KR102253849B1 - 복합 조립물 및 속방성 정제, 및 이들의 제조 방법 - Google Patents

복합 조립물 및 속방성 정제, 및 이들의 제조 방법 Download PDF

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Publication number
KR102253849B1
KR102253849B1 KR1020140157082A KR20140157082A KR102253849B1 KR 102253849 B1 KR102253849 B1 KR 102253849B1 KR 1020140157082 A KR1020140157082 A KR 1020140157082A KR 20140157082 A KR20140157082 A KR 20140157082A KR 102253849 B1 KR102253849 B1 KR 102253849B1
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South Korea
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mannitol
mass
granulated product
composite granulated
aqueous dispersion
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Korean (ko)
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KR20150056474A (ko
Inventor
야스유키 히라마
나오스케 마루야마
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신에쓰 가가꾸 고교 가부시끼가이샤
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020140157082A 2013-11-15 2014-11-12 복합 조립물 및 속방성 정제, 및 이들의 제조 방법 Active KR102253849B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JPJP-P-2013-237000 2013-11-15
JP2013237000 2013-11-15

Publications (2)

Publication Number Publication Date
KR20150056474A KR20150056474A (ko) 2015-05-26
KR102253849B1 true KR102253849B1 (ko) 2021-05-21

Family

ID=51951602

Family Applications (1)

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KR1020140157082A Active KR102253849B1 (ko) 2013-11-15 2014-11-12 복합 조립물 및 속방성 정제, 및 이들의 제조 방법

Country Status (6)

Country Link
US (2) US20150141517A1 (enExample)
EP (1) EP2873415B1 (enExample)
JP (1) JP6307417B2 (enExample)
KR (1) KR102253849B1 (enExample)
CN (1) CN104644581A (enExample)
IN (1) IN2014DE03239A (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016098459A1 (ja) * 2014-12-17 2016-06-23 株式会社ダイセル 遅延崩壊性粒子組成物
PL3949952T3 (pl) 2019-04-03 2024-10-14 Astellas Pharma Inc. Kompozycja farmaceutyczna
CN115397469A (zh) * 2020-04-10 2022-11-25 日本瓦姆&珀巴尔株式会社 粘合剂
CN115379861A (zh) * 2020-04-10 2022-11-22 日本瓦姆&珀巴尔株式会社 缓释性主剂
KR20230043904A (ko) 2020-07-24 2023-03-31 엘랑코 유에스 인코포레이티드 이속사졸린 화합물 및 이의 중간체의 제조 공정
JP7414668B2 (ja) * 2020-08-28 2024-01-16 信越化学工業株式会社 ポリビニルアルコール含有造粒物及び固形製剤
JP7590950B2 (ja) * 2020-12-18 2024-11-27 大鵬薬品工業株式会社 ビラスチンを含有する口腔内崩壊錠
KR20230146800A (ko) 2022-04-13 2023-10-20 주식회사 산흥이지 도로교통 표지판의 각도 조절장치
JP2023173283A (ja) * 2022-05-25 2023-12-07 フロイント産業株式会社 顆粒及びその製造方法、並びに錠剤
CN116510026B (zh) * 2023-07-04 2023-09-19 山东天力药业有限公司 一种甘露醇复合药用辅料及其制备方法
WO2025078588A1 (en) * 2023-10-12 2025-04-17 Dfe Pharma Gmbh & Co. Kg Method and system for preparing agglomerated excipient granules

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2210591A2 (en) 2009-01-26 2010-07-28 Shin-Etsu Chemical Co., Ltd. Wet granulation tableting method using aqueous dispersion of low-substituted hydroxypropyl cellulose
JP2012031138A (ja) * 2010-07-08 2012-02-16 Sawai Pharmaceutical Co Ltd ロラタジン含有口腔内崩壊錠の製造方法
EP2465495A1 (en) 2009-08-11 2012-06-20 Dainippon Sumitomo Pharma Co., Ltd. Tablet that disintegrates rapidly in the mouth and that contains two or more types of particles
WO2013058409A1 (en) 2011-10-21 2013-04-25 Takeda Pharmaceutical Company Limited Sustained-release preparation
EP2674149A1 (en) 2012-06-15 2013-12-18 Shin-Etsu Chemical Co., Ltd. Method for preparing composite granule comprising low-substituted hydroxypropyl cellulose and rapid release preparation

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3864406A (en) * 1973-04-25 1975-02-04 Suomen Sokeri Oy Process for the production of mannitol and sorbitol
WO2001064190A1 (en) * 2000-03-01 2001-09-07 Eisai Co., Ltd. Rapidly disintegrable tablet containing polyvinyl alcohol
JP3595765B2 (ja) * 2000-09-27 2004-12-02 信越化学工業株式会社 低置換度ヒドロキシプロピルセルロースを含む乾式直打用基剤
JP4279220B2 (ja) * 2004-09-09 2009-06-17 日信工業株式会社 複合材料及びその製造方法、複合金属材料及びその製造方法
TWI383809B (zh) 2005-06-29 2013-02-01 Otsuka Pharma Co Ltd 含有西洛他唑（ｃｉｌｏｓｔａｚｏｌ）之口腔崩解粉末
EP2368544A4 (en) * 2008-11-25 2012-08-15 Mitsubishi Tanabe Pharma Corp RASCH IN MOUTH DAMAGING TABLET AND METHOD FOR THEIR MANUFACTURE
JP5876418B2 (ja) 2010-12-28 2016-03-02 大鵬薬品工業株式会社 口腔内崩壊錠剤
JP2012236823A (ja) * 2011-04-28 2012-12-06 Fuji Chem Ind Co Ltd 耐湿安定性に優れた錠剤
WO2013098576A1 (en) * 2011-12-31 2013-07-04 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi Immediate release pharmaceutical composition of valsartan

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2210591A2 (en) 2009-01-26 2010-07-28 Shin-Etsu Chemical Co., Ltd. Wet granulation tableting method using aqueous dispersion of low-substituted hydroxypropyl cellulose
EP2465495A1 (en) 2009-08-11 2012-06-20 Dainippon Sumitomo Pharma Co., Ltd. Tablet that disintegrates rapidly in the mouth and that contains two or more types of particles
JP2012031138A (ja) * 2010-07-08 2012-02-16 Sawai Pharmaceutical Co Ltd ロラタジン含有口腔内崩壊錠の製造方法
WO2013058409A1 (en) 2011-10-21 2013-04-25 Takeda Pharmaceutical Company Limited Sustained-release preparation
EP2674149A1 (en) 2012-06-15 2013-12-18 Shin-Etsu Chemical Co., Ltd. Method for preparing composite granule comprising low-substituted hydroxypropyl cellulose and rapid release preparation
KR102011518B1 (ko) 2012-06-15 2019-08-16 신에쓰 가가꾸 고교 가부시끼가이샤 저치환도 히드록시프로필셀룰로오스를 포함하는 복합 조립물의 제조 방법 및 속방성 제제

Also Published As

Publication number Publication date
CN104644581A (zh) 2015-05-27
US20200038333A1 (en) 2020-02-06
KR20150056474A (ko) 2015-05-26
EP2873415B1 (en) 2018-08-29
EP2873415A1 (en) 2015-05-20
US20150141517A1 (en) 2015-05-21
JP2015117240A (ja) 2015-06-25
US11723872B2 (en) 2023-08-15
JP6307417B2 (ja) 2018-04-04
IN2014DE03239A (enExample) 2015-07-17

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