AU2015260906B2 - Crystalline form of 6-((4R)-4-methyl-1,2-dioxido-1,2,6-thiadiazinan-2-yl)isoquinoline-1-carbonitrile - Google Patents
Crystalline form of 6-((4R)-4-methyl-1,2-dioxido-1,2,6-thiadiazinan-2-yl)isoquinoline-1-carbonitrile Download PDFInfo
- Publication number
- AU2015260906B2 AU2015260906B2 AU2015260906A AU2015260906A AU2015260906B2 AU 2015260906 B2 AU2015260906 B2 AU 2015260906B2 AU 2015260906 A AU2015260906 A AU 2015260906A AU 2015260906 A AU2015260906 A AU 2015260906A AU 2015260906 B2 AU2015260906 B2 AU 2015260906B2
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- Australia
- Prior art keywords
- thiadiazinan
- dioxido
- isoquinoline
- methyl
- crystalline form
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- KZVYWCGVTGWQCR-XADCJTSKSA-N 6-[(4R)-4-methyl-2-oxido-1-oxo-1,2,6-thiadiazinan-2-ium-2-yl]isoquinoline-1-carbonitrile Chemical compound C[C@H]1C[N+](S(NC1)=O)([O-])C=1C=C2C=CN=C(C2=CC1)C#N KZVYWCGVTGWQCR-XADCJTSKSA-N 0.000 title description 2
- ZKAVFOXYJCREBQ-SNVBAGLBSA-N 6-[(4r)-4-methyl-1,1-dioxo-1,2,6-thiadiazinan-2-yl]isoquinoline-1-carbonitrile Chemical compound C1[C@H](C)CNS(=O)(=O)N1C1=CC=C(C(=NC=C2)C#N)C2=C1 ZKAVFOXYJCREBQ-SNVBAGLBSA-N 0.000 claims description 72
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- HJHXYSBRTVFEDD-UHFFFAOYSA-N isoquinoline-1-carbonitrile Chemical compound C1=CC=C2C(C#N)=NC=CC2=C1 HJHXYSBRTVFEDD-UHFFFAOYSA-N 0.000 claims description 36
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Applications Claiming Priority (5)
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| US201461993693P | 2014-05-15 | 2014-05-15 | |
| US61/993,693 | 2014-05-15 | ||
| US201562138037P | 2015-03-25 | 2015-03-25 | |
| US62/138,037 | 2015-03-25 | ||
| PCT/IB2015/053194 WO2015173684A1 (en) | 2014-05-15 | 2015-05-01 | Crystalline form of 6-[(4r)-4-methyl-1,2-dioxido-1,2,6-thiadiazinan-2-yl]isoquinoline-1-carbonitrile |
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| CA2950390C (en) * | 2014-05-30 | 2020-09-22 | Pfizer Inc. | Carbonitrile derivatives as selective androgen receptor modulators |
| WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
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| WO2005018573A2 (en) * | 2003-08-22 | 2005-03-03 | Ligand Pharmaceuticals Incorporated | 6-cycloamino-2-quinolinone derivatives as androgen receptor modulator compounds |
| WO2009082437A2 (en) * | 2007-12-21 | 2009-07-02 | Ligand Pharmaceuticals Incorporated | Selective androgen receptor modulators (sarms) and uses thereof |
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| EP0089139A2 (en) | 1982-03-16 | 1983-09-21 | Beecham Group Plc | Antibiotics, their preparation and use |
| US4489075A (en) * | 1982-05-15 | 1984-12-18 | Pfizer Inc. | Cyclic sulfonamidoalkyl substituted 4-piperidinoquinazoline cardiac stimulants |
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| GB9518953D0 (en) | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
| WO2000035296A1 (en) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Improved release of medicament active agents from a chewing gum coating |
| GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
| EP1636167A2 (en) | 2003-06-10 | 2006-03-22 | SmithKline Beecham Corporation | 1-aminonaphthalenes as modulators of androgen, glucocorticoid, mineralocorticoid and progesterone receptors |
| MY176727A (en) * | 2012-12-03 | 2020-08-20 | Pfizer | Selective androgen receptor modulators |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005018573A2 (en) * | 2003-08-22 | 2005-03-03 | Ligand Pharmaceuticals Incorporated | 6-cycloamino-2-quinolinone derivatives as androgen receptor modulator compounds |
| WO2009082437A2 (en) * | 2007-12-21 | 2009-07-02 | Ligand Pharmaceuticals Incorporated | Selective androgen receptor modulators (sarms) and uses thereof |
Also Published As
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| TWI553007B (zh) | 2016-10-11 |
| RU2016144671A (ru) | 2018-06-15 |
| MX2016014999A (es) | 2017-04-11 |
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| PT3143019T (pt) | 2021-01-28 |
| MX371014B (es) | 2020-01-10 |
| ZA201606796B (en) | 2018-04-25 |
| CN106459025A (zh) | 2017-02-22 |
| SI3143019T1 (sl) | 2021-03-31 |
| HUE052692T2 (hu) | 2021-05-28 |
| WO2015173684A1 (en) | 2015-11-19 |
| SG11201608320QA (en) | 2016-11-29 |
| AU2015260906A1 (en) | 2016-10-20 |
| CA2891398A1 (en) | 2015-11-15 |
| DK3143019T3 (da) | 2021-01-04 |
| KR20160144478A (ko) | 2016-12-16 |
| JP6523782B2 (ja) | 2019-06-05 |
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| CN106459025B (zh) | 2019-05-28 |
| CA2891398C (en) | 2019-09-24 |
| US20170073338A1 (en) | 2017-03-16 |
| RU2698194C2 (ru) | 2019-08-23 |
| IL248918A0 (en) | 2017-01-31 |
| KR101817889B1 (ko) | 2018-01-11 |
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