KR102076002B1 - Composition for improving hair and scalp condition coprising extract of korean fir - Google Patents

Abstract

The present specification relates to a composition for improving hair and scalp conditions, including a spherical tree extract. More specifically, by including a spherical tree extract has the effect of alleviating the itching, dandruff production of the scalp, and relates to a composition for improving hair and scalp conditions exhibiting hair loss prevention and hair growth promoting effect. Therefore, the composition for improving hair and scalp conditions of the present specification can be used as a pharmaceutical, food or cosmetic composition.

Description

COMPOSITION FOR IMPROVING HAIR AND SCALP CONDITION COPRISING EXTRACT OF KOREAN FIR}

The present specification relates to a composition for improving hair and scalp conditions, including a spherical tree extract.

In the modern society, which emphasizes beauty, hair dyes and perm agents are used to satisfy the needs of individual expression. In addition, various harmful substances from the outside are constantly polluting the scalp and hair. In some cases of sensitive scalp, such treatments as dyeing and perming may cause irritation and inflammation such as itching or stinging of the scalp. This irritation and inflammation leads to environmental hair loss, and thus, various studies are being actively conducted to prevent hair loss causing severe mental pain and to promote hair growth.

Therefore, there is an urgent need to develop compositions that are effective in improving the scalp condition due to the use of various hair dyes, permants, and the like, as well as preventing hair loss and promoting hair growth.

Recently, in order to solve the above problems, many external skin composition such as cosmetics using natural products have been developed. In this regard, the present inventors studied the possibility of application as an external preparation for skin from plants which are not widely known.

KR 10-0960054 B1

The inventors of the present specification solved the above problems and when using the hair and scalp to study the composition that can be used to suppress dandruff and improve scalp itching and at the same time provide a hair loss prevention and hair growth effect, when containing a spruce extract In order to solve this problem, the present invention has been completed.

Therefore, the problem to be solved by the present specification is to provide a composition that can improve the hair and scalp conditions.

In order to solve the above object, the present disclosure provides a composition for improving the hair and scalp state comprising the spherical tree extract as an active ingredient.

In one aspect of the present specification, the composition may be a composition for preventing dandruff or improving scalp itch and preventing hair loss and promoting hair growth.

        According to the composition for improving the hair and scalp condition comprising the spherical tree extract of the present disclosure, it is possible to provide a scalp itch improvement and anti-dandruff effect, hair loss prevention and hair growth promoting effect, such as a cosmetic composition and external pharmaceutical composition such as pharmaceutical composition Can be used as

In an aspect, the present disclosure may relate to a composition comprising an Abies Koreana extract as an active ingredient.

In one aspect of the present disclosure, the composition may be a pharmaceutical, food, or cosmetic composition.

In one aspect of the present specification, the composition may be a composition for improving hair or scalp condition.

In one aspect of the present disclosure, hair or scalp condition improvement comprises: relieving scalp irritation; Inhibiting scalp itching; Improving, preventing or treating dandruff; Improving, preventing or treating hair loss; Or promote hair growth.

In one aspect of the present specification, the globular tree may be one or more selected from the group consisting of a leaf, bark, and conifer of the globular tree.

In one aspect of the present specification, the spherical tree extract may be extracted by mixing the leaves, conifers and bark in a weight ratio of 7: 2: 1. The weight ratio may be a weight ratio of 1 to 10: 1 to 3: 1, or a weight ratio of 6 to 8: 1.5 to 2.5: 1.

In one aspect of the present specification, the globular tree extract may be one or more extracts selected from the group consisting of water, an organic solvent and a mixture thereof. The organic solvent may be one or more organic solvents selected from the group consisting of ethanol, butylene glycol, and propylene glycol.

In one aspect of the present specification, the composition may be a topical skin composition.

In the present specification, the spherical tree (Korean fir, Abies Koreana ) is a perennial coniferous plant of the family of pineaceae native to 500 ~ 2,000m above sea level of Halla, Jirisan, Deogyusan, Mudeungsan, and is a special plant that grows only in Korea. It is used as building materials and furniture materials, and it is planted for ornamental purposes in parks, botanical gardens and gardens. As used herein, the spherical tree was sampled from Amorepacific Institute of Technology as landscape water.

