KR101975938B1 - Compositions for improving dry skin comprising swiftlet´s nest extract and fucoidan - Google Patents

Abstract

The present invention relates to a composition for improving dryness of skin comprising an extract of Kumnyeon nest as an active ingredient, which comprises a Kumnyeon nest extract and a fucoidan component extracted from brown algae to provide moisture to the skin, alleviate pruritus, Atopic dermatitis, psoriasis, atopy and psoriasis.

Description

Technical Field [0001] The present invention relates to a composition for improving the dry skin of a skin comprising swollen nest extract and fucoidan as an active ingredient.

The present invention relates to a composition for improving dryness of skin comprising an extract of Kumnyeon nest and fucoidan as an active ingredient, and is useful for improving skin dryness, which is effective for moisturizing skin, including Kumnyeon nest extract, Fucoidan extract extracted from brown algae, and Leaf bark extract ≪ / RTI >

The skin functions as a protective film at the outermost part of the human body and functions to prevent loss of biocomponents such as water and electrolytes and to block the inflow of external harmful substances into the living body. Particularly, the stratum corneum forms an outermost layer of the skin, plays an important role in preventing moisture loss inside the skin from the dry external environment, and at the same time, the skin itself has proper moisture and shows flexibility or elasticity.

Normally, the skin's horny layer usually contains more than 10% water, giving it elasticity and flexibility. The degree of water content decreases from the deep dermis to the epidermis of the surface when viewed by the skin on the skin. The stratum corneum is composed of about 15% water, 70% protein and 15% lipid, while the dermis, especially keratinocyte, consists of 70% water, 15% protein and 5% lipid. The closer the keratinocytes are to the surface, the more the moisture content decreases and eventually reaches 5 ~ 10%. No matter how good the skin is, the outermost skin does not contain more than 20% water. Usually, the skin's moisture content is about 15%, which is called moist skin.

However, skin moisture balance is lost due to various factors such as aging, changes in hormone secretion, external environment such as wind, temperature and sunlight, and physical factors such as cleansing and shaving, resulting in dry skin having a moisture content of 10% or less in the stratum corneum . As a result, the elasticity and flexibility of the skin are lost, ultimately the protective function of the skin disappears, causing skin cracks, erythema, itching, and the like, and when it becomes worse, skin diseases such as psoriasis and atopy occur.

Atopy is a chronic recurrent inflammatory skin disease, the cause and pathogenesis of which is unclear. However, the incidence is high and the symptoms tend to be worse when the positive rate of the intradermal reaction is high, the antibody is present in the serum or various stresses are present in the family such as asthma and inflammation, or allergens.

Atopy is known to occur mainly in infancy and is known as fever, and it is known to occur mainly as the amount of ceramide in the stratum corneum is decreased. In particular, atopic dermatitis has a problem in that the skin becomes dry due to the lack of moisture retaining function of the stratum corneum, and the skin is easily damaged and the function as a protective barrier of the skin is lowered so that the stimulant penetrates into the stratum corneum to induce irritation. It is common for skin allergies to occur easily due to invasion of difficult antigen proteins and to show symptoms of pruritus that are difficult to tolerate.

Psoriasis is characterized by epidermal hyperplasia and inflammation of the epidermis and inflammation of the dermis due to erythematous skin lesions caused by abnormality of the stratum corneum. Genetic factors, environmental factors, drugs, skin irritation, upper inflammation, Causing it to become worse or worse.

Psoriasis is a small wheat-like rash that appears as a layer of white, dandruff-like keratin layers on its surface. It spreads around as new rashes grow around or grow together, causing dryness and slight pruritus symptoms.

In order to solve such problems, various methods of increasing skin moisturizing ability by applying various kinds of skin moisturizing agents or reducing the inflammation of skin by applying steroid components have been widely used.

