JP6490660B2 - 活性に基づくプローブの化合物、組成物、および使用方法 - Google Patents

活性に基づくプローブの化合物、組成物、および使用方法 Download PDF

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Publication number
JP6490660B2
JP6490660B2 JP2016503301A JP2016503301A JP6490660B2 JP 6490660 B2 JP6490660 B2 JP 6490660B2 JP 2016503301 A JP2016503301 A JP 2016503301A JP 2016503301 A JP2016503301 A JP 2016503301A JP 6490660 B2 JP6490660 B2 JP 6490660B2
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compound
group
compound according
probe
alkyl
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Japanese (ja)
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JP2016518341A5 (enExample
JP2016518341A (ja
Inventor
マシュー エス． ボギョー，
マシュー エス． ボギョー，
マルテイン フェルドウス，
マルテイン フェルドウス，
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Leland Stanford Junior University
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Leland Stanford Junior University
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A61K49/0034—Indocyanine green, i.e. ICG, cardiogreen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2016503301A 2013-03-15 2014-03-15 活性に基づくプローブの化合物、組成物、および使用方法 Active JP6490660B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361794296P 2013-03-15 2013-03-15
US61/794,296 2013-03-15
PCT/US2014/029990 WO2014145257A2 (en) 2013-03-15 2014-03-15 Activity-based probe compounds, compositions, and methods of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019034163A Division JP2019081791A (ja) 2013-03-15 2019-02-27 活性に基づくプローブの化合物、組成物、および使用方法

Publications (3)

Publication Number Publication Date
JP2016518341A JP2016518341A (ja) 2016-06-23
JP2016518341A5 JP2016518341A5 (enExample) 2017-04-20
JP6490660B2 true JP6490660B2 (ja) 2019-03-27

Family

ID=51538442

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2016503301A Active JP6490660B2 (ja) 2013-03-15 2014-03-15 活性に基づくプローブの化合物、組成物、および使用方法
JP2019034163A Withdrawn JP2019081791A (ja) 2013-03-15 2019-02-27 活性に基づくプローブの化合物、組成物、および使用方法
JP2021005558A Withdrawn JP2021059606A (ja) 2013-03-15 2021-01-18 活性に基づくプローブの化合物、組成物、および使用方法
JP2023060174A Active JP7689753B2 (ja) 2013-03-15 2023-04-03 活性に基づくプローブの化合物、組成物、および使用方法
JP2025084936A Pending JP2025124721A (ja) 2013-03-15 2025-05-21 活性に基づくプローブの化合物、組成物、および使用方法

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2019034163A Withdrawn JP2019081791A (ja) 2013-03-15 2019-02-27 活性に基づくプローブの化合物、組成物、および使用方法
JP2021005558A Withdrawn JP2021059606A (ja) 2013-03-15 2021-01-18 活性に基づくプローブの化合物、組成物、および使用方法
JP2023060174A Active JP7689753B2 (ja) 2013-03-15 2023-04-03 活性に基づくプローブの化合物、組成物、および使用方法
JP2025084936A Pending JP2025124721A (ja) 2013-03-15 2025-05-21 活性に基づくプローブの化合物、組成物、および使用方法

Country Status (7)

Country Link
US (4) US10100037B2 (enExample)
EP (2) EP2971065B1 (enExample)
JP (5) JP6490660B2 (enExample)
KR (1) KR102279618B1 (enExample)
CN (2) CN105431546A (enExample)
ES (1) ES2938225T3 (enExample)
WO (1) WO2014145257A2 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014145257A2 (en) * 2013-03-15 2014-09-18 The Board Of Trustees Of The Leland Stanford Junior University Activity-based probe compounds, compositions, and methods of use
CA2963305A1 (en) 2014-10-06 2016-04-14 Cortexyme, Inc. Inhibitors of lysine gingipain
CN107406872B (zh) 2015-01-22 2023-03-28 里兰斯坦福初级大学理事会 用于标记动物组织的化合物、组合物及其应用
CA3004095A1 (en) 2015-11-09 2017-05-18 Cortexyme, Inc. Inhibitors of arginine gingipain
CA3036862A1 (en) 2016-09-16 2018-03-22 Cortexyme, Inc. Ketone inhibitors of lysine gingipain
EP3526232A4 (en) * 2016-10-11 2019-11-20 The Regents of the University of California DETECTION, IDENTIFICATION AND CLEANING OF REMOVABLE AND NON-DEGRADABLE ENZYMES IN BIOLOGICAL SAMPLES
EP3510380B1 (en) 2016-12-23 2023-11-08 The Board of Trustees of the Leland Stanford Junior University Activity-based probe compounds, compositions, and methods of use
EP3601261A4 (en) 2017-03-30 2021-07-14 The Board of Trustees of the Leland Stanford Junior University CONTRAST AGENTS ACTIVATED BY A PROTEASE FOR IN VIVO IMAGING
US11635436B2 (en) 2017-04-24 2023-04-25 Georgetown University Compositions and methods for analyzing cysteine
CA3119793A1 (en) * 2017-11-28 2019-08-01 Board Of Regents Of The University Of Nebraska Radiopharmaceuticals and methods of use thereof
US12486293B2 (en) 2018-07-30 2025-12-02 Georgetown University Chirality sensing with molecular click chemistry probes
US11860084B2 (en) 2018-09-11 2024-01-02 Georgetown University Quantitative auxiliary-free chirality sensing with a metal probe
JP2022515112A (ja) * 2018-12-20 2022-02-17 武田薬品工業株式会社 システインプロテアーゼのためのプローブとしてのスルホキソニウムイリド誘導体
BR112021012036A2 (pt) * 2018-12-20 2021-09-21 Takeda Pharmaceutical Company Limited Novas sondas baseadas em atividade para elastase neutrofílica e seu uso