The method for producing the spherical tree extract used herein is not particularly limited, and in the present specification, the spherical tree extract may be a leaching solution obtained by leaching from a spherical tree, and a concentrate obtained by partially or completely concentrating the leaching solution, again Extraction extract prepared by drying the concentrate, or an oil obtained by distillation or containing a chemical substance itself which exhibits the main effect contained in the extract.

As used herein, the spherical tree may be included in the form of an extract, or may be included as a ground powder of the herbal medicine, or as a dry ground powder of the herbal medicine, but is not limited thereto. In addition, the spherical tree used in the present specification is not limited to the method of acquiring, may be grown and used or purchased commercially available, can be used part or all of the ground or root portion of the wood, preferably all of the ground portion Can be used. Specifically, one or more selected from the group consisting of leaves, bark and conifers of spherical tree wood may be used.

As used herein, the term "extract" includes all materials obtained by extracting the components of natural products, regardless of the extraction method, the extraction solvent, the extracted components, or the form of the extract. It is a broad concept that includes all of the materials that can be obtained by processing or processing in a method.

As used herein, the term "nobular tree extract" includes all materials obtained by extracting the nobular components regardless of the extraction method, the extraction solvent, the extracted components or the form of the extract, and in the process of extracting the components, heat, acid It may include materials obtained through extraction methods including processing with acid, base, enzyme and the like, and may be obtained by extracting the components of spherical wood and processing or treating them by other methods after extraction. It is a broad concept that includes all the substances present.

In one aspect of the present disclosure, the globular tree extract may include washing and drying the globular tree; Solvent extracting the dried globose; And it can be obtained through the step of filtering the extracted spherical tree. In the above, the solvent includes at least one selected from the group consisting of water, an organic solvent, and a mixture of water and an organic solvent. In the above, water includes distilled water or purified water, and the organic solvent is selected from the group consisting of alcohol, acetone, ether, ethyl acetate, diethyl ether, ethyl methyl ketone, and chloroform, including C ₁ to C ₅ lower alcohols. Including but not limited to one or more.

The spherical tree extract may include a spherical tree-C ₁ ~ C ₆ alcohol extract, specifically, the alcohol may be methanol or ethanol.

The spherical tree extract herein may be a crude extract of water, a C ₁ -C ₆ alcohol, and a solvent selected from the group consisting of a combination thereof. The C ₁ -C ₆ alcohol may be specifically methanol. When extracting the spherical tree with a solvent, it is preferable to extract by adding a solvent corresponding to about 5 to 15 times the spherical tree, specifically, it is preferable to extract by adding about 10 times the solvent, but is not limited thereto. The extraction may be a heat extraction, cold extraction, reflux cooling extraction, or ultrasonic extraction, and the like, there is no limitation if the extraction is obvious to those skilled in the art. The extraction may be performed at room temperature, but for more efficient extraction, the extraction may be performed under heating conditions, and preferably at about 40 to 100 ° C., more preferably at about 80 ° C., but is not limited thereto. It is not. The extraction time is preferably about 2 to 4 hours, more preferably about 3 hours, but is not limited thereto, and may vary depending on conditions such as extraction solvent and extraction temperature. The extraction may be extracted one or more times several times in order to obtain a larger amount of the active ingredient, preferably 1 to 5 times, more preferably three times the continuous extraction can be used combined extract.

In the present specification, the spherical tree extract may include the crude extract of the spherical tree as described above, and may include the crude extract as a soluble fraction of the organic solvent obtained by further extracting the organic extract with a low polarity. Hexane, methylene chloride, ethyl acetate, n-butanol, and the like may be used as the organic solvent, but is not limited thereto. The extract extracted by the above method or a soluble fraction of the extract may be used as it is, but may be used in the form of an extract by concentration after filtration, it may be used as a form of a lyophilized by lyophilization after concentration.

In the present specification, the term "hair" is a general term for body hair and hair, and may also be described as hair. The hair includes both human and animal hair.

The globular tree extract of the present specification comprises the steps of slicing and drying the globular tree; Adding reflux and adding water, an organic solvent, or a combination thereof to the dried spherical tree; Depositing the extract followed by filtration with a filter cloth; Centrifuging the filtrate to separate the residue and the filtrate; Concentrating the separated filtrate under reduced pressure to obtain a spherical tree extract; it can be obtained by a method comprising a.

