KR102117202B1 - 항ｃｄ19 항체 및 퓨린 유사체를 이용한 병용 요법 - Google Patents

항ｃｄ19 항체 및 퓨린 유사체를 이용한 병용 요법 Download PDF

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KR102117202B1
KR102117202B1 KR1020197022418A KR20197022418A KR102117202B1 KR 102117202 B1 KR102117202 B1 KR 102117202B1 KR 1020197022418 A KR1020197022418 A KR 1020197022418A KR 20197022418 A KR20197022418 A KR 20197022418A KR 102117202 B1 KR102117202 B1 KR 102117202B1
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KR20190094478A (ko
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주타 아메르스도르페르
슈테판 슈테이들
마르크 빈테리히
수잔 크론
리사 로즈크예르
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모르포시스 아게
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
KR1020197022418A 2011-08-16 2012-08-14 항ｃｄ19 항체 및 퓨린 유사체를 이용한 병용 요법 Active KR102117202B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161523862P 2011-08-16 2011-08-16
EP11177660 2011-08-16
US61/523,862 2011-08-16
EP11177660.5 2011-08-16
PCT/EP2012/065904 WO2013024095A1 (en) 2011-08-16 2012-08-14 Combination therapy with an anti - cd19 antibody and a purine analog

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020147006942A Division KR20140071368A (ko) 2011-08-16 2012-08-14 항ｃｄ19 항체 및 퓨린 유사체를 이용한 병용 요법

Related Child Applications (1)

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KR1020207014644A Division KR20200060779A (ko) 2011-08-16 2012-08-14 항ｃｄ19 항체 및 퓨린 유사체를 이용한 병용 요법

Publications (2)

Publication Number Publication Date
KR20190094478A KR20190094478A (ko) 2019-08-13
KR102117202B1 true KR102117202B1 (ko) 2020-06-01

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KR1020197022418A Active KR102117202B1 (ko) 2011-08-16 2012-08-14 항ｃｄ19 항체 및 퓨린 유사체를 이용한 병용 요법
KR1020207014644A Withdrawn KR20200060779A (ko) 2011-08-16 2012-08-14 항ｃｄ19 항체 및 퓨린 유사체를 이용한 병용 요법
KR1020147006942A Ceased KR20140071368A (ko) 2011-08-16 2012-08-14 항ｃｄ19 항체 및 퓨린 유사체를 이용한 병용 요법

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KR1020207014644A Withdrawn KR20200060779A (ko) 2011-08-16 2012-08-14 항ｃｄ19 항체 및 퓨린 유사체를 이용한 병용 요법
KR1020147006942A Ceased KR20140071368A (ko) 2011-08-16 2012-08-14 항ｃｄ19 항체 및 퓨린 유사체를 이용한 병용 요법

Country Status (25)

Country Link
US (3) US20140227277A1 (https=)
EP (2) EP4083071A3 (https=)
JP (1) JP6114273B2 (https=)
KR (3) KR102117202B1 (https=)
CN (1) CN103703027B (https=)
AU (1) AU2012296905B2 (https=)
BR (1) BR112013033916B1 (https=)
CA (1) CA2841738C (https=)
CY (1) CY1125148T1 (https=)
DK (1) DK2744826T3 (https=)
ES (1) ES2909720T3 (https=)
HR (1) HRP20220224T1 (https=)
HU (1) HUE058855T2 (https=)
IL (1) IL230295B (https=)
LT (1) LT2744826T (https=)
MX (1) MX353589B (https=)
PL (1) PL2744826T3 (https=)
PT (1) PT2744826T (https=)
RS (1) RS63121B1 (https=)
RU (1) RU2664462C9 (https=)
SG (1) SG10201606788VA (https=)
SI (1) SI2744826T1 (https=)
SM (1) SMT202200160T1 (https=)
WO (1) WO2013024095A1 (https=)
ZA (1) ZA201401835B (https=)

