CN104644581A - 粒状复合物、速释片及其制备方法 - Google Patents

粒状复合物、速释片及其制备方法 Download PDF

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Publication number
CN104644581A
CN104644581A CN201410648049.8A CN201410648049A CN104644581A CN 104644581 A CN104644581 A CN 104644581A CN 201410648049 A CN201410648049 A CN 201410648049A CN 104644581 A CN104644581 A CN 104644581A
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CN
China
Prior art keywords
weight
pearlitol
tablet
aqueous dispersion
granular complex
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201410648049.8A
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English (en)
Chinese (zh)
Inventor
平间康之
丸山直亮
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shin Etsu Chemical Co Ltd
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Shin Etsu Chemical Co Ltd
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Publication date
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Publication of CN104644581A publication Critical patent/CN104644581A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201410648049.8A 2013-11-15 2014-11-14 粒状复合物、速释片及其制备方法 Pending CN104644581A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2013-237000 2013-11-15
JP2013237000 2013-11-15

Publications (1)

Publication Number Publication Date
CN104644581A true CN104644581A (zh) 2015-05-27

Family

ID=51951602

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201410648049.8A Pending CN104644581A (zh) 2013-11-15 2014-11-14 粒状复合物、速释片及其制备方法

Country Status (6)

Country Link
US (2) US20150141517A1 (enExample)
EP (1) EP2873415B1 (enExample)
JP (1) JP6307417B2 (enExample)
KR (1) KR102253849B1 (enExample)
CN (1) CN104644581A (enExample)
IN (1) IN2014DE03239A (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115397469A (zh) * 2020-04-10 2022-11-25 日本瓦姆&珀巴尔株式会社 粘合剂

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016098459A1 (ja) * 2014-12-17 2016-06-23 株式会社ダイセル 遅延崩壊性粒子組成物
PL3949952T3 (pl) 2019-04-03 2024-10-14 Astellas Pharma Inc. Kompozycja farmaceutyczna
CN115379861A (zh) * 2020-04-10 2022-11-22 日本瓦姆&珀巴尔株式会社 缓释性主剂
KR20230043904A (ko) 2020-07-24 2023-03-31 엘랑코 유에스 인코포레이티드 이속사졸린 화합물 및 이의 중간체의 제조 공정
JP7414668B2 (ja) * 2020-08-28 2024-01-16 信越化学工業株式会社 ポリビニルアルコール含有造粒物及び固形製剤
JP7590950B2 (ja) * 2020-12-18 2024-11-27 大鵬薬品工業株式会社 ビラスチンを含有する口腔内崩壊錠
KR20230146800A (ko) 2022-04-13 2023-10-20 주식회사 산흥이지 도로교통 표지판의 각도 조절장치
JP2023173283A (ja) * 2022-05-25 2023-12-07 フロイント産業株式会社 顆粒及びその製造方法、並びに錠剤
CN116510026B (zh) * 2023-07-04 2023-09-19 山东天力药业有限公司 一种甘露醇复合药用辅料及其制备方法
WO2025078588A1 (en) * 2023-10-12 2025-04-17 Dfe Pharma Gmbh & Co. Kg Method and system for preparing agglomerated excipient granules

Citations (9)

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EP1192942A2 (en) * 2000-09-27 2002-04-03 Shin-Etsu Chemical Co., Ltd. Base material for dry direct tableting comprising low-substituted hydroxypropyl cellulose
EP1260215A1 (en) * 2000-03-01 2002-11-27 Eisai Co., Ltd. Rapidly disintegrable tablet containing polyvinyl alcohol
CN101212955A (zh) * 2005-06-29 2008-07-02 大塚制药株式会社 含西洛他唑和甘露醇的口腔崩解粉剂
EP2210591A2 (en) * 2009-01-26 2010-07-28 Shin-Etsu Chemical Co., Ltd. Wet granulation tableting method using aqueous dispersion of low-substituted hydroxypropyl cellulose
CN102223880A (zh) * 2008-11-25 2011-10-19 田边三菱制药株式会社 口腔速崩片及其制备方法
CN102548542A (zh) * 2009-08-11 2012-07-04 大日本住友制药株式会社 含有两种以上粒子的口腔速崩片
WO2013058409A1 (en) * 2011-10-21 2013-04-25 Takeda Pharmaceutical Company Limited Sustained-release preparation
CN103282051A (zh) * 2010-12-28 2013-09-04 大鹏药品工业株式会社 口腔内崩解片剂
CN103505433A (zh) * 2012-06-15 2014-01-15 信越化学工业株式会社 制备包含低取代羟丙基纤维素的复合颗粒的方法及快速释放制剂

