KR101996862B1 - 항균성 시클로펜타[c]피롤 치환 3,4-디하이드로-1h-[1,8]나프티리디논 - Google Patents

항균성 시클로펜타[c]피롤 치환 3,4-디하이드로-1h-[1,8]나프티리디논 Download PDF

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KR101996862B1
KR101996862B1 KR1020147005329A KR20147005329A KR101996862B1 KR 101996862 B1 KR101996862 B1 KR 101996862B1 KR 1020147005329 A KR1020147005329 A KR 1020147005329A KR 20147005329 A KR20147005329 A KR 20147005329A KR 101996862 B1 KR101996862 B1 KR 101996862B1
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compound
hydrogen
formula
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KR20140072034A (ko
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제롬 에밀 조르쥬 길레몽
다비드 프란시스 알라인 랑크와즈
마갈리 매들린 시몬 모떼
아닐 코울
벤디 미아 알버트 발레만스
에릭 피에르 알렉산드라 아르누드
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얀센 사이언시즈 아일랜드 언리미티드 컴퍼니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020147005329A 2011-08-10 2012-08-10 항균성 시클로펜타[c]피롤 치환 3,4-디하이드로-1h-[1,8]나프티리디논 Expired - Fee Related KR101996862B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11177119.2 2011-08-10
EP11177119 2011-08-10
PCT/EP2012/065733 WO2013021054A1 (en) 2011-08-10 2012-08-10 Antibacterial cyclopenta[c]pyrrole substituted 3,4-dihydro-1h-[1,8]naphthyridinones

Publications (2)

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KR20140072034A KR20140072034A (ko) 2014-06-12
KR101996862B1 true KR101996862B1 (ko) 2019-07-05

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KR1020147005329A Expired - Fee Related KR101996862B1 (ko) 2011-08-10 2012-08-10 항균성 시클로펜타[c]피롤 치환 3,4-디하이드로-1h-[1,8]나프티리디논

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Country Link
US (7) US8906923B2 (https=)
EP (1) EP2742045B1 (https=)
JP (2) JP5921687B2 (https=)
KR (1) KR101996862B1 (https=)
CN (2) CN103874698B (https=)
AR (1) AR087508A1 (https=)
AU (1) AU2012293621B2 (https=)
BR (1) BR112014003063B1 (https=)
CA (1) CA2842518C (https=)
CL (1) CL2014000289A1 (https=)
DK (1) DK2742045T3 (https=)
EA (1) EA201490438A1 (https=)
ES (1) ES2721658T3 (https=)
HU (1) HUE042978T2 (https=)
IL (1) IL230549A (https=)
JO (1) JO3611B1 (https=)
MX (1) MX348128B (https=)
PE (1) PE20141410A1 (https=)
PH (1) PH12014500317A1 (https=)
TR (1) TR201905537T4 (https=)
TW (1) TWI568731B (https=)
UA (1) UA111210C2 (https=)
UY (1) UY34253A (https=)
WO (1) WO2013021054A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3611B1 (ar) * 2011-08-10 2020-08-27 Janssen Sciences Ireland Uc سايكلو بنتا (سي (بيرول 4,3 ثاني هيدرو 1 hمستبدله [8,1] نافثيريدينونات مضادة للجراثيم
CN105503869A (zh) 2011-08-10 2016-04-20 爱尔兰詹森科学公司 抗细菌的哌啶基取代的3,4-二氢-1h-[1,8]萘啶酮
JP6250667B2 (ja) * 2012-08-10 2017-12-20 ヤンセン・サイエンシズ・アイルランド・ユーシー 新しい抗菌化合物
AR097794A1 (es) 2013-09-26 2016-04-13 Mnemosyne Pharmaceuticals Inc Moduladores octahidro-ciclopenta[c]pirrol negativos de nr2b
JO3579B1 (ar) 2014-09-26 2020-07-05 Luc Therapeutics Inc مُعدِلات تفاغرية سالبة لمستقبل nr2b من المركب n-ألكيل أريل-5-أوكسي أريل-ثامن هيدرو-خماسي الحلقة [c] بيرول
LT3483164T (lt) 2017-03-20 2020-05-11 Forma Therapeutics, Inc. Pirolpirolo kompozicijos kaip piruvato kinazės (pkr) aktyvatoriai
US11691967B2 (en) 2018-03-12 2023-07-04 The Board Of Trustees Of The University Of Illinois Antibiotics effective for gram-negative pathogens
EP3852791B1 (en) 2018-09-19 2024-07-03 Novo Nordisk Health Care AG Activating pyruvate kinase r
EP3853206B1 (en) 2018-09-19 2024-04-10 Novo Nordisk Health Care AG Treating sickle cell disease with a pyruvate kinase r activating compound
SMT202400519T1 (it) * 2018-11-12 2025-01-14 Debiopharm Int Sa Composti antibiotici. metodi di produzione degli stessi, composizioni farmaceutiche contenenti gli stessi e loro usi
HRP20251148T1 (hr) 2019-09-19 2025-11-21 Novo Nordisk Health Care Ag Pripravci koji aktiviraju piruvat-kinazu r (pkr)
CN117440958A (zh) * 2021-03-17 2024-01-23 爱尔兰詹森科学公司 抗菌化合物
US12128035B2 (en) 2021-03-19 2024-10-29 Novo Nordisk Health Care Ag Activating pyruvate kinase R

