into a wet state. The reason for injecting purified water after gradually increasing the rotational speed of the rotor in this way is to suppress the occurrence of aggregation between particles due to the electric charge on the particle surface of the herbal medicine, and to prevent the occurrence of sparks due to collision between charges.

When the pulverized material is converted to a wet state, the rotation speed of the rotor is increased to 800 rpm and the rotation speed is further rotated for 2 minutes, and the rotation speed of the reaction vessel is accelerated to 2,200 rpm. A secondary pulverized product having a particle diameter of 100 to 200 nm dispersed in a slurry state may be prepared.

In this case, when the average particle diameter of the secondary pulverized product is less than 100 nm, manufacturing cost may be excessively increased as well as difficult to manufacture in terms of mechanical equipment. In addition, if the average particle diameter of the secondary pulverized product exceeds 200 nm, there may be a problem in that the extraction efficiency of polyphenol and zinc is lowered.

If the rotational speed of the rotor is operated at the maximum speed of 800 rpm from the beginning without going through these steps during the secondary grinding, the herbal medicines constituting the primary grinding product in the reaction vessel are attached to the inner surface of the reaction vessel and 1 The secondary pulverized product is not properly dispersed, so it may be difficult to make the secondary pulverized product in a slurry state, or problems such as reduced homogeneity may occur.

In addition, if the homogeneity of the first pulverized product is lowered, collagen cannot be evenly dispersed in the second pulverized material when the collagen is mixed, which will be described later. can do.

Next, the secondary pulverized product is injected into a sterilizer to sterilize, and the process of mixing collagen with the sterilized secondary pulverized product is performed to make the secondary pulverized product in the form of a solid jelly suitable for ingestion ( S30).

The collagen powder is made into a liquid state by boiling the collagen powder in boiling water, and the sterilized secondary pulverized product is injected into the liquid collagen and then continuously stirred using a rotary stirrer, whereby the secondary pulverized product and collagen are mixed When mixed evenly and in the form of a jelly, the product for final sale can be completed by individually packaging, for example, 20 g of jelly-type herbal medicine per package using an automatic packaging device.

In this way, if collagen is mixed with the secondary pulverized material made of nanopowder slurry and made into a jelly-like formulation, it is easy to commercialize individually, and users can consume herbal medicines more conveniently, and polyphenols and zinc extracted from herbal medicines The absorption effect can also be improved.

The collagen powder used in this embodiment can be prepared through the following process.

First, cleanly washed fish fins are the main components, and a proteolytic enzyme is added to the fish fins for primary hydrolysis to prepare a primary hydrolyzate having a molecular weight of 500 to 1000 (Daltons).

Next, the primary hydrolyzate is mixed with 300 parts by weight or more of lactic acid bacteria with respect to 100 parts by weight of the primary hydrolyzate, and the secondary hydrolyzate has a molecular weight lower than that of the primary hydrolyzate by 100 to 400. Prepare the hydrolyzate.

The lactic acid bacteria are Lactobacillus Ali menta Julius (Lactobacillus alimentarius), Lactobacillus Kasei (Lactobacillus Casei), Lactobacillus biasing Li (Lactobacillus gasseri), Lactobacillus del Brewer ekki (Lactobacillus delbrueckii), Lactobacillus buffer momentum (Lactobacillus fermentum), Phedi Ococcus ( Pediococcus ), Lactococcus ( Lactococcus ) At least one selected from among may be used.

Then, the secondary hydrolyzate may be purified and dried to prepare collagen.

At this time, during the secondary hydrolysis, at least 1/2 of the mixed lactic acid bacteria remain unreacted and the collagen powder is decomposed into low molecular collagen peptides having a molecular weight of 100 to 400 and abundant hydroxyproline.

These low molecular weight collagen peptides having a molecular weight of 100 to 400 have a higher and faster absorption rate than high molecular weight collagen, and less interfere with the absorption of polyphenols into the body than proteins contained in high molecular weight collagen.