In one aspect of the present specification, the globular tree extract is composed of purified water, ethanol, butylene glycol, and propylene glycol such that the spherical tree concentrate concentrated under reduced pressure according to the above method is included in 5% by weight, based on the total weight of the extract. It may be prepared by dispersion / dissolution using one or more solvents selected from the group.

In addition, in the extraction process of the globular tree extract of the present specification, for example, water or an organic solvent is put in a fine and dried globular tree, reflux extraction is carried out, and the residue and the filtrate are separated by filtration and centrifugation. The separated filtrate can be concentrated under reduced pressure to obtain a spherical tree extract. The organic solvent usable herein may be selected from ethanol, methanol, butanol, ether, ethyl acetate, chloroform or a mixed solvent of these organic solvents and water, and considering the safety of the raw material, preferably 100% water, 70% ethanol Or butylene glycol (Butylene Glycol) is used. At this time, the extraction temperature is preferably 18 ~ 80 ℃ for water, 18 ~ 40 ℃ is preferable for 70% ethanol and butylene glycol, the extraction time is preferably 6 ~ 168 hours. Outside the extraction temperature and extraction time, extraction efficiency may decrease or components may change. After obtaining the extract using a solvent in the above can be obtained by cooling, heating and filtration at room temperature in a conventional manner known in the art to obtain a liquid, or may further evaporate the solvent, spray drying or freeze drying. In addition, freeze-drying may be carried out freeze-drying for 3 to 4 days at -50 to -70 ℃.

In the present specification, the spherical tree extract may be included in 0.00005 to 50% by weight based on the total weight of the composition. More preferably 0.1 to 1% by weight or 0.5 to 10% by weight may be used. Less than 0.00005% by weight of the bulbous tree extract is ineffective, and more than 50% by weight may cause stability or formulation problems. Specifically, the spherical tree extract is 0.0001% by weight, 0.0005% by weight, 0.001% by weight, 0.01% by weight, 0.1% by weight, 0.3% by weight, 0.5% by weight, 0.8% by weight or more based on the total weight of the composition , 1% by weight, 3% by weight, 5% by weight, 7% by weight, 10% by weight, 15% by weight, 20% by weight, 25% by weight, 30% by weight, 35% by weight Or, 40 wt% or more and 60 wt% or less or 50 wt% or less.

In one aspect of the present specification, the concentration of the globular tree extract may be 0.01 ug / mL to 100 ug / mL. In addition, the concentration of the globular tree extract is 0.01ug / mL or more, 0.1ug / mL or more, 0.3ug / mL or more, 0.4ug / mL or more, 0.5ug / mL or more, 0.6ug / mL or more, 0.7ug / mL or more, It may be at least 1 ug / mL, at least 5 ug / mL, at least 10 ug / mL, at least 100 ug / mL, or at least 1000 ug / mL and may be at most 100 mg / mL or at most 10 mg / mL.

The pharmaceutical composition according to the present disclosure may be various oral or parenteral formulations. When formulated, diluents or excipients such as fillers, extenders, binders, wetting agents, disintegrating agents and surfactants are usually used. Solid form preparations for oral administration include tablets, pills, powders, granules, soft or hard capsules, and the like, which may contain at least one excipient such as starch, calcium carbonate, sucrose, or the like. Or lactose, gelatin, or the like is mixed. In addition to simple excipients, lubricants such as magnesium stearate, talc and the like are also used. Liquid preparations for oral administration include suspensions, liquid solutions, emulsions, and syrups, and may include various excipients, such as wetting agents, sweeteners, fragrances, and preservatives, in addition to commonly used simple diluents such as water and liquid paraffin. have. Formulations for parenteral administration include sterile aqueous solutions, non-aqueous solvents, suspensions, emulsions, lyophilized preparations, suppositories. As the non-aqueous solvent and the suspension solvent, propylene glycol, polyethylene glycol, vegetable oils such as olive oil, injectable esters such as ethyl oleate, and the like can be used. As the base of the suppository, witepsol, macrogol, tween 61, cacao butter, laurin butter, glycerogelatin and the like can be used.

