KR102204578B1 - 알카프타딘 및 이의 약제학적으로 허용가능한 염의 제조 방법 - Google Patents

알카프타딘 및 이의 약제학적으로 허용가능한 염의 제조 방법 Download PDF

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Publication number
KR102204578B1
KR102204578B1 KR1020157030845A KR20157030845A KR102204578B1 KR 102204578 B1 KR102204578 B1 KR 102204578B1 KR 1020157030845 A KR1020157030845 A KR 1020157030845A KR 20157030845 A KR20157030845 A KR 20157030845A KR 102204578 B1 KR102204578 B1 KR 102204578B1
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South Korea
Prior art keywords
acid
formula
salt
alcaptadine
compound
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KR1020157030845A
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Korean (ko)
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KR20160018472A (ko
Inventor
안토니오 로렌테 본데-라르센
제수스 미구엘 이글레시아스 레투에르토
프랑시소 자비에르 갈로 니에토
주안 조세 페레이로 길
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크리스탈 파마 에스.에이.유.
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Publication of KR102204578B1 publication Critical patent/KR102204578B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020157030845A 2013-03-25 2014-03-24 알카프타딘 및 이의 약제학적으로 허용가능한 염의 제조 방법 Active KR102204578B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13160829 2013-03-25
EP13160829.1 2013-03-25
PCT/EP2014/055815 WO2014154620A1 (en) 2013-03-25 2014-03-24 Methods for the preparation of alcaftadine

Publications (2)

Publication Number Publication Date
KR20160018472A KR20160018472A (ko) 2016-02-17
KR102204578B1 true KR102204578B1 (ko) 2021-01-20

Family

ID=47913271

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Application Number Title Priority Date Filing Date
KR1020157030845A Active KR102204578B1 (ko) 2013-03-25 2014-03-24 알카프타딘 및 이의 약제학적으로 허용가능한 염의 제조 방법

Country Status (7)

Country Link
US (1) US9682984B2 (https=)
EP (1) EP2978765B1 (https=)
JP (1) JP6400672B2 (https=)
KR (1) KR102204578B1 (https=)
CA (1) CA2907396C (https=)
ES (1) ES2680933T3 (https=)
WO (1) WO2014154620A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104860920B (zh) * 2015-04-15 2017-08-25 武汉武药科技有限公司 一种阿卡他定中间体的制备方法
CN104987337B (zh) * 2015-07-28 2018-01-12 武汉武药科技有限公司 一种制备阿卡他定的氧化方法
US11951165B2 (en) 2016-12-30 2024-04-09 Vaxcyte, Inc. Conjugated vaccine carrier proteins
ES3024474T3 (en) 2016-12-30 2025-06-04 Vaxcyte Inc Polypeptide-antigen conjugates with non-natural amino acids

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997034897A1 (en) 1996-03-19 1997-09-25 Janssen Pharmaceutica N.V. Fused imidazole derivatives as multidrug resistance modulators
US20080139531A1 (en) 2006-12-04 2008-06-12 Alcon Manufacturing Ltd. Use of connective tissue mast cell stabilizers to facilitate ocular surface re-epithelization and wound repair
WO2014083571A1 (en) 2012-11-29 2014-06-05 Neuland Laboratories Limited A process for the preparation of alcaftadine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4070381A (en) * 1972-07-12 1978-01-24 Lever Brothers Company Certain 2-(hydroxyalkyl)-2,5-dialkyl-4-hydroxy-4,5-dihydrofuran-3-ones and method for their preparation
IL101850A (en) * 1991-06-13 1996-01-31 Janssen Pharmaceutica Nv 11-(4-Piperidinyl)-imidazo (2,1-b) (3) benzazepine derivatives their preparation and pharmaceutical compositions containing them

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997034897A1 (en) 1996-03-19 1997-09-25 Janssen Pharmaceutica N.V. Fused imidazole derivatives as multidrug resistance modulators
US20080139531A1 (en) 2006-12-04 2008-06-12 Alcon Manufacturing Ltd. Use of connective tissue mast cell stabilizers to facilitate ocular surface re-epithelization and wound repair
WO2014083571A1 (en) 2012-11-29 2014-06-05 Neuland Laboratories Limited A process for the preparation of alcaftadine

Also Published As

Publication number Publication date
CA2907396A1 (en) 2014-10-02
US9682984B2 (en) 2017-06-20
ES2680933T3 (es) 2018-09-11
JP2016515555A (ja) 2016-05-30
JP6400672B2 (ja) 2018-10-03
KR20160018472A (ko) 2016-02-17
EP2978765B1 (en) 2018-05-02
US20160280709A1 (en) 2016-09-29
CA2907396C (en) 2021-11-02
EP2978765A1 (en) 2016-02-03
WO2014154620A1 (en) 2014-10-02

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