KR101880245B1 - Food Composition for Anti-stress effect - Google Patents

Abstract

[0001] The present invention relates to a food composition for stress relief, and more particularly to a composition for suppressing the secretion of Cortisol, which is a stress hormone, including Canavalia gladiata , Arumium lappa L. , And to increase secretion of serotonin, which is a happy hormone. The present invention relates to a food composition for relieving stress which is free from side effects and is safe for the human body, and can be included in a health functional food or a pharmaceutical composition.

Description

[0001] Food Composition for Anti-stress Effect [

The present invention relates to a food composition for stress relief, and more particularly to a food composition for stress relief comprising a mixture of Canavalia gladiata and Arctium lappa L. to lower the secretion of the stress hormone Cortisol, The present invention relates to a food composition which increases the secretion of the hormone serotonin and which is free from side effects and is safe for the human body.

The origin of stress is 'Strictus: tight or narrow' or 'Stringere: tight', and in psychology Stress means the process of change of mind and body to cope with the stressors, which is also called mental pressure.

Stress is caused by the elements that are prevalent in everyday life and contributes to the occurrence of almost all diseases and medical diseases.

So far, many drug therapies such as sedatives, hypnotics, and hormone therapy have been studied to relieve stress. However, these pharmacologic therapies do not have side effects because they are resistant to drugs and risks of side effects during long-term use, A simple and effective way to take it is required.

The inventors of the present invention selected soybean curd and burdock as food materials having excellent stress relieving effect during screening of natural foods so as to avoid side effects even after long-term administration, and their effects were studied to complete the present invention.

This product was funded by the Ministry of Food, Agriculture, Forestry, and Livestock and was supported by the Ministry of Agriculture, Forestry and Fisheries Technology Planning and Evaluation and supported by the High Value Added Food Technology Development Project (115036-3).

Related Prior Art: Registration No. 0905386

Patent No. 1074914

Patent No. 1298568

It is an object of the present invention to provide a food composition for stress relief which is free from side effects by using natural food materials and has no harm to human body even when taken for a long period of time and which can be taken at any time before onset,

In order to achieve the above object, the present invention provides a food composition for stress relief comprising soybean curd, burdock or a mixture thereof. In addition, in embodiments of the present invention, it may include its bud instead of the soybean curd.

The composition according to the present invention may include soybean curd bean as a powder or extract, and these mixed extracts may be directly contained in the form of powders or dried and pulverized powders or concentrated and in the form of liquids.

According to one embodiment of the present invention, the mixed extract may include silver algae, burdock or a mixture thereof in the form of an organic solvent extract, a water extract, a supercritical extract, and a hot water extract.

Examples of the extraction solvent used for preparing the soybean curd, burdock, or mixed extract thereof include purified water; Lower alcohols having 1 to 10 carbon atoms such as methanol, ethanol, isopropyl alcohol and butanol; Polyhydric alcohols having 2 to 30 carbon atoms such as glycerol, ethylene glycol, propylene glycol, and 1,3-butylene glycol; And hydrocarbon solvents having 1 to 30 carbon atoms such as petroleum ether, methyl acetate, ethyl acetate, benzene, hexane, methylene chloride, diethyl ether, dichloromethane and chloroform.

According to an embodiment of the present invention, the extraction solvent is preferably an extract obtained by extracting 50 to 80% by volume of ethanol with respect to water.

The mixture of soybean and burdock is preferably a mixture of soybean and burdock at a weight ratio of 1: 3 to 1: 5

The mixed extracts of soybean and burdock can be extracted and mixed together, or the soybean and burdock raw materials can be mixed and extracted simultaneously by the above method.

According to one embodiment of the present invention, the food composition for stress relief can be used as a health functional food composition for prevention and / or treatment showing a stress relieving effect.

The food composition for stress relief according to the present invention may be contained in an amount of 0.0001 to 90% by weight based on the total weight of the food.

