KR102202004B1 - Casp2에 대한 이중-가닥 rna 화합물 및 그 용도 - Google Patents

Casp2에 대한 이중-가닥 rna 화합물 및 그 용도 Download PDF

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KR102202004B1
KR102202004B1 KR1020197035560A KR20197035560A KR102202004B1 KR 102202004 B1 KR102202004 B1 KR 102202004B1 KR 1020197035560 A KR1020197035560 A KR 1020197035560A KR 20197035560 A KR20197035560 A KR 20197035560A KR 102202004 B1 KR102202004 B1 KR 102202004B1
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KR20190137940A (ko
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샤이 에를리치
제임스 디. 톰슨
라비아 오즈덴
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쿠아크 파마수티칼스 인코퍼레이티드
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KR1020197035560A 2012-01-04 2013-01-03 Casp2에 대한 이중-가닥 rna 화합물 및 그 용도 Active KR102202004B1 (ko)

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Application Number Priority Date Filing Date Title
US201261582886P 2012-01-04 2012-01-04
US61/582,886 2012-01-04
US201261596231P 2012-02-08 2012-02-08
US61/596,231 2012-02-08
PCT/US2013/020012 WO2013103632A1 (en) 2012-01-04 2013-01-03 Double-stranded rna compounds to casp2 and uses thereof

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KR102202004B1 true KR102202004B1 (ko) 2021-01-12

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KR1020147019172A Ceased KR20140109430A (ko) 2012-01-04 2013-01-03 Casp2에 대한 이중-가닥 rna 화합물 및 그 용도

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US (2) US9382542B2 (cg-RX-API-DMAC7.html)
EP (1) EP2800812A1 (cg-RX-API-DMAC7.html)
JP (2) JP2015507478A (cg-RX-API-DMAC7.html)
KR (2) KR102202004B1 (cg-RX-API-DMAC7.html)
CN (1) CN104053776A (cg-RX-API-DMAC7.html)
AU (1) AU2013206951B2 (cg-RX-API-DMAC7.html)
BR (1) BR112014016640A2 (cg-RX-API-DMAC7.html)
CA (1) CA2858627C (cg-RX-API-DMAC7.html)
EA (1) EA036003B1 (cg-RX-API-DMAC7.html)
IL (1) IL233142B (cg-RX-API-DMAC7.html)
NZ (1) NZ625980A (cg-RX-API-DMAC7.html)
WO (1) WO2013103632A1 (cg-RX-API-DMAC7.html)

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WO2015136255A1 (en) * 2014-03-11 2015-09-17 The University Of Birmingham Combined inhibition of caspase-2 and caspase-6 in neuroprotection and axon regeneration
EP3548005A4 (en) 2016-11-29 2020-06-17 Puretech Health LLC Exosomes for delivery of therapeutic agents

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011072091A1 (en) 2009-12-09 2011-06-16 Quark Pharmaceuticals, Inc. Methods and compositions for treating diseases, disorders or injury of the cns
WO2011084193A1 (en) 2010-01-07 2011-07-14 Quark Pharmaceuticals, Inc. Oligonucleotide compounds comprising non-nucleotide overhangs