However, the raw materials of conventional humectants have some problems. For example, water-soluble polyhydric alcohols, such as glycerin and sorbitol, which are most frequently used as moisturizing agents, exhibit excellent moisture resistance, but they are very sticky and cause discomfort. They are easily separated from the skin surface due to physical influences, it's difficult. In addition, a large amount of raw materials such as propylene glycol may cause skin side effects such as erythema when used repeatedly. In addition, natural moisturizing factor (NMF) such as Na-lactate, sodium pyrrolidonecarboxylate (PCA-Na) and Urea are highly electrolytic, And there is a limit to the effect.

In addition, the steroid component exerts a temporary inhibitory effect on inflammation, but it causes side effects such as diabetes, hypertension, drug resistance, and inhibition of epidermal growth when used over a long period of time.

Therefore, in recent years, there has been a growing interest in therapeutic methods using natural materials to improve the skin dryness as described above, and efforts to develop herbal remedies capable of treating the root without side effects and resistance have continued.

The object of the present invention is to improve the dryness of the skin by increasing the moisturizing power of the skin without side effects or resistance and reducing the inflammation by further containing the gangbyeon noodle extract and fucoidan as an active ingredient and further containing the outbreak bark extract, hyaluronic acid and ceramide. And a gold nest extract which can be treated as an effective ingredient.

In order to attain the above object, the present invention provides a composition for improving dry skin condition comprising a gold nodule extract and fucoidan as an active ingredient, wherein the effective ingredient is a mixture of gold nodule extract and fucoidan in a weight ratio of 1: 1 to 1: And the fucoidan is prepared by extracting at least one selected from the group consisting of seaweed, kelp, large seaweed and seaweed.

The composition for improving dryness of the skin according to the present invention may further comprise 25 to 35 parts by weight of a Laai bark bark extract based on 100 parts by weight of the active ingredient.

The composition for improving dry skin of the present invention may further comprise 20 to 30 parts by weight of hyaluronic acid and 1 to 5 parts by weight of ceramides based on 100 parts by weight of the active ingredient.

1 to 5 parts by weight of BIO NEAT-WS (1,3-Butylene Glycol and Capryl hydroxamic acid and 1,2-hexanediol and Boswellia serrata resin extract) based on 100 parts by weight of the active ingredient, 1,3 BG (Butylene Glycol) in an amount of 40 to 50 parts by weight.

In the present invention, the dry skin condition is characterized by being atopic, psoriasis, itching or erythema. The composition for improving the dry skin condition may be a solution, a suspension, an emulsion, a paste, a gel, a cream, a lotion, a powder, ≪ / RTI >

The composition for improving dryness of the skin comprising the gold nodule extract of the present invention as an active ingredient can improve skin dryness such as atopy and psoriasis because it has skin moisturizing and anti-inflammatory effect and can relieve the feeling of dryness caused by dry skin .

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the drawings. Prior to the description, terms and words used in the present specification and claims should not be construed as limited to ordinary or dictionary meanings and should be construed in accordance with the technical concept of the present invention.

Throughout this specification, when an element is referred to as including an element, it is to be understood that the element may include other elements, without departing from the spirit or scope of the present invention.

Hereinafter, the composition for improving dryness of skin comprising the gold nodule extract of the present invention as an active ingredient will be described in more detail.

The present invention relates to a composition comprising a gold nodule extract and fucoidan as an active ingredient, and to a composition for improving dryness of skin, which has the advantage of improving skin dryness without side effects such as cytotoxicity and drug resistance, will be.

In the present specification, the Kumnyeon nest extract is an extract of a nest made of saliva of a small sea swallow called Swiftlet which mainly lives in Southeast Asia. It is composed of seaweeds such as seaweed and fish fins, which are combined with decomposition enzymes, and contain large amounts of proteins, amino acids, sugars, minerals and antioxidants. Promotion of cell regeneration, improvement of immunity and anti-inflammation.

Fucoidan is one of the mucous mucilages contained in brown algae. It is secreted from the mucosal tubules in the leaves and protects the invasion of bacteria when the leaves and stems of the seaweed are damaged by the flow of the tide and the sand. And also prevents seaweed exposed to the atmosphere from drying out.

Various physiological functions of fucoidan are similar to those of heparin, which is a sulfated polysaccharide present in blood, and various physiological functions such as anticancer, antiviral, antiallergic and immunity enhancement have been reported. , Kelp, big algae, and garlic.