According to one embodiment of the present invention, the food composition for stress relief can be used as a pharmaceutical composition for prevention and / or treatment showing a stress-relieving effect.

According to one embodiment of the present invention, the pharmaceutical composition may contain the stress-relieving composition in an effective amount of 1 to 100 mg / kg body weight per day.

The composition of the present invention is free from side effects, including natural materials such as soybean curd, burdock, or a mixture thereof, and can be used in a food composition without adverse effects even when taken on a long-term basis. In addition, the stress hormone Cortisol (Cortisol) secretion and lower the secretion of the hormone Serotonin (Serotonin) to increase the stress relieving effect is excellent. In particular, the composition of the present invention can be used for stress relief of modern people who are stressed, such as office workers, examinees, and housewives.

FIG. 1 shows the results of the blood IgA level change test by the ingestion of kojong and burdock complex in passivation stress-induced mice.
FIG. 2 shows the result of weight change test by consumption of soybean and burdock complex in immobilized stress-induced mice.
FIG. 3 shows the results of measurement of changes in blood cortisol (Cortisol) and serotonin (Serotonin) production by the ingestion of soybean curd and burdock complex in passivation stress-induced mice.
CG in the drawing is an abbreviation for soybean koji, and AL is an abbreviation for burdock.
IM_S in the drawing is an abbreviation for immobilization stress.

Hereinafter, the present invention will be described in more detail.

According to the present invention, there is provided a food composition for stress relief comprising Canavalia gladiata , Tobacco, burdock ( Arctium lappa L. ), or a mixture thereof.

Canavalia gladiata ) is a perennial vine plant belonging to the rosewood legume. It has no hairs on the stem. It has a length of 2 ~ 3 cm and a weight of 1.5 ~ 3 g. Leaves have long petiole and three small leaves. The flower of the soybean is light reddish purple or white, and a long flower stem grows from the axil of the leaf in the summer and runs with a gunshot. The end of the pod is curved or hooked, 20 ~ 30cm long, 5cm wide, and contains about 10 beans. The beans are about 3 cm long and have long seats on one side. The color of red beans is red or white, all of which can be used for food. Seeds, shells, leaves, stems and roots can be used as food materials. Soybean seeds contain the hydrolytic enzymes urease, hemagglutinin, canavalin, linolenic acid, saponin, choline, It contains various physiologically active substances such as lecithin, dietary fiber, and protein.

Soybean is called red bean in one room, red bean is used in pod, white bean is mainly used in white bean.

Burdock (Arctium lappa L. , Burdock) is 1.5 m high and the stem is purple and grows straight. Roots are thick and straight. Roots and seeds are used as medicinal herbs, and rootstocks are edible. The varieties have long roots, thick agar, good quality meat, and short roots.

The root of burdock contains acinic acid and some palmitic acid, and contains arctin, arctigenin, isoarctigenin, archidic acid, alkaloid, and fatty oil. Especially, isochlorogenic acid is contained in large quantity and it is oxidized and discolored when it is left to slice.

The soybean curd, burdock, or a mixture thereof may be contained in the form of an extract, and the mixed extract may be contained in the form of a lyophilized powder or a concentrated liquid.

The soybean curd, burdock, or a mixture thereof may be directly dried and pulverized and used as a powder. However, the powder may be used in the form of an extract to enhance the stress relieving effect and the absorption rate. In particular, the extract may be lyophilized or contained in a concentrated form .

According to one embodiment of the present invention, the mixed extract may be in the form of an organic solvent extract, a water extract, a supercritical extract, and a hot water extract.

Examples of the extraction solvent include purified water; Lower alcohols having 1 to 10 carbon atoms such as methanol, ethanol, isopropyl alcohol and butanol; Polyhydric alcohols having 2 to 30 carbon atoms such as glycerol, ethylene glycol, propylene glycol, and 1,3-butylene glycol; And hydrocarbon solvents having 1 to 30 carbon atoms such as petroleum ether, methyl acetate, ethyl acetate, benzene, hexane, methylene chloride, diethyl ether, dichloromethane and chloroform.

