KR102115630B1 - 약물 전달 단백질의 수송-증진 돌연변이체의 단리 - Google Patents

약물 전달 단백질의 수송-증진 돌연변이체의 단리 Download PDF

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KR102115630B1
KR102115630B1 KR1020157005438A KR20157005438A KR102115630B1 KR 102115630 B1 KR102115630 B1 KR 102115630B1 KR 1020157005438 A KR1020157005438 A KR 1020157005438A KR 20157005438 A KR20157005438 A KR 20157005438A KR 102115630 B1 KR102115630 B1 KR 102115630B1
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cell
pro
leu
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KR20150038543A (ko
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랄리 케이. 메디나-카우웨
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세다르스-신나이 메디칼 센터
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/075—Adenoviridae
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1058—Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
KR1020157005438A 2012-08-03 2013-08-02 약물 전달 단백질의 수송-증진 돌연변이체의 단리 Expired - Fee Related KR102115630B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261679306P 2012-08-03 2012-08-03
US61/679,306 2012-08-03
PCT/US2013/053493 WO2014022811A1 (en) 2012-08-03 2013-08-02 Isolating traffic-enhancing mutants of drug delivery protein

Publications (2)

Publication Number Publication Date
KR20150038543A KR20150038543A (ko) 2015-04-08
KR102115630B1 true KR102115630B1 (ko) 2020-05-27

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US (2) US10036009B2 (enExample)
EP (1) EP2880160B1 (enExample)
JP (2) JP6618360B2 (enExample)
KR (1) KR102115630B1 (enExample)
CN (1) CN104619839A (enExample)
AU (2) AU2013296218B2 (enExample)
BR (1) BR112015002004A2 (enExample)
CA (1) CA2881582A1 (enExample)
DK (1) DK2880160T3 (enExample)
ES (1) ES2703052T3 (enExample)
IL (1) IL236955A0 (enExample)
IN (1) IN2015DN01196A (enExample)
MX (1) MX366347B (enExample)
PL (1) PL2880160T3 (enExample)
PT (1) PT2880160T (enExample)
RU (1) RU2015105052A (enExample)
WO (1) WO2014022811A1 (enExample)
ZA (1) ZA201500739B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9078927B2 (en) 2007-07-06 2015-07-14 Cedars-Sinai Medical Center Self-assembling complex for targeting chemical agents to cells
WO2010085665A2 (en) 2009-01-23 2010-07-29 Cedars-Sinai Medical Center Targeted delivery system
KR102115630B1 (ko) * 2012-08-03 2020-05-27 세다르스-신나이 메디칼 센터 약물 전달 단백질의 수송-증진 돌연변이체의 단리
JP6640715B2 (ja) 2013-05-08 2020-02-05 セダーズ−シナイ メディカル センター 腫瘍毒性に対する標的コロールおよびｍｒｉ
CN106413738B (zh) 2014-01-17 2020-12-29 席德-西奈医疗中心 受体靶向构造物和其使用
CN106170305A (zh) 2014-04-04 2016-11-30 席德-西奈医疗中心 用her3靶向纳米粒子靶向曲妥珠单抗抗性her2+乳腺癌

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2009009441A2 (en) * 2007-07-06 2009-01-15 Cedars-Sinai Medical Center Self-assembling complex for targeting chemical agents to cells

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JP6640715B2 (ja) 2013-05-08 2020-02-05 セダーズ−シナイ メディカル センター 腫瘍毒性に対する標的コロールおよびｍｒｉ
CN106413738B (zh) 2014-01-17 2020-12-29 席德-西奈医疗中心 受体靶向构造物和其使用
CN106170305A (zh) 2014-04-04 2016-11-30 席德-西奈医疗中心 用her3靶向纳米粒子靶向曲妥珠单抗抗性her2+乳腺癌
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PL2880160T3 (pl) 2019-03-29
BR112015002004A2 (pt) 2017-07-04
KR20150038543A (ko) 2015-04-08
EP2880160A4 (en) 2016-04-20
IL236955A0 (en) 2015-03-31
AU2013296218A1 (en) 2015-02-19
US10036009B2 (en) 2018-07-31
PT2880160T (pt) 2018-12-17
WO2014022811A1 (en) 2014-02-06
JP6618360B2 (ja) 2019-12-11
EP2880160B1 (en) 2018-09-19
CN104619839A (zh) 2015-05-13
ZA201500739B (en) 2018-07-25
US20180298376A1 (en) 2018-10-18
US10752893B2 (en) 2020-08-25
RU2015105052A (ru) 2016-09-27
AU2013296218B2 (en) 2019-07-18
JP2020002138A (ja) 2020-01-09
EP2880160A1 (en) 2015-06-10
MX366347B (es) 2019-07-05
ES2703052T3 (es) 2019-03-06
DK2880160T3 (en) 2019-01-14
CA2881582A1 (en) 2014-02-06
IN2015DN01196A (enExample) 2015-06-26
MX2015001366A (es) 2015-08-13
AU2019204815A1 (en) 2019-07-25
JP2015527343A (ja) 2015-09-17
US20150240231A1 (en) 2015-08-27

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