KR102062716B1 - Ripening noni liquid containing do avail the hangover won beverage composition and its manufacturing method - Google Patents

Abstract

The present invention relates to a hangover relief beverage composition containing an aged noni juice and a preparing method thereof. More particularly, the present invention is to provide a hangover relief beverage prepared by mixing an aged noni juice with oriental raisin tree fruit concentrate, alder tree concentrate, kudzu-extracted powder, and a non-embryonic soybean fermented extract, sterilizing the same at low temperatures, mixing the same with xylitol, citric acid monohydrate, a composite scutellaria extract, mixing the same with purified water to be mixed with a mixed liquid sterilized at low temperatures, and sterilizing the same at high temperatures. The hangover relief beverage prepared by adding samples useful for relieving hangover to the aged noni juice increases the activity of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) to promote alcohol metabolism, thereby lowering alcohol concentration and acetaldehyde concentration. Therefore, the hangover relief beverage composition of the present invention is expected to be used as a hanover relief composition which can be useful for hangover relief.

Description

Ripening noni liquid containing do avail the hangover won beverage composition and its manufacturing method}

The present invention relates to a beverage composition for the hangover elimination containing aging Noni juice and a method for preparing the same, in more detail, in the aging Noni juice, lychee fruit extract, alder concentrate, 칡 extract powder, embryonic soybean extract Mix and sterilize at low temperature,

After mixing xylitol, hydrous citric acid and complex golden extract, blending purified water,

In order to provide a hangover solution prepared by mixing with the pasteurized compound solution and sterilized at a high temperature,

Hangover beverage prepared by adding the samples useful for hangover elimination of the matured noni solution of the present invention increases the activity of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) to promote alcohol metabolism, accordingly alcohol concentration And it can lower the concentration of acetaldehyde, and relates to a hangover relieving beverage composition containing a matured noni stock solution expected to be used as a hangover relieving composition that can be usefully used for hangover relief and a method of manufacturing the same.

The most suffering of modern people in social activities is conflict and discord from work and human relations. Alcohol is also an important medium to solve these problems, and alcohol has been one of the important life sharing people's love and joy. However, if acetaldehyde, which is produced during the decomposition of ethanol, the main ingredient of alcohol, is not rapidly degraded due to excessive drinking, it induces necrosis of cells as the whole body moves through the blood.

Especially in the case of brain cells, the toxicity is fatal damage. In women, the amount of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), which are alcohol degrading enzymes, is lower than that of men. If is not broken down in a timely manner, it can damage brain cells significantly.

In addition, people have high activity of alcohol dehydrogenase (ADH), which converts alcohol quickly, but accumulates acetaldehyde that induces the complete decomposition of alcohol, causing redness and dizziness, sweating, rapid pulse, and skin. Symptoms include skin flushing, nausea and vomiting, and hyperventilation.

In addition, excessive drinking temporarily causes hangovers such as palpitations, headaches, thirst, motion sickness, gastrointestinal disorders and diarrhea. In general, ethanol that enters the body is converted to acetate by the action of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) in the cytoplasm, and excreted out of hepatocytes through the circulation. In particular, ethanol metabolite acetaldehyde is highly reactive and toxic. It is strong and is known to be a major cause of hangover and alcoholic side effects. Therefore, hangover resolution methods have been developed by promoting alcohol decomposition and acetaldehyde decomposition. Among them, methods using natural products are attracting attention.

Alcohol is rapidly metabolized into acetaldehyde by the alcohol dehydrogenase (ADH), microsomal ethanol oxidizing system (MEOS) and perocidase in the liver. It is known that the effect of acetaldehyde, an alcohol metabolite, is greater.

On the other hand, acetaldehyde is oxidized to acetic acid by aldehyde dehydrogenase (ALDH) to prevent acetaldehyde accumulation and its side effects, alcohol dehydrogenation to confirm the hangover effect In addition to the enzyme (ADH), the effect on the activity of aldehyde dehydrogenase (ALDH) needs to be examined together.

Recently, drugs for reducing and eliminating hangovers after drinking have been developed, but due to their toxicity or side effects, much attention has been drawn to the development of safer natural-derived health drinks.