The extract may be extracted by adding 4 to 10 times the extraction solvent to soybean curd and / or ground burdock. When the extraction solvent is water, it is preferably subjected to hot water extraction at 70 to 120 hours for 3 hours to 12 hours. When the extraction solvent is an organic solvent, it is preferable to perform cold extraction at 20 to 40 hours for 12 hours to 72 hours. Or when it is extracted with a mixed solvent of water and an organic solvent, it is preferable to carry out cold extraction.

The extraction solvent is preferably a solvent in which ethanol is contained in an amount of 50 to 80% by volume with respect to water in order to extract the active ingredient better. The extracted extract is evaporated using a lyophilizer or a vacuum condenser to prepare a dry powder can do.

According to one embodiment of the present invention, the soybean curd (or an extract thereof) and the burdock (or an extract thereof) As a weight ratio of 1: 3 to 1: 5.

The soybean and burdock alone showed a stress relieving effect. However, when the soybean curd was mixed with the burdock, the desirable synergistic effect was exhibited.

The mixed extracts of soybean and burdock can be extracted and mixed, or the soybean and burdock raw materials can be mixed and extracted simultaneously by the above method. When the soybean and burdock raw materials are to be mixed and then extracted, it is preferable that the two raw materials are cut in the same or similar size or pulverized and mixed to be extracted.

According to one embodiment of the present invention, the stress relieving composition further comprises at least one of a carrier, a diluent, an excipient and an additive, and is selected from the group consisting of tablets, pills, powders, granules, powders, capsules, It may be used in a form which is formulated as one.

Examples of the additive that can be further included in the present invention include natural carbohydrates, flavors, nutrients, vitamins, minerals (electrolytes), flavors (synthetic flavors, natural flavors and the like), colorants, fillers (cheese, At least one component selected from the group consisting of fumaric acid and its salt, alginic acid and its salts, organic acid, protective colloid thickener, pH adjusting agent, stabilizer, preservative, antioxidant, glycerin, alcohol, .

Examples of the above-mentioned natural carbohydrates include monosaccharides such as glucose, fructose and the like; Disaccharides such as maltose, sucrose and the like; And polysaccharides, for example, conventional sugars such as dextrin, cyclodextrin and the like, and sugar alcohols such as xylitol, sorbitol and erythritol. Natural flavors (tautatin, stevia extract (e.g., rebaudioside A, glycyrrhizin, etc.) and synthetic flavors (saccharine, aspartame, etc.) can be advantageously used as the flavor.

In addition to the above, the composition according to the present invention can be used as a flavoring agent such as various nutrients, vitamins, minerals (electrolytes), synthetic flavors and natural flavors, colorants and heavies (cheese, chocolate etc.), pectic acid and its salts, Its salts, organic acids,

PH adjusters, stabilizers, antiseptics, glycerin, alcohols, carbonating agents used in carbonated drinks, and the like. In addition, the composition according to the present invention may contain flesh for the production of natural fruit juices and vegetable drinks.

These components may be used independently or in combination.

Specific examples of the carrier, excipient, diluent and additives include, but are not limited to, lactose, dextrose, sucrose, sorbitol, mannitol, erythritol, starch, acacia rubber, calcium phosphate, alginate, gelatin, calcium phosphate, calcium Silicate, microcrystalline cellulose, polyvinylpyrrolidone, cellulose, polyvinylpyrrolidone, methylcellulose, water, sugar syrup, methylcellulose, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate And a mineral oil are preferably used.

When the composition according to the present invention is formulated, it is prepared using diluents or excipients such as fillers, extenders, binders, humectants, disintegrants, surfactants and the like which are usually used.

According to one embodiment of the present invention, the food composition for stress relief can be used as a health functional food composition for prevention and / or treatment showing a stress relieving effect.

