KR102036932B1 - 축합 아자사이클 (칸나비노이드 수용체 조절제)의 결정질 형태 및 제조 방법 - Google Patents

축합 아자사이클 (칸나비노이드 수용체 조절제)의 결정질 형태 및 제조 방법 Download PDF

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KR102036932B1
KR102036932B1 KR1020137025057A KR20137025057A KR102036932B1 KR 102036932 B1 KR102036932 B1 KR 102036932B1 KR 1020137025057 A KR1020137025057 A KR 1020137025057A KR 20137025057 A KR20137025057 A KR 20137025057A KR 102036932 B1 KR102036932 B1 KR 102036932B1
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crystalline form
pyrazin
amide
oxy
propyl
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Korean (ko)
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KR20140025353A (ko
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안토니 씨. 블랙번
상돈 한
로버트 엠. 존스
안토니오 가리도 몬탈반
비만 비. 팔
제이미 카린 류터
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아레나 파마슈티칼스, 인크.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020137025057A 2011-02-25 2012-02-24 축합 아자사이클 (칸나비노이드 수용체 조절제)의 결정질 형태 및 제조 방법 Expired - Fee Related KR102036932B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161446732P 2011-02-25 2011-02-25
US61/446,732 2011-02-25
US201161448542P 2011-03-02 2011-03-02
US61/448,542 2011-03-02
PCT/US2012/026506 WO2012116276A1 (en) 2011-02-25 2012-02-24 Crystalline forms and processes for the preparation of condensed azacycles ( cannabinoid receptor modulators)

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KR20140025353A KR20140025353A (ko) 2014-03-04
KR102036932B1 true KR102036932B1 (ko) 2019-10-25

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EP (3) EP3395812B8 (enExample)
JP (1) JP5945554B2 (enExample)
KR (1) KR102036932B1 (enExample)
CN (1) CN103608343B (enExample)
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BR (1) BR112013021549B1 (enExample)
CA (1) CA2827057C (enExample)
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EA (1) EA035989B1 (enExample)
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MY (1) MY165767A (enExample)
PH (1) PH12013501726A1 (enExample)
SG (1) SG192817A1 (enExample)
WO (1) WO2012116276A1 (enExample)
ZA (1) ZA201306402B (enExample)

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EP4036082A1 (en) 2009-08-28 2022-08-03 Arena Pharmaceuticals, Inc. Cannabinoid receptor modulators
WO2012116277A1 (en) 2011-02-25 2012-08-30 Arena Pharmaceuticals, Inc. Cannabinoid receptor modulators
AU2012222146B2 (en) * 2011-02-25 2017-05-11 Arena Pharmaceuticals, Inc. Crystalline forms and processes for the preparation of condensed azacycles ( cannabinoid receptor modulators)
EP2678318A1 (en) 2011-02-25 2014-01-01 Arena Pharmaceuticals, Inc. Cannabinoid receptor modulators
WO2016085941A1 (en) * 2014-11-25 2016-06-02 Arena Pharmaceuticals, Inc. Processes for the preparation of cannabinoid receptor modulators
UA124626C2 (uk) * 2016-04-10 2021-10-20 Арена Фармасьютікалз, Інк. СПОСОБИ ЛІКУВАННЯ СЕЛЕКТИВНИМИ АГОНІСТАМИ РЕЦЕПТОРА СВ<sub>2</sub>
WO2018208847A1 (en) 2017-05-08 2018-11-15 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of pain from inflammatory bowel disease
MX2019013311A (es) * 2017-05-08 2020-08-03 Arena Pharm Inc Compuestos y metodos para el tratamiento del dolor visceral.
TWI768465B (zh) * 2019-09-12 2022-06-21 大陸商四川海思科製藥有限公司 四氫吲唑衍生物及其製備
WO2023059610A1 (en) 2021-10-05 2023-04-13 Arena Pharmaceuticals, Inc. Crystalline forms and processes for the preparation of cannabinoid receptor modulators

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ZA201306402B (en) 2022-03-30
SG192817A1 (en) 2013-09-30
KR20140025353A (ko) 2014-03-04
US20140135345A1 (en) 2014-05-15
EA201391233A1 (ru) 2014-02-28
EP3395812B8 (en) 2022-11-02
CA2827057C (en) 2022-06-07
CL2013002436A1 (es) 2014-01-24
IL227782A0 (en) 2013-09-30
WO2012116276A1 (en) 2012-08-30
US10981895B2 (en) 2021-04-20
EP4166552A1 (en) 2023-04-19
EP3395812A1 (en) 2018-10-31
AU2012222146A1 (en) 2013-09-19
US10183930B2 (en) 2019-01-22
MY165767A (en) 2018-04-23
MX346533B (es) 2017-03-14
IL227782A (en) 2017-02-28
US20210380560A1 (en) 2021-12-09
US9458136B2 (en) 2016-10-04
AU2012222146B2 (en) 2017-05-11
CO6852066A2 (es) 2014-01-30
CN103608343B (zh) 2019-02-01
US20170144993A1 (en) 2017-05-25
PH12013501726A1 (en) 2014-01-13
US20190308952A1 (en) 2019-10-10
CN103608343A (zh) 2014-02-26
JP5945554B2 (ja) 2016-07-05
JP2014506602A (ja) 2014-03-17
EA035989B1 (ru) 2020-09-09
DK3395812T3 (da) 2022-11-28
EP3395812B1 (en) 2022-09-28
CA2827057A1 (en) 2012-08-30
ES2932441T3 (es) 2023-01-19
MX2013009760A (es) 2014-06-11
US11560369B2 (en) 2023-01-24
BR112013021549A2 (pt) 2016-11-01
BR112013021549B1 (pt) 2022-01-11
NZ614787A (en) 2014-08-29
EP2678330A1 (en) 2014-01-01
EP4166552B1 (en) 2025-03-19

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