KR102129178B1 - 심근경색 예방 또는 치료용 재조합 단백질을 포함하는 심근경색 예방 또는 치료용 조성물 - Google Patents

심근경색 예방 또는 치료용 재조합 단백질을 포함하는 심근경색 예방 또는 치료용 조성물 Download PDF

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KR102129178B1
KR102129178B1 KR1020180128033A KR20180128033A KR102129178B1 KR 102129178 B1 KR102129178 B1 KR 102129178B1 KR 1020180128033 A KR1020180128033 A KR 1020180128033A KR 20180128033 A KR20180128033 A KR 20180128033A KR 102129178 B1 KR102129178 B1 KR 102129178B1
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South Korea
Prior art keywords
myocardial infarction
recombinant protein
preventing
prevention
protein
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KR1020180128033A
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English (en)
Korean (ko)
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KR20200046618A (ko
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조건식
안근호
이주현
권효성
우동훈
한충성
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(주) 넥셀
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Priority to KR1020180128033A priority Critical patent/KR102129178B1/ko
Priority to PCT/KR2018/012780 priority patent/WO2020085545A1/fr
Priority to US17/285,040 priority patent/US20210388041A1/en
Priority to EP19875681.9A priority patent/EP3870210A4/fr
Priority to JP2021547960A priority patent/JP2022509445A/ja
Priority to PCT/IB2019/001136 priority patent/WO2020084344A2/fr
Priority to CN201980086450.8A priority patent/CN113301914A/zh
Publication of KR20200046618A publication Critical patent/KR20200046618A/ko
Application granted granted Critical
Publication of KR102129178B1 publication Critical patent/KR102129178B1/ko
Priority to JP2024092192A priority patent/JP2024133483A/ja

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1808Epidermal growth factor [EGF] urogastrone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/485Epidermal growth factor [EGF], i.e. urogastrone

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
KR1020180128033A 2018-10-25 2018-10-25 심근경색 예방 또는 치료용 재조합 단백질을 포함하는 심근경색 예방 또는 치료용 조성물 KR102129178B1 (ko)

Priority Applications (8)

Application Number Priority Date Filing Date Title
KR1020180128033A KR102129178B1 (ko) 2018-10-25 2018-10-25 심근경색 예방 또는 치료용 재조합 단백질을 포함하는 심근경색 예방 또는 치료용 조성물
PCT/KR2018/012780 WO2020085545A1 (fr) 2018-10-25 2018-10-26 Protéine recombinante pour la prévention ou le traitement de l'infarctus du myocarde et composition la comprenant pour la prévention ou le traitement de l'infarctus du myocarde
US17/285,040 US20210388041A1 (en) 2018-10-25 2019-10-24 Compositions and methods for treating or preventing fibrosis
EP19875681.9A EP3870210A4 (fr) 2018-10-25 2019-10-24 Compositions et procédés de traitement ou de prévention de la fibrose
JP2021547960A JP2022509445A (ja) 2018-10-25 2019-10-24 線維症を治療又は予防するための組成物及び方法
PCT/IB2019/001136 WO2020084344A2 (fr) 2018-10-25 2019-10-24 Compositions et procédés de traitement ou de prévention de la fibrose
CN201980086450.8A CN113301914A (zh) 2018-10-25 2019-10-24 用于治疗和预防纤维化的组合物和方法
JP2024092192A JP2024133483A (ja) 2018-10-25 2024-06-06 線維症を治療又は予防するための組成物及び方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020180128033A KR102129178B1 (ko) 2018-10-25 2018-10-25 심근경색 예방 또는 치료용 재조합 단백질을 포함하는 심근경색 예방 또는 치료용 조성물

Publications (2)

Publication Number Publication Date
KR20200046618A KR20200046618A (ko) 2020-05-07
KR102129178B1 true KR102129178B1 (ko) 2020-07-01

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KR1020180128033A KR102129178B1 (ko) 2018-10-25 2018-10-25 심근경색 예방 또는 치료용 재조합 단백질을 포함하는 심근경색 예방 또는 치료용 조성물

Country Status (2)

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KR (1) KR102129178B1 (fr)
WO (1) WO2020085545A1 (fr)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101486114B1 (ko) * 2011-11-30 2015-01-28 고려대학교 산학협력단 Milk fat globule ― EGF factor 8(MFGE8)을 이용한 간 재생 및 간 질환 개선 용도
WO2015025956A1 (fr) * 2013-08-22 2015-02-26 国立大学法人九州大学 Composition pharmaceutique pour le traitement des lésions du myocarde, composition pharmaceutique pour la prévention des lésions du myocarde, composition pharmaceutique pour le traitement de l'insuffisance cardiaque, composition pharmaceutique pour la prévention de l'insuffisance cardiaque, procédé de traitement ou de prévention des lésions du myocarde ou de l'insuffisance cardiaque, mfg-e8, utilisations de mfg-e8 et procédé de criblage de composés permettant de traiter ou de prévenir les lésions du myocarde ou l'insuffisance cardiaque
KR20170013621A (ko) * 2015-07-28 2017-02-07 (주) 넥셀 Milk fat globule-EGF factor(MFG-E8)을 이용한 조직섬유화 예방 또는 치료용 조성물
WO2017118764A1 (fr) * 2016-01-07 2017-07-13 Thomas Brocker Nouvelles approches pour la visualisation in vivo et in vitro de cellules mourantes

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Barallobre-Barreiro J et al., Circulation. 2012, 125(6), pp.789-802 (2012.02.14.)
Deng et al., Hypertension, 2017,10, pp.770-779 (2017.10.)
Genebank, AAP36434.1, Homo sapiens milk fat globule-EGF factor 8 protein, partial [synthetic construct], (2016.07.25.)
Genebank, XP_016877695.1, lactadherin isoform X2 [Homo sapiens], (2018.05.26.)

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WO2020085545A1 (fr) 2020-04-30
KR20200046618A (ko) 2020-05-07

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