The stress-relieving food composition according to the present invention is characterized in that the stress-relieving food composition contains 0.0001 to 90% by weight, preferably 1 to 60% by weight, more preferably 30 To 50% by weight.

The foods to which the stress-relieving food composition of the present invention can be added include various foods, powders, granules, tablets, capsules, syrups, drinks, gums, tea, vitamin complexes, and health functional foods.

According to an embodiment of the present invention, the stress relieving composition can be used as a pharmaceutical composition for prevention and / or treatment showing a stress relieving effect.

The content of the extract according to the present invention as an active ingredient in the pharmaceutical composition may be appropriately adjusted depending on the mode and purpose of use, the condition of the patient, the type of symptoms and the severity of the symptoms. According to one embodiment of the present invention, The composition for stress relief may include 1 to 100 mg / kg of body weight as an effective amount per day, but is not limited thereto.

The composition according to the present invention relates to stress relief, and refers to a composition that contributes to relieving stress that is a cause of disease in the human body.

Markers to identify the function of stress relief (reduction) are physiological indicators and behavioral indicators, and psychological indicators through surveys in human application tests.

Physiological indicators include brain neuron survival rate, lactate dehydrogenase (LDH), tissue weight, serotonin and its metabolites (5-HIAA), dopamine and its metabolites (DOPAC, HVA), norepinephrine, corticosterone / Corticotropin-releasing hormone (CRH), nerve growth factor (NGF), cortisol, cortisol, cytokine (IL-6 and TNF-α), adrenocorticotropic hormone (ACTH) ), Synaptophysin, saliva amylase, saliva IgA, blood pressure, island clapping, and brain waves.

Behavioral indicators include stress-related behaviors, elevated cross-lab tests, defensive store tests, sucrose preference tests, forced swimming tests, tail suspensions, novelty suppression of feeding (NSF), and resident-intruder testing .

Cerebral nerve cell survival rate can be evaluated by measuring the cell survival rate by treating the test substance with the brain nerve cell (SK-N-BE (2) C cell, PC12 cell, etc.), the main cell constituting the nervous system.

Lactate dehydrogenase (LDH) L is an enzyme that catalyzes the reaction of L-lactic acid to L-pyruvic acid by dehydrogenation. It exists in most tissues. When the tissue is damaged, the intracellular enzyme is released and the lactate dehydrogenase is also liberated. Generally, a high concentration of lactate dehydrogenase means that the cells are damaged.

The degree of stress can be measured by measuring the adipose and spleen tissue weights. The adrenal gland is a small endocrine gland with one on each side of the left and right conus. Cortisol in the adrenal cortex is secreted in response to stress. Catecholamines in the adrenal gland secrete hormones that respond quickly to stress. Thus, in the spleen associated with adrenal hypertrophy and immunity due to stress, spleen atrophy may be caused by stress.

Serotonin is a 5-hydroxytryptamine (5HT) structure of physiologically active amine that is involved in functions related to mood, behavior, appetite, sleep and muscle contraction. Excessive serotonin stimulates the brain's function, stimulating it, and, if it is deficient, depresses the body's function. The serotonin metabolite is 5-hydroxy indolacetic acid (5-HIAA). Serotonin increases with increasing serenity.

Dopamine, a neurotransmitter, is a precursor of norepinephrine and epinephrine. Dopamine is involved in the regulation of emotions in the body and makes it feel good, and it is involved in cognition and concentration, compensation, and control of motor function. Dopamine (3,4-Dihydroxyphenyl acetic acid) and HVA (Homovanillic acid) have. An increase in dopamine means a decrease in stress.

Norepinephrine, also known as Noradrenaline, is a neurotransmitter. When stressed, norepinephrine increases the contractility and heart rate of the heart, contracts the blood vessels of the whole body, and increases blood pressure. It is also involved in mood. The higher the concentration of norepinephrine, the higher the stress.