Pharmaceutical dosage forms of the compositions herein may be used in the form of their pharmaceutically acceptable salts, and may be used alone or in combination with other pharmaceutically active compounds as well as in a suitable collection. The salt is not particularly limited as long as it is pharmaceutically acceptable. For example, hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, hydrofluoric acid, hydrobromic acid, formic acid acetic acid, tartaric acid, lactic acid, citric acid, fumaric acid, maleic acid, succinic acid, methanesulfonic acid , Benzene sulfonic acid, toluene sulfonic acid, naphthalene sulfonic acid and the like can be used.

The composition of the present disclosure may be parenterally or orally administered as desired, and may be administered in one to several times to be administered in an amount of 0.1 to 500 mg, preferably 1 to 100 mg per kg of body weight per day. have. The dosage for a particular patient may vary depending on the patient's weight, age, sex, health condition, diet, time of administration, method of administration, rate of excretion, severity of the disease, and the like.

The pharmaceutical composition according to the present specification may be a powder, granules, tablets, soft or hard capsules, suspensions, emulsions, syrups, oral formulations such as aerosols, ointments, creams, etc. And sterile injectable solutions and the like, and may be formulated in any form suitable for pharmaceutical preparations.

Compositions according to the present disclosure can be administered to mammals such as rats, mice, livestock, humans, etc. by various routes, such as parenteral, oral, and all modes of administration can be expected, for example, oral, rectal Or by intravenous, intramuscular, subcutaneous, intrauterine dural or intracerebroventricular injection.

In one aspect of the present disclosure, the food composition may be a nutraceutical composition.

The formulation of the food composition according to the present disclosure is not particularly limited, but may be, for example, formulated into a liquid such as tablets, granules, powders, drinks, caramels, gels, bars, and the like. In addition to the active ingredient, the food composition of each formulation may be suitably selected by those skilled in the art according to the formulation or purpose of use in addition to the active ingredient, and a synergistic effect may occur when simultaneously applied with other raw materials.

In the food composition according to the present specification, the dosage determination of the active ingredient is within the level of those skilled in the art, and the daily dosage thereof is, for example, 0.1 mg / kg / day to 5000 mg / kg / day, more specifically 50 It may be mg / kg / day to 500 mg / kg / day, but is not limited thereto, and may vary depending on various factors such as age, health condition, complications of the subject to be administered.

The food composition according to the present specification may be, for example, various functional foods such as chewing gum, caramel products, candy, ice cream, confectionery, beverage products such as soft drinks, mineral water, alcoholic drinks, vitamins and minerals, and the like. Can be.

In addition to the above, the food composition, which is an aspect of the present specification, may include various nutrients, vitamins, minerals (electrolytes), synthetic flavors such as synthetic and natural flavors, colorants and enhancers (such as cheese, chocolate), pectic acid and salts thereof, Alginic acid and salts thereof, organic acids, protective colloidal thickeners, pH regulators, stabilizers, preservatives, glycerin, alcohols, carbonation agents used in carbonated beverages, and the like. In addition, the functional food compositions of the present disclosure may include a natural fruit juice and a pulp for the production of fruit juice beverages and vegetable beverages. These components can be used independently or in combination. The proportion of such additives is not so critical but is typically included in the range of 0 to about 20 parts by weight per 100 parts by weight of the composition herein.

       In one aspect of the present specification, the composition is not particularly limited in formulating, but a cosmetic composition having a formulation such as hair tonic, hair nourishing longevity, scalp treatment, hair treatment, hair rinse, hair shampoo, hair lotion, etc. Can be.

In addition, in each formulation, other ingredients in addition to the above-mentioned essential ingredients may be appropriately selected and blended by those skilled in the art without difficulty depending on the kind of the external preparation or the purpose of use.

Cosmetic compositions according to the present disclosure may be provided in all formulations suitable for topical application. For example, it may be provided in the form of a solution, an emulsion obtained by dispersing an oil phase in an aqueous phase, an emulsion obtained by dispersing an aqueous phase in an oil phase, a suspension, a solid, a gel, a powder, a paste, a microneedle, a foam, or an aerosol composition. have. Compositions of such formulations may be prepared according to conventional methods in the art.