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GB2514591A (en) * 2013-05-30 2014-12-03 Mologen Ag Predictive biomarker for cancer therapy
ES2523901B1 (es) * 2013-05-31 2015-12-02 Universidad Autónoma de Madrid Uso de la deguelina como terapia suplementaria de la leucemia linfoide crónica
IL249533A0 (en) * 2014-06-16 2017-02-28 Xencor Inc Treatment of chronic lymphocytic leukemia
AU2015277516A1 (en) * 2014-06-16 2016-12-22 Xencor, Inc. Treatment for chronic lymphocytic leukemia (CLL)
LT3302550T (lt) 2015-05-26 2019-11-11 Morphosys Ag Anti-cd19 antikūno ir brutono tirozino kinazės inhibitoriaus derinys ir jo naudojimas
RU2767063C2 (ru) 2015-08-21 2022-03-16 МорфоСис АГ Комбинации и их использование
FI3916392T3 (fi) * 2016-05-30 2024-06-03 Incyte Corp Menetelmiä cd19-vasta-ainehoidon terapeuttisen hyödyn ennakoimiseksi potilailla
US12358983B2 (en) * 2016-10-28 2025-07-15 Incyte Corporation Combination of anti CD19 antibody with a BCL-2 inhibitor and uses thereof
LT3630177T (lt) * 2017-05-31 2023-10-25 Morphosys Ag Gydymo paradigma, skirta kompleksiniam gydymui anti-cd19 antikūnu ir venetoklaksu
EA202090020A1 (ru) 2017-07-10 2020-04-28 Интернэшнл - Драг - Дивелопмент - Байотек Лечение b-клеточных злокачественных новообразований с использованием афукозилированных проапоптотических анти-cd19 антител в сочетании с анти-cd20 антителами или химиотерапевтическими средствами
KR20200030337A (ko) 2018-09-12 2020-03-20 주식회사 녹십자랩셀 종양 치료를 위한 항-cd 19 항체 및 자연살해세포를 포함하는 약학적 조합물
WO2020150513A1 (en) * 2019-01-17 2020-07-23 Fred Hutchinson Cancer Research Center Methods to enhance the selectivity and effectiveness of cancer treatments
CA3255552A1 (en) * 2021-12-22 2023-06-29 Incyte Corporation TREATMENT PARADIGM FOR ANTI-CD19 ANTIBODY THERAPY
WO2025012080A1 (en) 2023-07-13 2025-01-16 Christian-Albrechts-Universität Zu Kiel Humanized anti-cd7 antibody

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US20110165152A1 (en) * 2009-08-14 2011-07-07 Martin Dreyling Combination therapy of an afucosylated cd20 antibody with fludarabine and/or mitoxantrone

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JP2004508420A (ja) 2000-09-18 2004-03-18 アイデック　ファーマスーティカルズ　コーポレイション Ｂ細胞枯渇抗体／免疫調節性抗体の組合せを用いて自己免疫疾患を治療するための併用療法
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US20100272723A1 (en) * 2006-08-14 2010-10-28 Xencor, Inc. Optimized Antibodies that Target CD19
US20110165152A1 (en) * 2009-08-14 2011-07-07 Martin Dreyling Combination therapy of an afucosylated cd20 antibody with fludarabine and/or mitoxantrone

Also Published As

Publication number Publication date
KR20140071368A (ko) 2014-06-11
RU2014103490A (ru) 2015-09-27
US20240424012A1 (en) 2024-12-26
LT2744826T (lt) 2022-04-25
CN103703027A (zh) 2014-04-02
JP6114273B2 (ja) 2017-04-12
HUE058855T2 (hu) 2022-09-28
RU2664462C9 (ru) 2018-09-28
CN103703027B (zh) 2018-01-12
ES2909720T3 (es) 2022-05-10
PT2744826T (pt) 2022-05-19
US20200352975A1 (en) 2020-11-12
US20140227277A1 (en) 2014-08-14
JP2014525925A (ja) 2014-10-02
KR20200060779A (ko) 2020-06-01
SMT202200160T1 (it) 2022-05-12
AU2012296905B2 (en) 2017-01-05
ZA201401835B (en) 2015-06-24
WO2013024095A1 (en) 2013-02-21
NZ617771A (en) 2016-01-29
RU2664462C2 (ru) 2018-08-17
DK2744826T3 (da) 2022-03-28
RS63121B1 (sr) 2022-05-31
IL230295B (en) 2018-03-29
EP4083071A3 (en) 2023-02-22
BR112013033916B1 (pt) 2022-11-16
CA2841738C (en) 2022-12-06
SI2744826T1 (sl) 2022-05-31
CY1125148T1 (el) 2024-12-13
MX2013014935A (es) 2014-07-09
SG10201606788VA (en) 2016-09-29
PL2744826T3 (pl) 2022-05-30
MX353589B (es) 2018-01-19
HRP20220224T1 (hr) 2022-04-29
BR112013033916A2 (pt) 2017-11-28
EP2744826B1 (en) 2022-02-09
KR20190094478A (ko) 2019-08-13
CA2841738A1 (en) 2013-02-21
EP2744826A1 (en) 2014-06-25
EP4083071A2 (en) 2022-11-02

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