Corticosterone or cortisol is a steroid hormone secreted from the adrenal cortex that is secreted in the form of corticosterone in rats and cortisol in humans and is the final agonist of the hypothalamus-pituitary-adrenal axis, It is involved in the regulation of the response and homeostasis of an individual. Corticosterone and cortisol increase micturition stress and increase blood pressure and pulse rate. The higher the concentration of corticosterone and cortisol, the higher the stress.

Cytokine is a protein that mediates intercellular signaling, including interleukin (IL), interferon (IFN), and tumor necrosis factors (TNF). Not only immune cells but also neurons secrete cytokines and are involved in the regulation of cranial nerve function. The inflammatory cytokines IL-1β, IL-2, and IL-6, TNF-α, are secreted by the central nervous system during the stress response. The greater the amount of IL-1β, IL-2, IL-6, and TNF-αβγ, which are inflammatory cytokines, the greater the degree of stress

Adrenocorticotropic hormone (ACTH) secreted from the pituitary gland stimulates the adrenal cortex to release steroid hormones such as cortisol. When the human body is stressed, the secretion of this hormone is promoted through the central nervous system.

Corticotropin-releasing hormone (CRH) is secreted into the pituitary portal system by the hypothalamic-pituitary nervous system and is involved in the secretion of adrenocortical stimulating hormone. The secretion is regulated by the concentration of adrenocortical hormone in the blood.

Nerve growth factor (NGF) is a neuro-trophic protein that plays a key role in neural development and maintenance of the sensory and sympathetic nerves. It is also transported into nerve cells from tissue and nerve fiber ends and contributes to the development of sensory neurons, peripheral adrenergic neurons and cholinergic nerve fibers of the central nervous system.

Synaptophysin is a glycoprotein present in the vesicle of neurons or neuroendocrine cells, which increases in proportion to the degree of neuronal synaptogenesis during development and is consistent with the distribution of neuronal synapses. It is a widely used protein.

Salivary amylase is an enzyme that hydrolyzes the α-1,4-glycosidic bond of starch and is produced in the glandular cells of the parotid gland and submandibular gland. Salivary amylase is secreted by sympathetic stimulation and increases secretion of saliva amylase under stress conditions.

Immunoglobulin A (IgA) is contained in mucous secretions such as serum, saliva, colostrum, tears, bile, urine, and feces and plays a defense role against various pathogens. Increased cortisol in stress conditions inhibits the secretion of salivary IgA.

The blood pressure is the pressure on the wall of the blood vessel, that is, the systolic blood pressure, which is the blood pressure when the ventricle contracts, and the diastolic blood pressure, which is the blood pressure when relaxing. Normal blood pressure is about 120-130 mmHg in systolic blood pressure, and 80-85 mmHg in diastolic blood pressure. Higher than a certain level of high blood pressure, low blood pressure is said. Stress stimulates the sympathetic nerves and causes an increase in blood pressure.

The heart rate refers to the number of times the heart plays for one minute, and the normal person is about 70 times / minute when stable, but the difference is large among individuals, so the normal range is about 50-100 times. Heart rate variability factors include body temperature, exercise, sleep, feeding, and emotions. Stress may stimulate sympathetic nerves and increase heart rate.

EEG records the currents that occur according to the activity of the brain. EEG has α, β, γ, δ, θ. As the power of the EEG wave increases, the stress decreases as the power of the EEG decreases.

Hereinafter, the present invention will be described in more detail with reference to examples and comparative examples. It should be understood, however, that the present invention is not limited to the above-described embodiments, and that various changes and modifications may be made without departing from the spirit and scope of the invention as defined in the appended claims. It is to be understood that equivalents and modifications are possible.