The cosmetic composition according to the present disclosure may further include functional additives and components included in general cosmetic compositions in addition to the spherical tree extract. The functional additive may include a component selected from the group consisting of water-soluble vitamins, oil-soluble vitamins, polymer peptides, polymer polysaccharides, sphingolipids and seaweed extract.

The cosmetic composition according to the present disclosure may include other components in addition to the spherical tree extract in a range that does not impair the main effect, and preferably may have a synergistic effect on the main effect. In addition, the cosmetic composition according to the present specification may further include a moisturizer, an emulsifier, a surfactant, a ultraviolet absorbent, a preservative, a bactericide, an antioxidant, a pH adjuster, an organic and an inorganic pigment, a perfume, a cooling agent, or a restricting agent. The blending amount of the above components can be easily selected by those skilled in the art within the range that does not impair the purpose and effect of the present specification, the blending amount may be 0.01 to 5% by weight, specifically 0.01 to 3% by weight based on the total weight of the composition. have.

Hereinafter, the present specification will be described in detail with reference to Examples, Comparative Examples, and Test Examples of the present specification. These are only presented by way of example only to more specifically describe the present specification, the scope of the present specification is not limited by these Examples, Comparative Examples and Test Examples.

Preparation Example 1 Preparation of Spruce Tree Extract

Whatman # 5 filter paper was extracted and cooled by refluxing the dried leaves, conifers, and bark of dry bulbous trees at a weight ratio of 7: 2: 1 and refluxing three times with a 70% aqueous ethanol solution for 24 hours three times. Filtered with. The filtered extract was concentrated under reduced pressure at 45 ° C. or below and freeze dried at −60 ° C. for 3 days.

A spherical tree extract was prepared by dispersing / dissolving using a ethanol such that the reduced pressure concentrate was included in an amount of 5 wt% based on the total weight of the spheroid extract.

Example 1 and Comparative Example 1

To prepare a shampoo in the composition of Table 1. Specifically, the surfactant and ethylene glycol distearate are added to purified water, heated to 80 ° C., uniformly dissolved, and then slowly cooled to 40 ° C. under stirring, and the spherical tree extract according to the present disclosure is effective in the mixture. Powder, preservative, viscosity regulator, fragrance, and hair conditioner were added and mixed, followed by cooling to room temperature under stirring.

In Comparative Example 1, the spherical tree extract was not included in Comparative Example 1 as a comparative example.

ingredient Example 1 (% by weight) Comparative Example 1 (% by weight) Ammonium Lauryl Sulfate 10 8.0 Polyoxyethylene Lauryl Ammonium Sulfate 5 5 Cocoamidopropylbetaine 2 2 Ethylene Glycol Distearate 1.5 1.5 Cocoyl Monoethanolamide 0.8 0.8 Polyquaternium-10 0.2 0.2 Blue No. 1 0.0002 0.0002 Yellow No. 4 0.0001 0.0001 Methylparaben 0.1 0.1 Spices 0.8 0.8 Citric acid 0.1 0.1 Dimethicone 1.0 1.0 Globular tree extract of Preparation Example 1 5.0 - Purified water To 100 To 100

Test Example 1 Dandruff Reduction Effect Test

Twenty-four males aged 19 to 35 years with relatively high dandruff were selected and used in two groups of 12 people each for Example 1 and Comparative Example 1 in the following manner for one month, and then the dandruff reduction rate was measured.

Trituration with a normal shampoo before the start of the test, and collected the dandruff accumulated for 2 days after the trike, and the weight of the collected dandruff and trituration once every two days with the shampoo of each Example 1, Comparative Example 1 and accumulated for 2 days after the end of the test. The weight of the isolated dandruff was evaluated. At this time, the accumulated dandruff was collected directly from the scalp with a vacuum suction device, to obtain a rate of dandruff reduction based on Equation 1 below and the results are shown in Table 2 below.