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5998203A (en) 1996-04-16 1999-12-07 Ribozyme Pharmaceuticals, Inc. Enzymatic nucleic acids containing 5'-and/or 3'-cap structures
US6251666B1 (en) 1997-03-31 2001-06-26 Ribozyme Pharmaceuticals, Inc. Nucleic acid catalysts comprising L-nucleotide analogs
US6444776B1 (en) 1998-12-21 2002-09-03 Novartis Ag Organic polymers
IT1305306B1 (it) * 1999-03-17 2001-05-04 Farmigea Spa Uso della pirenoxina per la protezione dei tessuti corneali ininterventi di fotocheratectomia.
US6444676B1 (en) * 1999-12-20 2002-09-03 Iok-Hou Pang Use of PARP inhibitors in the treatment of glaucoma
WO2004033620A2 (en) * 2001-11-02 2004-04-22 Insert Therapeutics, Inc. Methods and compositions for therapeutic use of rna interference
EP2392660A3 (en) * 2002-11-25 2012-03-28 Masafumi Matsuo ENA Nucleic Acid Drugs Modifying Splicing in mRNA Precursor
US7605249B2 (en) * 2002-11-26 2009-10-20 Medtronic, Inc. Treatment of neurodegenerative disease through intracranial delivery of siRNA
WO2005004794A2 (en) * 2003-06-09 2005-01-20 Alnylam Pharmaceuticals Inc. Method of treating neurodegenerative disease
EP1689864A2 (en) * 2003-10-21 2006-08-16 Dyad Pharmaceutical Corporation Method and compositions for treating 5alpha-reductase type 1 and type 2 dependent conditions
GB0403041D0 (en) * 2004-02-11 2004-03-17 Milner Anne J Induction of apoptosis
WO2007031091A2 (en) * 2005-09-15 2007-03-22 Santaris Pharma A/S Rna antagonist compounds for the modulation of p21 ras expression
US8168584B2 (en) * 2005-10-08 2012-05-01 Potentia Pharmaceuticals, Inc. Methods of treating age-related macular degeneration by compstatin and analogs thereof
JP2010507387A (ja) 2006-10-25 2010-03-11 クアーク・ファーマスーティカルス、インコーポレイテッド 新規のsiRNAおよびその使用方法
WO2008094860A2 (en) * 2007-01-30 2008-08-07 Allergan, Inc. Treating ocular diseases using peroxisome proliferator-activated receptor delta antagonists
CA2701845A1 (en) 2007-10-03 2009-04-09 Quark Pharmaceuticals, Inc. Novel sirna structures
WO2010048352A2 (en) * 2008-10-22 2010-04-29 Quark Pharmaceuticals, Inc. Methods for treating eye disorders
JP2010260857A (ja) * 2009-04-10 2010-11-18 Santen Pharmaceut Co Ltd シロリムス誘導体を有効成分として含有する網脈絡膜疾患の治療剤
JP2012533079A (ja) * 2009-07-16 2012-12-20 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 中枢神経系の炎症疾病の血液マーカーとしての切断およびリン酸化されたcrmp2
KR20120038544A (ko) * 2009-07-31 2012-04-23 판미라 파마슈티칼스, 엘엘씨 Dp2 수용체 길항제의 안과용 약학 조성물

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011072091A1 (en) 2009-12-09 2011-06-16 Quark Pharmaceuticals, Inc. Methods and compositions for treating diseases, disorders or injury of the cns
WO2011084193A1 (en) 2010-01-07 2011-07-14 Quark Pharmaceuticals, Inc. Oligonucleotide compounds comprising non-nucleotide overhangs

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CA2858627A1 (en) 2013-07-11
AU2013206951A1 (en) 2014-07-03
JP2015507478A (ja) 2015-03-12
JP2018099117A (ja) 2018-06-28
JP6774928B2 (ja) 2020-10-28
WO2013103632A1 (en) 2013-07-11
KR20140109430A (ko) 2014-09-15
BR112014016640A2 (pt) 2021-03-16
CN104053776A (zh) 2014-09-17
IL233142A0 (en) 2014-07-31
EA036003B1 (ru) 2020-09-11
NZ625980A (en) 2015-05-29
AU2013206951B2 (en) 2016-11-24
IL233142B (en) 2019-01-31
KR20190137940A (ko) 2019-12-11
CA2858627C (en) 2020-12-01
US20160304879A1 (en) 2016-10-20
US9382542B2 (en) 2016-07-05
EA201491048A1 (ru) 2015-09-30
EP2800812A1 (en) 2014-11-12
US20140371439A1 (en) 2014-12-18
US10570394B2 (en) 2020-02-25

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