The fucoidan and gold nest extract of the present invention are preferably contained in a weight ratio of 1: 1 to 1: 4. When the content of the extract of fucoidan and gold nest is less than the above range, There is a problem that stickiness becomes worse when it is higher than the above range.

It is used as a medicinal material such as anticancer in one room. The fruit is called the womb, and the bark of the tree is called confetti. The uterus is used as a diuretic for nephritis, edema, proteinuria, urine discomfort and the like. Confession blood is used for neuralgia, hepatitis, cholecystitis, jaundice, nephritis, pruritus and cancer.

In the composition for improving the dry skin of the present invention, the dried bark extract is included to improve skin barrier restoration and pruritus, and is contained in an amount of 25 to 35 parts by weight based on 100 parts by weight of the active ingredient. When the extract of Laai bark bark is contained in an amount of less than 25 parts by weight, the effect of improving skin barrier and pruritus is not exhibited, and when it is used in excess of 35 parts by weight, the effect is not increased further, which is economically undesirable.

In order to improve the moisturizing effect of the composition for improving dry skin according to the present invention, 20 to 30 parts by weight of hyaluronic acid and 1 to 5 parts by weight of ceramide may be further added based on 100 parts by weight of the active ingredient. The hyaluronic acid may be an amino acid and uronic acid One of the complicated polysaccharides is excellent in the ability to bind water and has the effect of temporarily moisturizing the stratum corneum. Conversely, ceramide replenishes lipid components to prevent moisture from escaping and gives a feeling of moisturization.

 When the content of hyaluronic acid and ceramide is less than the above range, the skin moisturizing effect is inferior. Even if it is contained in the above range, the effect thereof is not changed, which is economically undesirable.

The present invention relates to a composition for improving dryness of skin comprising BIO NEAT-WS (1,3-Butylene Glycol and Capryl Hydroxamic Acid & 1,2-Hexanediol and Boswellia Serrata Resin Extract), 1,3 BG (Butylene Glycol) As shown in FIG.

BIO NEAT-WS is a natural preservative. In general, antiseptic is a substance that prevents the propagation and decay of bacteria and microorganisms. It is a preservative that prevents the propagation and decay of microorganisms such as ethanol, propylparaben, butylparaben, methylparaben, ethylparaben, benzoic acid, imidazolidinyl urea, Chemical preservatives such as benzoic acid were used. Such conventional preservatives may irritate the skin and cause side effects such as causing contact dermatitis.

On the other hand, BIO NEAT-WS is a natural paraben-free preservative containing an extract of a moisturizing component having a preservative function. More specifically, it includes 1,3-Butylene Glycol, 1,2 Hexanediol, Caprylohydroxamic Acid (CHA) and Boswellia serrata Resin Extract.

1,3-Butylene Glycol is an amphipathic glycolline that is close to hydrophilic and has very low irritation to the skin. It exhibits antimicrobial properties against microorganisms and gives moisture to the skin. 1,2 Hexanediol is a vegetable glycerin that has excellent antimicrobial activity against fungi when it helps formulation stability. Caprylohydroxamic Acid (CHA) is effective at neutral pH, can prevent fungal growth by chelating effect, and has a surfactant effect. Finally, Boswellia serrata Resin Extract is a component extracted from Indian oriental resin, which has anti-inflammatory function and functions to reduce the burning sensation on the skin contact of polyhydric alcohols.

These BIO NEAT-WS exhibit effective repellency within the product and do not cause irritation or allergy. However, in the state of being completely dissolved and not being completely dissolved, it is not dissolved when applied to the skin, and the remaining components react with moisture to cause a weak feeling of heat, and when a small amount is contained, it does not show a preservative effect. Therefore, 1 to 5 parts by weight.

1,3 BG is a large organic alcohol. Although general alcohol rapidly evaporates moisture, the 1,3 BG has a function of attracting moisture and functions as a moisturizing agent for maintaining moisture of the skin. When the active ingredient is contained in an amount of 40 to 50 parts by weight based on 100 parts by weight of the effective ingredient This is preferable because it can effectively impart a moisturizing effect to the skin without stimulation.