[Equation 1]

Example 1 Comparative Example 1 Subject 1 12 1.6 Subject 2 18.9 -0.5 Subject 3 10.5 -0.9 Subject 4 7.8 1.8 Subject 5 15 2.5 Subject 6 5.1 1.1 Subject 7 9 5.9 Subject 8 8.9 3.2 Subject 9 13.8 3.4 Subject 10 15.4 4.8 Subject 11 9.2 3.2 Subject 12 8.5 3.9 medium 11.175 2.5 Standard Deviation 3.924776 2.009522784

As can be seen in Table 2 above, in Example 1 compared to Comparative Example 1, the amount of decrease in dandruff amount of the subjects on average was about 2 times increased. Therefore, in the case of Example 1 including the spherical tree extract it can be seen that it shows an excellent anti-dandruff effect than the case of no spherical tree extract.

Test Example 2 Scalp Itching Prevention Test

Twenty-four men and women aged 25 to 45 who feel severely itchy scalp were divided into two groups of 12 people each to use the shampoo of Example 1 and Comparative Example 1 once every three days for two weeks to prevent scalp itching. The effect was evaluated through the following evaluation criteria and the results are shown in Table 3 below.

[Evaluation standard]

Very good-5 points

Excellent-4 points

Normal-3 points

Poor-2 points

Very bad-1 point

Example 1 Comparative Example 1 Evaluation results 4.0 2.1

As can be seen in Table 3, it can be seen that the case of Example 1 including the spruce tree extract exhibits an effect of preventing better scalp itch compared to Comparative Example 1 (without the spruce tree extract).

[Test Example 3] hair follicle dermal papilla cell proliferation effect test

The keratin proteins that make up hair are produced in hair root keratinocytes, which are differentiated from dermal papilla cells. In order to evaluate the activity of the dermal papilla cells of the composition according to the present specification, human primary dermal papilla cells isolated from human tissue were used. Primary dermal dermal papilla cells were isolated from human tissues, followed by 5% CO2, 37 in DMEM medium (Dulbecco's modified Eagle's medium; Gibco BRL, Gaithersburg, MD, USA) containing 10% Fetal bovine serum (FBS). Incubation was performed for 24 hours in an incubator maintained at ℃.

The cultured human primary dermal papilla cells were treated with the globular tree extract of Preparation Example 1 as shown in Table 4 and incubated in a 96-well plate for 24 hours in a 37 ° C. incubator. Comparative Example 2 is an untreated group not treated with the extract. After 24 hours of drug treatment, cell proliferation was measured using the WST-1 kit (Roche), and the results are shown in Table 5.

Component (ppm) Preparation Example 1 Comparative Example 2 Globose extract 5 -

Preparation Example 1 Comparative Example 2 Cell proliferation rate (%) 123 ± 1.8 100 ± 2.3

In the results of Table 5, it can be seen that there is a papillary cell proliferation effect of Example 1 treated with the globular tree extract. Therefore, it was confirmed that the composition comprising the spherical tree extract according to the present disclosure may promote the growth of hair by promoting the growth of hair papilla cells of hair follicles when treated on the scalp.

Test Example 4 Hair Loss Prevention Effect Test

In order to confirm whether the present invention is effective in preventing hair loss of the scalp hair, the hair loss prevention effect was clinically tested. As a test method, only patients meeting all of the following criteria were enrolled.

1) Men who are over 20 years of age with good physical and mental health

2) Patients who will maintain the same hair during the study

3) Patients who will not stain during the study

4) Patients who will not have special hair products or hair care and manipulation during the study period.

Twenty spontaneous subjects who were subject to the above conditions were carefully selected and tested. The specific patient status was recorded and tested in the evaluation sheet.

The hair loss prevention evaluation method measured the number of hair falling out when the hair. Before using the shampoo corresponding to Example 1 and Comparative Example 1 and after 3 months of using shampoo. The number of hair falling out when the hair was recorded was recorded once daily, and the amount of hair loss was averaged on a monthly basis.

division Comparative Example 2 Preparation Example 1 After 1 month use 17.61 11.73 After 2 months of use 14.12 10.84 After 3 months 12.11 5.98

As such, it was found that the amount of hair loss was significantly reduced by more than half as the number of months after using the shampoo corresponding to Example 1 passed. From the above test results, the present specification confirmed that the present invention provides a composition using the spherical tree extract, which is safe for a living body and provides hair loss prevention and hair growth effects.

Examples of the formulation of the composition according to one aspect of the present specification will be described below, but it is also applicable to various other formulations, which are intended to explain in detail only and not intended to limit the present specification.

