KR101951220B1 - 조합 als 치료법 - Google Patents

조합 als 치료법 Download PDF

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Publication number
KR101951220B1
KR101951220B1 KR1020147000783A KR20147000783A KR101951220B1 KR 101951220 B1 KR101951220 B1 KR 101951220B1 KR 1020147000783 A KR1020147000783 A KR 1020147000783A KR 20147000783 A KR20147000783 A KR 20147000783A KR 101951220 B1 KR101951220 B1 KR 101951220B1
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KR
South Korea
Prior art keywords
riluzole
administered
delete delete
composition
composition according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1020147000783A
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English (en)
Korean (ko)
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KR20140074270A (ko
Inventor
제시 세달바움
존 마오
패디 말릭
앤드류 에이. 울프
Original Assignee
싸이토키네틱스, 인코포레이티드
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Publication of KR20140074270A publication Critical patent/KR20140074270A/ko
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Publication of KR101951220B1 publication Critical patent/KR101951220B1/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020147000783A 2011-07-13 2012-07-12 조합 als 치료법 Expired - Fee Related KR101951220B1 (ko)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201161507381P 2011-07-13 2011-07-13
US61/507,381 2011-07-13
US201161544533P 2011-10-07 2011-10-07
US61/544,533 2011-10-07
US201261637759P 2012-04-24 2012-04-24
US201261637770P 2012-04-24 2012-04-24
US61/637,759 2012-04-24
US61/637,770 2012-04-24
US201261646699P 2012-05-14 2012-05-14
US61/646,699 2012-05-14
PCT/US2012/046523 WO2013010015A2 (en) 2011-07-13 2012-07-12 Combination als therapy

Publications (2)

Publication Number Publication Date
KR20140074270A KR20140074270A (ko) 2014-06-17
KR101951220B1 true KR101951220B1 (ko) 2019-02-22

Family

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KR1020147000783A Expired - Fee Related KR101951220B1 (ko) 2011-07-13 2012-07-12 조합 als 치료법

Country Status (16)

Country Link
US (1) US10272082B2 (enExample)
EP (1) EP2731611B1 (enExample)
JP (2) JP6145946B2 (enExample)
KR (1) KR101951220B1 (enExample)
CN (2) CN109316480A (enExample)
AU (2) AU2012281042B2 (enExample)
BR (1) BR112014000742A2 (enExample)
CA (1) CA2849213A1 (enExample)
EA (2) EA028060B1 (enExample)
HK (1) HK1197178A1 (enExample)
IL (1) IL230391B (enExample)
IN (1) IN2014DN00200A (enExample)
PH (1) PH12014500094A1 (enExample)
SG (1) SG10201605707UA (enExample)
WO (1) WO2013010015A2 (enExample)
ZA (1) ZA201400236B (enExample)

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US20160263110A1 (en) * 2013-11-04 2016-09-15 Ab Science Use of masitinib for treatment of amyotrophic lateral sclerosis
US20170042890A1 (en) * 2014-04-29 2017-02-16 Cytokinetics, Inc. Methods of reducing decline in vital capacity
ES2751300T3 (es) * 2014-11-21 2020-03-31 Biohaven Therapeutics Ltd Formulación sublingual de riluzol
EA201791110A1 (ru) * 2014-11-21 2017-11-30 Биохэвен Фармасьютикэл Холдинг Компани Лтд. Сублингвальное введение рилузола
EP3072513A1 (en) * 2015-03-26 2016-09-28 Medday Biotin for treating Amyotrophic lateral sclerosis
CA3018635C (en) 2016-03-25 2023-09-26 Ab Science Use of masitinib for treatment of an amyotrophic lateral sclerosis patient subpopulation
WO2021055890A1 (en) 2019-09-20 2021-03-25 Icahn School Of Medicine At Mount Sinai Controlled release formulations of riluzole and their uses

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Also Published As

Publication number Publication date
PH12014500094A1 (en) 2014-03-17
US20140243344A1 (en) 2014-08-28
AU2016244263A1 (en) 2016-11-03
AU2012281042A1 (en) 2014-01-30
EA201791043A1 (ru) 2017-09-29
WO2013010015A3 (en) 2014-05-15
KR20140074270A (ko) 2014-06-17
CA2849213A1 (en) 2013-01-17
ZA201400236B (en) 2014-10-29
EA201490011A1 (ru) 2014-08-29
HK1197178A1 (en) 2015-01-09
US10272082B2 (en) 2019-04-30
AU2012281042B2 (en) 2016-07-14
WO2013010015A2 (en) 2013-01-17
IN2014DN00200A (enExample) 2015-06-05
CN109316480A (zh) 2019-02-12
JP2014520856A (ja) 2014-08-25
NZ619924A (en) 2016-02-26
SG10201605707UA (en) 2016-09-29
JP2017128610A (ja) 2017-07-27
EP2731611B1 (en) 2019-09-18
EP2731611A2 (en) 2014-05-21
IL230391B (en) 2019-03-31
CN104039148A (zh) 2014-09-10
JP6145946B2 (ja) 2017-06-14
BR112014000742A2 (pt) 2016-08-23
EP2731611A4 (en) 2015-02-18
EA028060B1 (ru) 2017-10-31

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