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US3864406A (en) * 1973-04-25 1975-02-04 Suomen Sokeri Oy Process for the production of mannitol and sorbitol
JP4279220B2 (ja) * 2004-09-09 2009-06-17 日信工業株式会社 複合材料及びその製造方法、複合金属材料及びその製造方法
JP6073543B2 (ja) * 2010-07-08 2017-02-01 沢井製薬株式会社 ロラタジン含有口腔内崩壊錠の製造方法
JP2012236823A (ja) * 2011-04-28 2012-12-06 Fuji Chem Ind Co Ltd 耐湿安定性に優れた錠剤
WO2013098576A1 (en) * 2011-12-31 2013-07-04 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi Immediate release pharmaceutical composition of valsartan

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EP1260215A1 (en) * 2000-03-01 2002-11-27 Eisai Co., Ltd. Rapidly disintegrable tablet containing polyvinyl alcohol
EP1192942A2 (en) * 2000-09-27 2002-04-03 Shin-Etsu Chemical Co., Ltd. Base material for dry direct tableting comprising low-substituted hydroxypropyl cellulose
US20020058714A1 (en) * 2000-09-27 2002-05-16 Naosuke Maruyama Base material for dry direct tableting comprising low-substituted hydroxypropyl cellulose
CN101212955A (zh) * 2005-06-29 2008-07-02 大塚制药株式会社 含西洛他唑和甘露醇的口腔崩解粉剂
CN102223880A (zh) * 2008-11-25 2011-10-19 田边三菱制药株式会社 口腔速崩片及其制备方法
EP2210591A2 (en) * 2009-01-26 2010-07-28 Shin-Etsu Chemical Co., Ltd. Wet granulation tableting method using aqueous dispersion of low-substituted hydroxypropyl cellulose
CN102548542A (zh) * 2009-08-11 2012-07-04 大日本住友制药株式会社 含有两种以上粒子的口腔速崩片
CN103282051A (zh) * 2010-12-28 2013-09-04 大鹏药品工业株式会社 口腔内崩解片剂
WO2013058409A1 (en) * 2011-10-21 2013-04-25 Takeda Pharmaceutical Company Limited Sustained-release preparation
CN103505433A (zh) * 2012-06-15 2014-01-15 信越化学工业株式会社 制备包含低取代羟丙基纤维素的复合颗粒的方法及快速释放制剂

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MIRA JIVRAJ，等: "An overview of the different excipients useful for the direct compression of tablets", 《PHARMACEUTICAL SCIENCE AND TECHNOLOGY TODAY》 *
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115397469A (zh) * 2020-04-10 2022-11-25 日本瓦姆&珀巴尔株式会社 粘合剂

Also Published As

Publication number Publication date
US20200038333A1 (en) 2020-02-06
KR20150056474A (ko) 2015-05-26
EP2873415B1 (en) 2018-08-29
EP2873415A1 (en) 2015-05-20
US20150141517A1 (en) 2015-05-21
KR102253849B1 (ko) 2021-05-21
JP2015117240A (ja) 2015-06-25
US11723872B2 (en) 2023-08-15
JP6307417B2 (ja) 2018-04-04
IN2014DE03239A (enExample) 2015-07-17

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Application publication date: 20150527