As such, a variety of beverages have been developed in various ways to relieve hangover, and each of them has unique characteristics, and as a result, it has proved its excellent antioxidant, anti-inflammatory effect, strength and energy recovery, and a new trend in the beverage market. Perched. However, most of them are commercially available in the form of 100% juice, and the method of producing a hangover relieving beverage using mature noni is still under development.

Looking at the prior published patent information, Republic of Korea Patent Publication No. 1997-000075 and Patent Publication No. 1998-076168 discloses a liver functional protective food using mung beans, Patent Publication No. 2002-0035813 Health food for hangover resolution using a plum, plum, cucumber extract is disclosed, and Patent Publication No. 10-2003-0062058, Hangover relief composition containing the decosinol of Angelica extract as an active ingredient, Patent Publication No. 10-2003 -0084666 is a beverage composition containing wood vinegar solution, Patent Publication No. 10-2003-0075099, anti-deodorant drink using the extract of the falconia, Patent Publication No. 10-2004-0005545, seaweed, yellow, onion, bean sprouts, and extracts Hangover-relieving drink using a drink, registered patent No. 10-0422966 is a beverage containing the extract of the bark tree, Patent Publication No. 10-2003-0079289 is a ginger, licorice, cinnamon, sesame, oak fruit seeds, etc. And it is hung by using the medicine extract disclosed many hangover beverages and foods, such as carbonated beverage plants, Korea Patent Registration No. 1301094 discloses a represents an anomaly of the hangover beverages using such sanyacho. As described above, the hangover-relieving beverage using wild grass has a variety of wild vegetables to produce a liquid composition to provide a food composition that is easy to ingest and beneficial to health.

In recent years, various researches have been conducted mainly on larches and alders, and there are many hangover releasing agents using a mixture of food ingredients and medicinal crops. However, unlike the advertising, the hangover elimination effect is insignificant and acetaldehyde is insignificant. It is a fact that less than 10% of the drinking population consumes hangovers after drinking alcohol.

In particular, most of the conventional hangover beverage composition prepared for the hangover is prepared by diluting nutrients through medicinal crops, vitamins, minerals or fermentation methods, and rapidly decrease the concentration of alcohol and acetaldehyde in the blood. In addition to the excellent hangover relieving effect, soy sauce and gastrointestinal protection and hangover remedy after drinking a significant hangover composition is urgently needed.

[Preceding technical literature]

Patent Literature

(Patent Document 0001) Republic of Korea Patent No. 10-0955027

(Patent Document 0002) Republic of Korea Patent Publication No. 10-0422966

However, the products of the hangover drink made by such a conventional manufacturing method takes a long time to promote the decomposition of acetaldehyde because a high molecular material and a low molecular material is mixed in the composition. On the other hand, since the faster the decomposition of acetaldehyde can reduce the damage to the brain cells as much as the conventional method of the conventional manufacturing method was limited to the rapid decomposition of acetaldehyde.

In addition, hangover-relieving drink using San-yacho has a problem of low preference because it does not remove the smell of Sanya-cho, and extracts using alcohol solvent to use beneficial ingredients of San-yacho. It is difficult to manufacture, and a large amount of waste is generated in the extraction and filtration process, which causes pollution to the ecosystem.

Accordingly, the present invention is to solve the conventional problems as described above, an object of the present invention, by combining the lychee fruit extract, alder concentrate, algae extract powder, embryonic soybean fermentation extract at a low temperature Sterilize,

After mixing xylitol, hydrous citric acid and complex golden extract, blending purified water,

In order to provide a hangover solution prepared by mixing with the pasteurized compound solution and sterilized at a high temperature,

Hangover beverage prepared by adding the samples useful for hangover to the aging Noni juice increases the activity of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) to promote alcohol metabolism, accordingly alcohol concentration and acetaldehyde It is possible to lower the concentration of the bar, to provide a hangover solution and a method for producing the hangover solution containing the matured Noni juice expected to be used as a hangover composition that can be usefully used for hangover.