Citations (2)

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WO2008009122A1 (en) 2006-07-20 2008-01-24 Affinium Pharmaceuticals, Inc. Acrylamide derivatives as fab i inhibitors
WO2011061214A1 (en) 2009-11-18 2011-05-26 Fab Pharma Sas Novel heterocyclic acrylamides and their use as pharmaceuticals

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US4215123A (en) * 1979-05-07 1980-07-29 American Home Products Corporation Antisecretory 4-oxy-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives
WO2001026652A1 (en) 1999-10-08 2001-04-19 Smithkline Beecham Corporation Fab i inhibitors
ATE294578T1 (de) 1999-10-08 2005-05-15 Affinium Pharm Inc Fab i hemmer
HU230030B1 (hu) 1999-10-08 2015-05-28 Debiopharm International Sa Fab I inhibitorok
EP1560584B1 (en) 2001-04-06 2009-01-14 Affinium Pharmaceuticals, Inc. Fab i inhibitors
DK1828167T3 (da) 2004-06-04 2014-10-20 Debiopharm Int Sa Acrylamidderivater som antibiotiske midler
US7732612B2 (en) 2004-09-09 2010-06-08 Janssen Pharmaceutica, N.V. 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
US7973060B2 (en) 2005-10-13 2011-07-05 Crystalgenomics, Inc. Fab I inhibitor and process for preparing same
EP2125802A4 (en) * 2007-02-16 2014-08-20 Debiopharm Int Sa SALTS, PRODRUGS AND POLYMORPHES OF FAB I INHIBITORS
CA2843643A1 (en) 2011-07-29 2013-02-07 The Children's Hospital Of Philadelphia Compositions and methods for the treatment of hiv
US8766017B2 (en) 2011-07-29 2014-07-01 Eastman Chemical Company Integrated process for the preparation of 1,4-cyclohexanedimethanol from terephthalic acid
CN105503869A (zh) 2011-08-10 2016-04-20 爱尔兰詹森科学公司 抗细菌的哌啶基取代的3,4-二氢-1h-[1,8]萘啶酮
JO3611B1 (ar) * 2011-08-10 2020-08-27 Janssen Sciences Ireland Uc سايكلو بنتا (سي (بيرول 4,3 ثاني هيدرو 1 hمستبدله [8,1] نافثيريدينونات مضادة للجراثيم
US9394295B2 (en) 2011-08-10 2016-07-19 Janssen Sciences Ireland Uc Antibacterial homopiperidinyl substituted 3,4-dihydro-1H-[1,8]naphthyridinones

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008009122A1 (en) 2006-07-20 2008-01-24 Affinium Pharmaceuticals, Inc. Acrylamide derivatives as fab i inhibitors
WO2011061214A1 (en) 2009-11-18 2011-05-26 Fab Pharma Sas Novel heterocyclic acrylamides and their use as pharmaceuticals

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Publication number Publication date
CN103874698B (zh) 2016-03-23
US20180105525A1 (en) 2018-04-19
US20160194324A1 (en) 2016-07-07
MX2014001600A (es) 2014-04-25
TW201313714A (zh) 2013-04-01
HK1223352A1 (zh) 2017-07-28
TR201905537T4 (tr) 2019-05-21
DK2742045T3 (en) 2019-04-23
US20190194194A1 (en) 2019-06-27
NZ620212A (en) 2015-10-30
US10155759B2 (en) 2018-12-18
US9290493B2 (en) 2016-03-22
JP2014531404A (ja) 2014-11-27
JO3611B1 (ar) 2020-08-27
EP2742045B1 (en) 2019-01-23
US9617262B2 (en) 2017-04-11
US20170174683A1 (en) 2017-06-22
UY34253A (es) 2013-02-28
CA2842518A1 (en) 2013-02-14
US10526331B2 (en) 2020-01-07
PE20141410A1 (es) 2014-10-13
HUE042978T2 (hu) 2019-07-29
US20190084982A1 (en) 2019-03-21
US10501463B2 (en) 2019-12-10
AR087508A1 (es) 2014-03-26
EA201490438A1 (ru) 2014-06-30
AU2012293621A1 (en) 2014-02-13
IL230549A0 (en) 2014-03-31
UA111210C2 (uk) 2016-04-11
CL2014000289A1 (es) 2014-07-11
TWI568731B (zh) 2017-02-01
JP5921687B2 (ja) 2016-05-24
US9884864B2 (en) 2018-02-06
CA2842518C (en) 2019-07-23
US20140171451A1 (en) 2014-06-19
WO2013021054A1 (en) 2013-02-14
ES2721658T3 (es) 2019-08-02
IL230549A (en) 2017-07-31
CN103874698A (zh) 2014-06-18
MX348128B (es) 2017-05-26
JP2016190843A (ja) 2016-11-10
AU2012293621B2 (en) 2016-07-21
HK1199243A1 (zh) 2015-06-26
CN105461684B (zh) 2018-09-25
PH12014500317A1 (en) 2014-04-14
CN105461684A (zh) 2016-04-06
BR112014003063B1 (pt) 2020-11-17
US8906923B2 (en) 2014-12-09
EP2742045A1 (en) 2014-06-18
KR20140072034A (ko) 2014-06-12
BR112014003063A2 (pt) 2017-02-21
US20150080413A1 (en) 2015-03-19

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