Example : Preparation of Soybean and Burdock Extracts

Soybean koji and burdock were mixed with ethanol and purified water according to the criteria of each pharmacopoeia, and 70% alcohol was added to the mixture at about 4 to 10 times, followed by cooling at room temperature (20 ± 5) for 5 days. The extracted extracts were filtered using Wattman # 3 filter paper, and the extracted extracts were completely evaporated at 45 using a vacuum concentrator to obtain dried extracts.

Experimental Example  One: dissimilation  In the stress-induced mice, IgA  Level change test

70% koji extract (CG70% E), 70% burdock extract (AL70% E), 70% koji bean extract and burdock 70 were used in the stressed mice for 2 hours each day for 2 hours in a narrow frame (CG + AL, 1: 4) mixed at a ratio of 1: 4 of the extracts of 1% to 4% of the extract was orally administered to C57BL / 6 at 8 weeks of passivation stress induction. As a result of measuring IgA levels in serum, 70% koji extract (CG70% E) 100 mg / kg (p <0.05) and 70% koji extract were mixed with 1: 4 ratio of 70% IgA levels were significantly increased in the 100 mg / kg (p <0.01) and 50 mg / kg (p <0.05) groups compared with the passive control group (IM_S-CTL) appear.

In particular, the highest IgA level was observed in the combination of 70% kojong extract and 70% burdock extract in a ratio of 1: 4.

The results are shown in Fig.

Experimental Example  2: dissimilation  Weight change test by ingestion of soybean and burdock complex in stress-induced mice

(CG + AL, 1: 4) mixture of 70% koji extract (CG70% E), 70% burdock extract (AL70% E), 70% koji extract and 70% 4) was orally administered to stress-induced 8 week old C57BL / 6 by immobilization for 21 days for 2 hours each day. (70%) of alcohol extract (CG70% E) 100 mg / kg, 70% of burdock extract (AL70% E) and 100% of body weight of immature control group (IM_S-CTL) (CG + AL, 1: 4) 100 mg / kg of the mixture of 1: 4 ratio of the extract of cormorant and 70% of the koji extract to the weight of the control group (IM_S-CTL) Decrease.

In particular, the lowest weight loss was observed in the combination of 70% koji extract with 70% koji extract and 1: 4 ratio.

The results are shown in Fig.

Experimental Example  3: dissimilation  In the stress-induced mice, Cortisol and  Serotonin ( Serotonin ) Production change measurement test

(CG + AL, 1: 4) mixture of 70% koji extract (CG70% E), 70% burdock extract (AL70% E), 70% koji extract and 70% 4) was orally administered to stress-induced 8 week old C57BL / 6 by immobilization for 21 days for 2 hours each day. Serotonin, a hormone that makes the sensation of happiness in the serum, was measured. The results showed that 70% kojong extract (CG70% E) 100 mg / kg (p <0.05) and 70% kojong extract and 70% (CG + AL, 1: 4) 100 mg / kg (p <0.01) and 50 mg / kg (p <0.05) Serotonin levels were found to be significantly increased. Cortisol levels in the serum were 70%, 70%, 70%, 70% and 70%, respectively, of the extracts of corn (70% (P <0.01) and 50 mg / kg (p <0.05) were significantly higher than the passive control group (IM_S-CTL) (Cortisol) levels were decreased.

In particular, the highest serotonin levels and the highest levels of cortisol levels were observed in the combination of 70% kojong extract and 70% burdock extract at a ratio of 1: 4.

The results are shown in Fig.

Examples of the formulations of health functional foods and pharmaceutical compositions containing the food composition for stress relief according to the present invention will be described, but the present invention is not limited thereto.

[Production Example 1: Food Composition for Stress Relief]

According to Example 1, 70% of the extracts of soybean curd and burdock were respectively prepared, dried and pulverized to prepare powders. The prepared powder was mixed with soybean curd and burdock at a weight ratio of 1: 4 to prepare a food composition for stress relief.

