KR102170609B1 - 박테리아 인공 염색체 - Google Patents

박테리아 인공 염색체 Download PDF

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KR102170609B1
KR102170609B1 KR1020157033335A KR20157033335A KR102170609B1 KR 102170609 B1 KR102170609 B1 KR 102170609B1 KR 1020157033335 A KR1020157033335 A KR 1020157033335A KR 20157033335 A KR20157033335 A KR 20157033335A KR 102170609 B1 KR102170609 B1 KR 102170609B1
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cdna
viral
rna
virus
vaccine
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KR20160003032A (ko
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카이 달메이어
요한 나이츠
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카트호리이케 유니버시타이트 로이펜
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C12N15/69—Increasing the copy number of the vector
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/18—Togaviridae; Flaviviridae
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
KR1020157033335A 2013-04-26 2014-04-25 박테리아 인공 염색체 Active KR102170609B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1307528.8A GB201307528D0 (en) 2013-04-26 2013-04-26 Bacterial artificial chromosomes
GB1307528.8 2013-04-26
PCT/EP2014/058459 WO2014174078A1 (en) 2013-04-26 2014-04-25 Bacterial artificial chromosomes

Publications (2)

Publication Number Publication Date
KR20160003032A KR20160003032A (ko) 2016-01-08
KR102170609B1 true KR102170609B1 (ko) 2020-10-28

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KR1020157033335A Active KR102170609B1 (ko) 2013-04-26 2014-04-25 박테리아 인공 염색체

Country Status (17)

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US (2) US10076564B2 (https=)
EP (2) EP2989205B1 (https=)
JP (1) JP6501756B2 (https=)
KR (1) KR102170609B1 (https=)
CN (2) CN120249337A (https=)
AU (1) AU2014259354B2 (https=)
BR (1) BR112015026531B1 (https=)
DK (1) DK2989205T3 (https=)
ES (1) ES2718187T3 (https=)
GB (1) GB201307528D0 (https=)
HU (1) HUE042886T2 (https=)
PL (1) PL2989205T3 (https=)
PT (1) PT2989205T (https=)
SI (1) SI2989205T1 (https=)
TR (1) TR201904215T4 (https=)
WO (1) WO2014174078A1 (https=)
ZA (1) ZA201507795B (https=)

Families Citing this family (11)

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Publication number Priority date Publication date Assignee Title
GB201716307D0 (en) 2017-10-05 2017-11-22 Univ Leuven Kath Chimeric yellow fever zika virus strain
GB201716254D0 (en) * 2017-10-05 2017-11-22 Univ Leuven Kath Live-attenuated flaviruses with heterologous antigens
WO2019204654A1 (en) * 2018-04-18 2019-10-24 Utah State University Compositions and methods for zika virus characterization and vaccine development
GB201814563D0 (en) 2018-09-07 2018-10-24 Univ Leuven Kath Chimeric flavivirus lyssavirus vaccines
US20220168412A1 (en) 2019-04-10 2022-06-02 Katholieke Universiteit Leuven Chimeric Zika-Japanese Encephalitis Virus
CN114728054A (zh) 2019-09-13 2022-07-08 勒芬天主教大学 拉沙病毒疫苗
EP4041301A1 (en) 2019-09-13 2022-08-17 Katholieke Universiteit Leuven Chimeric filovirus vaccines
CN114450408A (zh) * 2019-09-25 2022-05-06 鲁汶天主教大学 大载体和用于高产量生产的方法
CA3168673A1 (en) * 2020-02-27 2021-09-02 Kai DALLMEIER Coronavirus vaccines
WO2025012350A1 (en) * 2023-07-11 2025-01-16 Virovet Nv Vectors expressing attenuated rna virus of the family arteriviridae and uses thereof
WO2025171062A1 (en) * 2024-02-06 2025-08-14 The Regents Of The University Of California iMODULON GENE CLUSTERS AND METHODS TO IDENTIFY AND USE SAME

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US5665600A (en) 1991-09-18 1997-09-09 Research Corporation Technologies, Inc. Pichia pastoris linear plasmids and DNA fragments thereof
US5866404A (en) 1995-12-06 1999-02-02 Yale University Yeast-bacteria shuttle vector
US6962708B1 (en) 1997-02-28 2005-11-08 Acambis, Inc. Chimeric flavivirus vaccines
US5874259A (en) * 1997-11-21 1999-02-23 Wisconsin Alumni Research Foundation Conditionally amplifiable BAC vector
WO2000034497A2 (en) 1998-12-09 2000-06-15 The General Hospital Corporation Enhanced packaging of herpes virus amplicons and generation of recombinant virus vectors
ES2170622B1 (es) 1999-12-03 2004-05-16 Consejo Superior De Investigaciones Cientificas Clones y vectores infectivos derivados de coronavirus y sus aplicaciones.
GB2372991B (en) * 2001-03-09 2004-11-17 Fiocruz Fundacao Oswaldo Cruz Flavivirus expression vector
US6472177B1 (en) 2001-04-23 2002-10-29 Wisconsin Alumni Research Foundation Expression vector with dual control of replication and transcription
US6864087B2 (en) * 2001-07-31 2005-03-08 Wisconsin Alumni Research Foundation Method for converting single-copy BAC vectors to conditional high-copy pBAC/oriHC vectors
US20050106733A1 (en) 2001-12-25 2005-05-19 Kenzo Takada Double-stranded cyclic dna capable of proliferating as a bacterial e coli chromosome
WO2004033633A2 (en) 2002-10-04 2004-04-22 Embiosis Pharmaceuticals Compatible host/vector systems for expression of dna
WO2005042014A1 (en) 2003-10-29 2005-05-12 The University Of Queensland West nile virus vaccine
US20050214838A1 (en) 2004-03-10 2005-09-29 Waclaw Szybalski Methods for mapping and sequencing nucleic acids
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Journal of Virology. 2003, 77:6450-6465

Also Published As

Publication number Publication date
AU2014259354B2 (en) 2020-02-27
SI2989205T1 (sl) 2019-05-31
WO2014174078A1 (en) 2014-10-30
CN120249337A (zh) 2025-07-04
EP2989205B1 (en) 2019-01-02
AU2014259354A1 (en) 2015-11-05
EP2989205A1 (en) 2016-03-02
ZA201507795B (en) 2019-07-31
EP3540065A1 (en) 2019-09-18
GB201307528D0 (en) 2013-06-12
US10076564B2 (en) 2018-09-18
CN105229153A (zh) 2016-01-06
ES2718187T3 (es) 2019-06-28
JP2016518132A (ja) 2016-06-23
US20190111125A1 (en) 2019-04-18
BR112015026531A2 (https=) 2017-09-05
PT2989205T (pt) 2019-04-23
PL2989205T3 (pl) 2019-06-28
HUE042886T2 (hu) 2019-07-29
KR20160003032A (ko) 2016-01-08
BR112015026531B1 (pt) 2023-02-07
TR201904215T4 (tr) 2019-04-22
US20160206723A1 (en) 2016-07-21
DK2989205T3 (en) 2019-04-23
JP6501756B2 (ja) 2019-04-17

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