As described above, by using the hangover solution containing the ripened noni juice according to the present invention and the preparation method thereof, the hangover drink prepared by adding the samples useful for hangover elimination to the mature noni juice is alcohol dehydrogenase Increases the activity of (ADH) and aldehyde dehydrogenase (ALDH) to promote alcohol metabolism, thereby lowering the alcohol concentration and acetaldehyde concentration as a hangover composition that can be useful for hangover Has an effect,

Hangover drink according to the present invention significantly reduces the blood alcohol concentration and acetaldehyde concentration to provide an excellent hangover relief effect and is effective in maintaining the health of brain cells by rapid decomposition of the toxic substance acetaldehyde, alcohol excess It is a useful drink that prevents and protects the stomach and liver from ingestion and removes headache, nausea and bad breath after drinking due to the rapid decomposition of acetaldehyde. It has the potential to be used as a beverage and has a very useful effect industrially.

1 is a flow chart of a method for producing a hangover solution containing the inventors aged noni juice solution

Embodiments of the invention may be modified in many different forms and should not be construed as being limited to the scope of the invention by the embodiments described below.

The present invention is a hangover prepared by mixing purified water with a mixture of purified Noni fruit concentrate, alder tree extract, 칡 extract powder, embryonic soybean fermentation extract, xylitol, hydrous citric acid, complex golden extract to mature Noni stock solution In order to provide a refreshing drink,

Hangover beverage prepared by adding the samples useful for hangover elimination of the matured noni solution of the present invention increases the activity of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) to promote alcohol metabolism, accordingly alcohol concentration And it can lower the concentration of acetaldehyde, hangover relieving drink composition containing a matured Noni juice expected to be used as a hangover relieving composition that can be usefully used for relieving hangover and a method for preparing the same Specifically, it is as follows.

Noni (Moni) is the Morinda Citrifolia, a locust tree plant that is inhabited in 2000 years of volcanic soil Polynesia, South Pacific Islands, Tahiti, Hawaii, Malaysia, China, and its fruit. , Leaves, roots, and stem seeds have been widely used as natural remedies in the South Pacific, along with aloe vera, kelp, papaya, and parknozerol.

The mature Noni (Noni) is known to have the effect of increasing fatigue, pain relief, strengthening immunity, skin care, enhance liver function, and is also called 'plants presented by God'. In addition, Dongbogam called Haepageuk (海巴 戟) and the body's tonic, especially refreshing function, and also shows excellent efficacy in chronic inflammatory diseases. It helps men's energy and is known to women for menstrual irregularities and fatigue. Noni's hepatoprotective effects are paying attention to hangover efficacy. Liver Protective Effects of Morinda citrifolia (Noni), 2008]

The Hovenia dulcis Thunb is a leafy tall tree belonging to the genus Barberry and Barberry. There are many species of hawthorn in the world, and one species grows wild in Korea. The fruit of the barn tree is earth, the root is earth root, the bark is earth bark, the juice in the tree is earth tree juice, and the leaves are earth leaves. ) Are all used for medicinal purposes. The fruit of the barn tree is sweet and sour, and the property is flat, and it is characterized by acting on the heart and parenteral, stopping thirst, eliminating heat, detoxification, vomiting and urination disorders. In addition, the bark tree is effective for alcoholism, and is widely used as a medicine for liver disease in the private sector.

The alder is planted every five trees to indicate the distance. It is a deciduous broad-leaved arboreous tree that grows at the foot of a mountain or near the wetlands of rice fields. It is native to Korea and is distributed in Japan, Taiwan, and Siberia. Alder is widely known as a good hangover and alcohol addiction.

The 갈 (root) is a mechanism that lowers the heat while releasing the muscle to treat colds, high fever, headache, muscle pain, stiffness of the back neck and the like. It is also used to raise Yanggi and stop diarrhea. It is used to replenish the body's essences, quench thirst, and relieve alcohol poison. The fruit of is called Galgok (葛 穀) and effective in chronic diarrhea, Galhwa (칡 花) has the unique sweetness to release alcohol poison and strengthen the intestines. Dried brown dragon (葛 茸) is also used to help children grow.

The embryonic soybean extract is a natural material extracted from fermented soybeans and soybeans under alkaline conditions using natto bacteria, and the extract accelerates alcohol metabolism, lowers blood alcohol concentration, accelerates acetaldehyde decomposition and rapidly acetate. It is known to increase the rate of conversion to water and carbon dioxide.

