KR101954389B1 - 조절가능한 프로모터 - Google Patents

조절가능한 프로모터 Download PDF

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KR101954389B1
KR101954389B1 KR1020147009284A KR20147009284A KR101954389B1 KR 101954389 B1 KR101954389 B1 KR 101954389B1 KR 1020147009284 A KR1020147009284 A KR 1020147009284A KR 20147009284 A KR20147009284 A KR 20147009284A KR 101954389 B1 KR101954389 B1 KR 101954389B1
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promoter
sequence
poi
carbon source
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KR20140069112A (ko
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디트하드 마타노비치
브리지트 개서
마이클 마우러
롤랜드 프리엘호퍼
요아힘 클라인
자나 웽거
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론자 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01012—Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) (1.2.1.12)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
KR1020147009284A 2011-10-07 2012-10-05 조절가능한 프로모터 Active KR101954389B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161544451P 2011-10-07 2011-10-07
US61/544,451 2011-10-07
EP11184323.1 2011-10-07
EP11184323 2011-10-07
EP12171006.5 2012-06-06
EP12171006 2012-06-06
PCT/EP2012/069757 WO2013050551A1 (en) 2011-10-07 2012-10-05 Regulatable promoter

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020197005781A Division KR102128957B1 (ko) 2011-10-07 2012-10-05 조절가능한 프로모터

Publications (2)

Publication Number Publication Date
KR20140069112A KR20140069112A (ko) 2014-06-09
KR101954389B1 true KR101954389B1 (ko) 2019-03-06

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KR1020147009284A Active KR101954389B1 (ko) 2011-10-07 2012-10-05 조절가능한 프로모터
KR1020197005781A Active KR102128957B1 (ko) 2011-10-07 2012-10-05 조절가능한 프로모터

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Country Status (17)

Country Link
US (4) US9512432B2 (https=)
EP (2) EP2764016B1 (https=)
JP (1) JP6113736B2 (https=)
KR (2) KR101954389B1 (https=)
CN (3) CN113788884B (https=)
AR (1) AR088252A1 (https=)
AU (1) AU2012320421B2 (https=)
BR (1) BR112014008152A2 (https=)
CA (1) CA2849856C (https=)
DK (1) DK3508494T3 (https=)
ES (1) ES2913825T3 (https=)
IL (1) IL231859B (https=)
IN (1) IN2014DN03419A (https=)
PL (1) PL2764016T3 (https=)
SG (2) SG10201602673PA (https=)
TW (1) TWI560272B (https=)
WO (1) WO2013050551A1 (https=)

