KR101972619B1 - 페닐 유도체 - Google Patents
페닐 유도체 Download PDFInfo
- Publication number
- KR101972619B1 KR101972619B1 KR1020147007997A KR20147007997A KR101972619B1 KR 101972619 B1 KR101972619 B1 KR 101972619B1 KR 1020147007997 A KR1020147007997 A KR 1020147007997A KR 20147007997 A KR20147007997 A KR 20147007997A KR 101972619 B1 KR101972619 B1 KR 101972619B1
- Authority
- KR
- South Korea
- Prior art keywords
- group
- phenoxy
- hydroxy
- phenyl
- fluorophenoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
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- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Communicable Diseases (AREA)
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- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011213987 | 2011-09-29 | ||
| JPJP-P-2011-213987 | 2011-09-29 | ||
| PCT/JP2012/074968 WO2013047701A1 (ja) | 2011-09-29 | 2012-09-27 | フェニル誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20140077891A KR20140077891A (ko) | 2014-06-24 |
| KR101972619B1 true KR101972619B1 (ko) | 2019-04-25 |
Family
ID=47995728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020147007997A Expired - Fee Related KR101972619B1 (ko) | 2011-09-29 | 2012-09-27 | 페닐 유도체 |
Country Status (23)
| Country | Link |
|---|---|
| US (5) | US8975409B2 (https=) |
| EP (2) | EP3150577B1 (https=) |
| JP (2) | JP6052180B2 (https=) |
| KR (1) | KR101972619B1 (https=) |
| CN (1) | CN103958465B (https=) |
| AU (1) | AU2012317457B2 (https=) |
| BR (1) | BR112014007790A2 (https=) |
| CA (1) | CA2849000C (https=) |
| DK (1) | DK2762466T3 (https=) |
| ES (2) | ES2689132T3 (https=) |
| HU (1) | HUE036017T2 (https=) |
| IL (1) | IL231586A (https=) |
| IN (1) | IN2014CN02332A (https=) |
| MX (1) | MX343949B (https=) |
| MY (1) | MY185489A (https=) |
| PH (1) | PH12014500561A1 (https=) |
| PL (1) | PL2762466T3 (https=) |
| PT (1) | PT2762466T (https=) |
| RU (1) | RU2619105C2 (https=) |
| SG (1) | SG11201400954RA (https=) |
| TW (1) | TWI616435B (https=) |
| WO (1) | WO2013047701A1 (https=) |
| ZA (1) | ZA201401983B (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6052180B2 (ja) | 2011-09-29 | 2016-12-27 | 小野薬品工業株式会社 | フェニル誘導体 |
| NZ712540A (en) * | 2013-03-26 | 2018-06-29 | Ono Pharmaceutical Co | Phenyl derivative having s1p2 antagonistic activity |
| KR102243426B1 (ko) * | 2013-03-26 | 2021-04-21 | 오노 야꾸힝 고교 가부시키가이샤 | 페닐 유도체를 함유하는 의약 |
| WO2019091999A1 (en) | 2017-11-08 | 2019-05-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | S1pr2 antagonists for treating diseases involving abnormal immune responses |
| WO2020000092A1 (en) * | 2018-06-27 | 2020-01-02 | Algernon Pharmaceuticals Inc. | The use of actarit in the prophylaxis or treatment of renal fibrosis or kidney disease |
| CN115433107B (zh) * | 2022-09-19 | 2024-06-18 | 南京欧际医药科技服务有限公司 | S1pr2拮抗剂及其在制备治疗肺部疾病药物中的用途 |
| CN117736140B (zh) * | 2023-12-11 | 2025-10-03 | 辽宁中医药大学 | 马齿苋中一种吡啶类生物碱化合物及其提取分离方法与用途 |
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