Formulation Example 1 Soft Capsule

8 mg of spherical tree extract of Preparation Example 1, 9 mg of vitamin E, 9 mg of vitamin C, 2 mg of palm oil, 8 mg of vegetable hardened oil, 4 mg of lead wax and 9 mg of lecithin were mixed and mixed according to a conventional method to prepare a soft capsule filling solution. 400 mg per capsule is filled to prepare a soft capsule. In addition, a soft capsule sheet is prepared at a ratio of 66 parts by weight of gelatin, 24 parts by weight of glycerine, and 10 parts by weight of sorbitol solution and filled with the filler to prepare a soft capsule containing 400 mg of the composition according to the present specification.

Formulation Example 2 Tablet

8 mg of spherical tree extract of Preparation Example 1, 9 mg of vitamin C, 9 mg of vitamin C, 200 mg of galactooligosaccharide, 60 mg of lactose and 140 mg of maltose were granulated using a fluid bed dryer, and then 6 mg of sugar ester was granulated. Add. Tablets are prepared by tableting 500 mg of these compositions in a conventional manner.

[Formulation Example 3] Drinks

After mixing 8 mg of spherical tree extract of Preparation Example 1, 9 mg of vitamin E, 9 mg of vitamin C, 10 g of glucose, 0.6 g of citric acid, and 25 g of liquid oligosaccharide, 300 ml of purified water was added to each bottle to fill 200 ml. After filling the bottle sterilized for 4 to 5 seconds at 130 ℃ to prepare a drink.

Formulation Example 4 Granules

The spherical tree extract 8 mg, vitamin E 9 mg, vitamin C 9 mg, 250 mg of anhydrous glucose and 550 mg of starch of Preparation Example 1 were mixed, molded into granules using a fluidized bed granulator, and then filled into fabrics to prepare granules.

Formulation Example 5 Injection

Injectables were prepared by conventional methods according to the compositions set forth in Table 7 below.

Compounding ingredients content Globular tree extract of Preparation Example 1 10-50 mg Sterile Distilled Water for Injection Quantity pH regulator Quantity

Formulation Example 6 Health Functional Food

To prepare a health functional food in a conventional manner according to the composition shown in Table 8.

Compounding ingredients content Globular tree extract of Preparation Example 1 20mg Vitamin A Acetate 70 μg Vitamin E 1.0mg Vitamin B1 0.13mg Vitamin B2 0.15mg Vitamin B6 0.5mg Vitamin B12 0.2 μg Vitamin c 10mg Biotin 10 μg Nicotinic acid amide 1.7mg Folic acid 50 μg Calcium Pantothenate 0.5mg Ferrous sulfate 1.75mg Zinc oxide 0.82 mg Magnesium carbonate 25.3 mg Potassium phosphate monobasic 15 mg Dicalcium Phosphate 55 mg Potassium citrate 90 mg Calcium carbonate 100 mg Magnesium chloride 24.8 mg

Although the composition ratio of the said vitamin and mineral mixture was mixed and consisted with the component suitable for a health functional food in a preferable manufacture example, you may change arbitrarily the compounding ratio.

Formulation Example 7 Healthy Drinks

To prepare a health drink in a conventional manner according to the composition shown in Table 9.

Compounding ingredients content Globular tree extract of Preparation Example 1 1000 mg Citric acid 1000 mg oligosaccharide 100 g Taurine 1 g Purified water Remaining amount

The above ingredients are mixed according to a conventional method for preparing a health beverage, then stirred and heated at 85 ° C. for about 1 hour, and then the resulting solution is filtered and sterilized.

 Formulation Example 8 Softener (Skin Lotion)

According to the composition described in Table 10 below to prepare a flexible longevity in a conventional manner.

Compounding ingredients Content (% by weight) Globular tree extract of Preparation Example 1 0.2 glycerin 3.0 Butylene glycol 2.0 Propylene glycol 2.0 Carboxy Vinyl Polymer 0.1 Fiji-12 nonylphenyl ether 0.2 Polysorbate 80 0.4 ethanol 10.0 Triethanolamine 0.1 Preservative, coloring, flavoring Quantity Purified water Remaining amount

Formulation Example 9 Nutritious Longevity (Milk Lotion)

Nutrients were prepared in a conventional manner according to the composition shown in Table 11.