Furthermore, since unreacted lactic acid bacteria contained in the low-molecular-weight collagen peptides increase the absorption rate of polyphenols in the body, when the jelly containing the herbal medicine prepared according to this embodiment is consumed, the absorption rate of polyphenols is improved. By removing the fishy smell of fish, which is the main component of collagen, the commercial properties of jelly can be improved.

In the case of the jelly of the present invention, unreacted lactic acid bacteria mixed with the low molecular weight collagen peptides increase the absorption rate of polyphenols in the body, so that when the jelly containing the herbal medicine is consumed, it is possible to prevent the decrease in the absorption rate of polyphenols in the body.

In order to confirm the effect of the jelly containing the nanoparticulated herbal medicine according to the present invention, the herbal medicine extracted by the conventional high-temperature calorie extraction method and the nano-dispersed slurry-type herbal medicine of the present invention are jelly-like to form a polyphenol component. The extraction yields of chlorogenic acid and zinc (Zn), an inorganic component, were compared.

In Table 1 below, #1 to #3 are comparative examples, and #4 to #6 are examples. And, #1 and #4 are herbal medicines that use Indong, one of the herbal medicines of the first group, #2 and #5 are Chinese medicines that use Astragalus, one of the herbal medicines of the second group, and #3 and #6 are As a herbal medicine, cinnamon, one of the herbal medicines of the third group, is used.

A comparative example is to take 1 g of a freeze-dried herbal medicine sample, cut it into small pieces, extract it in a hot water method for 6 hours, and dry it in a vacuum at 25 ° C. In an example, 1 g of dried herbal medicine is taken and the primary dry pulverization and It is made into jelly with low molecular weight collagen peptides after secondary wet grinding.

Then, the extraction yields of chlorogenic acid and zinc, which are polyphenols, are measured for each comparative example and example. At this time, the chlorogenic acid is quantitatively analyzed through HPLC to measure the extraction yield, and in the case of the zinc, the sample is pretreated by microwave decomposition method and then analyzed by inductively coupled plasma method (ICP-OES) to measure the extraction yield.

# herbal medicine of chlorogenic acid
Extraction efficiency
(%) zinc
Extraction efficiency (%) One Indong 0.94 0.59 2 Astragalus 1.31 0.67 3 cinnamon 1.67 0.86 4 Indong 10.23 6.78 5 Astragalus 18.46 7.98 6 cinnamon 27.23 10.33

Referring to Table 1, in the case of the herbal medicine (#4, 5, 6) gelled according to the embodiment of the present invention, the case of chlorogenic acid compared to the herbal medicine extract by the hot water method of the comparative example (#1, 2, 3) The extraction efficiency is up to 16 times, and in the case of zinc, the extraction efficiency is up to 12 times higher.

This is because the polyphenols and zinc contained in the botanical herbal medicine were easily eluted to the outside as the size of the particles was broken down by the nano-dispersion without being destroyed by heat during the process of nano-particle formation.

Therefore, even if the same amount of herbal medicine is used, the extraction yield of polyphenols and zinc effective for antioxidant and immunity improvement can be increased if the nano-dispersion process and the gelation process of the present invention are performed instead of the conventional extraction method.

Next, the absorption rate of polyphenols (chlorogenic acid) in the human body was confirmed by gelling the herbal medicines extracted by the conventional hot-water extraction method and the nano-dispersed slurry-type herbal medicines of the present invention.

As a result, as in the present invention, when a low molecular weight collagen peptide is used and an excess of lactic acid bacteria is used together, the absorption of polyphenols in the body is not hindered by the low molecular weight collagen peptides but is supported by the residual lactic acid bacteria, and the polyphenols in jelly It can be expected that the absorption rate in the body is greatly improved compared to the hot water method, so that a larger amount of polyphenol can be consumed compared to the conventional hot water method with the same amount of herbal medicine.

