KR102214740B1 - Mir-122를 조정하기 위한 마이크로rna 화합물 및 방법 - Google Patents
Mir-122를 조정하기 위한 마이크로rna 화합물 및 방법 Download PDFInfo
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- KR102214740B1 KR102214740B1 KR1020157031078A KR20157031078A KR102214740B1 KR 102214740 B1 KR102214740 B1 KR 102214740B1 KR 1020157031078 A KR1020157031078 A KR 1020157031078A KR 20157031078 A KR20157031078 A KR 20157031078A KR 102214740 B1 KR102214740 B1 KR 102214740B1
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Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201508925WA (en) | 2013-05-01 | 2015-11-27 | Regulus Therapeutics Inc | Microrna compounds and methods for modulating mir-122 |
| CN105164261B (zh) * | 2013-05-01 | 2022-03-18 | 莱古路斯治疗法股份有限公司 | 用于增强的细胞摄取的化合物和方法 |
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| US9994846B2 (en) | 2013-10-25 | 2018-06-12 | Regulus Therapeutics Inc. | MicroRNA compounds and methods for modulating miR-21 activity |
| PE20170922A1 (es) | 2014-11-10 | 2017-07-12 | Glaxosmithkline Intellectual Property (No 2) Ltd | Composiciones de accion prolongada de combinacion y procedimientos para hepatitis c |
| US20170312297A1 (en) * | 2014-11-10 | 2017-11-02 | Glaxosmithkline Intellectual Property (No. 2) Limited | Long Acting Pharmaceutical Compositions For Hepatitis C |
| AU2016349625B2 (en) | 2015-11-06 | 2022-07-07 | Ionis Pharmaceuticals, Inc. | Modulating apolipoprotein (a) expression |
| US20190046555A1 (en) * | 2015-11-06 | 2019-02-14 | Ionis Pharmaceuticals, Inc. | Conjugated antisense compounds for use in therapy |
| KR102515329B1 (ko) | 2016-03-07 | 2023-03-29 | 애로우헤드 파마슈티컬스 인코포레이티드 | 치료용 화합물을 위한 표적화 리간드 |
| HUE064412T2 (hu) | 2016-06-21 | 2024-03-28 | Orion Ophthalmology LLC | Heterociklusos prolinamid-származékok |
| JP7164521B2 (ja) | 2016-06-21 | 2022-11-01 | オリオン・オフサルモロジー・エルエルシー | 炭素環式プロリンアミド誘導体 |
| MX2018009853A (es) | 2016-09-02 | 2018-11-09 | Arrowhead Pharmaceuticals Inc | Ligandos de direccion. |
| EP4035659A1 (en) | 2016-11-29 | 2022-08-03 | PureTech LYT, Inc. | Exosomes for delivery of therapeutic agents |
| EP3790972A1 (en) * | 2018-05-08 | 2021-03-17 | Regulus Therapeutics Inc. | Galnac conjugated modified oligonucleotide as mir-122 inhibitor having hcv antiviral activity with reduced hyperbilirubinemia side-effect |
| TW202019441A (zh) * | 2018-07-20 | 2020-06-01 | 美商雷格勒斯治療公司 | 用於經口遞送寡核苷酸之方法 |
| CN112843084A (zh) * | 2019-11-27 | 2021-05-28 | 中国人民解放军第四军医大学 | MiR-122-5p在制备促进创伤愈合药物中的应用 |
| CN114057816B (zh) * | 2020-07-30 | 2025-02-11 | 浙江柏拉阿图医药科技有限公司 | 富含腺嘌呤硫代磷酸酯化寡核苷酸及其抗肝炎病毒的应用 |
| CA3233014A1 (en) * | 2021-10-08 | 2023-04-13 | Denis Drygin | Methods and compositions for avoiding off-target effects |
| CA3234547A1 (en) | 2021-10-08 | 2023-04-13 | Regulus Therapeutics Inc. | Methods and compositions for treatment of polycystic kidney disease |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007027775A2 (en) | 2005-08-29 | 2007-03-08 | Isis Pharmaceuticals, Inc. | Methods for use in modulating mir-122a |
| WO2008091703A2 (en) | 2007-01-24 | 2008-07-31 | The Rockefeller University | Chemically modified oligonucleotides for use in modulating micro rna and uses thereof |