Compounding ingredients Content (% by weight) Globular tree extract of Preparation Example 1 1.0 glycerin 3.0 Butylene glycol 3.0 Propylene glycol 3.0 Carboxy Vinyl Polymer 0.1 Beeswax 4.0 Polysorbate 60 1.5 Caprylic / Capric Triglycerides 5.0 Squalane 5.0 Sorbitassquioleate 1.5 Liquid paraffin 0.5 Cetearyl Alcohol 1.0 Triethanolamine 0.2 Preservative, coloring, flavoring Quantity Purified water Remaining amount

Formulation Example 10 Nutrition Cream

Nutritional cream was prepared in a conventional manner according to the composition shown in Table 12.

Compounding ingredients Content (% by weight) Globular tree extract of Preparation Example 1 2.0 glycerin 3.0 Butylene glycol 3.0 Liquid paraffin 7.0 Beta Glucan 7.0 Carbomer 0.1 Caprylic / Capric Triglycerides 3.0 Squalane 5.0 Cetearyl Glucoside 1.5 Sorbitan stearate 0.4 Polysorbate 60 1.2 Triethanolamine 0.1 Preservative, coloring, flavoring Quantity Purified water Remaining amount

Formulation Example 11 Massage Cream

To prepare a massage cream in a conventional manner according to the composition described in Table 13.

Compounding ingredients Content (% by weight) Globular tree extract of Preparation Example 1 2.0 glycerin 8.0 Butylene glycol 4.0 Liquid paraffin 45.0 Beta Glucan 7.0 Carbomer 0.1 Caprylic / Capric Triglycerides 3.0 Beeswax 4.0 Cetearyl Glucoside 1.5 Sesqui oleic acid sorbitan 0.9 Vaseline 3.0 paraffin 1.5 Preservative, coloring, flavoring Quantity Purified water Remaining amount

Formulation Example 12 Preparation of Hair Lotion

A hair lotion is prepared according to a conventional method with the composition described in Table 14 below.

ingredient Content (% by weight) Purified water Remaining amount glycerin 3.0 Butylene glycol 3.0 Liquid paraffin 7.0 Beta Glucan 7.0 Carbomer 0.1 Edelweiss extract 2.0 Caprylic Capric Triglycerides 3.0 Squalene 5.0 Cetearyl Glucoside 1.5 Sorbitan stearate 0.4 Polysorbate 1.2 antiseptic Quantity incense Quantity Pigment Quantity Triethanol amine 0.1

As described above in detail specific parts of the present specification, it is apparent to those skilled in the art that these specific techniques are merely preferred embodiments, and thus the scope of the present specification is not limited thereto. Therefore, the substantial scope of the present specification will be defined by the appended claims and equivalents thereof.

Claims (10)

As a composition for improving hair or scalp condition,
The composition comprises an Abies Koreana extract as an active ingredient,
Improving the condition of the hair or the scalp inhibits scalp itching; Improving, preventing or treating dandruff; Improving, preventing or treating hair loss; Or a composition for improving hair or scalp condition that is promoting hair growth. delete The composition of claim 1, wherein the globular tree is at least one selected from the group consisting of globular tree leaves, bark and conifers. The composition of claim 1, wherein the globular tree extract is one or more extracts selected from the group consisting of water, organic solvents and mixtures thereof. The composition of claim 4, wherein the organic solvent is at least one selected from the group consisting of ethanol, butylene glycol, and propylene glycol. The composition of claim 1, wherein the globular tree extract is contained in an amount of 0.001 to 50% by weight based on the total weight of the composition. The composition of claim 6, wherein the globular tree extract is contained in an amount of 0.1 to 1% by weight based on the total weight of the composition. The composition according to any one of claims 1 and 3 to 7, wherein the composition is an external preparation for skin. 8. The composition of claim 1, wherein the composition is a food or cosmetic composition. 9. 8. The composition of claim 1, wherein the composition is a formulation selected from the group consisting of hair tonic, hair nourishing cosmetics, scalp treatments, hair treatments, hair rinses, hair shampoos and hair lotions. Composition.