KR102013566B1 - ６-(피페리딘-４-일옥시)-２ｈ-이소퀴놀린-１-온 하이드로클로라이드의 결정성 용매화물 - Google Patents

６-(피페리딘-４-일옥시)-２ｈ-이소퀴놀린-１-온 하이드로클로라이드의 결정성 용매화물 Download PDF

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KR102013566B1
KR102013566B1 KR1020147003354A KR20147003354A KR102013566B1 KR 102013566 B1 KR102013566 B1 KR 102013566B1 KR 1020147003354 A KR1020147003354 A KR 1020147003354A KR 20147003354 A KR20147003354 A KR 20147003354A KR 102013566 B1 KR102013566 B1 KR 102013566B1
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polymorph
hydrate
formula
yloxy
piperidin
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KR20140045550A (ko
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노르베르트 나겔
브루노 바움가르터너
하랄트 베르흐톨트
올리버 플레텐부륵
디터 카데라이트
만디 모흐닉케
지몬 게쓸러
요아힘 틸너
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사노피
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
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    • A61P11/06—Antiasthmatics
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
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  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
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  • Rheumatology (AREA)
  • Hematology (AREA)
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KR1020147003354A 2011-07-08 2012-06-27 ６-(피페리딘-４-일옥시)-２ｈ-이소퀴놀린-１-온 하이드로클로라이드의 결정성 용매화물 Active KR102013566B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP11305890.3 2011-07-08
EP11305890 2011-07-08
EP11306033.9 2011-12-29
EP11306033 2011-12-29
PCT/EP2012/062431 WO2013007518A1 (en) 2011-07-08 2012-06-27 Crystalline solvates of 6-(piperidin-4-yloxy)-2h-isoquinolin-1-one hydrochloride

Publications (2)

Publication Number Publication Date
KR20140045550A KR20140045550A (ko) 2014-04-16
KR102013566B1 true KR102013566B1 (ko) 2019-08-23

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KR1020147003354A Active KR102013566B1 (ko) 2011-07-08 2012-06-27 ６-(피페리딘-４-일옥시)-２ｈ-이소퀴놀린-１-온 하이드로클로라이드의 결정성 용매화물

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US (2) US8710078B2 (https=)
EP (1) EP2729460B1 (https=)
JP (1) JP6357100B2 (https=)
KR (1) KR102013566B1 (https=)
CN (1) CN103781778B (https=)
AU (1) AU2012283276B2 (https=)
CA (1) CA2843773C (https=)
CO (1) CO6870040A2 (https=)
CY (1) CY1118326T1 (https=)
DK (1) DK2729460T3 (https=)
ES (1) ES2568245T3 (https=)
HR (1) HRP20160356T1 (https=)
HU (1) HUE027309T2 (https=)
IN (1) IN2014CN00817A (https=)
MA (1) MA35340B1 (https=)
PH (1) PH12014500289B1 (https=)
PL (1) PL2729460T3 (https=)
RU (1) RU2619129C2 (https=)
SG (1) SG2014007520A (https=)
SI (1) SI2729460T1 (https=)
WO (1) WO2013007518A1 (https=)
ZA (1) ZA201400941B (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2729460B1 (en) * 2011-07-08 2016-01-13 Sanofi Crystalline solvates of 6-(piperidin-4-yloxy)-2h-isoquinolin-1-one hydrochloride

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008077550A1 (en) * 2006-12-27 2008-07-03 Sanofi-Aventis Substituted isoquinoline and isoquinolinone derivatives as inhibitors of rho-kinase

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001051919A2 (en) * 2000-01-07 2001-07-19 Transform Pharmaceuticals, Inc. High-throughput formation, identification, and analysis of diverse solid-forms
KR101373535B1 (ko) * 2005-07-26 2014-03-12 사노피 Ｒｈｏ-키나제 억제제로서의 피페리디닐-치환된 이소퀴놀론유도체
TW200738682A (en) 2005-12-08 2007-10-16 Organon Nv Isoquinoline derivatives
WO2007101242A1 (en) 2006-02-28 2007-09-07 Meadwestvaco Packaging Systems Llc Carton for tapered and cylindrical articles and blank therefor
WO2008077555A2 (en) * 2006-12-27 2008-07-03 Sanofi-Aventis Substituted isoquinolines and their use as rho-kinase inhibitors
CN101910123A (zh) * 2007-12-26 2010-12-08 塞诺菲-安万特股份有限公司 6-取代的-1-(2h)-异喹啉酮的制备方法
EP2729460B1 (en) * 2011-07-08 2016-01-13 Sanofi Crystalline solvates of 6-(piperidin-4-yloxy)-2h-isoquinolin-1-one hydrochloride

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008077550A1 (en) * 2006-12-27 2008-07-03 Sanofi-Aventis Substituted isoquinoline and isoquinolinone derivatives as inhibitors of rho-kinase

Also Published As

Publication number Publication date
IN2014CN00817A (https=) 2015-04-03
SG2014007520A (en) 2014-07-30
US8710078B2 (en) 2014-04-29
NZ620864A (en) 2015-08-28
EP2729460A1 (en) 2014-05-14
JP2014518235A (ja) 2014-07-28
EP2729460B1 (en) 2016-01-13
HRP20160356T1 (hr) 2016-05-06
AU2012283276A1 (en) 2014-02-27
CN103781778A (zh) 2014-05-07
CY1118326T1 (el) 2017-06-28
AU2012283276B2 (en) 2014-07-24
US20140221656A1 (en) 2014-08-07
RU2619129C2 (ru) 2017-05-12
PH12014500289B1 (en) 2019-06-28
DK2729460T3 (en) 2016-04-18
ZA201400941B (en) 2015-05-27
HUE027309T2 (en) 2016-10-28
CO6870040A2 (es) 2014-02-20
RU2014104358A (ru) 2015-08-20
HK1192546A1 (zh) 2014-08-22
WO2013007518A1 (en) 2013-01-17
ES2568245T3 (es) 2016-04-28
CN103781778B (zh) 2015-10-07
PH12014500289A1 (en) 2014-03-24
KR20140045550A (ko) 2014-04-16
MA35340B1 (fr) 2014-08-01
CA2843773C (en) 2018-11-06
SI2729460T1 (sl) 2016-05-31
PL2729460T3 (pl) 2016-07-29
US20130012444A1 (en) 2013-01-10
JP6357100B2 (ja) 2018-07-11
CA2843773A1 (en) 2013-01-17

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