Purified water controls the viscosity and specific gravity of the composition and maintains the stability of the formulation. The content of purified water can be adjusted according to the formulation to be produced.

In the present invention, the gold nodule extract and the firewood bark extract are hot water extracts of gold leaf nodule and firewood bark, and fucoidan is a hot water extract of brown algae such as seaweed, seaweed, 5 to 10 L are mixed and heated at 80 to 90 ° C for 3 to 5 hours for hot water extraction.

Generally, when extracting a natural product, it is generally extracted with a solvent in which purified water or a mixture of purified water and alcohols is mixed with a certain amount. However, in order to efficiently extract the active ingredient of the natural products, alkaline ionized water having a pH of 7.5 to 10.5 is extracted It is characterized by the use of water.

Alkali ionized water is composed of 6 units of molecular clusters and is smaller than water which forms hydrogen bonds at 13-15 units. It has good penetration power and high heat conductivity, so that component elution is efficient and absorption power is also excellent. Accordingly, in the present invention, by using alkaline ionized water as a solvent, the active ingredient can be safely extracted, and the original active function can be sufficiently exhibited.

The extracted water of the present invention is preferably a supernatant obtained by adding 100 to 400 g of calcium oxide per 1,000 ml of alkaline ionized water, stirring the mixture, and allowing the mixture to stand at room temperature for 3 to 10 hours. The calcium oxide acts to increase the osmotic pressure of the solvent against the solute, and thus the content of the active ingredient having an antibacterial effect in the extracted solution can be further increased. That is, the alkaline ionized water and calcium oxide may be used together to obtain a synergistic effect of increasing the antibacterial effect.

The extract of the present invention may be prepared in powder form by an additional process such as vacuum distillation and freeze-drying or spray drying.

The composition for dermatoses according to the present invention may have conventional formulations and may be prepared in formulations such as solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, oils or sprays. The composition of each of these formulations may contain various kinds of bases and additives necessary for formulation of the formulation, and the kinds and amounts of these ingredients can be easily selected by those skilled in the art.

The composition for improving dryness of the skin according to the present invention may be used according to a conventional method of use, and may be used in a different number of times depending on the skin condition or taste of the user.

Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims and their equivalents. shall.

[Test Example 1]

Manufacture of Kum-yeon-nest extract, Laok-dong bark extract and fucoidan

The gold nodule extract was prepared by mixing 10 L of alkaline ionized water of pH 8 per 1 ㎏ of gold nest and heating at 90 ℃ for 5 hours. Leaf bark extract was also obtained by hot water extraction in the same manner as above.

In the case of fucoidan, 10 l of alkaline ionized water having a pH of 8 per 1 kg of each of seaweed and sea tangle was added, and the mixture was heated at 90 ° C for 5 hours for hot water extraction to obtain a seaweed extract and sea tangle extract. Alginic acid was precipitated by reacting with calcium chloride and centrifuged at 13,000 rpm for 10 minutes to 30 minutes to remove the precipitate. The alginic acid and calcium chloride solution were mixed in a ratio of 1: 1 by volume of 10% calcium chloride solution. The extract from which the precipitate was removed was frozen at -80 ° C, dried using a freeze dryer, and finally fucoidan derived from seaweed and sea tangle was obtained. The fucoidan was mixed at a weight ratio of 1: 1.

[Test Example 2]

Recovery of skin barrier of gold nest extract + fucoidan

Skin barrier damage was induced using a 1% aqueous solution of sodium lauryl sulfate (SLS) in the aliquots of 8-12 week old nude mice under constant temperature and humidity conditions (24 ° C, 40% humidity). At this time, the degree of skin barrier damage can be judged by measuring TEWL (transepidermal water loss) with Tewameter TM210 (Courage + Khazaka, Cologne, Germany). If skin barrier is damaged, .

