KR101979042B1 - 세린/트레오닌 키나제 억제제로서의 퀴나졸린 화합물 - Google Patents

세린/트레오닌 키나제 억제제로서의 퀴나졸린 화합물 Download PDF

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Publication number
KR101979042B1
KR101979042B1 KR1020147005731A KR20147005731A KR101979042B1 KR 101979042 B1 KR101979042 B1 KR 101979042B1 KR 1020147005731 A KR1020147005731 A KR 1020147005731A KR 20147005731 A KR20147005731 A KR 20147005731A KR 101979042 B1 KR101979042 B1 KR 101979042B1
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methyl
quinazoline
fluoro
carboxamide
pyrazol
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Korean (ko)
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KR20140062057A (ko
Inventor
제임스 에프. 블레이크
후이펀 천
마크 조셉 치카렐리
제이슨 드미스
루스탐 퍼디낸드 가레이
존 가우디노
루이스 가자드
로버트 제이. 카우스
사무엘 킨츠
피터 제이. 모어
데이비드 에이. 모레노
제이콥 슈왈츠
크리스토퍼 에스. 시에뎀
엘리 엠. 월래스
Original Assignee
어레이 바이오파마 인크.
제넨테크, 인크.
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Publication of KR20140062057A publication Critical patent/KR20140062057A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020147005731A 2011-08-04 2012-08-03 세린/트레오닌 키나제 억제제로서의 퀴나졸린 화합물 Expired - Fee Related KR101979042B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161515165P 2011-08-04 2011-08-04
US61/515,165 2011-08-04
PCT/US2012/049551 WO2013020062A1 (en) 2011-08-04 2012-08-03 Quinazoline compounds as serine/threonine kinase inhibitors

Publications (2)

Publication Number Publication Date
KR20140062057A KR20140062057A (ko) 2014-05-22
KR101979042B1 true KR101979042B1 (ko) 2019-05-15

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KR1020147005731A Expired - Fee Related KR101979042B1 (ko) 2011-08-04 2012-08-03 세린/트레오닌 키나제 억제제로서의 퀴나졸린 화합물

Country Status (11)

Country Link
US (1) US9187462B2 (enExample)
EP (1) EP2739618B1 (enExample)
JP (1) JP6097289B2 (enExample)
KR (1) KR101979042B1 (enExample)
CN (1) CN103958502B (enExample)
BR (1) BR112014002675A2 (enExample)
CA (1) CA2844058A1 (enExample)
ES (1) ES2552989T3 (enExample)
MX (1) MX340756B (enExample)
RU (1) RU2014108140A (enExample)
WO (1) WO2013020062A1 (enExample)

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AU2013225737B2 (en) 2012-03-01 2018-03-01 Array Biopharma Inc. Serine/threonine kinase inhibitors
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MX2015004615A (es) 2012-10-16 2015-07-17 Hoffmann La Roche Inhibidores de serina/treonina cinasa.
CN103254142B (zh) * 2013-04-26 2015-10-28 浙江工业大学 4-[4-(2-取代氨基乙酰氨基)苯胺基]喹唑啉类衍生物及制备和应用
US9532987B2 (en) 2013-09-05 2017-01-03 Genentech, Inc. Use of a combination of a MEK inhibitor and an ERK inhibitor for treatment of hyperproliferative diseases
JP6449293B2 (ja) 2013-12-06 2019-01-09 ジェネンテック， インコーポレイテッド セリン／トレオニンキナーゼ阻害剤
WO2015103133A1 (en) * 2013-12-30 2015-07-09 Genentech, Inc. Serine/threonine kinase inhibitors
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WO2017180581A1 (en) 2016-04-15 2017-10-19 Genentech, Inc. Diagnostic and therapeutic methods for cancer
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WO2019158579A1 (en) 2018-02-13 2019-08-22 Vib Vzw Targeting minimal residual disease in cancer with rxr antagonists
WO2019213403A1 (en) 2018-05-02 2019-11-07 Kinnate Biopharma Inc. Inhibitors of cyclin-dependent kinases
AU2019291935A1 (en) 2018-06-29 2021-02-04 Kinnate Biopharma Inc. Inhibitors of cyclin-dependent kinases
CN117105933A (zh) 2018-10-31 2023-11-24 吉利德科学公司 具有hpk1抑制活性的取代的6-氮杂苯并咪唑化合物
CN113227089B (zh) 2018-10-31 2024-07-05 吉利德科学公司 作为hpk1抑制剂的取代的6-氮杂苯并咪唑化合物
EP3972695A1 (en) 2019-05-23 2022-03-30 Gilead Sciences, Inc. Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors
CA3154247A1 (en) * 2019-10-25 2021-04-29 Mitchell H. KEYLOR N-(heteroaryl) quinazolin-2-amine derivatives as lrrk2 inhibitors, pharmaceutical compositions, and uses thereof
CN115448864B (zh) * 2022-08-26 2023-12-22 上海方予健康医药科技有限公司 3-氟-3-（1-羟乙基）吡咯烷-1-羧酸叔丁酯的制备方法

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Also Published As

Publication number Publication date
RU2014108140A (ru) 2015-09-10
WO2013020062A1 (en) 2013-02-07
US9187462B2 (en) 2015-11-17
HK1199021A1 (zh) 2015-06-19
KR20140062057A (ko) 2014-05-22
JP6097289B2 (ja) 2017-03-15
MX2014001389A (es) 2014-11-13
MX340756B (es) 2016-07-25
CN103958502B (zh) 2016-02-10
US20150087664A1 (en) 2015-03-26
CN103958502A (zh) 2014-07-30
CA2844058A1 (en) 2013-02-07
HK1199248A1 (zh) 2015-06-26
EP2739618B1 (en) 2015-09-16
ES2552989T3 (es) 2015-12-03
BR112014002675A2 (pt) 2017-02-21
JP2014521696A (ja) 2014-08-28
EP2739618A1 (en) 2014-06-11

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