KR102279618B1 - 활성 기반 프로브 화합물, 조성물, 및 사용 방법 - Google Patents

활성 기반 프로브 화합물, 조성물, 및 사용 방법 Download PDF

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KR102279618B1
KR102279618B1 KR1020157029213A KR20157029213A KR102279618B1 KR 102279618 B1 KR102279618 B1 KR 102279618B1 KR 1020157029213 A KR1020157029213 A KR 1020157029213A KR 20157029213 A KR20157029213 A KR 20157029213A KR 102279618 B1 KR102279618 B1 KR 102279618B1
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KR20150129004A (ko
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매튜 에스. 보교
마르테인 베르도스
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더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A61K49/0043—Fluorescein, used in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A61K49/0034—Indocyanine green, i.e. ICG, cardiogreen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
KR1020157029213A 2013-03-15 2014-03-15 활성 기반 프로브 화합물, 조성물, 및 사용 방법 Active KR102279618B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361794296P 2013-03-15 2013-03-15
US61/794,296 2013-03-15
PCT/US2014/029990 WO2014145257A2 (en) 2013-03-15 2014-03-15 Activity-based probe compounds, compositions, and methods of use

Publications (2)

Publication Number Publication Date
KR20150129004A KR20150129004A (ko) 2015-11-18
KR102279618B1 true KR102279618B1 (ko) 2021-07-20

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Country Status (7)

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US (4) US10100037B2 (enExample)
EP (2) EP2971065B1 (enExample)
JP (5) JP6490660B2 (enExample)
KR (1) KR102279618B1 (enExample)
CN (2) CN105431546A (enExample)
ES (1) ES2938225T3 (enExample)
WO (1) WO2014145257A2 (enExample)

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WO2014145257A2 (en) * 2013-03-15 2014-09-18 The Board Of Trustees Of The Leland Stanford Junior University Activity-based probe compounds, compositions, and methods of use
CA2963305A1 (en) 2014-10-06 2016-04-14 Cortexyme, Inc. Inhibitors of lysine gingipain
CN107406872B (zh) 2015-01-22 2023-03-28 里兰斯坦福初级大学理事会 用于标记动物组织的化合物、组合物及其应用
CA3004095A1 (en) 2015-11-09 2017-05-18 Cortexyme, Inc. Inhibitors of arginine gingipain
CA3036862A1 (en) 2016-09-16 2018-03-22 Cortexyme, Inc. Ketone inhibitors of lysine gingipain
EP3526232A4 (en) * 2016-10-11 2019-11-20 The Regents of the University of California DETECTION, IDENTIFICATION AND CLEANING OF REMOVABLE AND NON-DEGRADABLE ENZYMES IN BIOLOGICAL SAMPLES
EP3510380B1 (en) 2016-12-23 2023-11-08 The Board of Trustees of the Leland Stanford Junior University Activity-based probe compounds, compositions, and methods of use
EP3601261A4 (en) 2017-03-30 2021-07-14 The Board of Trustees of the Leland Stanford Junior University CONTRAST AGENTS ACTIVATED BY A PROTEASE FOR IN VIVO IMAGING
US11635436B2 (en) 2017-04-24 2023-04-25 Georgetown University Compositions and methods for analyzing cysteine
CA3119793A1 (en) * 2017-11-28 2019-08-01 Board Of Regents Of The University Of Nebraska Radiopharmaceuticals and methods of use thereof
US12486293B2 (en) 2018-07-30 2025-12-02 Georgetown University Chirality sensing with molecular click chemistry probes
US11860084B2 (en) 2018-09-11 2024-01-02 Georgetown University Quantitative auxiliary-free chirality sensing with a metal probe
JP2022515112A (ja) * 2018-12-20 2022-02-17 武田薬品工業株式会社 システインプロテアーゼのためのプローブとしてのスルホキソニウムイリド誘導体
BR112021012036A2 (pt) * 2018-12-20 2021-09-21 Takeda Pharmaceutical Company Limited Novas sondas baseadas em atividade para elastase neutrofílica e seu uso

Citations (2)

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WO2012118715A2 (en) * 2011-02-28 2012-09-07 The Board Of Trustees Of Leland Stanford Junior University Non-peptidic quenched fluorescent imaging probes

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WO2009124265A1 (en) 2008-04-03 2009-10-08 The Board Of Trustees Of The Leland Stanford Junior University Probes for in vivo targeting of active cysteine proteases
WO2012118715A2 (en) * 2011-02-28 2012-09-07 The Board Of Trustees Of Leland Stanford Junior University Non-peptidic quenched fluorescent imaging probes

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Also Published As

Publication number Publication date
CN105431546A (zh) 2016-03-23
JP6490660B2 (ja) 2019-03-27
JP2019081791A (ja) 2019-05-30
JP2021059606A (ja) 2021-04-15
US20160039792A1 (en) 2016-02-11
US20210284626A1 (en) 2021-09-16
ES2938225T3 (es) 2023-04-05
US10100037B2 (en) 2018-10-16
EP4218829A3 (en) 2023-08-16
JP2023085423A (ja) 2023-06-20
JP2016518341A (ja) 2016-06-23
US10829477B2 (en) 2020-11-10
JP7689753B2 (ja) 2025-06-09
EP2971065A2 (en) 2016-01-20
CN120132004A (zh) 2025-06-13
US20230391750A1 (en) 2023-12-07
JP2025124721A (ja) 2025-08-26
US11655236B2 (en) 2023-05-23
EP2971065B1 (en) 2022-12-14
WO2014145257A2 (en) 2014-09-18
KR20150129004A (ko) 2015-11-18
EP4218829A2 (en) 2023-08-02
WO2014145257A3 (en) 2014-12-31
US20190270722A1 (en) 2019-09-05
EP2971065A4 (en) 2016-12-21

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