Seven compositions (Comparative Examples 1 to 4 and Examples 1 to 3) were prepared by measuring the amount of water-loss of the skin immediately after skin barrier damage, and measuring the amount of water-soluble extracts of Fusarium obtusacea and Fucoidan prepared according to Example 1, ) Was applied to the skin barrier damage area of nude mice by 10 mg.

Comparative Example 1 Comparative Example 2 Comparative Example 3 Example 1 Example 2 Example 3 Comparative Example 4 Goldsmith's nest extract 0 0 2.6 3.7 6.5 15.1 18.3 Fucoidan 0 15 15 15 15 15 15

(Unit: g)

In Table 1, Comparative Example 2 is a composition containing only fucoidan, Comparative Examples 3 and 4 are compositions combined with an optimum content ratio of gold nest extract and fucoidan according to the present invention, and Examples 1 to 3 show compositions , And the degree of restoration of skin barrier was confirmed in Comparative Examples 1 to 4 and Examples 1 to 3. The results are shown in Table 1.

After 6 hours from the application of the compositions, the amount of water loss was measured, and the recovery rate of the amount of water-loss of the skin (hereinafter referred to as? TEWL) was calculated as shown in equation (1) Respectively.

(1)

(One)

△ TEWL: Recovery rate (%) of the amount of moisture loss of the hard skin

T0: the amount of water-loss of the epidermis before application (immediately after damage)

T6: Light skin moisture loss after 6 hours of application

Comparative Example 1 Comparative Example 2 Comparative Example 3 Example 1 Example 2 Example 3 Comparative Example 4 △ TEWL 0.2 4.3 8.2 19.4 21.7 22.5 22.6

(unit:%)

According to Table 2, ΔTEWL was the lowest in Comparative Example 1, which is a non-coated region, and ΔTEWL slightly increased, in Comparative Example 2 where only Fucoidan was applied. However, in the case of Comparative Examples 3 to 4 and Examples 1 to 3 in which gold nodule extract and fucoidan were all included, it was found that ΔTEWL was greatly increased, and recovery of skin barrier damage was effective when applying gold nodule extract and fucoidan I could.

In addition, in the case of Example 1, ΔTEWL increased more than twice as much as that of Comparative Example 3, and therefore, the extract of gold nodule from 3.7 g of fucoidan was 3.7 g or more, and since the rate of increase of? TEWL is remarkably lowered from Example 3 onward, it is preferable that 15 g or less of gold nodule extract is contained in 15 g of fucoidan in terms of economy.

Therefore, the compositions most effective for restoring the damaged skin barrier are Examples 1 to 3, and it is understood that the most preferable composition is Example 2 because the stickiness increases and the water absorption rate tends to decrease as the content of the gold nodule extract increases.

[Test Example 3]

Skin barrier recovery effect of Fusarium nest extract + Fucoidan + Laodong bark extract

According to the results of Test Example 2, the composition of Example 2, which is most effective for restoring the damaged skin barrier, further contains 6.5 g of the open-shell bark extract prepared in the same manner as in Test Example 1 to prepare a composition. The above-mentioned composition was tested by the same method as in Test Example 2, and the result of? TEWL was 22.3%.

The ΔTEWL value was higher than that of ΔTEWL of 21.7% in Test Example 2, indicating that the open-shell bark extract was helpful in restoring the damaged skin barrier.

[Test Example 4]

Confirmation of skin dryness improvement effect through human body test

5 g of hyaluronic acid, 0.5 g of ceramide, and 0.5 g of BIO NEAT-WS 0.5 were added to 6.5 g of the gingko nest extract, 15 g of fucoidan and 6.5 g of the open mouth bark extract, g, 1,3 g of BG, and 62.5 g of purified water were mixed to prepare the composition of Example 4.
5 parts by weight of hyaluronic acid, 0.5 part by weight of ceramide, 0.5 part by weight of BIO NEAT-WS, and 10 parts by weight of 1,3 BG were added to 6.5 parts by weight of the gold nodule extract, 15 parts by weight of fucoidan, And 62.5 parts by weight of purified water.

In addition, the compositions of Comparative Example 5 were prepared by mixing the same amounts of the remaining compositions except for the gold nodule extract, fucoidan and the open bark extract as a control.

