EA201491048A1 - Соединения двухцепочечных рнк к casp2 и их применение - Google Patents

Соединения двухцепочечных рнк к casp2 и их применение

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Publication number
EA201491048A1
EA201491048A1 EA201491048A EA201491048A EA201491048A1 EA 201491048 A1 EA201491048 A1 EA 201491048A1 EA 201491048 A EA201491048 A EA 201491048A EA 201491048 A EA201491048 A EA 201491048A EA 201491048 A1 EA201491048 A1 EA 201491048A1
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EA
Eurasian Patent Office
Prior art keywords
casp2
connections
application
cellular rna
inhibits
Prior art date
Application number
EA201491048A
Other languages
English (en)
Other versions
EA036003B1 (ru
Inventor
Шай Эрлих
Джеймс Д. Томпсон
Рабия Озден
Original Assignee
Кварк Фармасьютикалс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Кварк Фармасьютикалс, Инк. filed Critical Кварк Фармасьютикалс, Инк.
Publication of EA201491048A1 publication Critical patent/EA201491048A1/ru
Publication of EA036003B1 publication Critical patent/EA036003B1/ru

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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Abstract

Данное описание касается способов лечения пациентов, страдающих от или с риском развития глазного заболевания, нарушения или повреждения, и включает схемы лечения с использованием соединения двухцепочечной РНК, угнетающей экспрессию CASP2, или его фармацевтически приемлемой соли.
EA201491048A 2012-01-04 2013-01-03 Способ лечения оптической нейропатии с применением двухцепочечной рнк к casp2 EA036003B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261582886P 2012-01-04 2012-01-04
US201261596231P 2012-02-08 2012-02-08
PCT/US2013/020012 WO2013103632A1 (en) 2012-01-04 2013-01-03 Double-stranded rna compounds to casp2 and uses thereof

Publications (2)

Publication Number Publication Date
EA201491048A1 true EA201491048A1 (ru) 2015-09-30
EA036003B1 EA036003B1 (ru) 2020-09-11

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201491048A EA036003B1 (ru) 2012-01-04 2013-01-03 Способ лечения оптической нейропатии с применением двухцепочечной рнк к casp2

Country Status (12)

Country Link
US (2) US9382542B2 (ru)
EP (1) EP2800812A1 (ru)
JP (2) JP2015507478A (ru)
KR (2) KR20140109430A (ru)
CN (1) CN104053776A (ru)
AU (1) AU2013206951B2 (ru)
BR (1) BR112014016640A2 (ru)
CA (1) CA2858627C (ru)
EA (1) EA036003B1 (ru)
IL (1) IL233142B (ru)
NZ (1) NZ625980A (ru)
WO (1) WO2013103632A1 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015136255A1 (en) * 2014-03-11 2015-09-17 The University Of Birmingham Combined inhibition of caspase-2 and caspase-6 in neuroprotection and axon regeneration
CN110177544A (zh) 2016-11-29 2019-08-27 普尔泰克健康有限公司 用于递送治疗剂的外泌体

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IT1305306B1 (it) * 1999-03-17 2001-05-04 Farmigea Spa Uso della pirenoxina per la protezione dei tessuti corneali ininterventi di fotocheratectomia.
US6444676B1 (en) * 1999-12-20 2002-09-03 Iok-Hou Pang Use of PARP inhibitors in the treatment of glaucoma
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WO2007031091A2 (en) * 2005-09-15 2007-03-22 Santaris Pharma A/S Rna antagonist compounds for the modulation of p21 ras expression
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JP2010507387A (ja) 2006-10-25 2010-03-11 クアーク・ファーマスーティカルス、インコーポレイテッド 新規のｓｉＲＮＡおよびその使用方法
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BRPI0817605A2 (pt) 2007-10-03 2017-05-09 Quark Pharmaceuticals Inc novas estruturas de sirna
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Also Published As

Publication number Publication date
KR20140109430A (ko) 2014-09-15
AU2013206951A1 (en) 2014-07-03
EP2800812A1 (en) 2014-11-12
JP2018099117A (ja) 2018-06-28
CA2858627A1 (en) 2013-07-11
JP6774928B2 (ja) 2020-10-28
NZ625980A (en) 2015-05-29
AU2013206951B2 (en) 2016-11-24
CN104053776A (zh) 2014-09-17
IL233142A0 (en) 2014-07-31
JP2015507478A (ja) 2015-03-12
EA036003B1 (ru) 2020-09-11
US20160304879A1 (en) 2016-10-20
US9382542B2 (en) 2016-07-05
WO2013103632A1 (en) 2013-07-11
KR20190137940A (ko) 2019-12-11
US20140371439A1 (en) 2014-12-18
US10570394B2 (en) 2020-02-25
IL233142B (en) 2019-01-31
KR102202004B1 (ko) 2021-01-12
BR112014016640A2 (pt) 2021-03-16
CA2858627C (en) 2020-12-01

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