ES2938225T3 - Compuestos de sondas basadas en la actividad, composiciones y métodos de uso - Google Patents
Compuestos de sondas basadas en la actividad, composiciones y métodos de uso Download PDFInfo
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- ES2938225T3 ES2938225T3 ES14764975T ES14764975T ES2938225T3 ES 2938225 T3 ES2938225 T3 ES 2938225T3 ES 14764975 T ES14764975 T ES 14764975T ES 14764975 T ES14764975 T ES 14764975T ES 2938225 T3 ES2938225 T3 ES 2938225T3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
- A61K49/0034—Indocyanine green, i.e. ICG, cardiogreen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0052—Small organic molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0056—Peptides, proteins, polyamino acids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Plural Heterocyclic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Medicinal Preparation (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361794296P | 2013-03-15 | 2013-03-15 | |
| PCT/US2014/029990 WO2014145257A2 (en) | 2013-03-15 | 2014-03-15 | Activity-based probe compounds, compositions, and methods of use |
Publications (1)
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|---|---|
| ES2938225T3 true ES2938225T3 (es) | 2023-04-05 |
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| EP (2) | EP2971065B1 (enExample) |
| JP (5) | JP6490660B2 (enExample) |
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| CN (2) | CN105431546A (enExample) |
| ES (1) | ES2938225T3 (enExample) |
| WO (1) | WO2014145257A2 (enExample) |
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| WO2014145257A2 (en) * | 2013-03-15 | 2014-09-18 | The Board Of Trustees Of The Leland Stanford Junior University | Activity-based probe compounds, compositions, and methods of use |
| CA2963305A1 (en) | 2014-10-06 | 2016-04-14 | Cortexyme, Inc. | Inhibitors of lysine gingipain |
| CN107406872B (zh) | 2015-01-22 | 2023-03-28 | 里兰斯坦福初级大学理事会 | 用于标记动物组织的化合物、组合物及其应用 |
| CA3004095A1 (en) | 2015-11-09 | 2017-05-18 | Cortexyme, Inc. | Inhibitors of arginine gingipain |
| CA3036862A1 (en) | 2016-09-16 | 2018-03-22 | Cortexyme, Inc. | Ketone inhibitors of lysine gingipain |
| EP3526232A4 (en) * | 2016-10-11 | 2019-11-20 | The Regents of the University of California | DETECTION, IDENTIFICATION AND CLEANING OF REMOVABLE AND NON-DEGRADABLE ENZYMES IN BIOLOGICAL SAMPLES |
| EP3510380B1 (en) | 2016-12-23 | 2023-11-08 | The Board of Trustees of the Leland Stanford Junior University | Activity-based probe compounds, compositions, and methods of use |
| EP3601261A4 (en) | 2017-03-30 | 2021-07-14 | The Board of Trustees of the Leland Stanford Junior University | CONTRAST AGENTS ACTIVATED BY A PROTEASE FOR IN VIVO IMAGING |
| US11635436B2 (en) | 2017-04-24 | 2023-04-25 | Georgetown University | Compositions and methods for analyzing cysteine |
| CA3119793A1 (en) * | 2017-11-28 | 2019-08-01 | Board Of Regents Of The University Of Nebraska | Radiopharmaceuticals and methods of use thereof |
| US12486293B2 (en) | 2018-07-30 | 2025-12-02 | Georgetown University | Chirality sensing with molecular click chemistry probes |
| US11860084B2 (en) | 2018-09-11 | 2024-01-02 | Georgetown University | Quantitative auxiliary-free chirality sensing with a metal probe |
| JP2022515112A (ja) * | 2018-12-20 | 2022-02-17 | 武田薬品工業株式会社 | システインプロテアーゼのためのプローブとしてのスルホキソニウムイリド誘導体 |
| BR112021012036A2 (pt) * | 2018-12-20 | 2021-09-21 | Takeda Pharmaceutical Company Limited | Novas sondas baseadas em atividade para elastase neutrofílica e seu uso |
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| US4172896A (en) | 1978-06-05 | 1979-10-30 | Dainippon Pharmaceutical Co., Ltd. | Methane-sulfonamide derivatives, the preparation thereof and composition comprising the same |
| US5055451A (en) * | 1986-12-22 | 1991-10-08 | Syntex Inc. | Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors |
| GB9217295D0 (en) | 1992-08-14 | 1992-09-30 | Wellcome Found | Controlled released tablets |
| US5541231A (en) | 1993-07-30 | 1996-07-30 | Glaxo Wellcome Inc. | Stabilized Pharmaceutical |
| US5358970A (en) | 1993-08-12 | 1994-10-25 | Burroughs Wellcome Co. | Pharmaceutical composition containing bupropion hydrochloride and a stabilizer |
| GB9315856D0 (en) | 1993-07-30 | 1993-09-15 | Wellcome Found | Stabilized pharmaceutical |