To examine the effect of the composition of Example 4 and Comparative Example 5 on dry skin dryness improvement, 20 adult male and female adults of 20 to 30 years were selected, and the score of scoring of atopic dermatitis index (SCORAD INDEX) Water content and pruritus VAS (visual analogue scale) were evaluated before and after use. The results are shown in Table 3.

At this time, the subject to be tested was selected as a person having dry skin on arms or legs having a score of 40 or less in the evaluation of atopic severity index by a specialist. The selected 20 human subjects were randomly assigned to each of the compositions of Example 4 and Comparative Example 5 by double blind, and were allowed to use for 8 weeks in the morning and evening.

On the other hand, the atopy severity index is a scoring of the degree of atopic symptoms. As the atopy is alleviated, the value decreases and the skin moisture content is measured using Corneometer CM820 (Courage + Khazaka, Cologne, Germany) The higher the value, the higher the value.

Assessment of pruritus VAS is an assessment of changes in skin pruritus, or itching. Record the absence of pruritus at one end on a 10 cm long line, record the most imaginable pruritus possible at the other end, and then list the pruritus presently felt by the human subject to be tested on the above line. At this time, all of the compositions are written on the same line before and after use, and the length thereof can be measured to confirm the change in pruritus.

Example 4 Comparative Example 5 Atopy severity index Before use 30.51 30.39 After 8 weeks of use 24.12 28.01 Rate of change (%) 20.9 7.8 Skin moisture content Before use 12.1 13.5 After 8 weeks of use 25.4 17.7 Rate of change (%) 109.9 31.1 Pruritus VAS
Before use 7.6 7.5 After 8 weeks of use 3.8 6.2 Rate of change (%) 50.0 17.3

In Table 3, the atopy severity index, the skin moisture content, and the percent change (%) before and after 8 weeks of use of the VAS can be calculated as shown in equation (2).

(2)

(2)

The atopic severity index, the skin moisture content and the rate of change of VAS of pruritus of Example 4 were higher than those of Comparative Example 5, and thus it was found to be more effective in improving the skin dryness.

Therefore, it was found that the composition for improving dryness of skin including the gold nodule extract, fucoidan and bamboo bark extract of the present invention as used in the present invention improves the dryness of skin and relieves pruritus without side effects or resistance.

Claims (2)

A method for preparing a composition for improving dryness of skin comprising a gold nest extract and fucoidan as an active ingredient,
The fucoidan is prepared by extracting from a raw material containing seaweed and sea tangle,
5 parts by weight of hyaluronic acid, 0.5 part by weight of ceramide, 0.5 part by weight of BIO NEAT-WS, 10 parts by weight of 1,3 BG and 62.5 parts by weight of purified water were added to 6.5 parts by weight of the gold nodule extract, 15 parts by weight of fucoidan, ≪ / RTI >
The skin dryness is atopic, psoriasis, itching or erythema,
Wherein the composition for improving dryness of the skin has a formulation selected from the group consisting of a solution, a suspension, an emulsion, a paste, a gel, a cream, a lotion, a powder, an oil and a spray,
The gold nest extract was prepared by mixing 10 L of alkaline ionized water having pH 8 per kg of gold nest and heating at 90 ° C for 5 hours,
The above-mentioned open-shell bark extract is prepared by mixing 10 L of alkaline ionized water having a pH of 8 per kg and heating the mixture at 90 ° C for 5 hours,
The fucoidan,
Seaweed extract and seaweed extract were mixed with each fucoidan at a weight ratio of 1: 1,
Each fucoidan through the seaweed extract and seaweed extract,
10 L of alkaline ionized water having a pH of 8 per 1 kg of seaweed and sea tangle was added and heated at 90 ° C for 5 hours to extract hot water to obtain a seaweed extract and sea tangle extract,
The alginic acid was precipitated by reacting with calcium chloride and centrifuged at 13,000 rpm for 10 minutes to 30 minutes to remove the precipitate,
Wherein the extract from which the precipitate has been removed is frozen at -80 ° C. and then dried using a freeze dryer. delete