CA2907396C - Methods for the preparation of alcaftadine - Google Patents

Methods for the preparation of alcaftadine Download PDF

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Publication number
CA2907396C
CA2907396C CA2907396A CA2907396A CA2907396C CA 2907396 C CA2907396 C CA 2907396C CA 2907396 A CA2907396 A CA 2907396A CA 2907396 A CA2907396 A CA 2907396A CA 2907396 C CA2907396 C CA 2907396C
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CA
Canada
Prior art keywords
acid
formula
salt
alcaftadine
process according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2907396A
Other languages
English (en)
French (fr)
Other versions
CA2907396A1 (en
Inventor
Antonio Lorente Bonde-Larsen
Jesus Miguel Iglesias RETUERTO
Franciso Javier Gallo Nieto
Juan Jose Ferreiro Gil
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Curia Spain SA
Original Assignee
Crystal Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Publication of CA2907396A1 publication Critical patent/CA2907396A1/en
Application granted granted Critical
Publication of CA2907396C publication Critical patent/CA2907396C/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2907396A 2013-03-25 2014-03-24 Methods for the preparation of alcaftadine Active CA2907396C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13160829 2013-03-25
EP13160829.1 2013-03-25
PCT/EP2014/055815 WO2014154620A1 (en) 2013-03-25 2014-03-24 Methods for the preparation of alcaftadine

Publications (2)

Publication Number Publication Date
CA2907396A1 CA2907396A1 (en) 2014-10-02
CA2907396C true CA2907396C (en) 2021-11-02

Family

ID=47913271

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2907396A Active CA2907396C (en) 2013-03-25 2014-03-24 Methods for the preparation of alcaftadine

Country Status (7)

Country Link
US (1) US9682984B2 (https=)
EP (1) EP2978765B1 (https=)
JP (1) JP6400672B2 (https=)
KR (1) KR102204578B1 (https=)
CA (1) CA2907396C (https=)
ES (1) ES2680933T3 (https=)
WO (1) WO2014154620A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104860920B (zh) * 2015-04-15 2017-08-25 武汉武药科技有限公司 一种阿卡他定中间体的制备方法
CN104987337B (zh) * 2015-07-28 2018-01-12 武汉武药科技有限公司 一种制备阿卡他定的氧化方法
US11951165B2 (en) 2016-12-30 2024-04-09 Vaxcyte, Inc. Conjugated vaccine carrier proteins
ES3024474T3 (en) 2016-12-30 2025-06-04 Vaxcyte Inc Polypeptide-antigen conjugates with non-natural amino acids

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4070381A (en) * 1972-07-12 1978-01-24 Lever Brothers Company Certain 2-(hydroxyalkyl)-2,5-dialkyl-4-hydroxy-4,5-dihydrofuran-3-ones and method for their preparation
IL101850A (en) * 1991-06-13 1996-01-31 Janssen Pharmaceutica Nv 11-(4-Piperidinyl)-imidazo (2,1-b) (3) benzazepine derivatives their preparation and pharmaceutical compositions containing them
TW527186B (en) * 1996-03-19 2003-04-11 Janssen Pharmaceutica Nv Fused imidazole derivatives as multidrug resistance modulators
US20080139531A1 (en) * 2006-12-04 2008-06-12 Alcon Manufacturing Ltd. Use of connective tissue mast cell stabilizers to facilitate ocular surface re-epithelization and wound repair
WO2014083571A1 (en) * 2012-11-29 2014-06-05 Neuland Laboratories Limited A process for the preparation of alcaftadine

Also Published As

Publication number Publication date
KR102204578B1 (ko) 2021-01-20
CA2907396A1 (en) 2014-10-02
US9682984B2 (en) 2017-06-20
ES2680933T3 (es) 2018-09-11
JP2016515555A (ja) 2016-05-30
JP6400672B2 (ja) 2018-10-03
KR20160018472A (ko) 2016-02-17
EP2978765B1 (en) 2018-05-02
US20160280709A1 (en) 2016-09-29
EP2978765A1 (en) 2016-02-03
WO2014154620A1 (en) 2014-10-02

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