KR101817889B1 - 6-[(4r)-4-메틸-1,2-다이옥사이도-1,2,6-티아다이아지난-2-일]이소퀴놀린-1-카보니트릴의 결정질 형태 - Google Patents

6-[(4r)-4-메틸-1,2-다이옥사이도-1,2,6-티아다이아지난-2-일]이소퀴놀린-1-카보니트릴의 결정질 형태 Download PDF

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KR101817889B1
KR101817889B1 KR1020167031696A KR20167031696A KR101817889B1 KR 101817889 B1 KR101817889 B1 KR 101817889B1 KR 1020167031696 A KR1020167031696 A KR 1020167031696A KR 20167031696 A KR20167031696 A KR 20167031696A KR 101817889 B1 KR101817889 B1 KR 101817889B1
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methyl
theta
isoquinoline
carbonitrile
dioxane
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KR20160144478A (ko
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유진 르보비치 피아트니트스키 체클러
로버타 루이스 도로우
제프리 브레이든 스페리
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화이자 인코포레이티드
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
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KR1020167031696A 2014-05-15 2015-05-01 6-[(4r)-4-메틸-1,2-다이옥사이도-1,2,6-티아다이아지난-2-일]이소퀴놀린-1-카보니트릴의 결정질 형태 Expired - Fee Related KR101817889B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461993693P 2014-05-15 2014-05-15
US61/993,693 2014-05-15
US201562138037P 2015-03-25 2015-03-25
US62/138,037 2015-03-25
PCT/IB2015/053194 WO2015173684A1 (en) 2014-05-15 2015-05-01 Crystalline form of 6-[(4r)-4-methyl-1,2-dioxido-1,2,6-thiadiazinan-2-yl]isoquinoline-1-carbonitrile

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KR20160144478A KR20160144478A (ko) 2016-12-16
KR101817889B1 true KR101817889B1 (ko) 2018-01-11

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US (1) US9920043B2 (enExample)
EP (1) EP3143019B1 (enExample)
JP (1) JP6523782B2 (enExample)
KR (1) KR101817889B1 (enExample)
CN (1) CN106459025B (enExample)
AU (1) AU2015260906B2 (enExample)
CA (1) CA2891398C (enExample)
CY (1) CY1123826T1 (enExample)
DK (1) DK3143019T3 (enExample)
ES (1) ES2845639T3 (enExample)
HU (1) HUE052692T2 (enExample)
IL (1) IL248918A0 (enExample)
MX (1) MX371014B (enExample)
PL (1) PL3143019T3 (enExample)
PT (1) PT3143019T (enExample)
RU (1) RU2698194C2 (enExample)
SG (1) SG11201608320QA (enExample)
SI (1) SI3143019T1 (enExample)
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Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2864079T3 (es) * 2014-05-30 2021-10-13 Pfizer Derivados de carbonitrilo como moduladores selectivos del receptor de andrógenos
WO2023275715A1 (en) * 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005018573A2 (en) 2003-08-22 2005-03-03 Ligand Pharmaceuticals Incorporated 6-cycloamino-2-quinolinone derivatives as androgen receptor modulator compounds
WO2009082437A2 (en) 2007-12-21 2009-07-02 Ligand Pharmaceuticals Incorporated Selective androgen receptor modulators (sarms) and uses thereof
WO2014087298A1 (en) 2012-12-03 2014-06-12 Pfizer Inc. Novel selective androgen receptor modulators

Family Cites Families (8)

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Publication number Priority date Publication date Assignee Title
EP0089139A2 (en) 1982-03-16 1983-09-21 Beecham Group Plc Antibiotics, their preparation and use
US4489075A (en) * 1982-05-15 1984-12-18 Pfizer Inc. Cyclic sulfonamidoalkyl substituted 4-piperidinoquinazoline cardiac stimulants
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
WO2000035298A1 (en) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Chewing gum containing medicament active agents
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
WO2004110978A2 (en) 2003-06-10 2004-12-23 Smithkline Beecham Corporation 1-aminonaphthalenes as modulators of androgen, glucocorticoid, mineralocorticoid and progesterone receptors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005018573A2 (en) 2003-08-22 2005-03-03 Ligand Pharmaceuticals Incorporated 6-cycloamino-2-quinolinone derivatives as androgen receptor modulator compounds
WO2009082437A2 (en) 2007-12-21 2009-07-02 Ligand Pharmaceuticals Incorporated Selective androgen receptor modulators (sarms) and uses thereof
WO2014087298A1 (en) 2012-12-03 2014-06-12 Pfizer Inc. Novel selective androgen receptor modulators

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CA2891398A1 (en) 2015-11-15
EP3143019B1 (en) 2020-12-16
PL3143019T3 (pl) 2021-03-22
HUE052692T2 (hu) 2021-05-28
AU2015260906B2 (en) 2017-08-31
EP3143019A1 (en) 2017-03-22
JP2015218166A (ja) 2015-12-07
TW201546069A (zh) 2015-12-16
AU2015260906A1 (en) 2016-10-20
DK3143019T3 (da) 2021-01-04
MX371014B (es) 2020-01-10
RU2698194C2 (ru) 2019-08-23
CN106459025B (zh) 2019-05-28
RU2016144671A (ru) 2018-06-15
PT3143019T (pt) 2021-01-28
SG11201608320QA (en) 2016-11-29
KR20160144478A (ko) 2016-12-16
US20170073338A1 (en) 2017-03-16
CY1123826T1 (el) 2022-05-27
CA2891398C (en) 2019-09-24
WO2015173684A1 (en) 2015-11-19
US9920043B2 (en) 2018-03-20
TWI553007B (zh) 2016-10-11
CN106459025A (zh) 2017-02-22
IL248918A0 (en) 2017-01-31
MX2016014999A (es) 2017-04-11
JP6523782B2 (ja) 2019-06-05
RU2016144671A3 (enExample) 2018-06-15
SI3143019T1 (sl) 2021-03-31
ZA201606796B (en) 2018-04-25
ES2845639T3 (es) 2021-07-27

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