KR102128957B1 - 조절가능한 프로모터 - Google Patents

조절가능한 프로모터 Download PDF

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KR102128957B1
KR102128957B1 KR1020197005781A KR20197005781A KR102128957B1 KR 102128957 B1 KR102128957 B1 KR 102128957B1 KR 1020197005781 A KR1020197005781 A KR 1020197005781A KR 20197005781 A KR20197005781 A KR 20197005781A KR 102128957 B1 KR102128957 B1 KR 102128957B1
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promoter
seq
nucleotide sequence
poi
pastoris
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KR20190025048A (ko
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디트하드 마타노비치
브리지트 개서
마이클 마우러
롤랜드 프리엘호퍼
요아힘 클라인
자나 웽거
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론자 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01012—Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) (1.2.1.12)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
KR1020197005781A 2011-10-07 2012-10-05 조절가능한 프로모터 Active KR102128957B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161544451P 2011-10-07 2011-10-07
EP11184323 2011-10-07
EP11184323.1 2011-10-07
US61/544,451 2011-10-07
EP12171006 2012-06-06
EP12171006.5 2012-06-06
PCT/EP2012/069757 WO2013050551A1 (en) 2011-10-07 2012-10-05 Regulatable promoter

Related Parent Applications (1)

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KR1020147009284A Division KR101954389B1 (ko) 2011-10-07 2012-10-05 조절가능한 프로모터

Publications (2)

Publication Number Publication Date
KR20190025048A KR20190025048A (ko) 2019-03-08
KR102128957B1 true KR102128957B1 (ko) 2020-07-02

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KR1020197005781A Active KR102128957B1 (ko) 2011-10-07 2012-10-05 조절가능한 프로모터
KR1020147009284A Active KR101954389B1 (ko) 2011-10-07 2012-10-05 조절가능한 프로모터

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US (4) US9512432B2 (cg-RX-API-DMAC7.html)
EP (2) EP3508494B1 (cg-RX-API-DMAC7.html)
JP (1) JP6113736B2 (cg-RX-API-DMAC7.html)
KR (2) KR102128957B1 (cg-RX-API-DMAC7.html)
CN (3) CN113788884B (cg-RX-API-DMAC7.html)
AR (1) AR088252A1 (cg-RX-API-DMAC7.html)
AU (1) AU2012320421B2 (cg-RX-API-DMAC7.html)
BR (1) BR112014008152A2 (cg-RX-API-DMAC7.html)
CA (1) CA2849856C (cg-RX-API-DMAC7.html)
DK (1) DK3508494T3 (cg-RX-API-DMAC7.html)
ES (1) ES2913825T3 (cg-RX-API-DMAC7.html)
IL (1) IL231859B (cg-RX-API-DMAC7.html)
IN (1) IN2014DN03419A (cg-RX-API-DMAC7.html)
PL (1) PL2764016T3 (cg-RX-API-DMAC7.html)
SG (2) SG11201400811QA (cg-RX-API-DMAC7.html)
TW (1) TWI560272B (cg-RX-API-DMAC7.html)
WO (1) WO2013050551A1 (cg-RX-API-DMAC7.html)

Families Citing this family (25)

