KR101978899B1 - 히스톤 라이신 탈메틸화 촉매 활성을 조절하기 위한 신규 피리도피리미디논 화합물 - Google Patents

히스톤 라이신 탈메틸화 촉매 활성을 조절하기 위한 신규 피리도피리미디논 화합물 Download PDF

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KR101978899B1
KR101978899B1 KR1020177014472A KR20177014472A KR101978899B1 KR 101978899 B1 KR101978899 B1 KR 101978899B1 KR 1020177014472 A KR1020177014472 A KR 1020177014472A KR 20177014472 A KR20177014472 A KR 20177014472A KR 101978899 B1 KR101978899 B1 KR 101978899B1
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methyl
pyrimidin
pyrido
amino
esi
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KR20170072943A (ko
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김명섭
박태선
윤태영
양승민
김해선
김준규
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동아에스티 주식회사
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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KR1020177014472A 2014-10-29 2015-10-27 히스톤 라이신 탈메틸화 촉매 활성을 조절하기 위한 신규 피리도피리미디논 화합물 Expired - Fee Related KR101978899B1 (ko)

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Application Number Priority Date Filing Date Title
US201462069915P 2014-10-29 2014-10-29
US62/069,915 2014-10-29
PCT/KR2015/011386 WO2016068580A2 (en) 2014-10-29 2015-10-27 Novel pyridopyrimidinone compounds for modulating the catalytic activity of histone lysine demethylases (kdms)

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KR20170072943A KR20170072943A (ko) 2017-06-27
KR101978899B1 true KR101978899B1 (ko) 2019-05-15

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US (1) US9834550B2 (https=)
EP (1) EP3212647B1 (https=)
JP (1) JP6505222B2 (https=)
KR (1) KR101978899B1 (https=)
CN (1) CN107001358A (https=)
AU (1) AU2015340215B2 (https=)
BR (1) BR112017008312A2 (https=)
CA (1) CA2962917C (https=)
MX (1) MX2017005346A (https=)
NZ (1) NZ730475A (https=)
RU (1) RU2684396C2 (https=)
SG (1) SG11201702075QA (https=)
WO (1) WO2016068580A2 (https=)

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EP3359154B1 (en) * 2015-10-08 2021-05-26 Suzhou Yunxuan Yiyao Keji Youxian Gongsi Wnt signaling pathway inhibitors and therapeutic applications thereof
JP7114076B2 (ja) 2015-12-22 2022-08-08 シャイ・セラピューティクス・エルエルシー がん及び炎症性疾患の処置のための化合物
JP7514005B2 (ja) 2017-06-21 2024-07-10 シャイ・セラピューティクス・エルエルシー がん、炎症性疾患、ラソパシー、及び線維性疾患の治療のためのｒａｓスーパーファミリーと相互作用する化合物
CN112119065B (zh) * 2018-07-13 2024-01-23 四川科伦博泰生物医药股份有限公司 苯并二氮杂环类化合物、其制备方法及用途
JP7407461B2 (ja) 2018-12-19 2024-01-04 シャイ・セラピューティクス・エルエルシー がん、炎症性疾患、ｒａｓ病、及び線維性疾患の処置のためのｒａｓスーパーファミリーと相互作用する化合物
US20230110603A1 (en) 2020-01-31 2023-04-13 Kumiai Chemical Industry Co., Ltd. 3-alkoxybenzamide derivative, and pest control agent
WO2021198191A1 (en) 2020-03-30 2021-10-07 Enyo Pharma Quinazolinone derivatives and uses thereof for treating a cancer
US20230150978A1 (en) * 2020-03-30 2023-05-18 Enyo Pharma Quinazolinone derivatives and uses thereof for treating a cancer
GB202114315D0 (en) * 2021-10-06 2021-11-17 Duke Street Bio Ltd Pharmaceutical compound
US20240217968A1 (en) * 2021-03-31 2024-07-04 Duke Street Bio Limited Pharmaceutical compound

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WO2013012915A1 (en) * 2011-07-19 2013-01-24 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
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WO2013012915A1 (en) * 2011-07-19 2013-01-24 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
WO2014087165A1 (en) * 2012-12-06 2014-06-12 University Of Bath Tankyrase inhibitors
CN103694255A (zh) * 2014-01-09 2014-04-02 华中师范大学 吡啶并噁嗪酮和吡啶并嘧啶酮类化合物及其制备方法与应用

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WO2016068580A3 (en) 2016-08-18
AU2015340215B2 (en) 2018-11-15
US20160122343A1 (en) 2016-05-05
MX2017005346A (es) 2017-08-02
CA2962917C (en) 2019-04-30
CA2962917A1 (en) 2016-05-06
US9834550B2 (en) 2017-12-05
KR20170072943A (ko) 2017-06-27
JP6505222B2 (ja) 2019-04-24
EP3212647B1 (en) 2019-04-03
RU2017113007A (ru) 2018-11-29
NZ730475A (en) 2018-09-28
AU2015340215A1 (en) 2017-04-13
BR112017008312A2 (pt) 2017-12-19
SG11201702075QA (en) 2017-04-27
EP3212647A2 (en) 2017-09-06
WO2016068580A2 (en) 2016-05-06
EP3212647A4 (en) 2018-04-18
CN107001358A (zh) 2017-08-01
RU2684396C2 (ru) 2019-04-09
RU2017113007A3 (https=) 2018-11-29
JP2017533215A (ja) 2017-11-09

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