The present invention is not limited by the above-described embodiments and the accompanying drawings. Therefore, various types of substitution, modification and change will be possible by those skilled in the art within the scope not departing from the technical spirit of the present invention described in the claims, and it is also said that it falls within the scope of the present invention. something to do.

S5: Step of pre-processing herbal medicines
S10: Dry-pulverizing herbal medicines to prepare a primary pulverized product
S20: Step of wet grinding the primary pulverized product to prepare a secondary pulverized product
S30: A step of mixing collagen with the secondary pulverized material to form a jelly

Claims (8)

A number of herbal medicines are divided into a first group that has an immune action, a second group that acts as a blood supply, and a third group that has a digestive action according to their efficacy. The herbal medicines of the group are washed and soaked with lukewarm water, and the herbal medicines of the third group are washed and soaked with hot water, then dried with hot air, rapidly frozen and frozen for 1 to 2 minutes, and then dry pulverized to a maximum particle diameter of 500 μm. A first step of preparing the following primary pulverized product;
a second step of injecting purified water into the first pulverized material and performing wet pulverization to prepare a second pulverized product comprising a powder slurry having an average particle diameter of 100 to 200 nm; and
a third step of mixing collagen with the second pulverized product to form a jelly; including,
In the second step, the primary pulverized product is injected into a rotary rocking mixer and reacted for 30 minutes, then placed in a reaction vessel of a planetary rotor mill and further rotated. , The planetary rotor mill rotates while increasing the speed from 100 rpm to 500 rpm for the first 1 minute, and then injects 30 to 50 ml of purified water per 100 ml of medicinal material to a wet state, and increases the rotation speed to 800 rpm 2 A second pulverized product consisting of a slurry is prepared by further rotating for a minute,
In the third step, the collagen is prepared by first hydrolyzing the fin of a fish with a proteolytic enzyme to prepare a primary hydrolyzate containing collagen having a molecular weight of 500 to 1000, and 100 parts by weight of the primary hydrolyzate To prepare a secondary hydrolyzate having a molecular weight lower than that of the primary hydrolyzate, while at least 1/2 of the mixed lactic acid bacteria remain as unreacted lactic acid bacteria by mixing 300 parts by weight or more of the lactic acid bacteria with respect to the secondary hydrolyzate, and A method for producing a jelly containing a nanoparticulated herbal medicine, characterized in that it is a collagen peptide having a molecular weight of 100 to 400 obtained by purifying and drying a hydrolyzate. [Claim 3] The method of claim 1, wherein the herbal medicines corresponding to seeds or roots among the herbal medicines are crushed before washing and soaking. delete The herbal medicine of claim 1, wherein the first group of herbal medicines is at least one selected from the group consisting of ginseng, ginseng, ginseng, ginseng, ginseng, red ginseng, and amethyst; Nanoparticulate herbal medicine, characterized in that at least one of cinnamon, garlic root, sage seed, rhizome, health, jujube, licorice, gwakhyang, mint, koongin and dermis A method for producing jelly comprising a. According to claim 1, wherein in the third step, the lactic acid bacteria mixed during the secondary hydrolysis are Lactobacillus alimentarius ( Lactobacillus alimentarius ), Lactobacillus Casei ( Lactobacillus Casei ), Lactobacillus gasseri ( Lactobacillus gasseri ), Lactobacillus Delbruecky ( Lactobacillus delbrueckii ), Lactobacillus fermentum ( Lactobacillus fermentum ), Pediococcus ( Pediococcus ), Lactococcus ( Lactococcus ) Preparation of jelly containing nanoparticulate herbal medicine, characterized in that at least one selected from the group consisting of method.
delete delete Claims 1, 2, 4 and 5, wherein any one of the manufacturing method according to any one of the manufacturing method comprising a nanoparticulated herbal medicine jellies containing.

Images