| WO2012037254A1 (en) * | 2010-09-15 | 2012-03-22 | Alnylam Pharmaceuticals, Inc. | MODIFIED iRNA AGENTS |
Family Cites Families (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10503364A (ja) | 1994-05-10 | 1998-03-31 | ザ ジェネラル ホスピタル コーポレーション | C型肝炎ウイルスのアンチセンス阻害 |
| AU1039397A (en) | 1995-11-22 | 1997-06-27 | Johns Hopkins University, The | Ligands to enhance cellular uptake of biomolecules |
| US6300319B1 (en) | 1998-06-16 | 2001-10-09 | Isis Pharmaceuticals, Inc. | Targeted oligonucleotide conjugates |
| US6656730B1 (en) | 1999-06-15 | 2003-12-02 | Isis Pharmaceuticals, Inc. | Oligonucleotides conjugated to protein-binding drugs |
| IL148916A0 (en) | 1999-10-04 | 2002-09-12 | Exiqon As | Design of high affinity rnase h recruiting oligonucleotide |
| US20020068709A1 (en) * | 1999-12-23 | 2002-06-06 | Henrik Orum | Therapeutic uses of LNA-modified oligonucleotides |
| US7491805B2 (en) | 2001-05-18 | 2009-02-17 | Sirna Therapeutics, Inc. | Conjugates and compositions for cellular delivery |
| US6906182B2 (en) | 2000-12-01 | 2005-06-14 | Cell Works Therapeutics, Inc. | Conjugates of glycosylated/galactosylated peptide, bifunctional linker, and nucleotidic monomers/polymers, and related compositions and method of use |
| CN1344803A (zh) | 2001-09-27 | 2002-04-17 | 吴昌 | 核酸靶分子选择及扩增方法 |
| CA2504694C (en) | 2002-11-05 | 2013-10-01 | Isis Pharmaceuticals, Inc. | Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation |
| DK1620544T3 (en) | 2003-04-17 | 2019-01-14 | Alnylam Pharmaceuticals Inc | MODIFIED iRNA AGENTS |
| US7683036B2 (en) | 2003-07-31 | 2010-03-23 | Regulus Therapeutics Inc. | Oligomeric compounds and compositions for use in modulation of small non-coding RNAs |
| EP1661905B9 (en) | 2003-08-28 | 2012-12-19 | IMANISHI, Takeshi | Novel artificial nucleic acids of n-o bond crosslinkage type |
| CA2536139A1 (en) | 2003-09-25 | 2005-04-07 | Coley Pharmaceutical Group, Inc. | Nucleic acid-lipophilic conjugates |
| RU2377301C2 (ru) | 2003-12-23 | 2009-12-27 | Сантарис Фарма А/С | ОЛИГОМЕРНОЕ СОЕДИНЕНИЕ, ПОНИЖАЮЩЕЕ ЭКСПРЕССИЮ ЧЕЛОВЕЧЕСКОГО ГЕНА Bcl-2, КОНЪЮГАТ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И ПРИМЕНЕНИЕ ОЛИГОМЕРНОГО СОЕДИНЕНИЯ ДЛЯ ЛЕЧЕНИЯ РАКА |
| AU2005325262B2 (en) | 2004-04-27 | 2011-08-11 | Alnylam Pharmaceuticals, Inc. | Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety |
| ES2361458T5 (es) | 2004-05-04 | 2016-04-20 | The Board Of Trustees Of The Leland Stanford Junior University | Procedimientos y composiciones para reducir las cantidades de genoma vírico de VHC en una célula diana |
| CA2574603C (en) | 2004-08-04 | 2014-11-04 | Alnylam Pharmaceuticals, Inc. | Oligonucleotides comprising a ligand tethered to a modified or non-natural nucleobase |
| US20090203132A1 (en) | 2004-09-09 | 2009-08-13 | Swayze Eric E | Pyrrolidinyl groups for attaching conjugates to oligomeric compounds |
| WO2006069584A2 (en) | 2004-12-29 | 2006-07-06 | Exiqon A/S | NOVEL OLIGONUCLEOTIDE COMPOSITIONS AND PROBE SEQUENCES USEFUL FOR DETECTION AND ANALYSIS OF microRNAs AND THEIR TARGET mRNAs |
| US20060148740A1 (en) | 2005-01-05 | 2006-07-06 | Prosensa B.V. | Mannose-6-phosphate receptor mediated gene transfer into muscle cells |