As described above, the present invention, after mixing the ripen Noni stock solution (N), the bark fruit concentrate, alder tree concentrate, 칡 extract powder, embryonic soybean fermentation extract, xylitol, hydrous citric acid, complex golden extract, mixed with purified water To provide a hangover drink prepared by blending,

When the aging Noni juice used in the method for producing a hangover solution containing the aging Noni juice of the present invention will be described in detail,

The aged Noni stock solution used in the present invention is the use of the aged Noni stock solution prepared by the present inventors filed in 2008 and registered in 2010 and registered in No. 10-0955027. The stock solution is selected from only ripe Noni fruit, and after washing the selected Noni fruit three times, after washing the residues in the groove of the fruit with a high-pressure water injector, rinsing with clean water and putting in a basket to remove water It is put into a aging tank with pores using the Noni fruit of the political process to politicize, and after 10 days, all the aging tanks are shaded to maintain 25 ~ 30 ℃ and to be matured in the natural state. ; 15 days from the start of aging, the second aging process of sealing the pores of the aging tank, and aged for 120 to 150 days; Through the valve at the bottom of the aging tank to recover the aged Noni stock solution is transferred to a separate container using the aged Noni stock solution (N) after the process of ripening Noni solution for 90 to 120 days.

The manufacturing step of the barberry fruit concentrate and alder concentrate,

A step of preparing each material by drying each of the barberry and alder;

For each material weight prepared in the preparation step,

A heat extraction step of mixing 2-10 times the weight of purified water for 8 hours by heat extraction in an extractor at 85 ° C to 95 ° C and 2 atmospheres;

A filtration step of filtering the extract of each material that has undergone the heat extraction step with a 200-250 mesh filter cloth to obtain only a liquid extract;

Including a reduced pressure concentration step of concentrating each material by concentrating for 8 hours under reduced pressure conditions of 55 ~ 60 ℃, -0.07 MPa to -0.09 Mpa to increase the concentration of the liquid extract of each material filtered in the filtration step,

The barberry fruit concentrate and alder concentrate concentrated using the above materials are used for the hangover drink. The barberry fruit concentrate is 65 to 68 brix, and the alder concentrate is 58 to 63 brix. (brix) was used.

갈 (brown) extract powder, chop the 칡 roots to dry for 24 hours in a dryer of 60 ~ 65 ℃ to prepare the 칡 root;

A heat extraction step of mixing 8 ~ 10 times the weight of purified water with respect to the root weight prepared in the preparation step, heating extraction at 85 ° C. to 95 ° C. for 2 hours using an extractor of 2 atm;

A filtration step of filtering the extract of the roots 거친 passed through the heat extraction step with a 200-250 mesh filter cloth to obtain only a liquid extract;

Concentrating under reduced pressure under reduced pressure conditions of 55 ~ 60 ℃, -0.07 MPa to -0.09 Mpa to increase the concentration of the liquid extract of the roots filtered in the filtration step;

In order to give a viscosity to the root root liquid concentrated in the vacuum concentration step,

Spray drying step of adding 10% by weight of maltodextrin to the root weight of the roots and spray-drying to powder the roots liquid to which the maltodextrin is added to give viscosity;

It is characterized in that it is used in the beverage for hangover to remove the 칡 extract powder prepared, including the obtaining step of obtaining the 칡 powder dried in the spray drying step,

Fermented soybean embryo extract is a natural material extracted from fermented soybean under alkaline conditions using natto bacteria. The extract promotes alcohol metabolism, lowers blood alcohol concentration, accelerates acetaldehyde decomposition, and rapidly It has the function of increasing the rate of water and carbon dioxide conversion.

The embryonic soybean extract of the present invention is an extract extracted with water, ethanol or a mixed solvent of ethanol and water, more preferably is obtained by using water as the extraction solvent.

The embryonic soybean fermented extract of the present invention is characterized in that it is prepared as an extract through a vacuum distillation process after extraction.

