KR101929774B1 - 락탐을 강력한 hdac 억제제로서 보유하는 신규 티오 유도체 및 약제로서 그의 용도 - Google Patents

락탐을 강력한 hdac 억제제로서 보유하는 신규 티오 유도체 및 약제로서 그의 용도 Download PDF

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KR101929774B1
KR101929774B1 KR1020147003177A KR20147003177A KR101929774B1 KR 101929774 B1 KR101929774 B1 KR 101929774B1 KR 1020147003177 A KR1020147003177 A KR 1020147003177A KR 20147003177 A KR20147003177 A KR 20147003177A KR 101929774 B1 KR101929774 B1 KR 101929774B1
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oxo
hexyl
phenylcarbamoyl
amino
ester
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지우세페 지안니니
월터 카브리
지안프란코 베티스추지
데이비드 비그놀라
니콜라 판토'
클라우디오 피사노
로레다나 베스치
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알파시그마 에스.피.에이.
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KR1020147003177A 2011-09-19 2012-09-17 락탐을 강력한 hdac 억제제로서 보유하는 신규 티오 유도체 및 약제로서 그의 용도 Active KR101929774B1 (ko)

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Application Number Priority Date Filing Date Title
EP11181832.4 2011-09-19
EP11181832 2011-09-19
PCT/EP2012/068230 WO2013041480A1 (en) 2011-09-19 2012-09-17 New thio derivatives bearing lactams as potent hdac inhibitors and their uses as medicaments

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KR20140066993A KR20140066993A (ko) 2014-06-03
KR101929774B1 true KR101929774B1 (ko) 2018-12-18

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US (1) US8927533B2 (https=)
EP (1) EP2758371B1 (https=)
JP (1) JP6053795B2 (https=)
KR (1) KR101929774B1 (https=)
CN (1) CN103732577B (https=)
AU (1) AU2012311640B2 (https=)
BR (1) BR112014006600B1 (https=)
CA (1) CA2843211C (https=)
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HU (1) HUE029687T2 (https=)
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Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CR20160308A (es) * 2013-12-03 2016-11-08 Acetylon Pharmaceuticals Inc Combinaciones de inhibidores de histona deacetilasa y farmacos inmunomoduladores
KR102359214B1 (ko) 2014-04-04 2022-02-07 델 마 파마슈티컬스 폐의 비소세포 암종 및 난소암을 치료하기 위한 디안하이드로갈락티톨 및 이의 유사체 또는 유도체
WO2016201374A1 (en) * 2015-06-11 2016-12-15 University Of Florida Research Foundation, Incorporated Sulfanide adenosine derivatives and uses thereof
AU2024265078A1 (en) 2023-05-04 2025-12-11 Revolution Medicines, Inc. Combination therapy for a ras related disease or disorder
IL326136A (en) 2023-08-07 2026-03-01 Revolution Medicines Inc RMC-6291 for use in the treatment of a disease or disorder associated with the RAS protein
US20250154171A1 (en) 2023-10-12 2025-05-15 Revolution Medicines, Inc. Ras inhibitors
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors
US20250375445A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Ras inhibitors
WO2026015796A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015825A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Use of ras inhibitor for treating pancreatic cancer
WO2026015801A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015790A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026050446A1 (en) 2024-08-29 2026-03-05 Revolution Medicines, Inc. Ras inhibitors
WO2026072904A2 (en) 2024-09-26 2026-04-02 Revolution Medicines, Inc. Compositions and methods for treating lung cancer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6511990B1 (en) 1999-09-08 2003-01-28 Sloan-Kettering Institute For Cancer Research Class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1231477B (it) * 1989-07-12 1991-12-07 Sigma Tau Ind Farmaceuti (pirrolidin-2-one-1-il) acetammidi quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti
IT1244507B (it) * 1991-04-11 1994-07-15 Sigma Tau Ind Farmaceuti Derivati dell'acido piroglutammico quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti
ITRM20010464A1 (it) * 2001-07-31 2003-01-31 Sigma Tau Ind Farmaceuti Derivati retinoidi ad attivita' antiangiogenica, antitumorale e pro-apoptotica.
US7163937B2 (en) * 2003-08-21 2007-01-16 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
US20080004290A1 (en) * 2003-11-28 2008-01-03 The University Of Queensland Anti-Cancer Agents
WO2005063259A1 (en) * 2003-12-19 2005-07-14 Jerini Ag Compounds for the inhibition of undesired cell proliferation and use thereof
JP2007238452A (ja) 2006-03-03 2007-09-20 Nippon Kayaku Co Ltd ヒストン脱アセチル化酵素を阻害する新規化合物
EP2100879A1 (en) * 2008-03-13 2009-09-16 4Sc Ag Novel N-substituted tetrahydroisoquinoline/isoindoline hydroxamic acid compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6511990B1 (en) 1999-09-08 2003-01-28 Sloan-Kettering Institute For Cancer Research Class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof

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HUE029687T2 (en) 2017-03-28
JP2014531441A (ja) 2014-11-27
CA2843211A1 (en) 2013-03-28
MX369508B (es) 2019-11-11
AU2012311640A1 (en) 2014-02-13
ZA201402790B (en) 2015-12-23
BR112014006600B1 (pt) 2022-04-19
ES2579321T3 (es) 2016-08-09
IL230717A (en) 2017-01-31
UA111231C2 (uk) 2016-04-11
WO2013041480A1 (en) 2013-03-28
CN103732577A (zh) 2014-04-16
EA201400365A1 (ru) 2014-06-30
CN103732577B (zh) 2017-04-05
EA023171B1 (ru) 2016-04-29
EP2758371A1 (en) 2014-07-30
US20140200205A1 (en) 2014-07-17
EP2758371B1 (en) 2016-06-15
PL2758371T3 (pl) 2017-01-31
CA2843211C (en) 2019-03-12
PT2758371T (pt) 2016-07-13
JP6053795B2 (ja) 2016-12-27
IL230717A0 (en) 2014-03-31
AU2012311640B2 (en) 2017-04-13
US8927533B2 (en) 2015-01-06
DK2758371T3 (en) 2016-08-01
NZ620336A (en) 2015-07-31
PH12014500249A1 (en) 2022-11-23
BR112014006600A2 (pt) 2017-03-28
MX2014003334A (es) 2014-05-21
KR20140066993A (ko) 2014-06-03

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