KR102058756B1 - 주사비 징후들의 치료용 옥시메타졸린의 약학 크림 조성물들 - Google Patents

주사비 징후들의 치료용 옥시메타졸린의 약학 크림 조성물들 Download PDF

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KR102058756B1
KR102058756B1 KR1020137024232A KR20137024232A KR102058756B1 KR 102058756 B1 KR102058756 B1 KR 102058756B1 KR 1020137024232 A KR1020137024232 A KR 1020137024232A KR 20137024232 A KR20137024232 A KR 20137024232A KR 102058756 B1 KR102058756 B1 KR 102058756B1
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cream
oxymethazolin
pharmaceutical composition
weight
pharmaceutically acceptable
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KR20140020912A (ko
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스튜어트 디. 쉔러
크리스토퍼 포왈라
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어클라리스 쎄라퓨틱스, 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
KR1020137024232A 2011-02-15 2012-02-14 주사비 징후들의 치료용 옥시메타졸린의 약학 크림 조성물들 Active KR102058756B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161443210P 2011-02-15 2011-02-15
US61/443,210 2011-02-15
PCT/US2012/025068 WO2012112566A1 (en) 2011-02-15 2012-02-14 Pharmaceutical cream compositions of oxymetazoline for treating symptoms of rosacea

Related Child Applications (1)

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KR1020197028285A Division KR20190114010A (ko) 2011-02-15 2012-02-14 주사비 징후들의 치료용 옥시메타졸린의 약학 크림 조성물들

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KR20140020912A KR20140020912A (ko) 2014-02-19
KR102058756B1 true KR102058756B1 (ko) 2020-01-22

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KR1020197028285A Withdrawn KR20190114010A (ko) 2011-02-15 2012-02-14 주사비 징후들의 치료용 옥시메타졸린의 약학 크림 조성물들
KR1020137024232A Active KR102058756B1 (ko) 2011-02-15 2012-02-14 주사비 징후들의 치료용 옥시메타졸린의 약학 크림 조성물들

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KR1020197028285A Withdrawn KR20190114010A (ko) 2011-02-15 2012-02-14 주사비 징후들의 치료용 옥시메타졸린의 약학 크림 조성물들

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US (4) US20120208858A1 (enExample)
EP (2) EP2675449B1 (enExample)
JP (3) JP6225030B2 (enExample)
KR (2) KR20190114010A (enExample)
CN (2) CN107007546A (enExample)
AU (3) AU2012217858A1 (enExample)
BR (1) BR112013020770A2 (enExample)
CA (1) CA2827373C (enExample)
ES (1) ES2742273T3 (enExample)
RU (1) RU2648439C2 (enExample)
WO (1) WO2012112566A1 (enExample)

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CN113164451A (zh) 2018-10-15 2021-07-23 奥库菲尔制药股份有限公司 治疗青光眼的方法和组合物及相关病症
EP3870170A4 (en) 2018-10-26 2022-07-20 Ocuphire Pharma, Inc. METHODS AND COMPOSITIONS FOR THE TREATMENT OF PRESBYOPIA, MYDRIASIS AND OTHER EYE DISEASES
SG11202104410SA (en) * 2018-11-26 2021-06-29 Cellix Bio Private Ltd Ophthalmic compositions and methods for the treatment of skin diseases and eye diseases
EP3964212A4 (en) * 2019-04-30 2023-01-04 Generos Biopharma Ltd. COMPOUND FOR THE TREATMENT OF INFLAMMATORY AUTOIMMUNEAL DISEASES AND USE THEREOF
CN115368310B (zh) 2021-05-18 2025-06-27 奥库菲尔医药公司 合成甲磺酸酚妥拉明的方法
KR102633256B1 (ko) * 2021-10-08 2024-02-05 (주)우리스마트바이오 참당귀 추출물을 이용한 피부개선용 화장품 조성물, 이를 포함한 피부개선용 화장품 및 피부개선용 화장품 제조방법
JP2025502006A (ja) * 2022-01-05 2025-01-24 アシンメトリック セラピューティクス，エルエルシー 皮膚の増殖性疾患及び他の皮膚症状を治療するための方法及び組成物
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Publication number Publication date
WO2012112566A1 (en) 2012-08-23
AU2017202726A1 (en) 2017-05-18
CN103458897A (zh) 2013-12-18
JP6389534B2 (ja) 2018-09-12
US20120208858A1 (en) 2012-08-16
BR112013020770A2 (pt) 2019-08-27
US20190167566A1 (en) 2019-06-06
ES2742273T3 (es) 2020-02-13
CA2827373A1 (en) 2012-08-23
AU2019203993B2 (en) 2020-05-28
US11541000B2 (en) 2023-01-03
RU2648439C2 (ru) 2018-03-26
JP2018193399A (ja) 2018-12-06
RU2013141845A (ru) 2015-03-27
US20200276108A1 (en) 2020-09-03
KR20190114010A (ko) 2019-10-08
EP2675449B1 (en) 2019-04-24
AU2017202726B2 (en) 2019-03-07
JP6225030B2 (ja) 2017-11-01
KR20140020912A (ko) 2014-02-19
CN107007546A (zh) 2017-08-04
CA2827373C (en) 2019-05-14
JP2014505733A (ja) 2014-03-06
JP2017066162A (ja) 2017-04-06
US20140113947A1 (en) 2014-04-24
EP2675449A1 (en) 2013-12-25
AU2019203993A1 (en) 2019-06-27
AU2012217858A1 (en) 2013-09-05
EP3578178A1 (en) 2019-12-11

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