As the sweetening agent, at least one sweetener selected from glucose, fructose, maltose, isomerized sugar, sugar, D-sorbitol, xylitol, honey, aspartame and stevioside, citric acid and its alkali or alkaline earth metal salts as organic acids, DL-peracid and its At least one organic acid selected from alkali or alkaline earth metal salts, tartaric acid and its alkali or alkaline earth metal salts, lactic acid and its alkali metal or alkaline earth metal salts, fruit juice, noni juice or noni extract, orange juice or orange extract, lemon juice or lemon Grapefruit juice, grapefruit juice or grapefruit extract, apple juice or apple extract, mango juice or mango extract and papaya juice, one or more selected from fruit juice or fruit extract selected from papaya extract, sodium benzoate, p-methylbenzoic acid as a preservative , p-ethyl benzoic acid, p-propyl benzoic acid, complex golden extract, It was used as the grapefruit seed extract or selected from the alkali metal sodium.

[Example 1] Drink composition for eliminating hangover containing aged Noni stock solution and preparation method

1 is a flow chart illustrating a method for preparing a hangover drink containing the matured Noni stock solution of the present invention, which will be described in detail as follows.

Hangover elimination drink containing the aged Noni juice of the present invention,

The mixed composition of the hangover solution containing the barberry fruit concentrate, alder tree concentrate, 칡 extract powder, embryonic soybean fermentation extract, xylitol, hydrous citric acid, complex golden extract, which is useful for hangover elimination in the aged Noni stock solution (N) ,

The aged Noni stock solution (N) in 20 to 25% by weight in 8.0 brix,

1.3 to 3% by weight of barberry fruit concentrate (65 to 68 brix), 1.5 to 4% by weight of alder concentrate (58 to 63 brix), 2.5 to 5% by weight of extract powder, and 1.3 to 3% by weight of embryonic soybean extract After that, the pasteurized compound (A) was pasteurized at 60 ° C to 70 ° C for 20 to 30 minutes,

Thereafter, 2 to 4% by weight of xylitol, 0.2 to 0.5% by weight of citric acid, 0.2 to 0.5% by weight of complex golden extract, and 55 to 71% by weight of purified water were added to prepare a mixed solution (B) dissolved in a stirrer.

Aged non-stock solution characterized in that the pasteurized solution (A) and the mixed solution (B) dissolved in the stirrer is subjected to a sterilization process at high temperature sterilization for 3 to 5 minutes at 85 ℃ to 95 ℃ It relates to a method for producing a hangover drink containing this.

Example 2 Alcohol Dehydrogenase (ADH) and Aldehyde Dehydrogenase (ALDH) Activity Tests According to the Hangover Relief Beverage

(1) Activity Determination of Alcohol Dehydrogenase (ADH)

ADH activity was measured by measuring the absorbance of NADH formed at 340nm using a spectrophotometer to indicate the activity. That is, the composition of the reaction solution was 1.4 ml of distilled water, 0.3 ml of ethanol, 0.3 ml of 20mM NAD + aqueous solution, 0.1 ml of each sample and 0.75 ml of 1.0 M Tris-Hcl buffer solution (pH 8.8). After adding so that

After reacting for 10 minutes in a 25 ° C thermostat, 0.15 ml of ADH (5 units / ml) was added to adjust the reaction capacity to 3 ml, pre-incubated for 3 minutes at 25 ° C, and the change in absorbance at 340 nm for 5 minutes was measured. Distilled water was used as a control.

ADH activity was expressed as the ratio of the maximum absorbance at the end of the reaction to the maximum absorbance of the control, it was calculated as follows.

ADH activity = (B / A) × 100

(A: maximum absorbance of the control, B: maximum absorbance of the experiment)

As a result of measuring activity against ADH,

Most of the experimental group showed higher activity than the control group, and in the experimental group of each sample at the concentration of 100 ug / ml showed a maximum activity of 189.54% of the hangang beverage formulation manufacturing group showed a much higher activity than the control group (Table 1).