[Food for stress relief]

(One) Wire  Produce

Brown rice, barley, glutinous rice, and yulmu were dried by a known method and dried, and then the mixture was prepared into powder having a particle size of 60 mesh by a pulverizer. Black beans, black sesame seeds and perilla seeds were each steamed and dried by known methods, and then power distribution and pulverization were carried out to prepare powder having a particle size of 60 mesh. Thereafter, 30% by weight of brown rice, 15% by weight of yulmu, 20% by weight of barley, 9% by weight of glutinous rice, 7% by weight of perilla seed, 8% by weight of black soybean, 7% by weight of black sesame seed, By weight, 0.5% by weight of Ganoderma lucidum, and 0.5% by weight of Sorbitol were mixed to prepare an electric wire.

(2) Chewing gum  Produce

Chewing gum was prepared in a conventional manner by mixing 20% by weight of a gum base, 76.9% by weight of sugar, 1% by weight of a flavor, 2% by weight of water and 0.1% by weight of a food composition for stress relief prepared in Preparation Example 1.

(3) Health drinks manufacturing

0.0001 wt.% Of niacinamide, 0.0001 wt.% Of sodium riboflavin, 0.0001 wt.% Of pyridoxine hydrochloride, 0.001 wt.% Of inositol, 0.002 wt.% Of orthoacetic acid, 98.7362 wt.% Of water and 0.2 wt. 1% by weight of a food composition for stress relief prepared in Preparation Example 1 was blended to prepare a health drink by a conventional method.

(4) health supplement manufacturing

A mixture of 55% by weight of spirulina, 10% by weight of guar gum enzyme hydrolyzate, 0.01% by weight of vitamin B1 hydrochloride, 0.01% by weight of vitamin B6 hydrochloride, 0.23% by weight of DL-methionine, 0.7% by weight of magnesium stearate, And 10% by weight of the food composition for stress relief prepared in Preparation Example 1 were mixed to prepare a refillable health supplement food by a conventional method.

(5) Manufacture of alcoholic beverages

0.5% by weight of the food composition for stress relief prepared in Preparation Example 1 was mixed with soju, beer, liquor or fruit wine into an emulsion state and then mixed at 9,000 rpm with a high-speed mixer to prepare a mixture containing soybean curd, burdock, Liquor was produced.

[Health functional food or pharmaceutical composition for relieving stress]

(One) Powder  Produce

2 g of the food composition for stress relief prepared in Preparation Example 1 was mixed with 1 g of lactose and filled in an airtight container to prepare a powder.

(2) Preparation of tablets

100 mg of corn starch, 100 mg of lactose, and 2 mg of magnesium stearate prepared in Preparation Example 1 were mixed, and tablets were prepared by tableting according to a conventional tablet preparation method.

(3) Capsule  Produce

100 mg of the food composition for stress relief prepared in Preparation Example 1, 100 mg of corn starch, 100 mg of lactose and 2 mg of magnesium stearate were mixed and filled in gelatin capsules to prepare capsules.

CG in the drawing is an abbreviation for soybean koji, and AL is an abbreviation for burdock.
IM_S in the drawing is an abbreviation for immobilization stress.

Claims (11)

It contains Canavalia gladiata (豆豆) and burdock ( Arctium lappa L. )
Wherein the soybean curd and the burdock are mixed in a weight ratio of 1: 4. The stress-relieving food composition according to claim 1, wherein the mixture of soybean curd and burdock is in the form of an extract. The stress-relieving food composition according to claim 2, wherein the extract is an ethanol extract. delete The stress-relieving food composition according to claim 3, wherein the extracting solvent of the extract is a solvent having 50 to 80% by volume of ethanol relative to water. delete [Claim 3] The composition for stress relief according to claim 2, wherein the extract is a mixed extract obtained by mixing extracts of soybean curd or burdock, or a mixed extract of soybean curd and burdock at the same time. delete A food comprising the food composition for stress relief according to any one of claims 1 to 3, 5, and 7, wherein the food composition for stress relief is 0.0001 wt% By weight to 90% by weight. delete delete

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