| US20120122801A1 (en) | 2005-01-05 | 2012-05-17 | Prosensa B.V. | Mannose-6-phosphate receptor mediated gene transfer into muscle cells |
| EP1841867A1 (en) | 2005-01-24 | 2007-10-10 | Avaris AB | COMPLEX CONTAINING SiRNA, ShRNA OR ANTISENSE MOLECULE AND FUNCTIONAL ENTITY, FOR IMPROVED SPECIFICITY AND DELIVERY |
| WO2007021896A2 (en) | 2005-08-10 | 2007-02-22 | Alnylam Pharmaceuticals, Inc. | Chemically modified oligonucleotides for use in modulating micro rna and uses thereof |
| WO2007027894A2 (en) | 2005-08-29 | 2007-03-08 | Isis Pharmaceuticals, Inc. | Antisense compounds having enhanced anti-microrna activity |
| JP5342881B2 (ja) | 2006-01-27 | 2013-11-13 | アイシス ファーマシューティカルズ, インコーポレーテッド | 6−修飾された二環式核酸類似体 |
| EP1984499B1 (en) | 2006-01-27 | 2015-05-27 | Isis Pharmaceuticals, Inc. | Oligomeric compounds and compositions for the use in modulation of micrornas |
| EP2666859B1 (en) | 2006-04-03 | 2019-01-02 | Roche Innovation Center Copenhagen A/S | Pharmaceutical composition comprising anti-mirna antisense oligonucleotides |
| CA2648132C (en) | 2006-04-03 | 2019-05-28 | Santaris Pharma A/S | Pharmaceutical composition comprising anti-mirna antisense oligonucleotides |
| EP3192788A1 (en) | 2006-10-03 | 2017-07-19 | Arbutus Biopharma Corporation | Lipid containing formulations |
| EP2152879B1 (en) | 2007-05-01 | 2012-11-14 | Santaris Pharma A/S | Rna antagonist compounds for the modulation of beta-catenin |
| EP2170917B1 (en) | 2007-05-30 | 2012-06-27 | Isis Pharmaceuticals, Inc. | N-substituted-aminomethylene bridged bicyclic nucleic acid analogs |
| EP2173760B2 (en) | 2007-06-08 | 2015-11-04 | Isis Pharmaceuticals, Inc. | Carbocyclic bicyclic nucleic acid analogs |
| CA2692579C (en) | 2007-07-05 | 2016-05-03 | Isis Pharmaceuticals, Inc. | 6-disubstituted bicyclic nucleic acid analogs |
| EP2623599B1 (en) * | 2007-10-04 | 2019-01-02 | Roche Innovation Center Copenhagen A/S | Micromirs |
| JP5872162B2 (ja) | 2007-11-26 | 2016-03-01 | エンゾン ファーマシューティカルズ,インコーポレーテッド | アンドロゲン受容体を標的化するlnaアンタゴニスト |
| WO2009082607A2 (en) | 2007-12-04 | 2009-07-02 | Alnylam Pharmaceuticals, Inc. | Targeting lipids |
| US20110257244A1 (en) | 2008-01-18 | 2011-10-20 | Alnylam Pharmaceuticals, Inc. | Chemically modified oligonucleotides and small molecules for use in reducing micro rna activity levels and uses thereof |
| EP2268811A1 (en) | 2008-03-07 | 2011-01-05 | Santaris Pharma A/S | Pharmaceutical compositions for treatment of microrna related diseases |
| JP5793423B2 (ja) | 2008-12-31 | 2015-10-14 | ロシュ・イノベーション・センター・コペンハーゲン・アクティーゼルスカブRoche Innovation Center Copenhagen A/S | 急性冠症候群の治療のためのLNAApoBアンチセンスオリゴマーの使用 |
| ES2599979T3 (es) | 2009-04-24 | 2017-02-06 | Roche Innovation Center Copenhagen A/S | Composiciones farmacéuticas para el tratamiento de pacientes de VHC que no responden al interferón |
| CA2765129A1 (en) | 2009-06-08 | 2010-12-16 | Miragen Therapeutics | Chemical modification motifs for mirna inhibitors and mimetics |
| KR20120095397A (ko) | 2009-10-16 | 2012-08-28 | 글락소 그룹 리미티드 | Hbv 안티센스 억제제 |
| DK2539451T3 (da) | 2010-02-24 | 2016-04-04 | Arrowhead Res Corp | Sammensætninger til målrettet tilførsel af siRNA |
| US8349308B2 (en) | 2010-03-26 | 2013-01-08 | Mersana Therapeutics, Inc. | Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof |
| WO2011130458A2 (en) | 2010-04-13 | 2011-10-20 | John Rossi | Rna aptamers against baff-r as cell-type specific delivery agents and methods for their use |
| WO2012007477A1 (en) | 2010-07-12 | 2012-01-19 | Santaris Pharma A/S | Anti hcv oligomers |
| EP2652134B1 (en) | 2010-12-17 | 2017-03-01 | Arrowhead Pharmaceuticals, Inc. | Galactose cluster-pharmacokinetic modulator targeting moiety for sirna |
| ES2605990T3 (es) | 2010-12-29 | 2017-03-17 | F. Hoffmann-La Roche Ag | Conjugados de molécula pequeña para la administración intracelular de ácidos nucleicos |
| EP3211082B1 (en) * | 2011-04-25 | 2021-02-17 | Sanofi | Microrna compounds and methods for modulating mir-21 activity |
| US20140248611A1 (en) * | 2011-06-16 | 2014-09-04 | Nippon Steel & Sumikin Eco-Tech Corporation | Nucleic acid probe for assaying nucleic acids |
| US20140127159A1 (en) | 2011-06-23 | 2014-05-08 | Stella Aps | HCV Combination Therapy |
| EP2726611A1 (en) | 2011-06-30 | 2014-05-07 | Stella ApS | Hcv combination therapy |
| KR20140064765A (ko) | 2011-06-30 | 2014-05-28 | 스텔라 에이피에스 | Hcv 조합 치료 |
| EP3453761A1 (en) * | 2011-08-29 | 2019-03-13 | Ionis Pharmaceuticals, Inc. | Oligomer-conjugate complexes and their use |
| EP2776590B1 (en) | 2011-11-07 | 2016-10-26 | Roche Innovation Center Copenhagen A/S | Prognostic method for checking efficacy of micro rna-122 inhibitors in hcv+ patients |
| WO2013068348A1 (en) | 2011-11-07 | 2013-05-16 | Santaris Pharma A/S | Lna oligomers for improvement in hepatic function |
| US9388408B2 (en) | 2012-06-21 | 2016-07-12 | MiRagen Therapeutics, Inc. | Oligonucleotide-based inhibitors comprising locked nucleic acid motif |
| CN104955950B (zh) | 2012-09-26 | 2019-04-26 | 米尔克斯治疗学公司 | 具有改善的脱靶特征谱的寡核苷酸 |
| US10077443B2 (en) | 2012-11-15 | 2018-09-18 | Roche Innovation Center Copenhagen A/S | Oligonucleotide conjugates |
| CN104955952A (zh) | 2013-01-30 | 2015-09-30 | 弗·哈夫曼-拉罗切有限公司 | Lna寡核苷酸碳水化合物缀合物 |
| WO2014118272A1 (en) | 2013-01-30 | 2014-08-07 | Santaris Pharma A/S | Antimir-122 oligonucleotide carbohydrate conjugates |
| CN105164261B (zh) | 2013-05-01 | 2022-03-18 | 莱古路斯治疗法股份有限公司 | 用于增强的细胞摄取的化合物和方法 |
| DK2991656T3 (da) | 2013-05-01 | 2020-03-23 | Ionis Pharmaceuticals Inc | Sammensætninger og fremgangsmåder til modulering af apolipoprotein c-iii-ekspression |
| SG11201508925WA (en) | 2013-05-01 | 2015-11-27 | Regulus Therapeutics Inc | Microrna compounds and methods for modulating mir-122 |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007027775A2 (en) | 2005-08-29 | 2007-03-08 | Isis Pharmaceuticals, Inc. | Methods for use in modulating mir-122a |
| WO2008091703A2 (en) | 2007-01-24 | 2008-07-31 | The Rockefeller University | Chemically modified oligonucleotides for use in modulating micro rna and uses thereof |
| WO2012037254A1 (en) * | 2010-09-15 | 2012-03-22 | Alnylam Pharmaceuticals, Inc. | MODIFIED iRNA AGENTS |
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| US9309513B2 (en) | 2016-04-12 |
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| CA2908939A1 (en) | 2014-11-06 |
| TW201446791A (zh) | 2014-12-16 |
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