 Activity Determination of Alcohol Dehydrogenase (ADH) sample Concentration (ug / ml) ADH activity (%) Control - 100 Experimental group Aging Noni 100 132.61 ± 0.80 Vacancy 100 118.78 ± 1.26 갈 100 125.32 ± 2.48 Alder 100 64.18 ± 1.45 Embryonic soybean fermentation solution group 100 57.45 ± 0.64 Hangover beverage formulation 100 189.54 ± 0.27

(2) Determination of the activity of aldehyde dehydrogenase (ALDH)

The activity of ALDH was measured at 340 nm in the change of absorbance according to NADH production. To determine the activity of ALDH, distilled water 2.1 mL, 1.0 M Tris-HCl buffer (pH 8.0), 0.3 mL, 20 mM NAD + 0.1 mL, 0.1 M acetaldehyde 0.1 mL, 3.0 M KCl 0.1 mL, 0.33 M 2-mercaptoethanol 0.1 mL, After mixing 0.1 mL of the sample, the reaction was carried out for 10 minutes at 25 ℃ and 0.1 mL of ALDH (1 unit / ml) was added, the reaction solution was adjusted to 3 mL and put in a cuvette and preincubated at 25 ℃ for 5 minutes For 5 minutes, the change in absorbance was measured at 340 nm, in which distilled water was used as a control.

ALDH activity calculation formula was calculated by the following formula.

    ALDH activity = (B / A) × 100

    (A: maximum absorbance of the control, B: maximum absorbance of the experiment)

As a result of measuring activity against ALDH,

Most of the experimental group showed higher activity than the control group, and in the experimental group of each sample at the concentration of 100 ug / ml, the maximum concentration of 168.75% was found to be higher than that of the control group.

Activity Determination of Aldealdehyde Dehydrogenase (ALDH) sample Concentration (ug / ml) ALDH Activity (%) Control - 100 Experimental group Aging Noni 100 124.51 ± 0.45 Vacancy 100 114.68 ± 2.75 갈 100 122.17 ± 1.27 Alder 100 61.05 ± 2.35 Embryonic soybean fermentation solution group 100 68.27 ± 0.89 Hangover beverage formulation 100 168.75 ± 1.56

The composition of the hangover solution containing the matured Noni stock solution of the present invention may be prepared in any one formulation selected from powder, granule, pill, tablet, capsule, candy, syrup effervescent tablet and beverage, preferably effervescent tablet or It is prepared as a beverage, but is not limited thereto. Hangover drink composition of the present invention is not particularly limited as long as it can be ingested to prevent or improve hangover relief. When the health functional food composition of the present invention is used as a food additive, the health functional food composition may be added as it is or used with other foods or food ingredients, and may be appropriately used according to a conventional method. The active ingredient may be appropriately used depending on the purpose of use (prevention or improvement).

Claims (4)

Select only the ripe Noni fruit, wash the selected Noni fruit three times, and then wash the residue in the grooves of the fruit with a high-pressure water sprayer, and then rinse with clean water and place it in a basket to remove water. Put the aging tank with pores using the Noni fruit of the political process, and after 10 days, the first maturing process to make all the maturing shade to maintain the 25 ~ 30 ℃ to be aged in the natural state; 15 days from the start of aging, the second aging process of sealing the pores of the aging tank, and aged for 120 to 150 days; In the aged Noni stock solution (N) that recovers the aged Noni stock solution through a valve at the bottom of the aging tank, and transfers it to a separate barrel for 90 to 120 days.

The aged Noni stock solution (N) from 8.0 brix to 20 to 25% by weight, 65 to 68 brix concentrate 1.3% by weight of the barberry fruit, 58-63 brix concentrate of alder 1.5 ~ 4% by weight, 칡 2.5 ~ 5% by weight of extract powder, 1.3 ~ 3% by weight of embryonic soybean extract, and then prepared pasteurized solution (A) at 60 ° C. to 70 ° C. for 20 to 30 minutes. and,
Thereafter, 2 to 4% by weight of xylitol, 0.2 to 0.5% by weight of hydrous citric acid, 0.2 to 0.5% by weight of complex golden extract, and 55 to 71% by weight of purified water were added thereto to prepare a mixed solution (B) dissolved in a stirrer.
Aged non-stock solution characterized in that the pasteurized solution (A) and the mixed solution (B) dissolved in the stirrer is subjected to a sterilization process at high temperature sterilization for 3 to 5 minutes at 85 ℃ to 95 ℃ Method of preparation for the hangover
delete delete Hangover releasing beverage containing the matured Noni juice, characterized in that the hangover beverage prepared by the method of claim 1

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