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EP2764016B1 (en) * 2011-10-07 2019-03-13 Lonza Ltd Regulatable promoter
CN104195165A (zh) * 2014-09-01 2014-12-10 北京爱必信生物技术有限公司 包含葡萄糖启动子的载体、宿主菌以及重组牛源胰蛋白酶的制备方法
WO2016077457A1 (en) 2014-11-11 2016-05-19 Clara Foods Co. Methods and compositions for egg white protein production
WO2017021541A1 (en) * 2015-08-05 2017-02-09 Lonza Ltd Promoter variants
EP3423588A1 (en) 2016-03-02 2019-01-09 Lonza Ltd Improved fermentation process
WO2018110616A1 (ja) * 2016-12-15 2018-06-21 株式会社カネカ 新規宿主細胞及びそれを用いた目的タンパク質の製造方法
JP7717459B2 (ja) * 2018-02-12 2025-08-04 ロンザ リミテッド 目的タンパク質を産生するための宿主細胞
EP3536784A1 (en) 2018-03-05 2019-09-11 ACIB GmbH Host cell engineered for improved metabolite production
US11866714B2 (en) 2018-06-07 2024-01-09 Basf Se Promoter for yeast
JP7061234B2 (ja) * 2019-01-11 2022-04-27 ロンザ リミテッド 組換え宿主細胞内での炭素源調節タンパク質産生
HRP20230560T1 (hr) * 2019-01-29 2023-08-18 Clariant Produkte (Deutschland) Gmbh Kimerni promotor za upotrebu u metaboličkom inženjeringu
JP7570346B2 (ja) 2019-04-01 2024-10-21 ウニヴェルズィテート・フューア・ボーデンクルトゥーア・ウィーン Ｍｕｔ－メチロトローフ酵母
WO2020200415A1 (en) 2019-04-01 2020-10-08 Lonza Ltd Mut- methylotrophic yeast
WO2020200414A1 (en) 2019-04-01 2020-10-08 Lonza Ltd Protein production in mut-methylotrophic yeast
US12096784B2 (en) 2019-07-11 2024-09-24 Clara Foods Co. Protein compositions and consumable products thereof
KR20220034848A (ko) 2019-07-11 2022-03-18 클라라 푸드즈 컴퍼니 단백질 조성물 및 이의 섭취 가능한 제품
US10927360B1 (en) 2019-08-07 2021-02-23 Clara Foods Co. Compositions comprising digestive enzymes
AU2021240417A1 (en) 2020-03-26 2022-10-20 AskBio Inc. Forskolin-inducible promoters and hypoxia-inducible promoters
ES3034258T3 (en) 2020-04-01 2025-08-14 Lonza Ag Helper factors for expressing proteins in yeast
EP4136237A1 (en) 2020-04-15 2023-02-22 Asklepios Biopharmaceutical, Inc. Forskolin-inducible promoters and hypoxia-inducible promoters
CN116490517A (zh) 2020-09-30 2023-07-25 龙沙有限公司 过表达翻译因子的宿主细胞
US20240141363A1 (en) 2021-02-12 2024-05-02 Boehringer Ingelheim Rcv Gmbh & Co Kg Signal peptides for increased protein secretion
WO2024133538A1 (en) 2022-12-20 2024-06-27 Lonza Ltd Host cells with pat1 knockout for increased specific protein productivity
WO2025247966A1 (en) 2024-05-29 2025-12-04 Mybios Gmbh Process for protein production in methylotrophic yeast host cell.
WO2026027251A1 (en) 2024-08-01 2026-02-05 Boehringer Ingelheim Rcv Gmbh & Co Kg Signal peptides for increased protein secretion

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Publication number Publication date
SG10201602673PA (en) 2016-05-30
CA2849856A1 (en) 2013-04-11
US9512432B2 (en) 2016-12-06
WO2013050551A1 (en) 2013-04-11
CN113788884B (zh) 2024-07-23
EP2764016A1 (en) 2014-08-13
IL231859B (en) 2020-08-31
US20190185866A1 (en) 2019-06-20
AU2012320421B2 (en) 2017-03-02
CN110055248A (zh) 2019-07-26
TWI560272B (en) 2016-12-01
US11976284B2 (en) 2024-05-07
ES2913825T3 (es) 2022-06-06
CN103998460A (zh) 2014-08-20
EP2764016B1 (en) 2019-03-13
JP6113736B2 (ja) 2017-04-12
KR102128957B1 (ko) 2020-07-02
US10301634B2 (en) 2019-05-28
DK3508494T3 (da) 2022-05-23
SG11201400811QA (en) 2014-08-28
US20140242636A1 (en) 2014-08-28
US11401523B2 (en) 2022-08-02
AU2012320421A1 (en) 2014-03-20
US20170037418A1 (en) 2017-02-09
IN2014DN03419A (https=) 2015-05-22
EP3508494A1 (en) 2019-07-10
IL231859A0 (en) 2014-05-28
JP2014530016A (ja) 2014-11-17
KR20190025048A (ko) 2019-03-08
CA2849856C (en) 2023-03-14
EP3508494B1 (en) 2022-02-23
CN113788884A (zh) 2021-12-14
TW201317350A (zh) 2013-05-01
BR112014008152A2 (pt) 2017-04-18
US20220259608A1 (en) 2022-08-18
KR20140069112A (ko) 2014-06-09
AR088252A1 (es) 2014-05-21
PL2764016T3 (pl) 2019-08-30

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