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KR102128957B1 (ko) * 2011-10-07 2020-07-02 론자 리미티드 조절가능한 프로모터
CN104195165A (zh) * 2014-09-01 2014-12-10 北京爱必信生物技术有限公司 包含葡萄糖启动子的载体、宿主菌以及重组牛源胰蛋白酶的制备方法
WO2016077457A1 (en) 2014-11-11 2016-05-19 Clara Foods Co. Methods and compositions for egg white protein production
CA2992170C (en) * 2015-08-05 2022-08-16 Lonza Ltd Artificial pg1-x promoters
IL261411B2 (en) 2016-03-02 2024-03-01 Lonza Ag Improved fermentation process
CN110088279A (zh) * 2016-12-15 2019-08-02 株式会社钟化 新型宿主细胞及使用了其的目标蛋白质的制造方法
BR112020016258A2 (pt) * 2018-02-12 2020-12-15 Lonza Ltd Uma célula hospedeira eucariótica modificada geneticamente projetada para reduzir a produção de proteínas da célula hospedeira, método de produzir uma proteína de interesse usando a célula hospedeira, método para reduzir a contaminação por proteína da célula hospedeira
EP3536784A1 (en) 2018-03-05 2019-09-11 ACIB GmbH Host cell engineered for improved metabolite production
WO2019236451A1 (en) * 2018-06-07 2019-12-12 Basf Se Promoter for yeast
ES2921137T5 (en) * 2019-01-11 2025-05-06 Lonza Ag Carbon-source regulated protein production in a recombinant host cell
EP3690052B1 (en) * 2019-01-29 2023-04-19 Clariant Produkte (Deutschland) GmbH Chimeric promoter for use in metabolic engineering
US12270034B2 (en) 2019-04-01 2025-04-08 Universität Für Bodenkultur Wien Mut- methylotrophic yeast
WO2020200415A1 (en) 2019-04-01 2020-10-08 Lonza Ltd Mut- methylotrophic yeast
WO2020200414A1 (en) 2019-04-01 2020-10-08 Lonza Ltd Protein production in mut-methylotrophic yeast
FI13395Y1 (fi) 2019-07-11 2023-06-06 Clara Foods Co Koostumuksia, jotka käsittävät rekombinanttia ovomukoidiproteiinia
US12096784B2 (en) 2019-07-11 2024-09-24 Clara Foods Co. Protein compositions and consumable products thereof
US10927360B1 (en) 2019-08-07 2021-02-23 Clara Foods Co. Compositions comprising digestive enzymes
CA3171636A1 (en) 2020-03-26 2021-09-30 Graham WHYTESIDE Forskolin-inducible promoters and hypoxia-inducible promoters
ES3034258T3 (en) 2020-04-01 2025-08-14 Lonza Ag Helper factors for expressing proteins in yeast
WO2021209743A1 (en) 2020-04-15 2021-10-21 Synpromics Limited Forskolin-inducible promoters and hypoxia-inducible promoters
KR20230075436A (ko) 2020-09-30 2023-05-31 론자 리미티드 번역 인자를 과발현하는 숙주 세포
EP4291659A1 (en) 2021-02-12 2023-12-20 Boehringer Ingelheim RCV GmbH & Co KG Signal peptides for increased protein secretion
EP4638756A1 (en) 2022-12-20 2025-10-29 Lonza Ltd. Host cells with pat1 knockout for increased specific protein productivity
WO2025247966A1 (en) 2024-05-29 2025-12-04 Mybios Gmbh Process for protein production in methylotrophic yeast host cell.
WO2026027251A1 (en) 2024-08-01 2026-02-05 Boehringer Ingelheim Rcv Gmbh & Co Kg Signal peptides for increased protein secretion

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WO2006089329A2 (en) 2005-02-23 2006-08-31 Technische Universität Graz Mutant aox 1 promoters

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KR102128957B1 (ko) * 2011-10-07 2020-07-02 론자 리미티드 조절가능한 프로모터
CA2992170C (en) 2015-08-05 2022-08-16 Lonza Ltd Artificial pg1-x promoters

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Also Published As

Publication number Publication date
JP2014530016A (ja) 2014-11-17
IL231859B (en) 2020-08-31
KR101954389B1 (ko) 2019-03-06
KR20190025048A (ko) 2019-03-08
US20170037418A1 (en) 2017-02-09
EP3508494A1 (en) 2019-07-10
US11976284B2 (en) 2024-05-07
EP2764016A1 (en) 2014-08-13
PL2764016T3 (pl) 2019-08-30
WO2013050551A1 (en) 2013-04-11
AU2012320421B2 (en) 2017-03-02
AR088252A1 (es) 2014-05-21
CN110055248A (zh) 2019-07-26
US10301634B2 (en) 2019-05-28
DK3508494T3 (da) 2022-05-23
TWI560272B (en) 2016-12-01
BR112014008152A2 (pt) 2017-04-18
CN113788884B (zh) 2024-07-23
CN113788884A (zh) 2021-12-14
US20220259608A1 (en) 2022-08-18
SG11201400811QA (en) 2014-08-28
CN103998460A (zh) 2014-08-20
IN2014DN03419A (cg-RX-API-DMAC7.html) 2015-05-22
US20190185866A1 (en) 2019-06-20
EP3508494B1 (en) 2022-02-23
US20140242636A1 (en) 2014-08-28
AU2012320421A1 (en) 2014-03-20
IL231859A0 (en) 2014-05-28
JP6113736B2 (ja) 2017-04-12
KR20140069112A (ko) 2014-06-09
TW201317350A (zh) 2013-05-01
ES2913825T3 (es) 2022-06-06
CA2849856A1 (en) 2013-04-11
EP2764016B1 (en) 2019-03-13
CA2849856C (en) 2023-03-14
US9512432B2 (en) 2016-12-06
US11401523B2 (en) 2022-08-02
SG10201602673PA (en) 2016-05-30

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