JP6887980B2 - 薬学的に活性な化合物の固体形態 - Google Patents
薬学的に活性な化合物の固体形態 Download PDFInfo
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- JP6887980B2 JP6887980B2 JP2018207854A JP2018207854A JP6887980B2 JP 6887980 B2 JP6887980 B2 JP 6887980B2 JP 2018207854 A JP2018207854 A JP 2018207854A JP 2018207854 A JP2018207854 A JP 2018207854A JP 6887980 B2 JP6887980 B2 JP 6887980B2
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Images
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Description
で表される。
a)化合物(1)の実質的に非晶質形態;
b)化合物(1)半水和物、水和物、半溶媒和物又は溶媒和物;
c)化合物の多形体(1);又は
d)化合物(1)の薬学的に許容可能な塩
からなる群から選択される化合物(1)の固体形態を提供する。
それ自体は鋭いX線ピークを示さない物質を意味する。非晶質物質のX線粉末回折(XRPD)パターンは、一つ以上の非晶質ハローにより特徴づけられる。より具体的には、本明細書で使用される用語「非晶質形態」は、非晶質形態が例えば、ポリマー等の支持材の任意の型と一緒の固体分散体又は微小沈殿原末(MBP)などの一相系を形成しないという条件で、4−{[(2R,3S,4R,5S)−4−(4−クロロ−2−フルオロ−フェニル)−3−(3−クロロ−2−フルオロ−フェニル)−4−シアノ−5−(2,2−ジメチル−プロピル)−ピロリジン−2−カルボニル]−アミノ}−3−メトキシ−安息香酸(化合物1)それ自体の非晶質形態を指す。
化合物(1)12.5gが487.5gのアセトンに溶解され、25℃で1時間撹拌された。続いてこの溶液をGF5−フィルターを通して濾過した。透明な溶液をBuechi Mini Spray Dryer B−290中で噴霧乾燥した;(入口温度:90℃、出口温度:130C、レスピレーター100%、流量220g/時間)。続いて、単離された物質を24時間真空下(0−20mbar)で50℃で乾燥した。
収率:6.0g(48.0%)
264.2gのTHF/酢酸エチル(70/30%−m/m)中の化合物(I)の15.8gの溶液に450.0gのn−プロパノールが添加された。混合物から358gの溶媒が留去された(115℃ AT)。得られた懸濁液を5時間以内に10℃に冷却し、10℃でさらに30分間保持した。懸濁液を濾過し、単離した結晶を50mLのn−プロパノールで洗浄し、16時間真空下(0−20mbar)で80℃で乾燥させた。
化合物(1)(形態I)の316gの懸濁液をアセトニトリル/水80:20(v/v)の3.0mLで25日間、周囲温度で平衡化した。生成物を濾過により単離し、4日間、25℃/200mbarで乾燥させた。
方法A
化合物(1)0.5gを5.0gのクロロホルムに懸濁させ、60℃で溶解させた。混合物をGF5フィルターを通して濾過した。続いて溶液を室温まで冷却し、結晶が自発的に形成された。室温で2時間後、結晶を濾過し、24時間真空下(0−20mbar)で50℃で乾燥させた。
収率:0.2g(40%)
方法B
化合物(1)20.0gが60℃(AT)で106.0gのテトラヒドロフランに溶解された。300.0gのアセトニトリルが添加され、混合物が300mlの体積に達するまで蒸留された(95℃)。得られた懸濁液を1−5時間以内に10℃に冷却された。懸濁液を濾過し、単離した結晶を39.1gのアセトニトリルで洗浄し、72時間真空下(0−20mbar)で80℃で乾燥させた。
収率:18.8g(94%)
15.8gのメタノール中の化合物(1)の2.0gの懸濁液を3日間25℃で撹拌した。続いて、白色の懸濁液を濾過し、単離した生成物をオープンウォーターボウル(内部に水蒸気を供給するため)を装備した真空オーブン中で5日間乾燥させた(0−20mbar、50℃)。
収率:1.9g(94.0%)
化合物(1)(形態I)の200mgを23日間、周囲温度で75%−Rhでデシケーター中でインキュベートし、同じ条件下で分析した。
化合物(1)(形態I)の350mgの懸濁液を2−メチルテトラヒドロフランの3.0mL中で28日間、周囲温度で撹拌した。生成物を濾過により単離し、24時間周囲の条件で保存した。
化合物(1)(形態I)の284mgの懸濁液を酢酸の4.0mL中で26日間、周囲温度で撹拌した。生成物を濾過により単離し、4日間、25℃/400mbarで乾燥させた。
Claims (5)
- 薬学的に許容可能なアジュバント又は賦形剤と一緒に、請求項1から4の何れか一項に記載の1つ又は幾つかの結晶を含む薬学的組成物。
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US (1) | US10227298B2 (ja) |
EP (2) | EP3131878A1 (ja) |
JP (2) | JP6621761B2 (ja) |
KR (1) | KR20160138307A (ja) |
CN (1) | CN106458886A (ja) |
AR (1) | AR100095A1 (ja) |
AU (1) | AU2015249018A1 (ja) |
