JP5945554B2 - 縮合型アザ環の結晶形およびその調製プロセス（カンナビノイド受容体モジュレーター） - Google Patents

縮合型アザ環の結晶形およびその調製プロセス（カンナビノイド受容体モジュレーター） Download PDF

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JP5945554B2
JP5945554B2 JP2013555597A JP2013555597A JP5945554B2 JP 5945554 B2 JP5945554 B2 JP 5945554B2 JP 2013555597 A JP2013555597 A JP 2013555597A JP 2013555597 A JP2013555597 A JP 2013555597A JP 5945554 B2 JP5945554 B2 JP 5945554B2
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pentalene
diaza
tetrahydro
oxy
propyl
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JP2014506602A (ja
JP2014506602A5 (enExample
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アンソニー シー． ブラックバーン，
アンソニー シー． ブラックバーン，
サンドン ハン，
サンドン ハン，
ロバート エム． ジョンズ，
ロバート エム． ジョンズ，
アントニオ ガリド モンタルバン，
アントニオ ガリド モンタルバン，
バイマン ビー． パル，
バイマン ビー． パル，
ジェイミー カリン ロイター，
ジェイミー カリン ロイター，
Original Assignee
アリーナ ファーマシューティカルズ， インコーポレイテッド
アリーナ ファーマシューティカルズ， インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2013555597A 2011-02-25 2012-02-24 縮合型アザ環の結晶形およびその調製プロセス（カンナビノイド受容体モジュレーター） Expired - Fee Related JP5945554B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161446732P 2011-02-25 2011-02-25
US61/446,732 2011-02-25
US201161448542P 2011-03-02 2011-03-02
US61/448,542 2011-03-02
PCT/US2012/026506 WO2012116276A1 (en) 2011-02-25 2012-02-24 Crystalline forms and processes for the preparation of condensed azacycles ( cannabinoid receptor modulators)

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JP2014506602A JP2014506602A (ja) 2014-03-17
JP2014506602A5 JP2014506602A5 (enExample) 2015-04-16
JP5945554B2 true JP5945554B2 (ja) 2016-07-05

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JP2013555597A Expired - Fee Related JP5945554B2 (ja) 2011-02-25 2012-02-24 縮合型アザ環の結晶形およびその調製プロセス（カンナビノイド受容体モジュレーター）

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US (4) US9458136B2 (enExample)
EP (3) EP2678330A1 (enExample)
JP (1) JP5945554B2 (enExample)
KR (1) KR102036932B1 (enExample)
CN (1) CN103608343B (enExample)
AU (1) AU2012222146B2 (enExample)
BR (1) BR112013021549B1 (enExample)
CA (1) CA2827057C (enExample)
CL (1) CL2013002436A1 (enExample)
CO (1) CO6852066A2 (enExample)
DK (1) DK3395812T3 (enExample)
EA (1) EA035989B1 (enExample)
ES (1) ES2932441T3 (enExample)
IL (1) IL227782A (enExample)
MX (1) MX346533B (enExample)
MY (1) MY165767A (enExample)
PH (1) PH12013501726A1 (enExample)
SG (1) SG192817A1 (enExample)
WO (1) WO2012116276A1 (enExample)
ZA (1) ZA201306402B (enExample)

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EP2470508A1 (en) * 2009-08-28 2012-07-04 Arena Pharmaceuticals, Inc. Cannabinoid receptor modulators
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MX392150B (es) 2011-02-25 2025-03-21 Arena Pharm Inc Moduladores de receptores canabinoides.
JP5945554B2 (ja) * 2011-02-25 2016-07-05 アリーナ ファーマシューティカルズ， インコーポレイテッド 縮合型アザ環の結晶形およびその調製プロセス（カンナビノイド受容体モジュレーター）
WO2016085941A1 (en) * 2014-11-25 2016-06-02 Arena Pharmaceuticals, Inc. Processes for the preparation of cannabinoid receptor modulators
CN109310673A (zh) * 2016-04-10 2019-02-05 艾尼纳制药公司 用选择性cb2受体激动剂治疗的方法
WO2018208847A1 (en) 2017-05-08 2018-11-15 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of pain from inflammatory bowel disease
US20200078358A1 (en) * 2017-05-08 2020-03-12 Arena Pharmaceuticals, Inc. Compounds and Methods for Treatment of Visceral Pain
CN114391011A (zh) * 2019-09-12 2022-04-22 四川海思科制药有限公司 一种六氢化苯并吡唑衍生物及其制备
WO2023059610A1 (en) 2021-10-05 2023-04-13 Arena Pharmaceuticals, Inc. Crystalline forms and processes for the preparation of cannabinoid receptor modulators
CN121987637A (zh) * 2026-03-18 2026-05-08 广东医科大学 Olorinab在制备治疗和/或预防缺血性心肌病的药物中的应用