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US4172896A (en) 1978-06-05 1979-10-30 Dainippon Pharmaceutical Co., Ltd. Methane-sulfonamide derivatives, the preparation thereof and composition comprising the same
US5055451A (en) * 1986-12-22 1991-10-08 Syntex Inc. Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors
GB9217295D0 (en) 1992-08-14 1992-09-30 Wellcome Found Controlled released tablets
US5541231A (en) 1993-07-30 1996-07-30 Glaxo Wellcome Inc. Stabilized Pharmaceutical
US5358970A (en) 1993-08-12 1994-10-25 Burroughs Wellcome Co. Pharmaceutical composition containing bupropion hydrochloride and a stabilizer
GB9315856D0 (en) 1993-07-30 1993-09-15 Wellcome Found Stabilized pharmaceutical
AU2704395A (en) * 1995-06-13 1997-01-09 Sanofi Winthrop, Inc. Calpain inhibitors for the treatment of neurodegenerative di seases
US5989823A (en) 1998-09-18 1999-11-23 Nexstar Pharmaceuticals, Inc. Homogeneous detection of a target through nucleic acid ligand-ligand beacon interaction
JP2002501892A (ja) 1998-01-29 2002-01-22 セプラコア インコーポレーテッド 光学的に純粋な（−）−ビュープロピオンの薬学的使用
US6197750B1 (en) * 1998-07-02 2001-03-06 Idun Pharmaceuticals, Inc. C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
US6544951B2 (en) * 1998-07-02 2003-04-08 Idun Pharmaceuticals, Inc. C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
CA2335359C (en) 1999-04-23 2007-07-17 Molecular Probes, Inc. Xanthene dyes and their application as luminescence quenching compounds
US7019129B1 (en) 2000-05-09 2006-03-28 Biosearch Technologies, Inc. Dark quenchers for donor-acceptor energy transfer
US20020052323A1 (en) * 2000-08-30 2002-05-02 Jinhai Wang Quinoline-(C=O)-(multiple amino acids)-leaving group compounds for pharmaceutical compositions and reagents
GB0112868D0 (en) 2001-05-25 2001-07-18 Secr Defence Detection system
US20050014160A1 (en) 2003-07-18 2005-01-20 Sriram Kumaraswamy Assays for protease enzyme activity
US8968700B2 (en) 2005-08-11 2015-03-03 The Board Of Trustees Of The Leland Stanford Junior University Imaging of protease activity in live cells using activity based probes
WO2009124265A1 (en) * 2008-04-03 2009-10-08 The Board Of Trustees Of The Leland Stanford Junior University Probes for in vivo targeting of active cysteine proteases
WO2012021800A2 (en) * 2010-08-13 2012-02-16 Banyan Biomarkers Caspase inhibitors as therapeutics for neural and organ injury and imaging
WO2012118715A2 (en) * 2011-02-28 2012-09-07 The Board Of Trustees Of Leland Stanford Junior University Non-peptidic quenched fluorescent imaging probes
KR20160037834A (ko) 2013-03-14 2016-04-06 루미셀, 아이엔씨. 의료 이미징 장치 및 사용 방법
WO2014145257A2 (en) * 2013-03-15 2014-09-18 The Board Of Trustees Of The Leland Stanford Junior University Activity-based probe compounds, compositions, and methods of use
EP3510380B1 (en) * 2016-12-23 2023-11-08 The Board of Trustees of the Leland Stanford Junior University Activity-based probe compounds, compositions, and methods of use

Also Published As

Publication number Publication date
CN105431546A (zh) 2016-03-23
JP2019081791A (ja) 2019-05-30
JP2021059606A (ja) 2021-04-15
US20160039792A1 (en) 2016-02-11
US20210284626A1 (en) 2021-09-16
ES2938225T3 (es) 2023-04-05
US10100037B2 (en) 2018-10-16
EP4218829A3 (en) 2023-08-16
JP2023085423A (ja) 2023-06-20
JP2016518341A (ja) 2016-06-23
US10829477B2 (en) 2020-11-10
JP7689753B2 (ja) 2025-06-09
EP2971065A2 (en) 2016-01-20
CN120132004A (zh) 2025-06-13
US20230391750A1 (en) 2023-12-07
KR102279618B1 (ko) 2021-07-20
JP2025124721A (ja) 2025-08-26
US11655236B2 (en) 2023-05-23
EP2971065B1 (en) 2022-12-14
WO2014145257A2 (en) 2014-09-18
KR20150129004A (ko) 2015-11-18
EP4218829A2 (en) 2023-08-02
WO2014145257A3 (en) 2014-12-31
US20190270722A1 (en) 2019-09-05
EP2971065A4 (en) 2016-12-21

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