BR (1) | BR112016023767A2 (ja) |
CA (1) | CA2943571A1 (ja) |
ES (1) | ES2928706T3 (ja) |
IL (1) | IL247974A0 (ja) |
MA (1) | MA39877A (ja) |
MX (1) | MX2016013439A (ja) |
PL (1) | PL3459933T3 (ja) |
RU (1) | RU2016144187A (ja) |
SG (1) | SG11201608559QA (ja) |
WO (1) | WO2015158648A1 (ja) |
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EP3458101B1 (en) | 2016-05-20 | 2020-12-30 | H. Hoffnabb-La Roche Ag | Protac antibody conjugates and methods of use |
WO2019213106A1 (en) | 2018-04-30 | 2019-11-07 | Teva Pharmaceuticals International Gmbh | Solid state forms of idasanutlin |
WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
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US8354444B2 (en) * | 2008-09-18 | 2013-01-15 | Hoffmann-La Roche Inc. | Substituted pyrrolidine-2-carboxamides |
US8993614B2 (en) * | 2012-03-15 | 2015-03-31 | F. Hoffmann-La Roche Ag | Substituted pyrrolidine-2-carboxamides |
US9216170B2 (en) * | 2012-03-19 | 2015-12-22 | Hoffmann-La Roche Inc. | Combination therapy for proliferative disorders |
US20130245089A1 (en) * | 2012-03-19 | 2013-09-19 | Hoffmann-La Roche Inc. | Method for administration |
RU2014150492A (ru) * | 2012-05-30 | 2016-07-20 | Ф. Хоффманн-Ля Рош Аг | Замещенные пирролидин-2-карбоксамиды |
AU2014210103B2 (en) * | 2013-01-22 | 2018-09-06 | F. Hoffmann-La Roche Ag | Pharmaceutical composition with improved bioavailability |
RU2015133939A (ru) | 2013-02-21 | 2017-03-27 | Ф. Хоффманн-Ля Рош Аг | Асимметрический синтез замещенного пирролидин-2-карбоксамида |
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US20170037005A1 (en) | 2017-02-09 |
AU2015249018A1 (en) | 2016-10-06 |
JP6621761B2 (ja) | 2019-12-18 |
WO2015158648A1 (en) | 2015-10-22 |
MA39877A (fr) | 2017-02-22 |
EP3459933B1 (en) | 2022-08-24 |
KR20160138307A (ko) | 2016-12-02 |
EP3459933A3 (en) | 2019-05-29 |
BR112016023767A2 (pt) | 2017-08-15 |
AR100095A1 (es) | 2016-09-07 |
EP3131878A1 (en) | 2017-02-22 |
CN106458886A (zh) | 2017-02-22 |
JP2017511362A (ja) | 2017-04-20 |
ES2928706T3 (es) | 2022-11-22 |
JP2019055960A (ja) | 2019-04-11 |
SG11201608559QA (en) | 2016-11-29 |
PL3459933T3 (pl) | 2023-01-23 |
MX2016013439A (es) | 2016-11-17 |
CA2943571A1 (en) | 2015-10-22 |
EP3459933A2 (en) | 2019-03-27 |
RU2016144187A3 (ja) | 2018-11-13 |
RU2016144187A (ru) | 2018-05-16 |
IL247974A0 (en) | 2016-11-30 |
ZA201606653B (en) | 2018-05-30 |
US10227298B2 (en) | 2019-03-12 |
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