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CA2586011C (en) 2004-07-12 2011-07-19 Cadila Healthcare Limited Tricyclic pyrazole derivatives as cannabinoid receptor modulators
FR2875230A1 (fr) * 2004-09-13 2006-03-17 Sanofi Aventis Sa Derives de pyrazole condense, leur preparation et leur application en therapeutique
DE102004054666A1 (de) 2004-11-12 2006-05-18 Bayer Cropscience Gmbh Substituierte Pyrazol-3-carboxamide, Verfahren zur Herstellung und Verwendung als Herbizide und Pflanzenwachstumsregulatoren
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CN101238107A (zh) * 2005-06-02 2008-08-06 格兰马克药品股份有限公司 新的大麻素受体配体，含有该配体的药物组合物及其制备方法
CA2654246A1 (en) 2006-07-04 2008-01-10 Janssen Pharmaceutica N.V. Benzimidazole cannabinoid agonists bearing a substituted heterocyclic group
KR20090069318A (ko) 2006-09-25 2009-06-30 베링거 인겔하임 인터내셔날 게엠베하 Ｃｂ2 수용체를 조절하는 화합물
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WO2012116278A1 (en) 2011-02-25 2012-08-30 Arena Pharmaceuticals, Inc. Cannabinoid receptor modulators
MX392150B (es) 2011-02-25 2025-03-21 Arena Pharm Inc Moduladores de receptores canabinoides.
US9597340B2 (en) 2011-02-25 2017-03-21 Arena Pharmaceuticals, Inc. Cannabinoid receptor modulators
JP5945554B2 (ja) 2011-02-25 2016-07-05 アリーナ ファーマシューティカルズ， インコーポレイテッド 縮合型アザ環の結晶形およびその調製プロセス（カンナビノイド受容体モジュレーター）

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Publication number Publication date
CO6852066A2 (es) 2014-01-30
CN103608343B (zh) 2019-02-01
US11560369B2 (en) 2023-01-24
DK3395812T3 (da) 2022-11-28
CA2827057A1 (en) 2012-08-30
EA201391233A1 (ru) 2014-02-28
AU2012222146B2 (en) 2017-05-11
KR20140025353A (ko) 2014-03-04
US10981895B2 (en) 2021-04-20
US20210380560A1 (en) 2021-12-09
EP4166552B1 (en) 2025-03-19
SG192817A1 (en) 2013-09-30
EP2678330A1 (en) 2014-01-01
ZA201306402B (en) 2022-03-30
US9458136B2 (en) 2016-10-04
CN103608343A (zh) 2014-02-26
KR102036932B1 (ko) 2019-10-25
AU2012222146A1 (en) 2013-09-19
EP3395812B1 (en) 2022-09-28
CL2013002436A1 (es) 2014-01-24
EP3395812A1 (en) 2018-10-31
IL227782A0 (en) 2013-09-30
MX2013009760A (es) 2014-06-11
IL227782A (en) 2017-02-28
JP2014506602A (ja) 2014-03-17
US20170144993A1 (en) 2017-05-25
EP4166552A1 (en) 2023-04-19
EA035989B1 (ru) 2020-09-09
US20140135345A1 (en) 2014-05-15
EP3395812B8 (en) 2022-11-02
BR112013021549A2 (pt) 2016-11-01
MY165767A (en) 2018-04-23
NZ614787A (en) 2014-08-29
CA2827057C (en) 2022-06-07
WO2012116276A1 (en) 2012-08-30
US10183930B2 (en) 2019-01-22
BR112013021549B1 (pt) 2022-01-11
ES2932441T3 (es) 2023-01-19
MX346533B (es) 2017-03-14
PH12013501726A1 (en) 2014-01-13
US20190308952A1 (en) 2019-10-10

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