| AU2704395A (en) * | 1995-06-13 | 1997-01-09 | Sanofi Winthrop, Inc. | Calpain inhibitors for the treatment of neurodegenerative di seases |
| US5989823A (en) | 1998-09-18 | 1999-11-23 | Nexstar Pharmaceuticals, Inc. | Homogeneous detection of a target through nucleic acid ligand-ligand beacon interaction |
| JP2002501892A (ja) | 1998-01-29 | 2002-01-22 | セプラコア インコーポレーテッド | 光学的に純粋な（−）−ビュープロピオンの薬学的使用 |
| US6197750B1 (en) * | 1998-07-02 | 2001-03-06 | Idun Pharmaceuticals, Inc. | C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
| US6544951B2 (en) * | 1998-07-02 | 2003-04-08 | Idun Pharmaceuticals, Inc. | C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
| CA2335359C (en) | 1999-04-23 | 2007-07-17 | Molecular Probes, Inc. | Xanthene dyes and their application as luminescence quenching compounds |
| US7019129B1 (en) | 2000-05-09 | 2006-03-28 | Biosearch Technologies, Inc. | Dark quenchers for donor-acceptor energy transfer |
| US20020052323A1 (en) * | 2000-08-30 | 2002-05-02 | Jinhai Wang | Quinoline-(C=O)-(multiple amino acids)-leaving group compounds for pharmaceutical compositions and reagents |
| GB0112868D0 (en) | 2001-05-25 | 2001-07-18 | Secr Defence | Detection system |
| US20050014160A1 (en) | 2003-07-18 | 2005-01-20 | Sriram Kumaraswamy | Assays for protease enzyme activity |
| US8968700B2 (en) | 2005-08-11 | 2015-03-03 | The Board Of Trustees Of The Leland Stanford Junior University | Imaging of protease activity in live cells using activity based probes |
| WO2009124265A1 (en) * | 2008-04-03 | 2009-10-08 | The Board Of Trustees Of The Leland Stanford Junior University | Probes for in vivo targeting of active cysteine proteases |
| WO2012021800A2 (en) * | 2010-08-13 | 2012-02-16 | Banyan Biomarkers | Caspase inhibitors as therapeutics for neural and organ injury and imaging |
| WO2012118715A2 (en) * | 2011-02-28 | 2012-09-07 | The Board Of Trustees Of Leland Stanford Junior University | Non-peptidic quenched fluorescent imaging probes |
| KR20160037834A (ko) | 2013-03-14 | 2016-04-06 | 루미셀, 아이엔씨. | 의료 이미징 장치 및 사용 방법 |
| WO2014145257A2 (en) * | 2013-03-15 | 2014-09-18 | The Board Of Trustees Of The Leland Stanford Junior University | Activity-based probe compounds, compositions, and methods of use |
| EP3510380B1 (en) * | 2016-12-23 | 2023-11-08 | The Board of Trustees of the Leland Stanford Junior University | Activity-based probe compounds, compositions, and methods of use |
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- 2014-03-15 EP EP14764975.0A patent/EP2971065B1/en active Active
- 2014-03-15 KR KR1020157029213A patent/KR102279618B1/ko active Active
- 2014-03-15 EP EP22213062.7A patent/EP4218829A3/en active Pending
- 2014-03-15 CN CN201480028287.7A patent/CN105431546A/zh active Pending
- 2014-03-15 JP JP2016503301A patent/JP6490660B2/ja active Active
- 2014-03-15 ES ES14764975T patent/ES2938225T3/es active Active
- 2014-03-15 US US14/777,024 patent/US10100037B2/en active Active
- 2014-03-15 CN CN202510298059.1A patent/CN120132004A/zh active Pending
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2018
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2019
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2025
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Also Published As
| Publication number | Publication date |
|---|---|
| CN105431546A (zh) | 2016-03-23 |
| JP6490660B2 (ja) | 2019-03-27 |
| JP2019081791A (ja) | 2019-05-30 |
| JP2021059606A (ja) | 2021-04-15 |
| US20160039792A1 (en) | 2016-02-11 |
| US20210284626A1 (en) | 2021-09-16 |
| US10100037B2 (en) | 2018-10-16 |
| EP4218829A3 (en) | 2023-08-16 |
| JP2023085423A (ja) | 2023-06-20 |
| JP2016518341A (ja) | 2016-06-23 |
| US10829477B2 (en) | 2020-11-10 |
| JP7689753B2 (ja) | 2025-06-09 |
| EP2971065A2 (en) | 2016-01-20 |
| CN120132004A (zh) | 2025-06-13 |
| US20230391750A1 (en) | 2023-12-07 |
| KR102279618B1 (ko) | 2021-07-20 |
| JP2025124721A (ja) | 2025-08-26 |
| US11655236B2 (en) | 2023-05-23 |
| EP2971065B1 (en) | 2022-12-14 |
| WO2014145257A2 (en) | 2014-09-18 |
| KR20150129004A (ko) | 2015-11-18 |
| EP4218829A2 (en) | 2023-08-02 |
| WO2014145257A3 (en) | 2014-12-31 |
| US20190270722A1 (en) | 2019-09-05 |
| EP2971065A4 (en) | 2016-12-21 |
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